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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9002

FusionGeneSummary for CUL9_MUC7

check button Fusion gene summary
Fusion gene informationFusion gene name: CUL9_MUC7
Fusion gene ID: 9002
HgeneTgene
Gene symbol

CUL9

MUC7

Gene ID

23113

4589

Gene namecullin 9mucin 7, secreted
SynonymsH7AP1|PARCMG2
Cytomap

6p21.1

4q13.3

Type of geneprotein-codingprotein-coding
Descriptioncullin-9CUL-9UbcH7-associated protein 1p53-associated parkin-like cytoplasmic proteinparkin-like cytoplasmic p53 binding proteinmucin-7MUC-7apo-MG2mucin 7, salivarysalivary mucin-7
Modification date2018052220180522
UniProtAcc

Q8IWT3

Q8TAX7

Ensembl transtripts involved in fusion geneENST00000252050, ENST00000354495, 
ENST00000372647, ENST00000502937, 
ENST00000413702, ENST00000456088, 
ENST00000304887, ENST00000514512, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 4 X 3=48
# samples 25
** MAII scorelog2(2/8*10)=1.32192809488736log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CUL9 [Title/Abstract] AND MUC7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCUL9

GO:0016567

protein ubiquitination

24793696

TgeneMUC7

GO:0031640

killing of cells of other organism

12543672

TgeneMUC7

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

12543672


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BX537739CUL9chr6

43150467

+MUC7chr4

71346688

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000252050ENST00000413702CUL9chr6

43150467

+MUC7chr4

71346688

+
intron-3CDSENST00000252050ENST00000456088CUL9chr6

43150467

+MUC7chr4

71346688

+
intron-3CDSENST00000252050ENST00000304887CUL9chr6

43150467

+MUC7chr4

71346688

+
intron-3UTRENST00000252050ENST00000514512CUL9chr6

43150467

+MUC7chr4

71346688

+
intron-3CDSENST00000354495ENST00000413702CUL9chr6

43150467

+MUC7chr4

71346688

+
intron-3CDSENST00000354495ENST00000456088CUL9chr6

43150467

+MUC7chr4

71346688

+
intron-3CDSENST00000354495ENST00000304887CUL9chr6

43150467

+MUC7chr4

71346688

+
intron-3UTRENST00000354495ENST00000514512CUL9chr6

43150467

+MUC7chr4

71346688

+
intron-3CDSENST00000372647ENST00000413702CUL9chr6

43150467

+MUC7chr4

71346688

+
intron-3CDSENST00000372647ENST00000456088CUL9chr6

43150467

+MUC7chr4

71346688

+
intron-3CDSENST00000372647ENST00000304887CUL9chr6

43150467

+MUC7chr4

71346688

+
intron-3UTRENST00000372647ENST00000514512CUL9chr6

43150467

+MUC7chr4

71346688

+
intron-3CDSENST00000502937ENST00000413702CUL9chr6

43150467

+MUC7chr4

71346688

+
intron-3CDSENST00000502937ENST00000456088CUL9chr6

43150467

+MUC7chr4

71346688

+
intron-3CDSENST00000502937ENST00000304887CUL9chr6

43150467

+MUC7chr4

71346688

+
intron-3UTRENST00000502937ENST00000514512CUL9chr6

43150467

+MUC7chr4

71346688

+

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FusionProtFeatures for CUL9_MUC7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CUL9

Q8IWT3

MUC7

Q8TAX7

Core component of a Cul9-RING ubiquitin-protein ligasecomplex, a complex that mediates ubiquitination and subsequentdegradation of BIRC5 and is required to maintain microtubuledynamics and genome integrity. Acts downstream of the 3M complex,which inhibits CUL9 activity, leading to prevent ubiquitination ofBIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localizationof p53/TP53 and subsequent function (PubMed:12526791,PubMed:17332328). {ECO:0000269|PubMed:12526791,ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:24793696}. May function in a protective capacity by promoting theclearance of bacteria in the oral cavity and aiding inmastication, speech, and swallowing. Binds P.aeruginosa pili.{ECO:0000269|PubMed:11378823, ECO:0000269|PubMed:8104046}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CUL9_MUC7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CUL9_MUC7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CUL9_MUC7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CUL9_MUC7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource