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Fusion gene ID: 9002 |
FusionGeneSummary for CUL9_MUC7 |
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Fusion gene information | Fusion gene name: CUL9_MUC7 | Fusion gene ID: 9002 | Hgene | Tgene | Gene symbol | CUL9 | MUC7 | Gene ID | 23113 | 4589 |
Gene name | cullin 9 | mucin 7, secreted | |
Synonyms | H7AP1|PARC | MG2 | |
Cytomap | 6p21.1 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | cullin-9CUL-9UbcH7-associated protein 1p53-associated parkin-like cytoplasmic proteinparkin-like cytoplasmic p53 binding protein | mucin-7MUC-7apo-MG2mucin 7, salivarysalivary mucin-7 | |
Modification date | 20180522 | 20180522 | |
UniProtAcc | Q8IWT3 | Q8TAX7 | |
Ensembl transtripts involved in fusion gene | ENST00000252050, ENST00000354495, ENST00000372647, ENST00000502937, | ENST00000413702, ENST00000456088, ENST00000304887, ENST00000514512, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 4 X 3=48 |
# samples | 2 | 5 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CUL9 [Title/Abstract] AND MUC7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CUL9 | GO:0016567 | protein ubiquitination | 24793696 |
Tgene | MUC7 | GO:0031640 | killing of cells of other organism | 12543672 |
Tgene | MUC7 | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 12543672 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BX537739 | CUL9 | chr6 | 43150467 | + | MUC7 | chr4 | 71346688 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000252050 | ENST00000413702 | CUL9 | chr6 | 43150467 | + | MUC7 | chr4 | 71346688 | + |
intron-3CDS | ENST00000252050 | ENST00000456088 | CUL9 | chr6 | 43150467 | + | MUC7 | chr4 | 71346688 | + |
intron-3CDS | ENST00000252050 | ENST00000304887 | CUL9 | chr6 | 43150467 | + | MUC7 | chr4 | 71346688 | + |
intron-3UTR | ENST00000252050 | ENST00000514512 | CUL9 | chr6 | 43150467 | + | MUC7 | chr4 | 71346688 | + |
intron-3CDS | ENST00000354495 | ENST00000413702 | CUL9 | chr6 | 43150467 | + | MUC7 | chr4 | 71346688 | + |
intron-3CDS | ENST00000354495 | ENST00000456088 | CUL9 | chr6 | 43150467 | + | MUC7 | chr4 | 71346688 | + |
intron-3CDS | ENST00000354495 | ENST00000304887 | CUL9 | chr6 | 43150467 | + | MUC7 | chr4 | 71346688 | + |
intron-3UTR | ENST00000354495 | ENST00000514512 | CUL9 | chr6 | 43150467 | + | MUC7 | chr4 | 71346688 | + |
intron-3CDS | ENST00000372647 | ENST00000413702 | CUL9 | chr6 | 43150467 | + | MUC7 | chr4 | 71346688 | + |
intron-3CDS | ENST00000372647 | ENST00000456088 | CUL9 | chr6 | 43150467 | + | MUC7 | chr4 | 71346688 | + |
intron-3CDS | ENST00000372647 | ENST00000304887 | CUL9 | chr6 | 43150467 | + | MUC7 | chr4 | 71346688 | + |
intron-3UTR | ENST00000372647 | ENST00000514512 | CUL9 | chr6 | 43150467 | + | MUC7 | chr4 | 71346688 | + |
intron-3CDS | ENST00000502937 | ENST00000413702 | CUL9 | chr6 | 43150467 | + | MUC7 | chr4 | 71346688 | + |
intron-3CDS | ENST00000502937 | ENST00000456088 | CUL9 | chr6 | 43150467 | + | MUC7 | chr4 | 71346688 | + |
intron-3CDS | ENST00000502937 | ENST00000304887 | CUL9 | chr6 | 43150467 | + | MUC7 | chr4 | 71346688 | + |
intron-3UTR | ENST00000502937 | ENST00000514512 | CUL9 | chr6 | 43150467 | + | MUC7 | chr4 | 71346688 | + |
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FusionProtFeatures for CUL9_MUC7 |
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Hgene | Tgene |
CUL9 | MUC7 |
Core component of a Cul9-RING ubiquitin-protein ligasecomplex, a complex that mediates ubiquitination and subsequentdegradation of BIRC5 and is required to maintain microtubuledynamics and genome integrity. Acts downstream of the 3M complex,which inhibits CUL9 activity, leading to prevent ubiquitination ofBIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localizationof p53/TP53 and subsequent function (PubMed:12526791,PubMed:17332328). {ECO:0000269|PubMed:12526791,ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:24793696}. | May function in a protective capacity by promoting theclearance of bacteria in the oral cavity and aiding inmastication, speech, and swallowing. Binds P.aeruginosa pili.{ECO:0000269|PubMed:11378823, ECO:0000269|PubMed:8104046}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CUL9_MUC7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CUL9_MUC7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CUL9_MUC7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CUL9_MUC7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |