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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 9000

FusionGeneSummary for CUL7_USP10

check button Fusion gene summary
Fusion gene informationFusion gene name: CUL7_USP10
Fusion gene ID: 9000
HgeneTgene
Gene symbol

CUL7

USP10

Gene ID

9820

84669

Gene namecullin 7ubiquitin specific peptidase 32
Synonyms3M1|CUL-7|KIAA0076|dJ20C7.5NY-REN-60|USP10
Cytomap

6p21.1

17q23.1-q23.2

Type of geneprotein-codingprotein-coding
Descriptioncullin-7ubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32
Modification date2018051920180523
UniProtAcc

Q14999

Q14694

Ensembl transtripts involved in fusion geneENST00000265348, ENST00000535468, 
ENST00000478630, 
ENST00000219473, 
ENST00000570191, ENST00000562743, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 5 X 5=150
# samples 36
** MAII scorelog2(3/8*10)=1.90689059560852log2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CUL7 [Title/Abstract] AND USP10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCUL7

GO:0001837

epithelial to mesenchymal transition

20139075

HgeneCUL7

GO:0001890

placenta development

20139075

HgeneCUL7

GO:0016567

protein ubiquitination

18498745


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1430-01ACUL7chr6

43013724

-USP10chr16

84808766

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000265348ENST00000219473CUL7chr6

43013724

-USP10chr16

84808766

+
Frame-shitENST00000265348ENST00000570191CUL7chr6

43013724

-USP10chr16

84808766

+
5CDS-intronENST00000265348ENST00000562743CUL7chr6

43013724

-USP10chr16

84808766

+
Frame-shitENST00000535468ENST00000219473CUL7chr6

43013724

-USP10chr16

84808766

+
Frame-shitENST00000535468ENST00000570191CUL7chr6

43013724

-USP10chr16

84808766

+
5CDS-intronENST00000535468ENST00000562743CUL7chr6

43013724

-USP10chr16

84808766

+
5UTR-3CDSENST00000478630ENST00000219473CUL7chr6

43013724

-USP10chr16

84808766

+
5UTR-3CDSENST00000478630ENST00000570191CUL7chr6

43013724

-USP10chr16

84808766

+
5UTR-intronENST00000478630ENST00000562743CUL7chr6

43013724

-USP10chr16

84808766

+

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FusionProtFeatures for CUL7_USP10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CUL7

Q14999

USP10

Q14694

Core component of the 3M and Cul7-RING(FBXW8) complexes,which mediates the ubiquitination of target proteins. Corecomponent of the 3M complex, a complex required to regulatemicrotubule dynamics and genome integrity. It is unclear how the3M complex regulates microtubules, it could act by controlling thelevel of a microtubule stabilizer (PubMed:24793695). Interactionwith CUL9 is required to inhibit CUL9 activity and ubiquitinationof BIRC5 (PubMed:24793696). Core component of a Cul7-RINGubiquitin-protein ligase with FBXW8, which mediates ubiquitinationand consequent degradation of target proteins such as GORASP1,IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026).Ubiquitination of GORASP1 regulates Golgi morphogenesis anddendrite patterning in brain (PubMed:21572988). Mediatesubiquitination and degradation of IRS1 in a mTOR-dependent manner:the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previouslyphosphorylated by S6 kinase (RPS6KB1 or RPS6KB2)(PubMed:18498745). The Cul7-RING(FBXW8) complex also mediatesubiquitination of MAP4K1/HPK1: recognizes and bindsautophosphorylated MAP4K1/HPK1, leading to its degradation,thereby affecting cell proliferation and differentiation(PubMed:24362026). Acts as a regulator in trophoblast cellepithelial-mesenchymal transition and placental development(PubMed:20139075). Does not promote polyubiquitination andproteasomal degradation of p53/TP53 (PubMed:16547496,PubMed:17332328). While the Cul7-RING(FBXW8) and the 3M complexesare associated and involved in common processes, CUL7 and theCul7-RING(FBXW8) complex may be have additional functions.{ECO:0000269|PubMed:16547496, ECO:0000269|PubMed:17332328,ECO:0000269|PubMed:18498745, ECO:0000269|PubMed:20139075,ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24362026,ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}. Hydrolase that can remove conjugated ubiquitin fromtarget proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as anessential regulator of p53/TP53 stability: in unstressed cells,specifically deubiquitinates p53/TP53 in the cytoplasm, leading tocounteract MDM2 action and stabilize p53/TP53. Following DNAdamage, translocates to the nucleus and deubiquitinates p53/TP53,leading to regulate the p53/TP53-dependent DNA damage response.Component of a regulatory loop that controls autophagy andp53/TP53 levels: mediates deubiquitination of BECN1, a keyregulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexesregulate USP10 stability, suggesting the existence of a regulatorysystem by which PIK3C3/VPS34-containing complexes regulatep53/TP53 protein levels via USP10 and USP13. Does notdeubiquitinate MDM2. Deubiquitinates CFTR in early endosomes,enhancing its endocytic recycling. Involved in a TANK-dependentnegative feedback response to attenuate NF-kappaB activation viadeubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta(IL1B) stimulation or upon DNA damage (PubMed:25861989).Deubiquitinates TBX21 leading to its stabilization(PubMed:24845384). {ECO:0000269|PubMed:11439350,ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555,ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518,ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CUL7_USP10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CUL7_USP10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CUL7RBX1, SKP1, FBXW8, TP53, CCND1, COMMD1, UBE2M, ASB2, OBSL1, PLXNB3, SIRT7, CUL9, FBXO2, ERCC6, TBC1D3, CUL7, MRPL13, MRPL52, VCP, SOX2, MAPK11, LATS2, MAP4K1, MAPK14, CEP250, AAAS, ABCB1, ACAT1, ACIN1, ACLY, ACSL3, ACTA1, ACTBL2, ACTN1, ACTN4, ACTR2, ACTR3, ADAR, AHCY, AHNAK, ANXA1, ANXA2, ANXA5, APP, APRT, ARF1, ARGLU1, ARHGDIA, ARPC1A, ARPC2, ARPC3, ASNA1, ATAD3A, ATIC, ATP1A1, ATP2A2, ATP5A1, ATP5B, ATP5F1, ATP5O, ATP6V1A, AURKB, BAG2, BAG6, BAZ1B, BCLAF1, BOP1, BPTF, BRIX1, C1QBP, APMAP, RTCB, CAD, CALD1, CALR, CANX, CAPZA1, CAPZA2, CAPZB, CBR1, CBX1, CBX3, CBX5, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8, CDC5L, CDK1, CENPF, CFL1, CHCHD3, CHD1, CHD4, CIT, CIZ1, CKAP4, CKB, CLIC1, CLTC, COPA, CORO1C, COX5A, CPSF1, CPSF6, CPSF7, CRKL, CS, CSNK2A1, CSNK2B, CSTF2, CSTF3, CYR61, DARS, DAZAP1, DDB1, DDOST, DDX1, DDX17, DDX18, DDX21, DDX23, DDX27, DDX39B, DDX3X, DDX42, DDX46, DDX47, DDX5, DDX50, DDX56, DDX6, DEK, DHCR7, DHX15, DHX16, DHX9, DKC1, DNAJB11, DNAJC7, DRG1, DSG2, DSP, DYNC1H1, EBNA1BP2, ECHS1, EEF1A1, EEF1B2, EEF1D, EEF1G, EFTUD2, EIF4A1, EIF4A3, EIF4G1, EIF4H, EIF5A, EIF6, ELAVL1, EMD, ENO1, EPPK1, EPRS, ERLIN1, ERP44, ETFA, ETFB, EWSR1, EZR, FASN, FBL, FIP1L1, FKBP4, FLNA, FLNB, FLOT1, FLOT2, FUBP1, FUBP3, FUS, FXR1, GANAB, GAPDH, GART, GCN1L1, GLO1, GLUD1, GNA13, GNB2L1, GNL2, GNL3, GOLGB1, GOT2, GPD2, GPI, GRN, GSN, GSTP1, GTPBP4, H1FX, H2AFV, H2AFY, H2AFY2, HADHA, HADHB, HBA1, HBA2, HDAC2, HEATR1, HINT2, HIST1H1E, HIST1H2BN, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H2AA3, HIST2H2AA4, HIST2H2AB, HIST2H2BE, HIST2H3A, HIST2H3C, HIST2H3D, HIST2H4A, HIST2H4B, HIST4H4, HLA-A, HLA-C, HMGA1, HNRNPA0, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPAB, HNRNPC, HNRNPD, HNRNPF, HNRNPH1, HNRNPH2, HNRNPH3, HNRNPK, HNRNPL, HNRNPR, HNRNPU, HNRNPUL1, HNRNPUL2, HNRNPDL, HP1BP3, HPRT1, HSD17B10, HSD17B4, HSP90AB1, HSP90B1, HSPA5, HSPA9, HSPD1, HYOU1, IARS, IDH3A, IDH3B, IGF2BP1, IGF2BP3, IGHG1, IGLC1, IK, ILF2, ILF3, IMMT, IMPDH2, INA, IPO5, IQGAP1, ITM2C, JUP, KHDRBS1, KHSRP, EMC1, KIF5B, KPNA2, KPNB1, KRT14, KRT17, KRT18, KRT5, KRT6C, LAS1L, LBR, LDHA, LGALS3BP, LIMA1, LMNA, LMNB1, LMNB2, LONP1, LRPPRC, LRRC59, LRWD1, LUC7L3, MACF1, MAP1B, MAPK1, MARS, MATR3, MCM7, MDC1, MDH2, MDN1, MIF, MKI67, NIFK, MLLT4, MMAB, MRE11A, COX2, MTHFD1, MYBBP1A, MYEF2, MYO1B, NAP1L1, NAT10, NCL, NCOA5, NDUFS3, NIPSNAP1, NNT, NOC2L, NOL11, NOL7, NOLC1, NONO, NOP2, NOP56, NOP58, NPEPPS, NPM1, NUDC, NUDT16L1, NUDT21, NUMA1, NUP107, NUP155, NUP160, NUP205, NUP210, NUP214, NUP35, NUP43, NUP93, NUP98, OLA1, P4HB, PA2G4, PABPC1, PABPC4, PAFAH1B3, PARP1, PCBP1, PCBP2, PCMT1, PCNA, PDCD11, PDIA3, PDIA4, PDIA6, PDLIM1, PELP1, PES1, PFKL, PFKP, PFN1, PGK1, PGRMC1, PHB, PHGDH, PHIP, PIN1, PKM, PLD3, PLEC, PNN, POLDIP3, POLR2A, POLR2E, PPAN, PPIA, PPIB, PPP1CA, PPP2R1A, PRDX1, PRDX3, PRDX6, PRKAR1A, PRKCSH, PRKDC, PRMT1, PRMT5, PRPF19, PRPF40A, PRPF6, PRPF8, PSIP1, PSMA5, PSMC5, PSMD11, PSMD2, PSMD6, PSPC1, PTBP1, PTPLAD1, PTPRF, PUF60, PWP2, QARS, RAB10, RAB11B, RAB14, RAB1A, RAB21, RAB5B, RAB5C, RAB7A, RAB9A, RACGAP1, RAD50, RAE1, RALA, RALY, RAN, RANBP2, RANGAP1, RBBP4, RBM10, RBM14, RBM14-RBM4, RBM15, RBM25, RBM39, RBM4, RBMX, RCC1, RCC2, RCN1, RIF1, RNPS1, RPA1, RPF2, RPL10, RPL10A, RPL11, RPL12, RPL13, RPL14, RPL15, RPL18, RPL19, RPL21, RPL23, RPL23A, RPL27A, RPL29, RPL3, RPL35, RPL36, RPL6, RPL7, RPL7A, RPL7L1, RPL8, RPL9, RPLP0, RPLP2, RPS10, RPS13, RPS14, RPS18, RPS2, RPS25, RPS26, UBC, RPS3, RPS3A, RPS4X, RPS5, RPS6, RPS8, RPS9, RPSA, RRBP1, RRP12, RRP15, RRP1B, RRP9, RRS1, RSL1D1, RUVBL1, RUVBL2, SAFB, SAFB2, SAR1A, SART1, SEC22B, SEC23A, SERPINH1, SF1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B6, SF3B2, SF3B3, SFPQ, SHMT2, SLC12A2, SLC1A5, SLC20A1, SLC25A5, SLC3A2, SMARCA5, SMC1A, SMC3, SMCHD1, SMU1, SND1, SNRNP200, SNRNP40, SNRNP70, SNRPA, SNRPA1, SNRPB, SNRPD2, SNRPD3, SNRPE, SNW1, SON, SPEN, SPINT2, SQSTM1, SRRM2, SRRT, SRSF1, SRSF10, SRSF3, SRSF6, SRSF7, SRSF9, SSRP1, STAU1, STIP1, STOML2, SUMO1, SUPT16H, SUPT5H, SUPT6H, SURF4, SYNCRIP, SYNE2, TAF15, TAGLN2, TARDBP, TARS, TBL3, TCOF1, TCP1, TECR, TEX10, TFAM, TFG, TFRC, THOC2, ALYREF, THRAP3, TIAL1, TIMM50, TJP1, TLN1, TMED9, TMEM59, TMOD3, TMPO, TNPO1, TOP1, TOP2A, TOP2B, TOR1A, TPI1, TPM3, TPR, TRAP1, TRIM25, TRIM28, TTN, TUBA1B, TUBA4A, TUBB2B, TUBB4B, TUBB6, TUFM, TXNDC5, U2AF1, U2AF2, U2SURP, UBA1, UBTF, UCHL1, USP39, VTN, WDR18, WDR3, WDR36, WDR43, WDR75, XRCC1, XRCC5, XRCC6, XRN2, YBX1, YES1, YWHAB, YWHAE, YWHAG, YWHAQ, YWHAZ, ZC3H11A, ZC3H14, ZFR, ZNF326, ZNF638, CCDC8, CASQ2, AMBRA1, GLMN, FBXW7, ANKRA2, HDAC4, HDAC5, CDC14A, ZNF669, KLHL2, ZNF408, SSX2, ZNF263, KLHL28, CETN1, APEX2, ZFC3H1, IRS1, MTNR1AUSP10G3BP1, SNX3, SCNN1A, EIF4G1, EIF4G3, G3BP2, CELF1, GAR1, ULK1, TP53, MDM2, CFTR, UBC, AR, WAPAL, ZC3H18, USP15, UBE2S, TSKS, TRPM8, ZNF281, PABPC1, VCP, TARDBP, ANKRD28, PPP6R1, PPP6R3, HECW2, PTEN, ZC3H12A, IKBKG, PCNA, TBX21, USP10, SIRT6, KLHDC3, SF3B3, NTRK1, RAD51, NPM1, RPL10, NOP56, IBTK, PRKAA1, PRKAA2, YBX1, KMT2E, CDC5L, TBP, TANK, TRAF6, HIST2H2AC, MSH2, SNAI1, ANKRD44, ANKRD52, AARSD1, SMEK1, GFAP, PPP6R2, PPP4R2, CYLD, ZEB1, RNF168, RPS6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CUL7_USP10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CUL7_USP10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCUL7C2678312Three M Syndrome 12UNIPROT
HgeneCUL7C0004352Autistic Disorder1CTD_human
HgeneCUL7C0007134Renal Cell Carcinoma1CTD_human