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Fusion gene ID: 9000 |
FusionGeneSummary for CUL7_USP10 |
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Fusion gene information | Fusion gene name: CUL7_USP10 | Fusion gene ID: 9000 | Hgene | Tgene | Gene symbol | CUL7 | USP10 | Gene ID | 9820 | 84669 |
Gene name | cullin 7 | ubiquitin specific peptidase 32 | |
Synonyms | 3M1|CUL-7|KIAA0076|dJ20C7.5 | NY-REN-60|USP10 | |
Cytomap | 6p21.1 | 17q23.1-q23.2 | |
Type of gene | protein-coding | protein-coding | |
Description | cullin-7 | ubiquitin carboxyl-terminal hydrolase 32deubiquitinating enzyme 32renal carcinoma antigen NY-REN-60ubiquitin specific protease 32ubiquitin thioesterase 32ubiquitin thiolesterase 32ubiquitin-specific-processing protease 32 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q14999 | Q14694 | |
Ensembl transtripts involved in fusion gene | ENST00000265348, ENST00000535468, ENST00000478630, | ENST00000219473, ENST00000570191, ENST00000562743, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 5 X 5=150 |
# samples | 3 | 6 | |
** MAII score | log2(3/8*10)=1.90689059560852 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CUL7 [Title/Abstract] AND USP10 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CUL7 | GO:0001837 | epithelial to mesenchymal transition | 20139075 |
Hgene | CUL7 | GO:0001890 | placenta development | 20139075 |
Hgene | CUL7 | GO:0016567 | protein ubiquitination | 18498745 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-24-1430-01A | CUL7 | chr6 | 43013724 | - | USP10 | chr16 | 84808766 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000265348 | ENST00000219473 | CUL7 | chr6 | 43013724 | - | USP10 | chr16 | 84808766 | + |
Frame-shift | ENST00000265348 | ENST00000570191 | CUL7 | chr6 | 43013724 | - | USP10 | chr16 | 84808766 | + |
5CDS-intron | ENST00000265348 | ENST00000562743 | CUL7 | chr6 | 43013724 | - | USP10 | chr16 | 84808766 | + |
Frame-shift | ENST00000535468 | ENST00000219473 | CUL7 | chr6 | 43013724 | - | USP10 | chr16 | 84808766 | + |
Frame-shift | ENST00000535468 | ENST00000570191 | CUL7 | chr6 | 43013724 | - | USP10 | chr16 | 84808766 | + |
5CDS-intron | ENST00000535468 | ENST00000562743 | CUL7 | chr6 | 43013724 | - | USP10 | chr16 | 84808766 | + |
5UTR-3CDS | ENST00000478630 | ENST00000219473 | CUL7 | chr6 | 43013724 | - | USP10 | chr16 | 84808766 | + |
5UTR-3CDS | ENST00000478630 | ENST00000570191 | CUL7 | chr6 | 43013724 | - | USP10 | chr16 | 84808766 | + |
5UTR-intron | ENST00000478630 | ENST00000562743 | CUL7 | chr6 | 43013724 | - | USP10 | chr16 | 84808766 | + |
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FusionProtFeatures for CUL7_USP10 |
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Hgene | Tgene |
CUL7 | USP10 |
Core component of the 3M and Cul7-RING(FBXW8) complexes,which mediates the ubiquitination of target proteins. Corecomponent of the 3M complex, a complex required to regulatemicrotubule dynamics and genome integrity. It is unclear how the3M complex regulates microtubules, it could act by controlling thelevel of a microtubule stabilizer (PubMed:24793695). Interactionwith CUL9 is required to inhibit CUL9 activity and ubiquitinationof BIRC5 (PubMed:24793696). Core component of a Cul7-RINGubiquitin-protein ligase with FBXW8, which mediates ubiquitinationand consequent degradation of target proteins such as GORASP1,IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026).Ubiquitination of GORASP1 regulates Golgi morphogenesis anddendrite patterning in brain (PubMed:21572988). Mediatesubiquitination and degradation of IRS1 in a mTOR-dependent manner:the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previouslyphosphorylated by S6 kinase (RPS6KB1 or RPS6KB2)(PubMed:18498745). The Cul7-RING(FBXW8) complex also mediatesubiquitination of MAP4K1/HPK1: recognizes and bindsautophosphorylated MAP4K1/HPK1, leading to its degradation,thereby affecting cell proliferation and differentiation(PubMed:24362026). Acts as a regulator in trophoblast cellepithelial-mesenchymal transition and placental development(PubMed:20139075). Does not promote polyubiquitination andproteasomal degradation of p53/TP53 (PubMed:16547496,PubMed:17332328). While the Cul7-RING(FBXW8) and the 3M complexesare associated and involved in common processes, CUL7 and theCul7-RING(FBXW8) complex may be have additional functions.{ECO:0000269|PubMed:16547496, ECO:0000269|PubMed:17332328,ECO:0000269|PubMed:18498745, ECO:0000269|PubMed:20139075,ECO:0000269|PubMed:21572988, ECO:0000269|PubMed:24362026,ECO:0000269|PubMed:24793695, ECO:0000269|PubMed:24793696}. | Hydrolase that can remove conjugated ubiquitin fromtarget proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as anessential regulator of p53/TP53 stability: in unstressed cells,specifically deubiquitinates p53/TP53 in the cytoplasm, leading tocounteract MDM2 action and stabilize p53/TP53. Following DNAdamage, translocates to the nucleus and deubiquitinates p53/TP53,leading to regulate the p53/TP53-dependent DNA damage response.Component of a regulatory loop that controls autophagy andp53/TP53 levels: mediates deubiquitination of BECN1, a keyregulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexesregulate USP10 stability, suggesting the existence of a regulatorysystem by which PIK3C3/VPS34-containing complexes regulatep53/TP53 protein levels via USP10 and USP13. Does notdeubiquitinate MDM2. Deubiquitinates CFTR in early endosomes,enhancing its endocytic recycling. Involved in a TANK-dependentnegative feedback response to attenuate NF-kappaB activation viadeubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta(IL1B) stimulation or upon DNA damage (PubMed:25861989).Deubiquitinates TBX21 leading to its stabilization(PubMed:24845384). {ECO:0000269|PubMed:11439350,ECO:0000269|PubMed:18632802, ECO:0000269|PubMed:19398555,ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:21962518,ECO:0000269|PubMed:24845384, ECO:0000269|PubMed:25861989}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CUL7_USP10 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CUL7_USP10 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CUL7 | RBX1, SKP1, FBXW8, TP53, CCND1, COMMD1, UBE2M, ASB2, OBSL1, PLXNB3, SIRT7, CUL9, FBXO2, ERCC6, TBC1D3, CUL7, MRPL13, MRPL52, VCP, SOX2, MAPK11, LATS2, MAP4K1, MAPK14, CEP250, AAAS, ABCB1, ACAT1, ACIN1, ACLY, ACSL3, ACTA1, ACTBL2, ACTN1, ACTN4, ACTR2, ACTR3, ADAR, AHCY, AHNAK, ANXA1, ANXA2, ANXA5, APP, APRT, ARF1, ARGLU1, ARHGDIA, ARPC1A, ARPC2, ARPC3, ASNA1, ATAD3A, ATIC, ATP1A1, ATP2A2, ATP5A1, ATP5B, ATP5F1, ATP5O, ATP6V1A, AURKB, BAG2, BAG6, BAZ1B, BCLAF1, BOP1, BPTF, BRIX1, C1QBP, APMAP, RTCB, CAD, CALD1, CALR, CANX, CAPZA1, CAPZA2, CAPZB, CBR1, CBX1, CBX3, CBX5, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8, CDC5L, CDK1, CENPF, CFL1, CHCHD3, CHD1, CHD4, CIT, CIZ1, CKAP4, CKB, CLIC1, CLTC, COPA, CORO1C, COX5A, CPSF1, CPSF6, CPSF7, CRKL, CS, CSNK2A1, CSNK2B, CSTF2, CSTF3, CYR61, DARS, DAZAP1, DDB1, DDOST, DDX1, DDX17, DDX18, DDX21, DDX23, DDX27, DDX39B, DDX3X, DDX42, DDX46, DDX47, DDX5, DDX50, DDX56, DDX6, DEK, DHCR7, DHX15, DHX16, DHX9, DKC1, DNAJB11, DNAJC7, DRG1, DSG2, DSP, DYNC1H1, EBNA1BP2, ECHS1, EEF1A1, EEF1B2, EEF1D, EEF1G, EFTUD2, EIF4A1, EIF4A3, EIF4G1, EIF4H, EIF5A, EIF6, ELAVL1, EMD, ENO1, EPPK1, EPRS, ERLIN1, ERP44, ETFA, ETFB, EWSR1, EZR, FASN, FBL, FIP1L1, FKBP4, FLNA, FLNB, FLOT1, FLOT2, FUBP1, FUBP3, FUS, FXR1, GANAB, GAPDH, GART, GCN1L1, GLO1, GLUD1, GNA13, GNB2L1, GNL2, GNL3, GOLGB1, GOT2, GPD2, GPI, GRN, GSN, GSTP1, GTPBP4, H1FX, H2AFV, H2AFY, H2AFY2, HADHA, HADHB, HBA1, HBA2, HDAC2, HEATR1, HINT2, HIST1H1E, HIST1H2BN, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H2AA3, HIST2H2AA4, HIST2H2AB, HIST2H2BE, HIST2H3A, HIST2H3C, HIST2H3D, HIST2H4A, HIST2H4B, HIST4H4, HLA-A, HLA-C, HMGA1, HNRNPA0, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPAB, HNRNPC, HNRNPD, HNRNPF, HNRNPH1, HNRNPH2, HNRNPH3, HNRNPK, HNRNPL, HNRNPR, HNRNPU, HNRNPUL1, HNRNPUL2, HNRNPDL, HP1BP3, HPRT1, HSD17B10, HSD17B4, HSP90AB1, HSP90B1, HSPA5, HSPA9, HSPD1, HYOU1, IARS, IDH3A, IDH3B, IGF2BP1, IGF2BP3, IGHG1, IGLC1, IK, ILF2, ILF3, IMMT, IMPDH2, INA, IPO5, IQGAP1, ITM2C, JUP, KHDRBS1, KHSRP, EMC1, KIF5B, KPNA2, KPNB1, KRT14, KRT17, KRT18, KRT5, KRT6C, LAS1L, LBR, LDHA, LGALS3BP, LIMA1, LMNA, LMNB1, LMNB2, LONP1, LRPPRC, LRRC59, LRWD1, LUC7L3, MACF1, MAP1B, MAPK1, MARS, MATR3, MCM7, MDC1, MDH2, MDN1, MIF, MKI67, NIFK, MLLT4, MMAB, MRE11A, COX2, MTHFD1, MYBBP1A, MYEF2, MYO1B, NAP1L1, NAT10, NCL, NCOA5, NDUFS3, NIPSNAP1, NNT, NOC2L, NOL11, NOL7, NOLC1, NONO, NOP2, NOP56, NOP58, NPEPPS, NPM1, NUDC, NUDT16L1, NUDT21, NUMA1, NUP107, NUP155, NUP160, NUP205, NUP210, NUP214, NUP35, NUP43, NUP93, NUP98, OLA1, P4HB, PA2G4, PABPC1, PABPC4, PAFAH1B3, PARP1, PCBP1, PCBP2, PCMT1, PCNA, PDCD11, PDIA3, PDIA4, PDIA6, PDLIM1, PELP1, PES1, PFKL, PFKP, PFN1, PGK1, PGRMC1, PHB, PHGDH, PHIP, PIN1, PKM, PLD3, PLEC, PNN, POLDIP3, POLR2A, POLR2E, PPAN, PPIA, PPIB, PPP1CA, PPP2R1A, PRDX1, PRDX3, PRDX6, PRKAR1A, PRKCSH, PRKDC, PRMT1, PRMT5, PRPF19, PRPF40A, PRPF6, PRPF8, PSIP1, PSMA5, PSMC5, PSMD11, PSMD2, PSMD6, PSPC1, PTBP1, PTPLAD1, PTPRF, PUF60, PWP2, QARS, RAB10, RAB11B, RAB14, RAB1A, RAB21, RAB5B, RAB5C, RAB7A, RAB9A, RACGAP1, RAD50, RAE1, RALA, RALY, RAN, RANBP2, RANGAP1, RBBP4, RBM10, RBM14, RBM14-RBM4, RBM15, RBM25, RBM39, RBM4, RBMX, RCC1, RCC2, RCN1, RIF1, RNPS1, RPA1, RPF2, RPL10, RPL10A, RPL11, RPL12, RPL13, RPL14, RPL15, RPL18, RPL19, RPL21, RPL23, RPL23A, RPL27A, RPL29, RPL3, RPL35, RPL36, RPL6, RPL7, RPL7A, RPL7L1, RPL8, RPL9, RPLP0, RPLP2, RPS10, RPS13, RPS14, RPS18, RPS2, RPS25, RPS26, UBC, RPS3, RPS3A, RPS4X, RPS5, RPS6, RPS8, RPS9, RPSA, RRBP1, RRP12, RRP15, RRP1B, RRP9, RRS1, RSL1D1, RUVBL1, RUVBL2, SAFB, SAFB2, SAR1A, SART1, SEC22B, SEC23A, SERPINH1, SF1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B6, SF3B2, SF3B3, SFPQ, SHMT2, SLC12A2, SLC1A5, SLC20A1, SLC25A5, SLC3A2, SMARCA5, SMC1A, SMC3, SMCHD1, SMU1, SND1, SNRNP200, SNRNP40, SNRNP70, SNRPA, SNRPA1, SNRPB, SNRPD2, SNRPD3, SNRPE, SNW1, SON, SPEN, SPINT2, SQSTM1, SRRM2, SRRT, SRSF1, SRSF10, SRSF3, SRSF6, SRSF7, SRSF9, SSRP1, STAU1, STIP1, STOML2, SUMO1, SUPT16H, SUPT5H, SUPT6H, SURF4, SYNCRIP, SYNE2, TAF15, TAGLN2, TARDBP, TARS, TBL3, TCOF1, TCP1, TECR, TEX10, TFAM, TFG, TFRC, THOC2, ALYREF, THRAP3, TIAL1, TIMM50, TJP1, TLN1, TMED9, TMEM59, TMOD3, TMPO, TNPO1, TOP1, TOP2A, TOP2B, TOR1A, TPI1, TPM3, TPR, TRAP1, TRIM25, TRIM28, TTN, TUBA1B, TUBA4A, TUBB2B, TUBB4B, TUBB6, TUFM, TXNDC5, U2AF1, U2AF2, U2SURP, UBA1, UBTF, UCHL1, USP39, VTN, WDR18, WDR3, WDR36, WDR43, WDR75, XRCC1, XRCC5, XRCC6, XRN2, YBX1, YES1, YWHAB, YWHAE, YWHAG, YWHAQ, YWHAZ, ZC3H11A, ZC3H14, ZFR, ZNF326, ZNF638, CCDC8, CASQ2, AMBRA1, GLMN, FBXW7, ANKRA2, HDAC4, HDAC5, CDC14A, ZNF669, KLHL2, ZNF408, SSX2, ZNF263, KLHL28, CETN1, APEX2, ZFC3H1, IRS1, MTNR1A | USP10 | G3BP1, SNX3, SCNN1A, EIF4G1, EIF4G3, G3BP2, CELF1, GAR1, ULK1, TP53, MDM2, CFTR, UBC, AR, WAPAL, ZC3H18, USP15, UBE2S, TSKS, TRPM8, ZNF281, PABPC1, VCP, TARDBP, ANKRD28, PPP6R1, PPP6R3, HECW2, PTEN, ZC3H12A, IKBKG, PCNA, TBX21, USP10, SIRT6, KLHDC3, SF3B3, NTRK1, RAD51, NPM1, RPL10, NOP56, IBTK, PRKAA1, PRKAA2, YBX1, KMT2E, CDC5L, TBP, TANK, TRAF6, HIST2H2AC, MSH2, SNAI1, ANKRD44, ANKRD52, AARSD1, SMEK1, GFAP, PPP6R2, PPP4R2, CYLD, ZEB1, RNF168, RPS6 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CUL7_USP10 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CUL7_USP10 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CUL7 | C2678312 | Three M Syndrome 1 | 2 | UNIPROT |
Hgene | CUL7 | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | CUL7 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |