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Fusion gene ID: 8997 |
FusionGeneSummary for CUL5_OPCML |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CUL5_OPCML | Fusion gene ID: 8997 | Hgene | Tgene | Gene symbol | CUL5 | OPCML | Gene ID | 8065 | 4978 |
| Gene name | cullin 5 | opioid binding protein/cell adhesion molecule like | |
| Synonyms | CUL-5|VACM-1|VACM1 | IGLON1|OBCAM|OPCM | |
| Cytomap | 11q22.3 | 11q25 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cullin-5Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1)Vasopressin-activated calcium-mobilizing receptor-1vasopressin-activated calcium-mobilizing receptor 1 | opioid-binding protein/cell adhesion moleculeIgLON family member 1opioid binding protein/cell adhesion molecule-like preprotein | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q93034 | Q14982 | |
| Ensembl transtripts involved in fusion gene | ENST00000393094, ENST00000531843, | ENST00000524381, ENST00000529038, ENST00000331898, ENST00000374778, ENST00000541867, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 5 X 4 X 5=100 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CUL5 [Title/Abstract] AND OPCML [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-FC-A4JI-01A | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000393094 | ENST00000524381 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
| 5CDS-5UTR | ENST00000393094 | ENST00000529038 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
| 5CDS-5UTR | ENST00000393094 | ENST00000331898 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
| 5CDS-5UTR | ENST00000393094 | ENST00000374778 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
| 5CDS-5UTR | ENST00000393094 | ENST00000541867 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
| intron-3CDS | ENST00000531843 | ENST00000524381 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
| intron-5UTR | ENST00000531843 | ENST00000529038 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
| intron-5UTR | ENST00000531843 | ENST00000331898 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
| intron-5UTR | ENST00000531843 | ENST00000374778 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
| intron-5UTR | ENST00000531843 | ENST00000541867 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
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FusionProtFeatures for CUL5_OPCML |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CUL5 | OPCML |
| Core component of multiple SCF-like ECS (Elongin-Cullin2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, whichmediate the ubiquitination and subsequent proteasomal degradationof target proteins. As a scaffold protein may contribute tocatalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3ubiquitin-protein ligase complex depends on the variable substraterecognition component. ECS(SOCS1) seems to direct ubiquitinationof JAK2. Seems to be involved in proteosomal degradation ofp53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form acell surface vasopressin receptor. | Binds opioids in the presence of acidic lipids; probablyinvolved in cell contact. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CUL5_OPCML |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CUL5_OPCML |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CUL5 | RNF7, ASB3, TCEB2, TCEB1, VHL, DCUN1D1, RBX1, ANAPC11, ASB4, COPS6, ASB2, ASB1, ASB6, ASB7, ASB12, DIO2, CISH, HSP90AA1, HSPA4, ERBB2, COMMD1, DNMT3B, NOS2, SOCS2, ASB9, SKP2, SOCS6, CAND1, ARRB2, CBFB, FEM1B, WSB1, RAB40B, PCMTD2, KLHDC3, KLHDC2, CUL3, CUL4A, CUL4B, ACTB, ACTBL2, AGL, AHSA1, AIFM1, ANXA1, ANXA11, ANXA6, ANXA7, ASB13, ATAD3B, ATP5A1, BAG4, BTBD1, CCDC184, C14orf166, C1QBP, TEX35, RTCB, DFFB, CARM1, CIRBP, CLTC, COPS2, COPS3, COPS4, COPS5, COPS7A, COPS7B, COPS8, YBX3, CTPS1, CTSD, CUL1, CUL2, DARS, DAZAP1, DCTPP1, DDB1, DDB2, DDX1, DDX56, DDX3X, DDX5, DHX15, DHX30, DHX9, DIS3, LDHD, DNAJA1, DNAJA3, DNAJC10, DPY19L4, EEF1A1, EEF1A2, EEF1B2, EEF1D, EEF2, EFTUD2, AGO2, AGO3, ELAVL1, ENO1, ERCC8, EWSR1, FAM98A, FAR1, FBXO17, FBXW10, FCHO1, FUS, GARS, GART, GDI1, GEMIN5, GLS, GPN1, GPN3, GPS1, GRSF1, HIST1H1C, HIST2H2BE, HNRNPA0, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPAB, HNRNPC, HNRNPCL1, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPK, HNRNPR, HNRNPU, HNRNPUL1, HNRNPDL, HP1BP3, HPRT1, HSD17B10, HSP90AA2P, HSP90AB1, HSP90B1, HSPA1A, HSPA1B, HSPA1L, HSPA5, HSPA7, HSPA8, HSPA9, TOR1AIP2, IGF2BP1, ILF2, ILF3, ILK, CCT4, KHSRP, KLHL42, KLHL15, KLHL18, KRT1, KRT10, KRT13, KRT14, KRT2, KRT24, KRT3, KRT5, KRT6A, KRT6B, KRT75, KRT77, KRT9, LARP1, LDHA, LGALS3BP, IGHV3OR15-7, LRRC41, LUZP1, MAN1B1, MCM7, MRPS2, MUM1, MYEOV2, NAMPT, NAP1L1, NAP1L4, NCBP1, NCL, NEDD8, NFKB1, NKAP, NPM1, NSUN2, NT5DC4, NUDT1, NUP62, OSMR, PABPC1, PABPC4, PABPN1, PCBD1, PCBP1, PCK1, PCMTD1, PCNA, PDCD6, PDIA6, PHGDH, PKM, PLOD1, PLS3, POLR2A, POLR2B, POLR2C, POLR2D, POLR2I, LRR1, PPP2CA, PRDX1, PRDX3, PRKDC, PRPF39, PTBP1, QPCT, RAB40C, RBM3, RCBTB1, RECQL5, RNMT, RPL10A, RPL10P16, RPL11, RPL12, RPL13A, RPL15, RPL18, RPL19, RPL21P19, RPL21, RPL21P16, RPL22, RPL23A, RPL24, RPL26L1, RPL27, RPL27A, RPL29P30, RPL3, RPL31, RPL35, RPL36AP37, HNRNPH2, RPL38, RPL4, RPL5, RPL6, RPL7, RPL7P32, RPL7AP9, RPL7AP27, RPL8, RPLP0, RPLP1, RPLP2, RPS10, RPS13, RPS14, RPS15A, RPS16, RPS18P5, RPS19, RPS2, RPS20, RPS24, RPS25, RPS26P54, RPS28, RPS3, RPS3A, RPS4X, RPS5, RPS6, RPS7, RPS8, RPS9, RPSAP12, RPSAP55, RWDD4, S100A7, S100A9, SAMHD1, SCFD1, SDHA, SERPINB4, SRSF2, SRSF3, SRSF7, SKP1, SLC25A5, SMARCA5, SNRNP200, SNRNP70, SNRPA, SNRPB, SNRPB2, SNRPC, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPG, SOCS4, SOCS7, SPSB3, SSBP1, SSR4, STK4, SYNCRIP, TAF15, TCEB1P3, TFG, TIA1, TIAL1, TNKS2, TOP2A, TOP2B, ACD, TRA2A, TRA2B, TRAP1, TRIM27, TUBA1C, TUBA4A, TUBA4B, TUBB, TUBB1, TUBB4B, TUBB4A, TUFM, TULP4, U2AF2, UBC, UPF1, UPF3B, VPRBP, VPS36, DCAF11, DCAF7, WSB2, XPOT, XRCC6, ZCCHC11, ZNF525, ZNF846, HIST1H4J, HIST4H4, HIST1H4E, HIST1H4H, HIST1H4K, HIST2H4A, HIST1H4D, HIST1H4F, HIST2H4B, HIST1H4C, HIST1H4B, HIST1H4I, HIST1H4L, HIST1H4A, HIST1H2AB, HIST1H2AE, HIST1H2AG, HIST1H2AL, HIST1H2AJ, HIST1H2AK, HIST1H2AI, HIST1H2AM, SOCS3, RHOBTB1, RHOBTB2, UBE2F, DCUN1D2, DCUN1D3, DCUN1D4, DCUN1D5, VCP, SPSB1, SPSB2, SPSB4, SMAD2, SOX30, PTPN5, ARIH2, HIST1H1B, PDE12, SAE1, SHMT2, TPD52L2, UBQLN2, UNC13D, WDR4, ASB5, ASB8, ASB10, ASB14, ASB15, ASB16, ASB18, NEDD4, GOLGA2, CCNDBP1, NXF1, ASB11, RNF2, UBE2M, RAB40A, RAB40AL, DEPTOR, NTRK1, GHR, RHOU, TRAF6, TCEB3, LRRC28, SOCS5, LRRC58, RNF187, FEM1A, FEM1C, NOSIP, METAP2, BTRC, TRIM16, TRIM25 | OPCML | ATXN1, KRT40, KRTAP10-3, NTM, MBLAC2, TRIP12, TMEM214, CANX, NCAM1, FBXO2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CUL5_OPCML |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CUL5_OPCML |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CUL5 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | OPCML | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | OPCML | C1140680 | Malignant neoplasm of ovary | 1 | UNIPROT |
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