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Fusion gene ID: 8997 |
FusionGeneSummary for CUL5_OPCML |
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Fusion gene information | Fusion gene name: CUL5_OPCML | Fusion gene ID: 8997 | Hgene | Tgene | Gene symbol | CUL5 | OPCML | Gene ID | 8065 | 4978 |
Gene name | cullin 5 | opioid binding protein/cell adhesion molecule like | |
Synonyms | CUL-5|VACM-1|VACM1 | IGLON1|OBCAM|OPCM | |
Cytomap | 11q22.3 | 11q25 | |
Type of gene | protein-coding | protein-coding | |
Description | cullin-5Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1)Vasopressin-activated calcium-mobilizing receptor-1vasopressin-activated calcium-mobilizing receptor 1 | opioid-binding protein/cell adhesion moleculeIgLON family member 1opioid binding protein/cell adhesion molecule-like preprotein | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q93034 | Q14982 | |
Ensembl transtripts involved in fusion gene | ENST00000393094, ENST00000531843, | ENST00000524381, ENST00000529038, ENST00000331898, ENST00000374778, ENST00000541867, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 5 X 4 X 5=100 |
# samples | 3 | 5 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CUL5 [Title/Abstract] AND OPCML [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-FC-A4JI-01A | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000393094 | ENST00000524381 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
5CDS-5UTR | ENST00000393094 | ENST00000529038 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
5CDS-5UTR | ENST00000393094 | ENST00000331898 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
5CDS-5UTR | ENST00000393094 | ENST00000374778 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
5CDS-5UTR | ENST00000393094 | ENST00000541867 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
intron-3CDS | ENST00000531843 | ENST00000524381 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
intron-5UTR | ENST00000531843 | ENST00000529038 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
intron-5UTR | ENST00000531843 | ENST00000331898 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
intron-5UTR | ENST00000531843 | ENST00000374778 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
intron-5UTR | ENST00000531843 | ENST00000541867 | CUL5 | chr11 | 107880098 | + | OPCML | chr11 | 132307253 | - |
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FusionProtFeatures for CUL5_OPCML |
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Hgene | Tgene |
CUL5 | OPCML |
Core component of multiple SCF-like ECS (Elongin-Cullin2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, whichmediate the ubiquitination and subsequent proteasomal degradationof target proteins. As a scaffold protein may contribute tocatalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3ubiquitin-protein ligase complex depends on the variable substraterecognition component. ECS(SOCS1) seems to direct ubiquitinationof JAK2. Seems to be involved in proteosomal degradation ofp53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form acell surface vasopressin receptor. | Binds opioids in the presence of acidic lipids; probablyinvolved in cell contact. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CUL5_OPCML |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CUL5_OPCML |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CUL5 | RNF7, ASB3, TCEB2, TCEB1, VHL, DCUN1D1, RBX1, ANAPC11, ASB4, COPS6, ASB2, ASB1, ASB6, ASB7, ASB12, DIO2, CISH, HSP90AA1, HSPA4, ERBB2, COMMD1, DNMT3B, NOS2, SOCS2, ASB9, SKP2, SOCS6, CAND1, ARRB2, CBFB, FEM1B, WSB1, RAB40B, PCMTD2, KLHDC3, KLHDC2, CUL3, CUL4A, CUL4B, ACTB, ACTBL2, AGL, AHSA1, AIFM1, ANXA1, ANXA11, ANXA6, ANXA7, ASB13, ATAD3B, ATP5A1, BAG4, BTBD1, CCDC184, C14orf166, C1QBP, TEX35, RTCB, DFFB, CARM1, CIRBP, CLTC, COPS2, COPS3, COPS4, COPS5, COPS7A, COPS7B, COPS8, YBX3, CTPS1, CTSD, CUL1, CUL2, DARS, DAZAP1, DCTPP1, DDB1, DDB2, DDX1, DDX56, DDX3X, DDX5, DHX15, DHX30, DHX9, DIS3, LDHD, DNAJA1, DNAJA3, DNAJC10, DPY19L4, EEF1A1, EEF1A2, EEF1B2, EEF1D, EEF2, EFTUD2, AGO2, AGO3, ELAVL1, ENO1, ERCC8, EWSR1, FAM98A, FAR1, FBXO17, FBXW10, FCHO1, FUS, GARS, GART, GDI1, GEMIN5, GLS, GPN1, GPN3, GPS1, GRSF1, HIST1H1C, HIST2H2BE, HNRNPA0, HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPAB, HNRNPC, HNRNPCL1, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPK, HNRNPR, HNRNPU, HNRNPUL1, HNRNPDL, HP1BP3, HPRT1, HSD17B10, HSP90AA2P, HSP90AB1, HSP90B1, HSPA1A, HSPA1B, HSPA1L, HSPA5, HSPA7, HSPA8, HSPA9, TOR1AIP2, IGF2BP1, ILF2, ILF3, ILK, CCT4, KHSRP, KLHL42, KLHL15, KLHL18, KRT1, KRT10, KRT13, KRT14, KRT2, KRT24, KRT3, KRT5, KRT6A, KRT6B, KRT75, KRT77, KRT9, LARP1, LDHA, LGALS3BP, IGHV3OR15-7, LRRC41, LUZP1, MAN1B1, MCM7, MRPS2, MUM1, MYEOV2, NAMPT, NAP1L1, NAP1L4, NCBP1, NCL, NEDD8, NFKB1, NKAP, NPM1, NSUN2, NT5DC4, NUDT1, NUP62, OSMR, PABPC1, PABPC4, PABPN1, PCBD1, PCBP1, PCK1, PCMTD1, PCNA, PDCD6, PDIA6, PHGDH, PKM, PLOD1, PLS3, POLR2A, POLR2B, POLR2C, POLR2D, POLR2I, LRR1, PPP2CA, PRDX1, PRDX3, PRKDC, PRPF39, PTBP1, QPCT, RAB40C, RBM3, RCBTB1, RECQL5, RNMT, RPL10A, RPL10P16, RPL11, RPL12, RPL13A, RPL15, RPL18, RPL19, RPL21P19, RPL21, RPL21P16, RPL22, RPL23A, RPL24, RPL26L1, RPL27, RPL27A, RPL29P30, RPL3, RPL31, RPL35, RPL36AP37, HNRNPH2, RPL38, RPL4, RPL5, RPL6, RPL7, RPL7P32, RPL7AP9, RPL7AP27, RPL8, RPLP0, RPLP1, RPLP2, RPS10, RPS13, RPS14, RPS15A, RPS16, RPS18P5, RPS19, RPS2, RPS20, RPS24, RPS25, RPS26P54, RPS28, RPS3, RPS3A, RPS4X, RPS5, RPS6, RPS7, RPS8, RPS9, RPSAP12, RPSAP55, RWDD4, S100A7, S100A9, SAMHD1, SCFD1, SDHA, SERPINB4, SRSF2, SRSF3, SRSF7, SKP1, SLC25A5, SMARCA5, SNRNP200, SNRNP70, SNRPA, SNRPB, SNRPB2, SNRPC, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPG, SOCS4, SOCS7, SPSB3, SSBP1, SSR4, STK4, SYNCRIP, TAF15, TCEB1P3, TFG, TIA1, TIAL1, TNKS2, TOP2A, TOP2B, ACD, TRA2A, TRA2B, TRAP1, TRIM27, TUBA1C, TUBA4A, TUBA4B, TUBB, TUBB1, TUBB4B, TUBB4A, TUFM, TULP4, U2AF2, UBC, UPF1, UPF3B, VPRBP, VPS36, DCAF11, DCAF7, WSB2, XPOT, XRCC6, ZCCHC11, ZNF525, ZNF846, HIST1H4J, HIST4H4, HIST1H4E, HIST1H4H, HIST1H4K, HIST2H4A, HIST1H4D, HIST1H4F, HIST2H4B, HIST1H4C, HIST1H4B, HIST1H4I, HIST1H4L, HIST1H4A, HIST1H2AB, HIST1H2AE, HIST1H2AG, HIST1H2AL, HIST1H2AJ, HIST1H2AK, HIST1H2AI, HIST1H2AM, SOCS3, RHOBTB1, RHOBTB2, UBE2F, DCUN1D2, DCUN1D3, DCUN1D4, DCUN1D5, VCP, SPSB1, SPSB2, SPSB4, SMAD2, SOX30, PTPN5, ARIH2, HIST1H1B, PDE12, SAE1, SHMT2, TPD52L2, UBQLN2, UNC13D, WDR4, ASB5, ASB8, ASB10, ASB14, ASB15, ASB16, ASB18, NEDD4, GOLGA2, CCNDBP1, NXF1, ASB11, RNF2, UBE2M, RAB40A, RAB40AL, DEPTOR, NTRK1, GHR, RHOU, TRAF6, TCEB3, LRRC28, SOCS5, LRRC58, RNF187, FEM1A, FEM1C, NOSIP, METAP2, BTRC, TRIM16, TRIM25 | OPCML | ATXN1, KRT40, KRTAP10-3, NTM, MBLAC2, TRIP12, TMEM214, CANX, NCAM1, FBXO2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CUL5_OPCML |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CUL5_OPCML |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CUL5 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | OPCML | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | OPCML | C1140680 | Malignant neoplasm of ovary | 1 | UNIPROT |