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Fusion gene ID: 8988 |
FusionGeneSummary for CUL4A_DLEU7 |
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Fusion gene information | Fusion gene name: CUL4A_DLEU7 | Fusion gene ID: 8988 | Hgene | Tgene | Gene symbol | CUL4A | DLEU7 | Gene ID | 8451 | 220107 |
Gene name | cullin 4A | deleted in lymphocytic leukemia, 7 | |
Synonyms | - | - | |
Cytomap | 13q34 | 13q14.3 | |
Type of gene | protein-coding | protein-coding | |
Description | cullin-4ACUL-4A | leukemia-associated protein 7 | |
Modification date | 20180523 | 20180329 | |
UniProtAcc | Q13619 | Q6UYE1 | |
Ensembl transtripts involved in fusion gene | ENST00000375441, ENST00000451881, ENST00000326335, ENST00000375440, ENST00000463426, | ENST00000400393, ENST00000443723, ENST00000504404, | |
Fusion gene scores | * DoF score | 7 X 10 X 9=630 | 2 X 2 X 2=8 |
# samples | 13 | 2 | |
** MAII score | log2(13/630*10)=-2.27684020535882 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: CUL4A [Title/Abstract] AND DLEU7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-EJ-A7NH-01A | CUL4A | chr13 | 113864402 | + | DLEU7 | chr13 | 51397656 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-intron | ENST00000375441 | ENST00000400393 | CUL4A | chr13 | 113864402 | + | DLEU7 | chr13 | 51397656 | - |
5UTR-intron | ENST00000375441 | ENST00000443723 | CUL4A | chr13 | 113864402 | + | DLEU7 | chr13 | 51397656 | - |
5UTR-intron | ENST00000375441 | ENST00000504404 | CUL4A | chr13 | 113864402 | + | DLEU7 | chr13 | 51397656 | - |
5UTR-intron | ENST00000451881 | ENST00000400393 | CUL4A | chr13 | 113864402 | + | DLEU7 | chr13 | 51397656 | - |
5UTR-intron | ENST00000451881 | ENST00000443723 | CUL4A | chr13 | 113864402 | + | DLEU7 | chr13 | 51397656 | - |
5UTR-intron | ENST00000451881 | ENST00000504404 | CUL4A | chr13 | 113864402 | + | DLEU7 | chr13 | 51397656 | - |
intron-intron | ENST00000326335 | ENST00000400393 | CUL4A | chr13 | 113864402 | + | DLEU7 | chr13 | 51397656 | - |
intron-intron | ENST00000326335 | ENST00000443723 | CUL4A | chr13 | 113864402 | + | DLEU7 | chr13 | 51397656 | - |
intron-intron | ENST00000326335 | ENST00000504404 | CUL4A | chr13 | 113864402 | + | DLEU7 | chr13 | 51397656 | - |
5CDS-intron | ENST00000375440 | ENST00000400393 | CUL4A | chr13 | 113864402 | + | DLEU7 | chr13 | 51397656 | - |
5CDS-intron | ENST00000375440 | ENST00000443723 | CUL4A | chr13 | 113864402 | + | DLEU7 | chr13 | 51397656 | - |
5CDS-intron | ENST00000375440 | ENST00000504404 | CUL4A | chr13 | 113864402 | + | DLEU7 | chr13 | 51397656 | - |
3UTR-intron | ENST00000463426 | ENST00000400393 | CUL4A | chr13 | 113864402 | + | DLEU7 | chr13 | 51397656 | - |
3UTR-intron | ENST00000463426 | ENST00000443723 | CUL4A | chr13 | 113864402 | + | DLEU7 | chr13 | 51397656 | - |
3UTR-intron | ENST00000463426 | ENST00000504404 | CUL4A | chr13 | 113864402 | + | DLEU7 | chr13 | 51397656 | - |
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FusionProtFeatures for CUL4A_DLEU7 |
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Hgene | Tgene |
CUL4A | DLEU7 |
Core component of multiple cullin-RING-based E3ubiquitin-protein ligase complexes which mediate theubiquitination of target proteins. As a scaffold protein maycontribute to catalysis through positioning of the substrate andthe ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligaseactivity of the complex is dependent on the neddylation of thecullin subunit and is inhibited by the association of thedeneddylated cullin subunit with TIP120A/CAND1. The functionalspecificity of the E3 ubiquitin-protein ligase complex depends onthe variable substrate recognition component. DCX(DET1-COP1)directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination ofXPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required forefficient histone deposition during replication-coupled (H3.1) andreplication-independent (H3.3) nucleosome assembly, probably byfacilitating the transfer of H3 from ASF1A/ASF1B to otherchaperones involved in histone deposition. DCX(DTL) plays a rolein PCNA-dependent polyubiquitination of CDT1 and MDM2-dependentubiquitination of TP53 in response to radiation-induced DNA damageand during DNA replication. In association with DDB1 and SKP2probably is involved in ubiquitination of CDKN1B/p27kip. Isinvolved in ubiquitination of HOXA9. DCX(DTL) directsautoubiquitination of DTL. {ECO:0000269|PubMed:14578910,ECO:0000269|PubMed:14609952, ECO:0000269|PubMed:15448697,ECO:0000269|PubMed:15548678, ECO:0000269|PubMed:16537899,ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:23478445,ECO:0000269|PubMed:24209620}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CUL4A_DLEU7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CUL4A_DLEU7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CUL4A | RNF7, DET1, RFWD2, CAND1, RBX1, HSPA1A, HSP90AA1, NEDD8, TUBA1B, CDKN1A, DDB1, DDB2, CUL4B, FBXW5, NF2, SAP130, CDKN1B, COPS5, COPS6, PTGS2, UBC, PCNA, TRPC4AP, DDA1, CRBN, COPS3, COPS4, COPS2, COPS8, COPS7B, COPS7A, DCAF11, DCAF5, BRWD1, PHIP, DCAF6, DCAF12, DCAF10, DCAF4, WDTC1, SKP2, TOR1AIP2, BANF1, EMD, DTL, WDR26, GRWD1, RBBP5, WDR5B, POC1B, SNRNP40, WDR61, WDR76, WDR82, WDR5, TLE2, EED, HIST1H3A, CDT1, CHEK1, COMMD1, DNMT3B, VPRBP, UBXN7, MYC, KAT2A, RASSF1, RAG1, SALL2, RAD21, HOXA9, HOXB4, GPS1, GLMN, MCM10, NACC1, CTNNB1, TP53, MDM2, CUL1, RBBP7, FBXW8, WSB1, WSB2, NUP43, BTRC, PWP1, RBBP4, ERCC8, CUL4A, DCUN1D1, AK9, DCST1, DCAF8, AMBRA1, DCAF12L2, DCAF16, CUL5, DCAF4L1, IGF2BP1, IGHV3OR15-7, MYEOV2, ANAPC5, CDY2B, CDY2A, OTULIN, LOC285556, NXPH3, RGS12, SCAF11, SH3RF2, SLA, TCHP, USP7, MAP4, ABCA10, XXYLT1, SYNM, ZNF407, ZNF525, CSRP2BP, RPL26, SLC25A22, SFXN1, HSPA8, TFG, CUL3, KRT10, DCAF7, CA2, KLHL9, KRT1, TUBA4B, FUS, HSPA1B, KRT9, TUBB4B, HSP90B1, PSMC6, SKP1, TUBA4A, EWSR1, H2AFV, HAX1, HNRNPA2B1, HNRNPUL1, HSPA1L, IARS, KRT2, KRT24, PCBD1, SNRPD1, TUBA1C, TUBB1, HNRNPH1, HNRNPH3, HSPA5, LGALS3BP, NCL, PABPC1, PPP2R1A, SNRPA, SNRPB, CCT5, DNAJC10, EEF1A1, EEF1A2, ENO1, HNRNPAB, HNRNPF, HNRNPDL, HSPA7, HSPA9, KRT76, PRDX1, QPCT, RPL15, RPL7A, RPLP2, RPS2, SRSF3, SLC25A5, SLC25A6, SSBP1, TAF15, TUBB, BAG4, C1QBP, DDX21, DDX5, DHX15, DHX9, HIST1H2AB, HIST1H2AE, HIST1H2AG, HIST1H2AL, HIST1H2AJ, HIST1H2AK, HIST1H2AI, HIST1H2AM, HNRNPD, HSP90AB1, HSPD1, KRT75, NFKB1, NPM1, PABPC4, RPL10A, RPL11, RPL19, RPL22, RPL23A, RPL38, RPL4, RPL7AP27, RPLP1, RPS14, RPS15A, RPS18, RPS20, RPS3, SDHA, SNRNP70, SNRPD3, SNRPE, TIA1, TIAL1, CSN1S1, MYB, LRWD1, ERCC6, UBE2E3, GRK5, SENP8, DCAF15, SUGT1, CHEK2, RPTOR, DCUN1D2, DCUN1D3, DCUN1D4, DCUN1D5, DDIT4, SF3B3, DICER1, DLC1, CAST, PRMT5, ASB4, HIST1H1C, DAB2IP, DCAF17, IP6K1, HIST1H1A, VCP, ARIH1, ABCE1, CLCN1, DCAF4L2, C9orf41, MRPS11, CCNG1, TUBG1, SAMHD1, UNK, MTM1, IFI16, CENPA, HIST1H2BG, PYGO2, GNB2, GNB1, GNB3, GNB4, GNB5, MCM2, DPPA4, NANOG, POU5F1, UVRAG, SLBP, FKBP8, IKZF3, ATP6V0D1, TMCO3, CRYBA4, TRIM16, TRIM25, LATS1, TWIST1, TES, SIRT7 | DLEU7 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CUL4A_DLEU7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CUL4A_DLEU7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CUL4A | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |