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Fusion gene ID: 8987 |
FusionGeneSummary for CUL4A_CUL4A |
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Fusion gene information | Fusion gene name: CUL4A_CUL4A | Fusion gene ID: 8987 | Hgene | Tgene | Gene symbol | CUL4A | CUL4A | Gene ID | 8451 | 8451 |
Gene name | cullin 4A | cullin 4A | |
Synonyms | - | - | |
Cytomap | 13q34 | 13q34 | |
Type of gene | protein-coding | protein-coding | |
Description | cullin-4ACUL-4A | cullin-4ACUL-4A | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q13619 | Q13619 | |
Ensembl transtripts involved in fusion gene | ENST00000375441, ENST00000451881, ENST00000326335, ENST00000375440, ENST00000463426, | ENST00000375441, ENST00000451881, ENST00000326335, ENST00000375440, ENST00000463426, | |
Fusion gene scores | * DoF score | 7 X 10 X 9=630 | 5 X 7 X 5=175 |
# samples | 13 | 8 | |
** MAII score | log2(13/630*10)=-2.27684020535882 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/175*10)=-1.12928301694497 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CUL4A [Title/Abstract] AND CUL4A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW389415 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + | ||
ChiTaRS3.1 | BE925870 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + | ||
ChiTaRS3.1 | AA995801 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + | ||
ChiTaRS3.1 | BF327003 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000375441 | ENST00000375441 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
intron-intron | ENST00000375441 | ENST00000451881 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
intron-intron | ENST00000375441 | ENST00000326335 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
intron-intron | ENST00000375441 | ENST00000375440 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
intron-3UTR | ENST00000375441 | ENST00000463426 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
intron-intron | ENST00000451881 | ENST00000375441 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
intron-intron | ENST00000451881 | ENST00000451881 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
intron-intron | ENST00000451881 | ENST00000326335 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
intron-intron | ENST00000451881 | ENST00000375440 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
intron-3UTR | ENST00000451881 | ENST00000463426 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
intron-intron | ENST00000326335 | ENST00000375441 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
intron-intron | ENST00000326335 | ENST00000451881 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
intron-intron | ENST00000326335 | ENST00000326335 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
intron-intron | ENST00000326335 | ENST00000375440 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
intron-3UTR | ENST00000326335 | ENST00000463426 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
intron-intron | ENST00000375440 | ENST00000375441 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
intron-intron | ENST00000375440 | ENST00000451881 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
intron-intron | ENST00000375440 | ENST00000326335 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
intron-intron | ENST00000375440 | ENST00000375440 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
intron-3UTR | ENST00000375440 | ENST00000463426 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
3UTR-intron | ENST00000463426 | ENST00000375441 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
3UTR-intron | ENST00000463426 | ENST00000451881 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
3UTR-intron | ENST00000463426 | ENST00000326335 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
3UTR-intron | ENST00000463426 | ENST00000375440 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
3UTR-3UTR | ENST00000463426 | ENST00000463426 | CUL4A | chr13 | 113884340 | - | CUL4A | chr13 | 113884071 | + |
In-frame | ENST00000375441 | ENST00000375441 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
In-frame | ENST00000375441 | ENST00000451881 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
In-frame | ENST00000375441 | ENST00000326335 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
In-frame | ENST00000375441 | ENST00000375440 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
5CDS-intron | ENST00000375441 | ENST00000463426 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
In-frame | ENST00000451881 | ENST00000375441 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
In-frame | ENST00000451881 | ENST00000451881 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
In-frame | ENST00000451881 | ENST00000326335 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
In-frame | ENST00000451881 | ENST00000375440 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
5CDS-intron | ENST00000451881 | ENST00000463426 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
In-frame | ENST00000326335 | ENST00000375441 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
In-frame | ENST00000326335 | ENST00000451881 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
In-frame | ENST00000326335 | ENST00000326335 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
In-frame | ENST00000326335 | ENST00000375440 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
5CDS-intron | ENST00000326335 | ENST00000463426 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
In-frame | ENST00000375440 | ENST00000375441 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
In-frame | ENST00000375440 | ENST00000451881 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
In-frame | ENST00000375440 | ENST00000326335 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
In-frame | ENST00000375440 | ENST00000375440 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
5CDS-intron | ENST00000375440 | ENST00000463426 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
intron-3CDS | ENST00000463426 | ENST00000375441 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
intron-3CDS | ENST00000463426 | ENST00000451881 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
intron-3CDS | ENST00000463426 | ENST00000326335 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
intron-3CDS | ENST00000463426 | ENST00000375440 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
intron-intron | ENST00000463426 | ENST00000463426 | CUL4A | chr13 | 113909032 | - | CUL4A | chr13 | 113909351 | + |
intron-intron | ENST00000375441 | ENST00000375441 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
intron-3UTR | ENST00000375441 | ENST00000451881 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
intron-3UTR | ENST00000375441 | ENST00000326335 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
intron-intron | ENST00000375441 | ENST00000375440 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
intron-intron | ENST00000375441 | ENST00000463426 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
3UTR-intron | ENST00000451881 | ENST00000375441 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
3UTR-3UTR | ENST00000451881 | ENST00000451881 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
3UTR-3UTR | ENST00000451881 | ENST00000326335 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
3UTR-intron | ENST00000451881 | ENST00000375440 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
3UTR-intron | ENST00000451881 | ENST00000463426 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
3UTR-intron | ENST00000326335 | ENST00000375441 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
3UTR-3UTR | ENST00000326335 | ENST00000451881 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
3UTR-3UTR | ENST00000326335 | ENST00000326335 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
3UTR-intron | ENST00000326335 | ENST00000375440 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
3UTR-intron | ENST00000326335 | ENST00000463426 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
intron-intron | ENST00000375440 | ENST00000375441 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
intron-3UTR | ENST00000375440 | ENST00000451881 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
intron-3UTR | ENST00000375440 | ENST00000326335 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
intron-intron | ENST00000375440 | ENST00000375440 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
intron-intron | ENST00000375440 | ENST00000463426 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
intron-intron | ENST00000463426 | ENST00000375441 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
intron-3UTR | ENST00000463426 | ENST00000451881 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
intron-3UTR | ENST00000463426 | ENST00000326335 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
intron-intron | ENST00000463426 | ENST00000375440 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
intron-intron | ENST00000463426 | ENST00000463426 | CUL4A | chr13 | 113918502 | - | CUL4A | chr13 | 113918587 | + |
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FusionProtFeatures for CUL4A_CUL4A |
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Hgene | Tgene |
CUL4A | CUL4A |
Core component of multiple cullin-RING-based E3ubiquitin-protein ligase complexes which mediate theubiquitination of target proteins. As a scaffold protein maycontribute to catalysis through positioning of the substrate andthe ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligaseactivity of the complex is dependent on the neddylation of thecullin subunit and is inhibited by the association of thedeneddylated cullin subunit with TIP120A/CAND1. The functionalspecificity of the E3 ubiquitin-protein ligase complex depends onthe variable substrate recognition component. DCX(DET1-COP1)directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination ofXPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required forefficient histone deposition during replication-coupled (H3.1) andreplication-independent (H3.3) nucleosome assembly, probably byfacilitating the transfer of H3 from ASF1A/ASF1B to otherchaperones involved in histone deposition. DCX(DTL) plays a rolein PCNA-dependent polyubiquitination of CDT1 and MDM2-dependentubiquitination of TP53 in response to radiation-induced DNA damageand during DNA replication. In association with DDB1 and SKP2probably is involved in ubiquitination of CDKN1B/p27kip. Isinvolved in ubiquitination of HOXA9. DCX(DTL) directsautoubiquitination of DTL. {ECO:0000269|PubMed:14578910,ECO:0000269|PubMed:14609952, ECO:0000269|PubMed:15448697,ECO:0000269|PubMed:15548678, ECO:0000269|PubMed:16537899,ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:23478445,ECO:0000269|PubMed:24209620}. | Core component of multiple cullin-RING-based E3ubiquitin-protein ligase complexes which mediate theubiquitination of target proteins. As a scaffold protein maycontribute to catalysis through positioning of the substrate andthe ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligaseactivity of the complex is dependent on the neddylation of thecullin subunit and is inhibited by the association of thedeneddylated cullin subunit with TIP120A/CAND1. The functionalspecificity of the E3 ubiquitin-protein ligase complex depends onthe variable substrate recognition component. DCX(DET1-COP1)directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination ofXPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required forefficient histone deposition during replication-coupled (H3.1) andreplication-independent (H3.3) nucleosome assembly, probably byfacilitating the transfer of H3 from ASF1A/ASF1B to otherchaperones involved in histone deposition. DCX(DTL) plays a rolein PCNA-dependent polyubiquitination of CDT1 and MDM2-dependentubiquitination of TP53 in response to radiation-induced DNA damageand during DNA replication. In association with DDB1 and SKP2probably is involved in ubiquitination of CDKN1B/p27kip. Isinvolved in ubiquitination of HOXA9. DCX(DTL) directsautoubiquitination of DTL. {ECO:0000269|PubMed:14578910,ECO:0000269|PubMed:14609952, ECO:0000269|PubMed:15448697,ECO:0000269|PubMed:15548678, ECO:0000269|PubMed:16537899,ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:23478445,ECO:0000269|PubMed:24209620}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CUL4A_CUL4A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CUL4A_CUL4A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CUL4A_CUL4A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CUL4A_CUL4A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CUL4A | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |
Tgene | CUL4A | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |