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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8963

FusionGeneSummary for CTU2_ZC3H18

check button Fusion gene summary
Fusion gene informationFusion gene name: CTU2_ZC3H18
Fusion gene ID: 8963
HgeneTgene
Gene symbol

CTU2

ZC3H18

Gene ID

348180

124245

Gene namecytosolic thiouridylase subunit 2zinc finger CCCH-type containing 18
SynonymsC16orf84|NCS2|UPF0432NHN1
Cytomap

16q24.3

16q24.2

Type of geneprotein-codingprotein-coding
Descriptioncytoplasmic tRNA 2-thiolation protein 2cytosolic thiouridylase subunit 2 homologzinc finger CCCH domain-containing protein 18conserved nuclear protein NHN1nuclear protein NHN1
Modification date2018052320180519
UniProtAcc

Q2VPK5

Q86VM9

Ensembl transtripts involved in fusion geneENST00000453996, ENST00000378384, 
ENST00000312060, ENST00000567949, 
ENST00000301011, ENST00000452588, 
Fusion gene scores* DoF score3 X 3 X 3=275 X 5 X 4=100
# samples 35
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTU2 [Title/Abstract] AND ZC3H18 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-39-5035-01ACTU2chr16

88773618

+ZC3H18chr16

88675342

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000453996ENST00000301011CTU2chr16

88773618

+ZC3H18chr16

88675342

+
In-frameENST00000453996ENST00000452588CTU2chr16

88773618

+ZC3H18chr16

88675342

+
5UTR-3CDSENST00000378384ENST00000301011CTU2chr16

88773618

+ZC3H18chr16

88675342

+
5UTR-3CDSENST00000378384ENST00000452588CTU2chr16

88773618

+ZC3H18chr16

88675342

+
In-frameENST00000312060ENST00000301011CTU2chr16

88773618

+ZC3H18chr16

88675342

+
In-frameENST00000312060ENST00000452588CTU2chr16

88773618

+ZC3H18chr16

88675342

+
In-frameENST00000567949ENST00000301011CTU2chr16

88773618

+ZC3H18chr16

88675342

+
In-frameENST00000567949ENST00000452588CTU2chr16

88773618

+ZC3H18chr16

88675342

+

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FusionProtFeatures for CTU2_ZC3H18


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTU2

Q2VPK5

ZC3H18

Q86VM9

Plays a central role in 2-thiolation of mcm(5)S(2)U attRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Mayact by forming a heterodimer with CTU1/ATPBD3 that ligates sulfurfrom thiocarboxylated URM1 onto the uridine of tRNAs at wobbleposition. {ECO:0000255|HAMAP-Rule:MF_03054,ECO:0000269|PubMed:19017811}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZC3H18chr16:88773618chr16:88675342ENST00000301011+518399_464362954Coiled coilOntology_term=ECO:0000255
TgeneZC3H18chr16:88773618chr16:88675342ENST00000301011+518921_950362954Coiled coilOntology_term=ECO:0000255
TgeneZC3H18chr16:88773618chr16:88675342ENST00000301011+518532_746362954Compositional biasNote=Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZC3H18chr16:88773618chr16:88675342ENST00000301011+518105_134362954Coiled coilOntology_term=ECO:0000255
TgeneZC3H18chr16:88773618chr16:88675342ENST00000301011+518201_204362954Compositional biasNote=Poly-Asp
TgeneZC3H18chr16:88773618chr16:88675342ENST00000301011+518259_296362954Compositional biasNote=Pro-rich
TgeneZC3H18chr16:88773618chr16:88675342ENST00000301011+518219_245362954Zinc fingerC3H1-type


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FusionGeneSequence for CTU2_ZC3H18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTU2_ZC3H18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTU2CTU1, MMS19, FAM96B, CIAO1, KLHL20, WISP2, UROS, KCTD17, RRAGA, NFKBIA, FAS, FAM219A, VAPB, CCNDBP1, LBHD1, TINAG, MYCL, THUMPD3, ZMAT5, CCDC120, PFDN4, POLM, RAB8B, RGS20, FAM174A, CEP72, APEX2, FAM19A3, SLC5A5, PROSER2ZC3H18OSBPL10, SMARCAD1, SF3A2, SIRT7, TERF1, TERF2, CUL3, NHP2L1, CDC5L, UBE2S, USP10, BUD31, SAFB, SF3B3, SF3B6, S100A9, USP39, NCSTN, SEPT2, HNRNPC, SMU1, SF3A1, HNRNPU, PSIP1, TRPM8, WDR70, VASN, RBM14, RBMX, HP1BP3, LGR4, CSNK2A2, MOV10, NXF1, LUC7L, LUC7L2, C9orf41, PTGER3, EPB41L3, NTRK1, RNPS1, RPL6, RTF1, SLC3A2, SRRM2, ACIN1, BRD4, LEO1, NUMA1, PNN, SNRPD2, SRRT, SSRP1, SUPT16H, KRAS, FBXW11, SRPK2, CLK1, CCNA2, RBM7, FERMT3, MZT1, FBXW7, ZC3H13, FNBP4, KIAA1429, CLK4, CLK3, RBBP6, YTHDC1, C10orf2, PRPF38B, CLK2, PRPF40A, TOPORS, ZFC3H1, RBM15B, RBMXL1, ZCCHC8, PRPF4B, SRSF12, PPHLN1, NKTR, SRSF8, CAMKV, ZC3H14, RBM25, CPSF4, WDR33, APOBEC3F, RBM6, TRA2A, TSPYL1, ERMAP, EXOSC10, SRSF1, RSBN1, AQR, RALY, CRNKL1, ELAVL2, DHX35, XAB2, PPIG, MKRN2, WDR83, U2AF2, ZC3H11A, SYF2, ZNF816, NKAP, PIP5K1A, SRSF10, TSPYL2, RBM15, NFKBIL1, CDC40, FIP1L1, SLTM, UPF1, KEAP1, CTR9, JPH4, SRRM1, ZNF214, GSPT2, ISY1, VANGL1, PPIE, SNW1, ZCCHC3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTU2_ZC3H18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTU2_ZC3H18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource