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Fusion gene ID: 8963 |
FusionGeneSummary for CTU2_ZC3H18 |
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Fusion gene information | Fusion gene name: CTU2_ZC3H18 | Fusion gene ID: 8963 | Hgene | Tgene | Gene symbol | CTU2 | ZC3H18 | Gene ID | 348180 | 124245 |
Gene name | cytosolic thiouridylase subunit 2 | zinc finger CCCH-type containing 18 | |
Synonyms | C16orf84|NCS2|UPF0432 | NHN1 | |
Cytomap | 16q24.3 | 16q24.2 | |
Type of gene | protein-coding | protein-coding | |
Description | cytoplasmic tRNA 2-thiolation protein 2cytosolic thiouridylase subunit 2 homolog | zinc finger CCCH domain-containing protein 18conserved nuclear protein NHN1nuclear protein NHN1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q2VPK5 | Q86VM9 | |
Ensembl transtripts involved in fusion gene | ENST00000453996, ENST00000378384, ENST00000312060, ENST00000567949, | ENST00000301011, ENST00000452588, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 5 X 5 X 4=100 |
# samples | 3 | 5 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CTU2 [Title/Abstract] AND ZC3H18 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-39-5035-01A | CTU2 | chr16 | 88773618 | + | ZC3H18 | chr16 | 88675342 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000453996 | ENST00000301011 | CTU2 | chr16 | 88773618 | + | ZC3H18 | chr16 | 88675342 | + |
In-frame | ENST00000453996 | ENST00000452588 | CTU2 | chr16 | 88773618 | + | ZC3H18 | chr16 | 88675342 | + |
5UTR-3CDS | ENST00000378384 | ENST00000301011 | CTU2 | chr16 | 88773618 | + | ZC3H18 | chr16 | 88675342 | + |
5UTR-3CDS | ENST00000378384 | ENST00000452588 | CTU2 | chr16 | 88773618 | + | ZC3H18 | chr16 | 88675342 | + |
In-frame | ENST00000312060 | ENST00000301011 | CTU2 | chr16 | 88773618 | + | ZC3H18 | chr16 | 88675342 | + |
In-frame | ENST00000312060 | ENST00000452588 | CTU2 | chr16 | 88773618 | + | ZC3H18 | chr16 | 88675342 | + |
In-frame | ENST00000567949 | ENST00000301011 | CTU2 | chr16 | 88773618 | + | ZC3H18 | chr16 | 88675342 | + |
In-frame | ENST00000567949 | ENST00000452588 | CTU2 | chr16 | 88773618 | + | ZC3H18 | chr16 | 88675342 | + |
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FusionProtFeatures for CTU2_ZC3H18 |
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Hgene | Tgene |
CTU2 | ZC3H18 |
Plays a central role in 2-thiolation of mcm(5)S(2)U attRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Mayact by forming a heterodimer with CTU1/ATPBD3 that ligates sulfurfrom thiocarboxylated URM1 onto the uridine of tRNAs at wobbleposition. {ECO:0000255|HAMAP-Rule:MF_03054,ECO:0000269|PubMed:19017811}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >ZC3H18 | chr16:88773618 | chr16:88675342 | ENST00000301011 | + | 5 | 18 | 399_464 | 362 | 954 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >ZC3H18 | chr16:88773618 | chr16:88675342 | ENST00000301011 | + | 5 | 18 | 921_950 | 362 | 954 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | >ZC3H18 | chr16:88773618 | chr16:88675342 | ENST00000301011 | + | 5 | 18 | 532_746 | 362 | 954 | Compositional bias | Note=Ser-rich |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | ZC3H18 | chr16:88773618 | chr16:88675342 | ENST00000301011 | + | 5 | 18 | 105_134 | 362 | 954 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | ZC3H18 | chr16:88773618 | chr16:88675342 | ENST00000301011 | + | 5 | 18 | 201_204 | 362 | 954 | Compositional bias | Note=Poly-Asp |
Tgene | ZC3H18 | chr16:88773618 | chr16:88675342 | ENST00000301011 | + | 5 | 18 | 259_296 | 362 | 954 | Compositional bias | Note=Pro-rich |
Tgene | ZC3H18 | chr16:88773618 | chr16:88675342 | ENST00000301011 | + | 5 | 18 | 219_245 | 362 | 954 | Zinc finger | C3H1-type |
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FusionGeneSequence for CTU2_ZC3H18 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CTU2_ZC3H18 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CTU2 | CTU1, MMS19, FAM96B, CIAO1, KLHL20, WISP2, UROS, KCTD17, RRAGA, NFKBIA, FAS, FAM219A, VAPB, CCNDBP1, LBHD1, TINAG, MYCL, THUMPD3, ZMAT5, CCDC120, PFDN4, POLM, RAB8B, RGS20, FAM174A, CEP72, APEX2, FAM19A3, SLC5A5, PROSER2 | ZC3H18 | OSBPL10, SMARCAD1, SF3A2, SIRT7, TERF1, TERF2, CUL3, NHP2L1, CDC5L, UBE2S, USP10, BUD31, SAFB, SF3B3, SF3B6, S100A9, USP39, NCSTN, SEPT2, HNRNPC, SMU1, SF3A1, HNRNPU, PSIP1, TRPM8, WDR70, VASN, RBM14, RBMX, HP1BP3, LGR4, CSNK2A2, MOV10, NXF1, LUC7L, LUC7L2, C9orf41, PTGER3, EPB41L3, NTRK1, RNPS1, RPL6, RTF1, SLC3A2, SRRM2, ACIN1, BRD4, LEO1, NUMA1, PNN, SNRPD2, SRRT, SSRP1, SUPT16H, KRAS, FBXW11, SRPK2, CLK1, CCNA2, RBM7, FERMT3, MZT1, FBXW7, ZC3H13, FNBP4, KIAA1429, CLK4, CLK3, RBBP6, YTHDC1, C10orf2, PRPF38B, CLK2, PRPF40A, TOPORS, ZFC3H1, RBM15B, RBMXL1, ZCCHC8, PRPF4B, SRSF12, PPHLN1, NKTR, SRSF8, CAMKV, ZC3H14, RBM25, CPSF4, WDR33, APOBEC3F, RBM6, TRA2A, TSPYL1, ERMAP, EXOSC10, SRSF1, RSBN1, AQR, RALY, CRNKL1, ELAVL2, DHX35, XAB2, PPIG, MKRN2, WDR83, U2AF2, ZC3H11A, SYF2, ZNF816, NKAP, PIP5K1A, SRSF10, TSPYL2, RBM15, NFKBIL1, CDC40, FIP1L1, SLTM, UPF1, KEAP1, CTR9, JPH4, SRRM1, ZNF214, GSPT2, ISY1, VANGL1, PPIE, SNW1, ZCCHC3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CTU2_ZC3H18 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CTU2_ZC3H18 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |