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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8956

FusionGeneSummary for CTTN_PSME2

check button Fusion gene summary
Fusion gene informationFusion gene name: CTTN_PSME2
Fusion gene ID: 8956
HgeneTgene
Gene symbol

CTTN

PSME2

Gene ID

2017

5721

Gene namecortactinproteasome activator subunit 2
SynonymsEMS1PA28B|PA28beta|REGbeta
Cytomap

11q13.3

14q12

Type of geneprotein-codingprotein-coding
Descriptionsrc substrate cortactin1110020L01Rikamplaxinems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)oncogene EMS1proteasome activator complex subunit 211S regulator complex beta subunit11S regulator complex subunit betaMCP activator, 31-kD subunitREG-betaactivator of multicatalytic protease subunit 2cell migration-inducing protein 22proteasome (prosome, macro
Modification date2018052220180523
UniProtAcc

Q14247

Q9UL46

Ensembl transtripts involved in fusion geneENST00000346329, ENST00000301843, 
ENST00000527622, ENST00000376561, 
ENST00000538675, 
ENST00000560410, 
ENST00000216802, ENST00000471700, 
Fusion gene scores* DoF score24 X 15 X 9=32402 X 2 X 2=8
# samples 262
** MAII scorelog2(26/3240*10)=-3.63941028474353
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: CTTN [Title/Abstract] AND PSME2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A2-A0EQ-01ACTTNchr11

70244720

+PSME2chr14

24612880

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000346329ENST00000560410CTTNchr11

70244720

+PSME2chr14

24612880

-
5UTR-3CDSENST00000346329ENST00000216802CTTNchr11

70244720

+PSME2chr14

24612880

-
5UTR-5UTRENST00000346329ENST00000471700CTTNchr11

70244720

+PSME2chr14

24612880

-
5UTR-3CDSENST00000301843ENST00000560410CTTNchr11

70244720

+PSME2chr14

24612880

-
5UTR-3CDSENST00000301843ENST00000216802CTTNchr11

70244720

+PSME2chr14

24612880

-
5UTR-5UTRENST00000301843ENST00000471700CTTNchr11

70244720

+PSME2chr14

24612880

-
3UTR-3CDSENST00000527622ENST00000560410CTTNchr11

70244720

+PSME2chr14

24612880

-
3UTR-3CDSENST00000527622ENST00000216802CTTNchr11

70244720

+PSME2chr14

24612880

-
3UTR-5UTRENST00000527622ENST00000471700CTTNchr11

70244720

+PSME2chr14

24612880

-
5UTR-3CDSENST00000376561ENST00000560410CTTNchr11

70244720

+PSME2chr14

24612880

-
5UTR-3CDSENST00000376561ENST00000216802CTTNchr11

70244720

+PSME2chr14

24612880

-
5UTR-5UTRENST00000376561ENST00000471700CTTNchr11

70244720

+PSME2chr14

24612880

-
intron-3CDSENST00000538675ENST00000560410CTTNchr11

70244720

+PSME2chr14

24612880

-
intron-3CDSENST00000538675ENST00000216802CTTNchr11

70244720

+PSME2chr14

24612880

-
intron-5UTRENST00000538675ENST00000471700CTTNchr11

70244720

+PSME2chr14

24612880

-

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FusionProtFeatures for CTTN_PSME2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTTN

Q14247

PSME2

Q9UL46

Contributes to the organization of the actincytoskeleton and cell shape (PubMed:21296879). Plays a role in theformation of lamellipodia and in cell migration. Plays a role inthe regulation of neuron morphology, axon growth and formation ofneuronal growth cones (By similarity). Through its interactionwith CTTNBP2, involved in the regulation of neuronal spine density(By similarity). Plays a role in the invasiveness of cancer cells,and the formation of metastases (PubMed:16636290). Plays a role infocal adhesion assembly and turnover (By similarity). In complexwith ABL1 and MYLK regulates cortical actin-based cytoskeletalrearrangement critical to sphingosine 1-phosphate (S1P)-mediatedendothelial cell (EC) barrier enhancement (PubMed:20861316). Playsa role in intracellular protein transport and endocytosis, and inmodulating the levels of potassium channels present at the cellmembrane (PubMed:17959782). Plays a role in receptor-mediatedendocytosis via clathrin-coated pits (By similarity). Required forstabilization of KCNH1 channels at the cell membrane(PubMed:23144454). {ECO:0000250|UniProtKB:Q60598,ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290,ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879,ECO:0000269|PubMed:23144454}. Implicated in immunoproteasome assembly and required forefficient antigen processing. The PA28 activator complex enhancesthe generation of class I binding peptides by altering thecleavage pattern of the proteasome.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTTN_PSME2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTTN_PSME2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTTNSHANK2, WIPF1, CTNND1, CHD3, FER, WASL, ARHGAP17, CRB2, CASP3, MYLK, ACTR2, ACTR3, ARPC2, ARPC4, ARPC3, KCNA2, SYK, SDC3, SIRT1, EP300, HDAC6, RAD21, BTRC, ELAVL1, ARRB1, ARRB2, CD2AP, ASAP1, SH3PXD2A, PTK2, TINF2, ACD, CBLL1, CUL3, PXN, TNK2, GRB2, SDHAF2, SART3, THY1, PLAUR, UBL4A, SUCLG2, OXCT1, ABI1, NONO, CORO1B, DNM2, ATF2, NCF1, PAN2, NPM1, LMNA, ACTG1, APEH, ATG7, ATP6V1C1, CTNNA1, GARS, IDE, ME1, RDX, SHMT1, SHMT2, SSB, STAT1, VTA1, GSPT1, GSPT2, SARS, SNX1, SNX2, UGDH, RPA3, RPA2, RPA1, CTTN, CDC37, SPRR2A, OBSL1, EGFR, COPS7A, HEXIM1, MYO1E, USO1, NTRK1, EWSR1, CAPZA2, DBN1, FLNA, KIFC3, MLH1, MYH9, PPP1CB, IQGAP1, SYNCRIP, SYNPO, MYO5C, MYO19, NOP9, MYO18A, TRIM15, NEDD9, SNW1, KCNA3, SMURF1, YES1, CDH1, PDHA1, TES, KEAP1, TXNIPPSME2PSME2, PSME1, MGMT, PARD3, PSMA2, PSMB6, PSMB9, PSMA4, PSMD6, PSMB7, PSMB8, PSMB10, APP, PSMC5, PSMC2, PSMA5, PSMA1, PSMB3, PSMA6, PSMA3, PSMB1, PSMD7, PSMC1, PSMD2, PSMC4, PSMB5, PSMD1, CAP1, PTMA, GARS, DDTL, TNN, CFTR, PARK2, BAG3, NHLH1, EPHA2, MYOD1, SHFM1, PSMD14, NAA10, CTRL, PSMB4, NTRK1, MCM2, U2AF2, PSMB2, SPPL2B, FBXO7, TMCO3, CDK15, SDCBP, FGB, RNF26, HSD17B10, SOD1, CCND2, SIRT7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTTN_PSME2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTTN_PSME2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCTTNC0007137Squamous cell carcinoma1CTD_human
HgeneCTTNC0023531Leukoplakia1CTD_human
HgeneCTTNC3495559Juvenile arthritis1CTD_human
TgenePSME2C0019693HIV Infections1CTD_human
TgenePSME2C0023893Liver Cirrhosis, Experimental1CTD_human
TgenePSME2C0279626Squamous cell carcinoma of esophagus1CTD_human