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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8955

FusionGeneSummary for CTTN_PPP6R3

check button Fusion gene summary
Fusion gene informationFusion gene name: CTTN_PPP6R3
Fusion gene ID: 8955
HgeneTgene
Gene symbol

CTTN

PPP6R3

Gene ID

2017

55291

Gene namecortactinprotein phosphatase 6 regulatory subunit 3
SynonymsEMS1C11orf23|PP6R3|SAP190|SAPL|SAPLa|SAPS3
Cytomap

11q13.3

11q13.2

Type of geneprotein-codingprotein-coding
Descriptionsrc substrate cortactin1110020L01Rikamplaxinems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate)oncogene EMS1serine/threonine-protein phosphatase 6 regulatory subunit 3SAPS domain family, member 3sporulation-induced transcript 4-associated protein SAPL
Modification date2018052220180520
UniProtAcc

Q14247

Q5H9R7

Ensembl transtripts involved in fusion geneENST00000346329, ENST00000301843, 
ENST00000527622, ENST00000376561, 
ENST00000538675, 
ENST00000393799, 
ENST00000530427, ENST00000393800, 
ENST00000534534, ENST00000524845, 
ENST00000265637, ENST00000524904, 
ENST00000393801, ENST00000265636, 
ENST00000529710, ENST00000527403, 
Fusion gene scores* DoF score24 X 15 X 9=324015 X 15 X 6=1350
# samples 2619
** MAII scorelog2(26/3240*10)=-3.63941028474353
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(19/1350*10)=-2.82888808360725
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTTN [Title/Abstract] AND PPP6R3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPP6R3

GO:0043666

regulation of phosphoprotein phosphatase activity

16716191


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E9-A1NA-01ACTTNchr11

70265962

+PPP6R3chr11

68315535

+
TCGALDSKCMTCGA-YG-AA3P-06ACTTNchr11

70271507

+PPP6R3chr11

68350511

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000346329ENST00000393799CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000346329ENST00000530427CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000346329ENST00000393800CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000346329ENST00000534534CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000346329ENST00000524845CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000346329ENST00000265637CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000346329ENST00000524904CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000346329ENST00000393801CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000346329ENST00000265636CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000346329ENST00000529710CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000346329ENST00000527403CTTNchr11

70265962

+PPP6R3chr11

68315535

+
Frame-shitENST00000301843ENST00000393799CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000301843ENST00000530427CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000301843ENST00000393800CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000301843ENST00000534534CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000301843ENST00000524845CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000301843ENST00000265637CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000301843ENST00000524904CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000301843ENST00000393801CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000301843ENST00000265636CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000301843ENST00000529710CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000301843ENST00000527403CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-3CDSENST00000527622ENST00000393799CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000527622ENST00000530427CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000527622ENST00000393800CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000527622ENST00000534534CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000527622ENST00000524845CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000527622ENST00000265637CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000527622ENST00000524904CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000527622ENST00000393801CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000527622ENST00000265636CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000527622ENST00000529710CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000527622ENST00000527403CTTNchr11

70265962

+PPP6R3chr11

68315535

+
Frame-shitENST00000376561ENST00000393799CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000376561ENST00000530427CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000376561ENST00000393800CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000376561ENST00000534534CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000376561ENST00000524845CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000376561ENST00000265637CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000376561ENST00000524904CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000376561ENST00000393801CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000376561ENST00000265636CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000376561ENST00000529710CTTNchr11

70265962

+PPP6R3chr11

68315535

+
5CDS-intronENST00000376561ENST00000527403CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-3CDSENST00000538675ENST00000393799CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000538675ENST00000530427CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000538675ENST00000393800CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000538675ENST00000534534CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000538675ENST00000524845CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000538675ENST00000265637CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000538675ENST00000524904CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000538675ENST00000393801CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000538675ENST00000265636CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000538675ENST00000529710CTTNchr11

70265962

+PPP6R3chr11

68315535

+
intron-intronENST00000538675ENST00000527403CTTNchr11

70265962

+PPP6R3chr11

68315535

+
Frame-shitENST00000346329ENST00000393799CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000346329ENST00000530427CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000346329ENST00000393800CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000346329ENST00000534534CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000346329ENST00000524845CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000346329ENST00000265637CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000346329ENST00000524904CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000346329ENST00000393801CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000346329ENST00000265636CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000346329ENST00000529710CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000346329ENST00000527403CTTNchr11

70271507

+PPP6R3chr11

68350511

+
Frame-shitENST00000301843ENST00000393799CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000301843ENST00000530427CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000301843ENST00000393800CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000301843ENST00000534534CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000301843ENST00000524845CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000301843ENST00000265637CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000301843ENST00000524904CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000301843ENST00000393801CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000301843ENST00000265636CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000301843ENST00000529710CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000301843ENST00000527403CTTNchr11

70271507

+PPP6R3chr11

68350511

+
intron-3CDSENST00000527622ENST00000393799CTTNchr11

70271507

+PPP6R3chr11

68350511

+
intron-intronENST00000527622ENST00000530427CTTNchr11

70271507

+PPP6R3chr11

68350511

+
intron-intronENST00000527622ENST00000393800CTTNchr11

70271507

+PPP6R3chr11

68350511

+
intron-intronENST00000527622ENST00000534534CTTNchr11

70271507

+PPP6R3chr11

68350511

+
intron-intronENST00000527622ENST00000524845CTTNchr11

70271507

+PPP6R3chr11

68350511

+
intron-intronENST00000527622ENST00000265637CTTNchr11

70271507

+PPP6R3chr11

68350511

+
intron-intronENST00000527622ENST00000524904CTTNchr11

70271507

+PPP6R3chr11

68350511

+
intron-intronENST00000527622ENST00000393801CTTNchr11

70271507

+PPP6R3chr11

68350511

+
intron-intronENST00000527622ENST00000265636CTTNchr11

70271507

+PPP6R3chr11

68350511

+
intron-intronENST00000527622ENST00000529710CTTNchr11

70271507

+PPP6R3chr11

68350511

+
intron-intronENST00000527622ENST00000527403CTTNchr11

70271507

+PPP6R3chr11

68350511

+
Frame-shitENST00000376561ENST00000393799CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000376561ENST00000530427CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000376561ENST00000393800CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000376561ENST00000534534CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000376561ENST00000524845CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000376561ENST00000265637CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000376561ENST00000524904CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000376561ENST00000393801CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000376561ENST00000265636CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000376561ENST00000529710CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000376561ENST00000527403CTTNchr11

70271507

+PPP6R3chr11

68350511

+
Frame-shitENST00000538675ENST00000393799CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000538675ENST00000530427CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000538675ENST00000393800CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000538675ENST00000534534CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000538675ENST00000524845CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000538675ENST00000265637CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000538675ENST00000524904CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000538675ENST00000393801CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000538675ENST00000265636CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000538675ENST00000529710CTTNchr11

70271507

+PPP6R3chr11

68350511

+
5CDS-intronENST00000538675ENST00000527403CTTNchr11

70271507

+PPP6R3chr11

68350511

+

Top

FusionProtFeatures for CTTN_PPP6R3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTTN

Q14247

PPP6R3

Q5H9R7

Contributes to the organization of the actincytoskeleton and cell shape (PubMed:21296879). Plays a role in theformation of lamellipodia and in cell migration. Plays a role inthe regulation of neuron morphology, axon growth and formation ofneuronal growth cones (By similarity). Through its interactionwith CTTNBP2, involved in the regulation of neuronal spine density(By similarity). Plays a role in the invasiveness of cancer cells,and the formation of metastases (PubMed:16636290). Plays a role infocal adhesion assembly and turnover (By similarity). In complexwith ABL1 and MYLK regulates cortical actin-based cytoskeletalrearrangement critical to sphingosine 1-phosphate (S1P)-mediatedendothelial cell (EC) barrier enhancement (PubMed:20861316). Playsa role in intracellular protein transport and endocytosis, and inmodulating the levels of potassium channels present at the cellmembrane (PubMed:17959782). Plays a role in receptor-mediatedendocytosis via clathrin-coated pits (By similarity). Required forstabilization of KCNH1 channels at the cell membrane(PubMed:23144454). {ECO:0000250|UniProtKB:Q60598,ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:16636290,ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:21296879,ECO:0000269|PubMed:23144454}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTTN_PPP6R3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTTN_PPP6R3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTTNSHANK2, WIPF1, CTNND1, CHD3, FER, WASL, ARHGAP17, CRB2, CASP3, MYLK, ACTR2, ACTR3, ARPC2, ARPC4, ARPC3, KCNA2, SYK, SDC3, SIRT1, EP300, HDAC6, RAD21, BTRC, ELAVL1, ARRB1, ARRB2, CD2AP, ASAP1, SH3PXD2A, PTK2, TINF2, ACD, CBLL1, CUL3, PXN, TNK2, GRB2, SDHAF2, SART3, THY1, PLAUR, UBL4A, SUCLG2, OXCT1, ABI1, NONO, CORO1B, DNM2, ATF2, NCF1, PAN2, NPM1, LMNA, ACTG1, APEH, ATG7, ATP6V1C1, CTNNA1, GARS, IDE, ME1, RDX, SHMT1, SHMT2, SSB, STAT1, VTA1, GSPT1, GSPT2, SARS, SNX1, SNX2, UGDH, RPA3, RPA2, RPA1, CTTN, CDC37, SPRR2A, OBSL1, EGFR, COPS7A, HEXIM1, MYO1E, USO1, NTRK1, EWSR1, CAPZA2, DBN1, FLNA, KIFC3, MLH1, MYH9, PPP1CB, IQGAP1, SYNCRIP, SYNPO, MYO5C, MYO19, NOP9, MYO18A, TRIM15, NEDD9, SNW1, KCNA3, SMURF1, YES1, CDH1, PDHA1, TES, KEAP1, TXNIPPPP6R3KDM6A, TNFAIP3, USP21, USP36, USP49, PPP6C, PRKDC, HDAC1, HDAC2, ELAVL1, SIRT7, TERF2IP, TINF2, TFAP4, GRK5, PFAS, BRCA1, ECT2, NOTCH1, LATS1, GPSM1, HDAC11, USP10, ANKRD28, MOB1A, MOB1B, ACAD11, ANKRD44, ANKRD52, AP1B1, AP2A1, AP2A2, AURKA, DNAJC11, ECH1, ERLIN2, PPP6R1, PPP6R2, CDC37, ENAH, ETFA, HSP90AA1, HSP90AB1, RUVBL2, SRRT, TPM1, USP7, CSNK1E, SNAI2, RNF2, GPHA2, RPS6KB2, UNK, DIEXF, NSUN5, EIF4A3, TIPRL, NTRK1, CEP44, CEP19, XPO1, ZNRF2, ZNF746, TRMT2A, TRIM25, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTTN_PPP6R3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTTN_PPP6R3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCTTNC0007137Squamous cell carcinoma1CTD_human
HgeneCTTNC0023531Leukoplakia1CTD_human
HgeneCTTNC3495559Juvenile arthritis1CTD_human