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Fusion gene ID: 8921 |
FusionGeneSummary for CTSS_STYX |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CTSS_STYX | Fusion gene ID: 8921 | Hgene | Tgene | Gene symbol | CTSS | STYX | Gene ID | 1520 | 6815 |
| Gene name | cathepsin S | serine/threonine/tyrosine interacting protein | |
| Synonyms | - | - | |
| Cytomap | 1q21.3 | 14q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cathepsin S | serine/threonine/tyrosine-interacting proteinprotein tyrosine phosphatase-like protein | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P25774 | Q8WUJ0 | |
| Ensembl transtripts involved in fusion gene | ENST00000368985, ENST00000448301, ENST00000480760, | ENST00000442123, ENST00000354586, ENST00000556861, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 5 X 5 X 2=50 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/50*10)=0 | |
| Context | PubMed: CTSS [Title/Abstract] AND STYX [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CTSS | GO:0006508 | proteolysis | 12788072|22864553 |
| Hgene | CTSS | GO:0010447 | response to acidic pH | 22864553 |
| Hgene | CTSS | GO:0016485 | protein processing | 22864553 |
| Hgene | CTSS | GO:0030574 | collagen catabolic process | 22952693 |
| Hgene | CTSS | GO:0034769 | basement membrane disassembly | 22952693 |
| Hgene | CTSS | GO:0048002 | antigen processing and presentation of peptide antigen | 8612130 |
| Hgene | CTSS | GO:0051603 | proteolysis involved in cellular protein catabolic process | 22952693 |
| Hgene | CTSS | GO:2001259 | positive regulation of cation channel activity | 22864553 |
| Tgene | STYX | GO:0032091 | negative regulation of protein binding | 28007894 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CA748546 | CTSS | chr1 | 150705276 | + | STYX | chr14 | 53241158 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000368985 | ENST00000442123 | CTSS | chr1 | 150705276 | + | STYX | chr14 | 53241158 | - |
| intron-3UTR | ENST00000368985 | ENST00000354586 | CTSS | chr1 | 150705276 | + | STYX | chr14 | 53241158 | - |
| intron-intron | ENST00000368985 | ENST00000556861 | CTSS | chr1 | 150705276 | + | STYX | chr14 | 53241158 | - |
| intron-3UTR | ENST00000448301 | ENST00000442123 | CTSS | chr1 | 150705276 | + | STYX | chr14 | 53241158 | - |
| intron-3UTR | ENST00000448301 | ENST00000354586 | CTSS | chr1 | 150705276 | + | STYX | chr14 | 53241158 | - |
| intron-intron | ENST00000448301 | ENST00000556861 | CTSS | chr1 | 150705276 | + | STYX | chr14 | 53241158 | - |
| intron-3UTR | ENST00000480760 | ENST00000442123 | CTSS | chr1 | 150705276 | + | STYX | chr14 | 53241158 | - |
| intron-3UTR | ENST00000480760 | ENST00000354586 | CTSS | chr1 | 150705276 | + | STYX | chr14 | 53241158 | - |
| intron-intron | ENST00000480760 | ENST00000556861 | CTSS | chr1 | 150705276 | + | STYX | chr14 | 53241158 | - |
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FusionProtFeatures for CTSS_STYX |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CTSS | STYX |
| Thiol protease. Key protease responsible for the removalof the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to thespecificities of cathepsin L. | Catalytically inactive phosphatase (PubMed:23847209).Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2)(PubMed:23847209). Modulates cell-fate decisions and cellmigration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2)(PubMed:23847209). By binding to the F-box of FBXW7, prevents theassembly of FBXW7 into the SCF E3 ubiquitin-protein ligasecomplex, and thereby inhibits degradation of its substrates(PubMed:28007894). Plays a role in spermatogenesis (Bysimilarity). {ECO:0000250|UniProtKB:Q60969,ECO:0000269|PubMed:23847209, ECO:0000269|PubMed:28007894}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CTSS_STYX |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CTSS_STYX |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CTSS_STYX |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CTSS_STYX |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CTSS | C0011616 | Contact Dermatitis | 1 | CTD_human |
| Hgene | CTSS | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | CTSS | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Hgene | CTSS | C0028754 | Obesity | 1 | CTD_human |
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