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Fusion gene ID: 8912 |
FusionGeneSummary for CTSH_RASGRF1 |
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Fusion gene information | Fusion gene name: CTSH_RASGRF1 | Fusion gene ID: 8912 | Hgene | Tgene | Gene symbol | CTSH | RASGRF1 | Gene ID | 1512 | 5923 |
Gene name | cathepsin H | Ras protein specific guanine nucleotide releasing factor 1 | |
Synonyms | ACC-4|ACC-5|ACC4|ACC5|CPSB | CDC25|CDC25L|GNRP|GRF1|GRF55|H-GRF55|PP13187|ras-GRF1 | |
Cytomap | 15q25.1 | 15q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | pro-cathepsin HN-benzoylarginine-beta-naphthylamide hydrolasealeuraincathepsin B3cathepsin BA | ras-specific guanine nucleotide-releasing factor 1Ras-specific guanine nucleotide-releasing factor, CDC25 homologRas-specific nucleotide exchange factor CDC25guanine nucleotide exchange factorguanine nucleotide-releasing factor 1guanine nucleotide-re | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P09668 | Q13972 | |
Ensembl transtripts involved in fusion gene | ENST00000220166, ENST00000534533, | ENST00000558480, ENST00000419573, ENST00000560334, ENST00000394745, | |
Fusion gene scores | * DoF score | 2 X 3 X 3=18 | 3 X 4 X 3=36 |
# samples | 3 | 3 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CTSH [Title/Abstract] AND RASGRF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CTSH | GO:0002764 | immune response-regulating signaling pathway | 16822283 |
Hgene | CTSH | GO:0006508 | proteolysis | 6203523|8811434 |
Hgene | CTSH | GO:0010628 | positive regulation of gene expression | 21217776 |
Hgene | CTSH | GO:0010813 | neuropeptide catabolic process | 15127951 |
Hgene | CTSH | GO:0010815 | bradykinin catabolic process | 15127951 |
Hgene | CTSH | GO:0010952 | positive regulation of peptidase activity | 20435891 |
Hgene | CTSH | GO:0030335 | positive regulation of cell migration | 21217776 |
Hgene | CTSH | GO:0031638 | zymogen activation | 20435891 |
Hgene | CTSH | GO:0033619 | membrane protein proteolysis | 14766755 |
Hgene | CTSH | GO:0043129 | surfactant homeostasis | 18216060 |
Hgene | CTSH | GO:0070371 | ERK1 and ERK2 cascade | 21217776 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-D8-A27R-01A | CTSH | chr15 | 79221754 | - | RASGRF1 | chr15 | 79254578 | - |
TCGA | RV | LUAD | TCGA-86-8056-01A | CTSH | chr15 | 79237233 | - | RASGRF1 | chr15 | 79320201 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000220166 | ENST00000558480 | CTSH | chr15 | 79221754 | - | RASGRF1 | chr15 | 79254578 | - |
Frame-shift | ENST00000220166 | ENST00000419573 | CTSH | chr15 | 79221754 | - | RASGRF1 | chr15 | 79254578 | - |
5CDS-intron | ENST00000220166 | ENST00000560334 | CTSH | chr15 | 79221754 | - | RASGRF1 | chr15 | 79254578 | - |
5CDS-intron | ENST00000220166 | ENST00000394745 | CTSH | chr15 | 79221754 | - | RASGRF1 | chr15 | 79254578 | - |
5UTR-3CDS | ENST00000534533 | ENST00000558480 | CTSH | chr15 | 79221754 | - | RASGRF1 | chr15 | 79254578 | - |
5UTR-3CDS | ENST00000534533 | ENST00000419573 | CTSH | chr15 | 79221754 | - | RASGRF1 | chr15 | 79254578 | - |
5UTR-intron | ENST00000534533 | ENST00000560334 | CTSH | chr15 | 79221754 | - | RASGRF1 | chr15 | 79254578 | - |
5UTR-intron | ENST00000534533 | ENST00000394745 | CTSH | chr15 | 79221754 | - | RASGRF1 | chr15 | 79254578 | - |
Frame-shift | ENST00000220166 | ENST00000558480 | CTSH | chr15 | 79237233 | - | RASGRF1 | chr15 | 79320201 | - |
Frame-shift | ENST00000220166 | ENST00000419573 | CTSH | chr15 | 79237233 | - | RASGRF1 | chr15 | 79320201 | - |
5CDS-5UTR | ENST00000220166 | ENST00000560334 | CTSH | chr15 | 79237233 | - | RASGRF1 | chr15 | 79320201 | - |
5CDS-intron | ENST00000220166 | ENST00000394745 | CTSH | chr15 | 79237233 | - | RASGRF1 | chr15 | 79320201 | - |
intron-3CDS | ENST00000534533 | ENST00000558480 | CTSH | chr15 | 79237233 | - | RASGRF1 | chr15 | 79320201 | - |
intron-3CDS | ENST00000534533 | ENST00000419573 | CTSH | chr15 | 79237233 | - | RASGRF1 | chr15 | 79320201 | - |
intron-5UTR | ENST00000534533 | ENST00000560334 | CTSH | chr15 | 79237233 | - | RASGRF1 | chr15 | 79320201 | - |
intron-intron | ENST00000534533 | ENST00000394745 | CTSH | chr15 | 79237233 | - | RASGRF1 | chr15 | 79320201 | - |
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FusionProtFeatures for CTSH_RASGRF1 |
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Hgene | Tgene |
CTSH | RASGRF1 |
Important for the overall degradation of proteins inlysosomes. | Promotes the exchange of Ras-bound GDP by GTP.{ECO:0000269|PubMed:11389730}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CTSH_RASGRF1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CTSH_RASGRF1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CTSH | CSTA, CSTB, XRN1, SLC25A41, TCTN3, CTSL, MMRN1, CST1, ZIC1, AIRE, SLCO6A1, TBC1D22B, POC5, SF3A1, CCDC103, NONO, BPNT1, HSPD1 | RASGRF1 | MARK3, YWHAB, HRAS, PPP1R9B, MYC, EHD4, ADRBK1, CEBPA, SNRNP70, SRC, SRPK2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CTSH_RASGRF1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CTSH_RASGRF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CTSH | C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | CTD_human |
Hgene | CTSH | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Tgene | RASGRF1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | RASGRF1 | C0013386 | Dyskinesia, Drug-Induced | 1 | CTD_human |
Tgene | RASGRF1 | C0027092 | Myopia | 1 | CTD_human |
Tgene | RASGRF1 | C0034951 | Refractive Errors | 1 | CTD_human |