![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 8882 |
FusionGeneSummary for CTPS2_TMSB15A |
![]() |
Fusion gene information | Fusion gene name: CTPS2_TMSB15A | Fusion gene ID: 8882 | Hgene | Tgene | Gene symbol | CTPS2 | TMSB15A | Gene ID | 56474 | 11013 |
Gene name | CTP synthase 2 | thymosin beta 15a | |
Synonyms | - | TMSB15|TMSB15B|TMSL8|TMSNB|Tb15|TbNB | |
Cytomap | Xp22.2 | Xq22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | CTP synthase 2CTP synthase IICTP synthetase type 2UTP-ammonia ligase 2cytidine 5'-triphosphate synthetase 2 | thymosin beta-15ANB thymosin betaThymosin beta-15Bthymosin, beta, identified in neuroblastoma cellsthymosin-like 8thymosin-like protein 8 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q9NRF8 | P0CG34 | |
Ensembl transtripts involved in fusion gene | ENST00000443824, ENST00000359276, ENST00000380241, ENST00000483053, | ENST00000289373, | |
Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: CTPS2 [Title/Abstract] AND TMSB15A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-CH-5740-01A | CTPS2 | chrX | 16685637 | - | TMSB15A | chrX | 101770108 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000443824 | ENST00000289373 | CTPS2 | chrX | 16685637 | - | TMSB15A | chrX | 101770108 | - |
5CDS-5UTR | ENST00000359276 | ENST00000289373 | CTPS2 | chrX | 16685637 | - | TMSB15A | chrX | 101770108 | - |
5CDS-5UTR | ENST00000380241 | ENST00000289373 | CTPS2 | chrX | 16685637 | - | TMSB15A | chrX | 101770108 | - |
intron-5UTR | ENST00000483053 | ENST00000289373 | CTPS2 | chrX | 16685637 | - | TMSB15A | chrX | 101770108 | - |
Top |
FusionProtFeatures for CTPS2_TMSB15A |
![]() |
Hgene | Tgene |
CTPS2 | TMSB15A |
Catalyzes the ATP-dependent amination of UTP to CTP witheither L-glutamine or ammonia as the source of nitrogen.Constitutes the rate-limiting enzyme in the synthesis of cytosinenucleotides. {ECO:0000269|PubMed:10899599,ECO:0000269|PubMed:16179339}. | Plays an important role in the organization of thecytoskeleton. Binds to and sequesters actin monomers (G actin) andtherefore inhibits actin polymerization (By similarity).{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CTPS2_TMSB15A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CTPS2_TMSB15A |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CTPS2 | CTPS2, SPG21, OTUD5, CTBP2, FGFR1, RPL23A, RPL37A, DHPS, EHD1, EHD4, GTF2I, KTN1, METTL1, NUCB1, PRKDC, WARS, HSF1, LRSAM1, MTMR2, PLIN3, RNF2, COL9A1, SLAMF1, ENPP6, NTRK1, XPO1, NASP, SNX3, ATOH1, TIGD3, CTPS1, SUGP1, MTNR1A | TMSB15A |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CTPS2_TMSB15A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CTPS2_TMSB15A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |