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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8819

FusionGeneSummary for CTNNA2_UBXN4

check button Fusion gene summary
Fusion gene informationFusion gene name: CTNNA2_UBXN4
Fusion gene ID: 8819
HgeneTgene
Gene symbol

CTNNA2

UBXN4

Gene ID

1496

23190

Gene namecatenin alpha 2UBX domain protein 4
SynonymsCAP-R|CAPR|CT114|CTNRUBXD2|UBXDC1|erasin
Cytomap

2p12

2q21.3

Type of geneprotein-codingprotein-coding
Descriptioncatenin alpha-2alpha-N-cateninalpha-catenin-related proteincadherin-associated protein, relatedcancer/testis antigen 114catenin (cadherin-associated protein), alpha 2UBX domain-containing protein 4UBX domain containing 2UBX domain-containing 1UBX domain-containing protein 2
Modification date2018052220180519
UniProtAcc

P26232

Q92575

Ensembl transtripts involved in fusion geneENST00000466387, ENST00000496558, 
ENST00000361291, ENST00000402739, 
ENST00000540488, ENST00000541047, 
ENST00000343114, ENST00000496251, 
ENST00000409266, 
ENST00000272638, 
ENST00000490163, 
Fusion gene scores* DoF score4 X 5 X 2=405 X 5 X 1=25
# samples 55
** MAII scorelog2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/25*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CTNNA2 [Title/Abstract] AND UBXN4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA278207CTNNA2chr2

80414815

-UBXN4chr2

136540628

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000466387ENST00000272638CTNNA2chr2

80414815

-UBXN4chr2

136540628

-
intron-3UTRENST00000466387ENST00000490163CTNNA2chr2

80414815

-UBXN4chr2

136540628

-
intron-3UTRENST00000496558ENST00000272638CTNNA2chr2

80414815

-UBXN4chr2

136540628

-
intron-3UTRENST00000496558ENST00000490163CTNNA2chr2

80414815

-UBXN4chr2

136540628

-
intron-3UTRENST00000361291ENST00000272638CTNNA2chr2

80414815

-UBXN4chr2

136540628

-
intron-3UTRENST00000361291ENST00000490163CTNNA2chr2

80414815

-UBXN4chr2

136540628

-
intron-3UTRENST00000402739ENST00000272638CTNNA2chr2

80414815

-UBXN4chr2

136540628

-
intron-3UTRENST00000402739ENST00000490163CTNNA2chr2

80414815

-UBXN4chr2

136540628

-
intron-3UTRENST00000540488ENST00000272638CTNNA2chr2

80414815

-UBXN4chr2

136540628

-
intron-3UTRENST00000540488ENST00000490163CTNNA2chr2

80414815

-UBXN4chr2

136540628

-
intron-3UTRENST00000541047ENST00000272638CTNNA2chr2

80414815

-UBXN4chr2

136540628

-
intron-3UTRENST00000541047ENST00000490163CTNNA2chr2

80414815

-UBXN4chr2

136540628

-
intron-3UTRENST00000343114ENST00000272638CTNNA2chr2

80414815

-UBXN4chr2

136540628

-
intron-3UTRENST00000343114ENST00000490163CTNNA2chr2

80414815

-UBXN4chr2

136540628

-
intron-3UTRENST00000496251ENST00000272638CTNNA2chr2

80414815

-UBXN4chr2

136540628

-
intron-3UTRENST00000496251ENST00000490163CTNNA2chr2

80414815

-UBXN4chr2

136540628

-
intron-3UTRENST00000409266ENST00000272638CTNNA2chr2

80414815

-UBXN4chr2

136540628

-
intron-3UTRENST00000409266ENST00000490163CTNNA2chr2

80414815

-UBXN4chr2

136540628

-

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FusionProtFeatures for CTNNA2_UBXN4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTNNA2

P26232

UBXN4

Q92575

Involved in endoplasmic reticulum-associated proteindegradation (ERAD). Acts as a platform to recruit both UBQLN1 andVCP to the ER during ERAD (PubMed:19822669).{ECO:0000269|PubMed:16968747, ECO:0000269|PubMed:19822669}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTNNA2_UBXN4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTNNA2_UBXN4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTNNA2_UBXN4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTNNA2_UBXN4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCTNNA2C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneCTNNA2C0036341Schizophrenia1PSYGENET
HgeneCTNNA2C0038356Stomach Neoplasms1CTD_human