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Fusion gene ID: 8818 |
FusionGeneSummary for CTNNA2_RNU5F-1 |
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Fusion gene information | Fusion gene name: CTNNA2_RNU5F-1 | Fusion gene ID: 8818 | Hgene | Tgene | Gene symbol | CTNNA2 | RNU5F-1 | Gene ID | 1496 | 26828 |
Gene name | catenin alpha 2 | RNA, U5F small nuclear 1 | |
Synonyms | CAP-R|CAPR|CT114|CTNR | RNU5F|U5F | |
Cytomap | 2p12 | 1p34.1 | |
Type of gene | protein-coding | snRNA | |
Description | catenin alpha-2alpha-N-cateninalpha-catenin-related proteincadherin-associated protein, relatedcancer/testis antigen 114catenin (cadherin-associated protein), alpha 2 | - | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | P26232 | ||
Ensembl transtripts involved in fusion gene | ENST00000466387, ENST00000496558, ENST00000361291, ENST00000402739, ENST00000540488, ENST00000541047, ENST00000343114, ENST00000496251, ENST00000409266, | ENST00000362507, | |
Fusion gene scores | * DoF score | 4 X 5 X 2=40 | 5 X 6 X 1=30 |
# samples | 5 | 6 | |
** MAII score | log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/30*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CTNNA2 [Title/Abstract] AND RNU5F-1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BM666334 | CTNNA2 | chr2 | 79664036 | - | RNU5F-1 | chr1 | 220238518 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000466387 | ENST00000362507 | CTNNA2 | chr2 | 79664036 | - | RNU5F-1 | chr1 | 220238518 | + |
intron-intron | ENST00000496558 | ENST00000362507 | CTNNA2 | chr2 | 79664036 | - | RNU5F-1 | chr1 | 220238518 | + |
intron-intron | ENST00000361291 | ENST00000362507 | CTNNA2 | chr2 | 79664036 | - | RNU5F-1 | chr1 | 220238518 | + |
intron-intron | ENST00000402739 | ENST00000362507 | CTNNA2 | chr2 | 79664036 | - | RNU5F-1 | chr1 | 220238518 | + |
intron-intron | ENST00000540488 | ENST00000362507 | CTNNA2 | chr2 | 79664036 | - | RNU5F-1 | chr1 | 220238518 | + |
intron-intron | ENST00000541047 | ENST00000362507 | CTNNA2 | chr2 | 79664036 | - | RNU5F-1 | chr1 | 220238518 | + |
intron-intron | ENST00000343114 | ENST00000362507 | CTNNA2 | chr2 | 79664036 | - | RNU5F-1 | chr1 | 220238518 | + |
intron-intron | ENST00000496251 | ENST00000362507 | CTNNA2 | chr2 | 79664036 | - | RNU5F-1 | chr1 | 220238518 | + |
intron-intron | ENST00000409266 | ENST00000362507 | CTNNA2 | chr2 | 79664036 | - | RNU5F-1 | chr1 | 220238518 | + |
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FusionProtFeatures for CTNNA2_RNU5F-1 |
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Hgene | Tgene |
CTNNA2 | RNU5F-1 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CTNNA2_RNU5F-1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CTNNA2_RNU5F-1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CTNNA2_RNU5F-1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CTNNA2_RNU5F-1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CTNNA2 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | CTNNA2 | C0036341 | Schizophrenia | 1 | PSYGENET |
Hgene | CTNNA2 | C0038356 | Stomach Neoplasms | 1 | CTD_human |