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Fusion gene ID: 8804 |
FusionGeneSummary for CTNNA1_COTL1 |
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Fusion gene information | Fusion gene name: CTNNA1_COTL1 | Fusion gene ID: 8804 | Hgene | Tgene | Gene symbol | CTNNA1 | COTL1 | Gene ID | 1495 | 23406 |
Gene name | catenin alpha 1 | coactosin like F-actin binding protein 1 | |
Synonyms | CAP102|MDPT2 | CLP | |
Cytomap | 5q31.2 | 16q24.1 | |
Type of gene | protein-coding | protein-coding | |
Description | catenin alpha-1alpha-E-catenincatenin (cadherin-associated protein), alpha 1, 102kDarenal carcinoma antigen NY-REN-13 | coactosin-like proteincoactosin-like 1 | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | P35221 | Q14019 | |
Ensembl transtripts involved in fusion gene | ENST00000355078, ENST00000302763, ENST00000518825, ENST00000520400, ENST00000540387, | ENST00000262428, ENST00000567278, ENST00000564057, | |
Fusion gene scores | * DoF score | 13 X 10 X 9=1170 | 4 X 3 X 3=36 |
# samples | 15 | 4 | |
** MAII score | log2(15/1170*10)=-2.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CTNNA1 [Title/Abstract] AND COTL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CTNNA1 | GO:0071681 | cellular response to indole-3-methanol | 10868478 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-V1-A9ZR-01A | CTNNA1 | chr5 | 138119061 | + | COTL1 | chr16 | 84600561 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000355078 | ENST00000262428 | CTNNA1 | chr5 | 138119061 | + | COTL1 | chr16 | 84600561 | - |
intron-5UTR | ENST00000355078 | ENST00000567278 | CTNNA1 | chr5 | 138119061 | + | COTL1 | chr16 | 84600561 | - |
intron-5UTR | ENST00000355078 | ENST00000564057 | CTNNA1 | chr5 | 138119061 | + | COTL1 | chr16 | 84600561 | - |
In-frame | ENST00000302763 | ENST00000262428 | CTNNA1 | chr5 | 138119061 | + | COTL1 | chr16 | 84600561 | - |
5CDS-5UTR | ENST00000302763 | ENST00000567278 | CTNNA1 | chr5 | 138119061 | + | COTL1 | chr16 | 84600561 | - |
5CDS-5UTR | ENST00000302763 | ENST00000564057 | CTNNA1 | chr5 | 138119061 | + | COTL1 | chr16 | 84600561 | - |
In-frame | ENST00000518825 | ENST00000262428 | CTNNA1 | chr5 | 138119061 | + | COTL1 | chr16 | 84600561 | - |
5CDS-5UTR | ENST00000518825 | ENST00000567278 | CTNNA1 | chr5 | 138119061 | + | COTL1 | chr16 | 84600561 | - |
5CDS-5UTR | ENST00000518825 | ENST00000564057 | CTNNA1 | chr5 | 138119061 | + | COTL1 | chr16 | 84600561 | - |
intron-3CDS | ENST00000520400 | ENST00000262428 | CTNNA1 | chr5 | 138119061 | + | COTL1 | chr16 | 84600561 | - |
intron-5UTR | ENST00000520400 | ENST00000567278 | CTNNA1 | chr5 | 138119061 | + | COTL1 | chr16 | 84600561 | - |
intron-5UTR | ENST00000520400 | ENST00000564057 | CTNNA1 | chr5 | 138119061 | + | COTL1 | chr16 | 84600561 | - |
intron-3CDS | ENST00000540387 | ENST00000262428 | CTNNA1 | chr5 | 138119061 | + | COTL1 | chr16 | 84600561 | - |
intron-5UTR | ENST00000540387 | ENST00000567278 | CTNNA1 | chr5 | 138119061 | + | COTL1 | chr16 | 84600561 | - |
intron-5UTR | ENST00000540387 | ENST00000564057 | CTNNA1 | chr5 | 138119061 | + | COTL1 | chr16 | 84600561 | - |
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FusionProtFeatures for CTNNA1_COTL1 |
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Hgene | Tgene |
CTNNA1 | COTL1 |
Associates with the cytoplasmic domain of a variety ofcadherins. The association of catenins to cadherins produces acomplex which is linked to the actin filament network, and whichseems to be of primary importance for cadherins cell-adhesionproperties. Can associate with both E- and N-cadherins. Originallybelieved to be a stable component of E-cadherin/catenin adhesioncomplexes and to mediate the linkage of cadherins to the actincytoskeleton at adherens junctions. In contrast, cortical actinwas found to be much more dynamic than E-cadherin/catenincomplexes and CTNNA1 was shown not to bind to F-actin whenassembled in the complex suggesting a different linkage betweenactin and adherens junctions components. The homodimeric form mayregulate actin filament assembly and inhibit actin branching bycompeting with the Arp2/3 complex for binding to actin filaments.May play a crucial role in cell differentiation.{ECO:0000269|PubMed:25653389}. | Binds to F-actin in a calcium-independent manner. Has nodirect effect on actin depolymerization. Acts as a chaperone forALOX5 (5LO), influencing both its stability and activity inleukotrienes synthesis. {ECO:0000269|PubMed:11583571,ECO:0000269|PubMed:19807693}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CTNNA1_COTL1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_CTNNA1_ENST00000302763_chr5_138119061_+_COTL1_ENST00000262428_chr16_84600561_-_137aa MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEEL >In-frame_CTNNA1_ENST00000518825_chr5_138119061_+_COTL1_ENST00000262428_chr16_84600561_-_137aa MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEEL |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_CTNNA1_ENST00000302763_chr5_138119061_+_COTL1_ENST00000262428_chr16_84600561_-_412nt ATGACTGCTGTCCATGCAGGCAACATAAACTTCAAGTGGGATCCTAAAAGTCTAGAGATCAGGACTCTGGCAGTTGAGAGACTGTTGGAG CCTCTTGTTACACAGGTTACAACCCTTGTAAACACCAATAGTAAAGGGCCCTCTAATAAGAAGAGAGGTCGTTCTAAGAAGGCCCATGTT TTGGCTGCATCTGTTGAACAAGCAACTGAGAATTTCTTGGAGAAGGGGGATAAAATTGCGAAGGAGAGCCAGTTTCTCAAGGAGGAGCTT GTGGCTGCTGTAGAAGATGTTCGAAAACAAGAATTTCGCTAAGGAGTTTGTGATCAGTGATCGGAAGGAGCTGGAGGAAGATTTCATCAA >In-frame_CTNNA1_ENST00000518825_chr5_138119061_+_COTL1_ENST00000262428_chr16_84600561_-_412nt ATGACTGCTGTCCATGCAGGCAACATAAACTTCAAGTGGGATCCTAAAAGTCTAGAGATCAGGACTCTGGCAGTTGAGAGACTGTTGGAG CCTCTTGTTACACAGGTTACAACCCTTGTAAACACCAATAGTAAAGGGCCCTCTAATAAGAAGAGAGGTCGTTCTAAGAAGGCCCATGTT TTGGCTGCATCTGTTGAACAAGCAACTGAGAATTTCTTGGAGAAGGGGGATAAAATTGCGAAGGAGAGCCAGTTTCTCAAGGAGGAGCTT GTGGCTGCTGTAGAAGATGTTCGAAAACAAGAATTTCGCTAAGGAGTTTGTGATCAGTGATCGGAAGGAGCTGGAGGAAGATTTCATCAA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_CTNNA1_ENST00000302763_chr5_138119061_+_COTL1_ENST00000262428_chr16_84600561_-_1753nt TCCTCCTCCTAGCCGGACTGGAGGGAGACAAAGCAGCGCCCGTCTGCTTCGGGCCTCTGGAATTTAGCGCTCGCCCAGCTAGCCGCAGAA ATGACTGCTGTCCATGCAGGCAACATAAACTTCAAGTGGGATCCTAAAAGTCTAGAGATCAGGACTCTGGCAGTTGAGAGACTGTTGGAG CCTCTTGTTACACAGGTTACAACCCTTGTAAACACCAATAGTAAAGGGCCCTCTAATAAGAAGAGAGGTCGTTCTAAGAAGGCCCATGTT TTGGCTGCATCTGTTGAACAAGCAACTGAGAATTTCTTGGAGAAGGGGGATAAAATTGCGAAGGAGAGCCAGTTTCTCAAGGAGGAGCTT GTGGCTGCTGTAGAAGATGTTCGAAAACAAGAATTTCGCTAAGGAGTTTGTGATCAGTGATCGGAAGGAGCTGGAGGAAGATTTCATCAA GAGCGAGCTGAAGAAGGCGGGGGGAGCCAATTACGACGCCCAGACGGAGTAACCCCAGCCCCCGCCACACCACCCCTTGCCAAAGTCATC TGCCTGCTCCCCGGGGGAGAGGACCGCCGGCCTCAGCTACTAGCCCACCAGCCCACCAGGGAGAAAAGAAGCCATGAGAGGCAGCGCCCG CCACCCTGTGTCCACAGCCCCCACCTTCCCGCTTCCCTTAGAACCCTGCCGTGTCCTATCTCATGACGCTCATGGAACCTCTTTCTTTGA TCTTCTTTTTCTTTTCTCCCCCTCTTTTTTGTTCTAAAGAAAAGTCATTTTGATGCAAGGTCCTGCCTGCCATCAGATCCGAGGTGCCTC CTGCAGTGACCCCTTTTCCTGGCATTTCTCTTCCACGCGACGAGGTCTGCCTAGTGAGATCTGCATGACCTCACGTTGCTTTCCAGAGCC CGGGCCTATTTTGCCATCTCAGTTTTCCTGGACCCTGCTTCCTGTGTACCACTGAGGGGCAGCTGGGCCAGGAGCTGTGCCCGGTGCCTG CAGCCTTCATAAGCACACACGTCCATTCCCTACTAAGGCCCAGACCTCCTGGTATCTGCCCCGGGCTCCCTCATCCCACCTCCATCCGGA GTTGCCTAAGATGCATGTCCAGCATAGGCAGGATTGCTCGGTGGTGAGAAGGTTAGGTCCGGCTCAGACTGAATAAGAAGAGATAAAATT TGCCTTAAAACTTACCTGGCAGTGGCTTTGCTGCACGGTCTGAAACCACCTGTTCCCACCCTCTTGACCGAAATTTCCTTGTGACACAGA GAAGGGCAAAGGTCTGAGCCCAGAGTTGACGGAGGGAGTATTTCAGGGTTCACTTCAGGGGCTCCCAAAGCGACAAGATCGTTAGGGAGA GAGGCCCAGGGTGGGGACTGGGAATTTAAGGAGAGCTGGGAACGGATCCCTTAGGTTCAGGAAGCTTCTGTGTAAGCTGCGAGGATGGCT TGGGCCGAAGGGTTGCTCTGCCCGCCGCGCTAGCTGTGAGCTGAGCAAAGCCCTGGGCTCACAGCACCCCAAAAGCCTGTGGCTTCAGTC CTGCGTCTGCACCACACATTCAAAAGGATCGTTTTGTTTTGTTTTTAAAGAAAGGTGAGATTGGCTTGGTTCTTCATGAGCACATTTGAT ATAGCTCTTTTTCTGTTTTTCCTTGCTCATTTCGTTTTGGGGAAGAAATCTGTACTGTATTGGGATTGTAAAGAACATCTCTGCACTCAG >In-frame_CTNNA1_ENST00000518825_chr5_138119061_+_COTL1_ENST00000262428_chr16_84600561_-_1665nt AAATGACTGCTGTCCATGCAGGCAACATAAACTTCAAGTGGGATCCTAAAAGTCTAGAGATCAGGACTCTGGCAGTTGAGAGACTGTTGG AGCCTCTTGTTACACAGGTTACAACCCTTGTAAACACCAATAGTAAAGGGCCCTCTAATAAGAAGAGAGGTCGTTCTAAGAAGGCCCATG TTTTGGCTGCATCTGTTGAACAAGCAACTGAGAATTTCTTGGAGAAGGGGGATAAAATTGCGAAGGAGAGCCAGTTTCTCAAGGAGGAGC TTGTGGCTGCTGTAGAAGATGTTCGAAAACAAGAATTTCGCTAAGGAGTTTGTGATCAGTGATCGGAAGGAGCTGGAGGAAGATTTCATC AAGAGCGAGCTGAAGAAGGCGGGGGGAGCCAATTACGACGCCCAGACGGAGTAACCCCAGCCCCCGCCACACCACCCCTTGCCAAAGTCA TCTGCCTGCTCCCCGGGGGAGAGGACCGCCGGCCTCAGCTACTAGCCCACCAGCCCACCAGGGAGAAAAGAAGCCATGAGAGGCAGCGCC CGCCACCCTGTGTCCACAGCCCCCACCTTCCCGCTTCCCTTAGAACCCTGCCGTGTCCTATCTCATGACGCTCATGGAACCTCTTTCTTT GATCTTCTTTTTCTTTTCTCCCCCTCTTTTTTGTTCTAAAGAAAAGTCATTTTGATGCAAGGTCCTGCCTGCCATCAGATCCGAGGTGCC TCCTGCAGTGACCCCTTTTCCTGGCATTTCTCTTCCACGCGACGAGGTCTGCCTAGTGAGATCTGCATGACCTCACGTTGCTTTCCAGAG CCCGGGCCTATTTTGCCATCTCAGTTTTCCTGGACCCTGCTTCCTGTGTACCACTGAGGGGCAGCTGGGCCAGGAGCTGTGCCCGGTGCC TGCAGCCTTCATAAGCACACACGTCCATTCCCTACTAAGGCCCAGACCTCCTGGTATCTGCCCCGGGCTCCCTCATCCCACCTCCATCCG GAGTTGCCTAAGATGCATGTCCAGCATAGGCAGGATTGCTCGGTGGTGAGAAGGTTAGGTCCGGCTCAGACTGAATAAGAAGAGATAAAA TTTGCCTTAAAACTTACCTGGCAGTGGCTTTGCTGCACGGTCTGAAACCACCTGTTCCCACCCTCTTGACCGAAATTTCCTTGTGACACA GAGAAGGGCAAAGGTCTGAGCCCAGAGTTGACGGAGGGAGTATTTCAGGGTTCACTTCAGGGGCTCCCAAAGCGACAAGATCGTTAGGGA GAGAGGCCCAGGGTGGGGACTGGGAATTTAAGGAGAGCTGGGAACGGATCCCTTAGGTTCAGGAAGCTTCTGTGTAAGCTGCGAGGATGG CTTGGGCCGAAGGGTTGCTCTGCCCGCCGCGCTAGCTGTGAGCTGAGCAAAGCCCTGGGCTCACAGCACCCCAAAAGCCTGTGGCTTCAG TCCTGCGTCTGCACCACACATTCAAAAGGATCGTTTTGTTTTGTTTTTAAAGAAAGGTGAGATTGGCTTGGTTCTTCATGAGCACATTTG ATATAGCTCTTTTTCTGTTTTTCCTTGCTCATTTCGTTTTGGGGAAGAAATCTGTACTGTATTGGGATTGTAAAGAACATCTCTGCACTC |
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FusionGenePPI for CTNNA1_COTL1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CTNNA1 | APC, CTNNB1, CDH1, CTNNA1, JUP, CDH3, CDH5, CTNND1, CDH2, CA9, PTPN14, MLLT4, VEZT, MYO7A, TJP2, PSEN1, ACTN1, VCL, DLG1, SPTBN1, FAM84B, RNF219, ZGPAT, RYK, CTBP1, ARRB2, SIRT7, ARMC8, COPS5, APP, VCP, CTNNA3, GARS, OSBP, SEC23A, USP11, XRCC6, CTTN, CUL2, EIF4B, HSPH1, PRMT3, XPO7, FBXW11, OBSL1, CCDC8, UBE2I, ARAF, ILK, BTRC, UNK, DMD, NTRK1, HERC2, GSK3A, HSPA5, AXIN1, MAPRE1, EGFR, MCM2, CDC5L, C21orf59, IQSEC1, CSNK2A1, CTDSPL, CDH8, CTNNBIP1, SAPCD1, SLAMF7, NEK4, SLC9A3R2, MTNR1A, MTNR1B, DLD, HSD17B10, PDHA1, TRIM25, UBE2A, BRCA1, TES | COTL1 | ALOX5, ACTA1, ELAVL1, TERF2IP, CD2BP2, ACTG1, ACTB, PDE6H, ARHGDIA, CFL1, FSCN1, HEBP1, TMTC3, CRIP1, DUT, HN1, MDH2, PCBP1, SH3BGRL, TAGLN2, TIAL1, TKT, UBE2M, MCM2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CTNNA1_COTL1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CTNNA1_COTL1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CTNNA1 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Hgene | CTNNA1 | C1837029 | Macular Dystrophy, Butterfly-Shaped Pigmentary, 2 | 1 | UNIPROT |
Hgene | CTNNA1 | C1868569 | Patterned dystrophy of retinal pigment epithelium | 1 | CTD_human |
Hgene | CTNNA1 | C3463824 | MYELODYSPLASTIC SYNDROME | 1 | CTD_human |
Tgene | COTL1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | COTL1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |