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Fusion gene ID: 879 |
FusionGeneSummary for ADH7_CXCR5 |
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Fusion gene information | Fusion gene name: ADH7_CXCR5 | Fusion gene ID: 879 | Hgene | Tgene | Gene symbol | ADH7 | CXCR5 | Gene ID | 131 | 643 |
Gene name | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide | C-X-C motif chemokine receptor 5 | |
Synonyms | ADH4 | BLR1|CD185|MDR15 | |
Cytomap | 4q23 | 11q23.3 | |
Type of gene | protein-coding | protein-coding | |
Description | alcohol dehydrogenase class 4 mu/sigma chainalcohol dehydrogenase VIIalcohol dehydrogenase class IV mu/sigma chainalcohol dehydrogenase-7class IV sigma-1 alcohol dehydrogenaseclass IV sigmasigma alcohol dehydrogenasegastric alcohol dehydrogenaseret | C-X-C chemokine receptor type 5Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5)Burkitt lymphoma receptor 1, GTP-binding proteinCXC-R5CXCR-5MDR-15chemokine (C-X-C motif) receptor 5monocyte-derived receptor 15 | |
Modification date | 20180519 | 20180527 | |
UniProtAcc | P40394 | P32302 | |
Ensembl transtripts involved in fusion gene | ENST00000209665, ENST00000437033, ENST00000482593, ENST00000476959, | ENST00000292174, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 11 X 3 X 7=231 |
# samples | 1 | 11 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(11/231*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ADH7 [Title/Abstract] AND CXCR5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ADH7 | GO:0001523 | retinoid metabolic process | 9600267 |
Hgene | ADH7 | GO:0006069 | ethanol oxidation | 7876099|10969996 |
Hgene | ADH7 | GO:0009617 | response to bacterium | 11410738 |
Hgene | ADH7 | GO:0010430 | fatty acid omega-oxidation | 9600267 |
Hgene | ADH7 | GO:0045471 | response to ethanol | 9600267 |
Hgene | ADH7 | GO:0055114 | oxidation-reduction process | 7876099 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-CV-6940-01A | ADH7 | chr4 | 100333418 | - | CXCR5 | chr11 | 118754475 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000209665 | ENST00000292174 | ADH7 | chr4 | 100333418 | - | CXCR5 | chr11 | 118754475 | + |
Frame-shift | ENST00000437033 | ENST00000292174 | ADH7 | chr4 | 100333418 | - | CXCR5 | chr11 | 118754475 | + |
intron-3CDS | ENST00000482593 | ENST00000292174 | ADH7 | chr4 | 100333418 | - | CXCR5 | chr11 | 118754475 | + |
intron-3CDS | ENST00000476959 | ENST00000292174 | ADH7 | chr4 | 100333418 | - | CXCR5 | chr11 | 118754475 | + |
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FusionProtFeatures for ADH7_CXCR5 |
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Hgene | Tgene |
ADH7 | CXCR5 |
Could function in retinol oxidation for the synthesis ofretinoic acid, a hormone important for cellular differentiation.Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde)compounds are the best substrates. Ethanol is not a good substratebut at the high ethanol concentrations reached in the digestivetract, it plays a role in the ethanol oxidation and contributes tothe first pass ethanol metabolism. | Cytokine receptor that binds to B-lymphocytechemoattractant (BLC). Involved in B-cell migration into B-cellfollicles of spleen and Peyer patches but not into those ofmesenteric or peripheral lymph nodes. May have a regulatoryfunction in Burkitt lymphoma (BL) lymphomagenesis and/or B-celldifferentiation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ADH7_CXCR5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ADH7_CXCR5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ADH7 | ADH7, CAND1, UBC, PI4KA | CXCR5 | CXCR4, GNB3, GNG8, GNAI2, GNA11, GNA13 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ADH7_CXCR5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ADH7_CXCR5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ADH7 | C0001973 | Alcoholic Intoxication, Chronic | 5 | PSYGENET |
Hgene | ADH7 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Hgene | ADH7 | C0023055 | Laryngeal neoplasm | 1 | CTD_human |
Hgene | ADH7 | C0026640 | Mouth Neoplasms | 1 | CTD_human |
Hgene | ADH7 | C0031347 | Pharyngeal Neoplasms | 1 | CTD_human |
Tgene | CXCR5 | C0023892 | Biliary cirrhosis | 1 | CTD_human |