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Fusion gene ID: 8764 |
FusionGeneSummary for CTDSP2_HMGA2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CTDSP2_HMGA2 | Fusion gene ID: 8764 | Hgene | Tgene | Gene symbol | CTDSP2 | HMGA2 | Gene ID | 10106 | 8091 |
| Gene name | CTD small phosphatase 2 | high mobility group AT-hook 2 | |
| Synonyms | OS4|PSR2|SCP2 | BABL|HMGI-C|HMGIC|LIPO|STQTL9 | |
| Cytomap | 12q14.1 | 12q14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2NLI-interacting factor 2conserved gene amplified in osteosarcomanuclear LIM interactor-intera | high mobility group protein HMGI-CHMGA2/KRT121P fusionhigh-mobility group (nonhistone chromosomal) protein isoform I-C | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O14595 | P52926 | |
| Ensembl transtripts involved in fusion gene | ENST00000398073, ENST00000548823, ENST00000547701, | ENST00000403681, ENST00000541363, ENST00000393577, ENST00000393578, ENST00000425208, ENST00000536545, ENST00000354636, | |
| Fusion gene scores | * DoF score | 26 X 5 X 7=910 | 7 X 4 X 3=84 |
| # samples | 22 | 6 | |
| ** MAII score | log2(22/910*10)=-2.0483630215614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/84*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CTDSP2 [Title/Abstract] AND HMGA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CTDSP2 | GO:0006470 | protein dephosphorylation | 12721286 |
| Tgene | HMGA2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 14627817 |
| Tgene | HMGA2 | GO:0002062 | chondrocyte differentiation | 21484705 |
| Tgene | HMGA2 | GO:0006284 | base-excision repair | 19465398 |
| Tgene | HMGA2 | GO:0007095 | mitotic G2 DNA damage checkpoint | 16061642 |
| Tgene | HMGA2 | GO:0010564 | regulation of cell cycle process | 14645522 |
| Tgene | HMGA2 | GO:0010628 | positive regulation of gene expression | 18832382 |
| Tgene | HMGA2 | GO:0031052 | chromosome breakage | 19549901 |
| Tgene | HMGA2 | GO:0031507 | heterochromatin assembly | 16901784 |
| Tgene | HMGA2 | GO:0035978 | histone H2A-S139 phosphorylation | 16061642 |
| Tgene | HMGA2 | GO:0035986 | senescence-associated heterochromatin focus assembly | 16901784 |
| Tgene | HMGA2 | GO:0035988 | chondrocyte proliferation | 21484705 |
| Tgene | HMGA2 | GO:0042769 | DNA damage response, detection of DNA damage | 19465398 |
| Tgene | HMGA2 | GO:0043065 | positive regulation of apoptotic process | 16061642 |
| Tgene | HMGA2 | GO:0043066 | negative regulation of apoptotic process | 19465398 |
| Tgene | HMGA2 | GO:0043392 | negative regulation of DNA binding | 14645522 |
| Tgene | HMGA2 | GO:0043922 | negative regulation by host of viral transcription | 17005673 |
| Tgene | HMGA2 | GO:0045869 | negative regulation of single stranded viral RNA replication via double stranded DNA intermediate | 17005673 |
| Tgene | HMGA2 | GO:0045892 | negative regulation of transcription, DNA-templated | 18832382 |
| Tgene | HMGA2 | GO:0045893 | positive regulation of transcription, DNA-templated | 15225648|15755872|17005673|17324944|17426251 |
| Tgene | HMGA2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 14645522|18832382 |
| Tgene | HMGA2 | GO:0071158 | positive regulation of cell cycle arrest | 16061642 |
| Tgene | HMGA2 | GO:0090402 | oncogene-induced cell senescence | 16901784 |
| Tgene | HMGA2 | GO:2000648 | positive regulation of stem cell proliferation | 21484705 |
| Tgene | HMGA2 | GO:2000679 | positive regulation of transcription regulatory region DNA binding | 18832382 |
| Tgene | HMGA2 | GO:2000685 | positive regulation of cellular response to X-ray | 16061642 |
| Tgene | HMGA2 | GO:2001022 | positive regulation of response to DNA damage stimulus | 16061642|19465398 |
| Tgene | HMGA2 | GO:2001033 | negative regulation of double-strand break repair via nonhomologous end joining | 19549901 |
| Tgene | HMGA2 | GO:2001038 | regulation of cellular response to drug | 16061642 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-IF-A3RQ-01A | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000398073 | ENST00000403681 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| Frame-shift | ENST00000398073 | ENST00000541363 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| In-frame | ENST00000398073 | ENST00000393577 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| 5CDS-intron | ENST00000398073 | ENST00000393578 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| 5CDS-intron | ENST00000398073 | ENST00000425208 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| 5CDS-intron | ENST00000398073 | ENST00000536545 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| 5CDS-intron | ENST00000398073 | ENST00000354636 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| In-frame | ENST00000548823 | ENST00000403681 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| Frame-shift | ENST00000548823 | ENST00000541363 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| In-frame | ENST00000548823 | ENST00000393577 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| 5CDS-intron | ENST00000548823 | ENST00000393578 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| 5CDS-intron | ENST00000548823 | ENST00000425208 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| 5CDS-intron | ENST00000548823 | ENST00000536545 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| 5CDS-intron | ENST00000548823 | ENST00000354636 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| intron-3CDS | ENST00000547701 | ENST00000403681 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| intron-3CDS | ENST00000547701 | ENST00000541363 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| intron-3CDS | ENST00000547701 | ENST00000393577 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| intron-intron | ENST00000547701 | ENST00000393578 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| intron-intron | ENST00000547701 | ENST00000425208 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| intron-intron | ENST00000547701 | ENST00000536545 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
| intron-intron | ENST00000547701 | ENST00000354636 | CTDSP2 | chr12 | 58240155 | - | HMGA2 | chr12 | 66345163 | + |
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FusionProtFeatures for CTDSP2_HMGA2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CTDSP2 | HMGA2 |
| Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain(CTD) of the largest RNA polymerase II subunit POLR2A. Negativelyregulates RNA polymerase II transcription, possibly by controllingthe transition from initiation/capping to processive transcriptelongation. Recruited by REST to neuronal genes that contain RE-1elements, leading to neuronal gene silencing in non-neuronalcells. May contribute to the development of sarcomas.{ECO:0000269|PubMed:12721286, ECO:0000269|PubMed:15681389}. | Functions as a transcriptional regulator. Functions incell cycle regulation through CCNA2. Plays an important role inchromosome condensation during the meiotic G2/M transition ofspermatocytes. Plays a role in postnatal myogenesis, is involvedin satellite cell activation (By similarity).{ECO:0000250|UniProtKB:P52927, ECO:0000269|PubMed:14645522}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >HMGA2 | chr12:58240155 | chr12:66345163 | ENST00000354636 | + | 0 | 4 | 24_34 | -271 | 107 | DNA binding | Note=A.T hook 1 |
| Tgene | >HMGA2 | chr12:58240155 | chr12:66345163 | ENST00000354636 | + | 0 | 4 | 44_54 | -271 | 107 | DNA binding | Note=A.T hook 2 |
| Tgene | >HMGA2 | chr12:58240155 | chr12:66345163 | ENST00000354636 | + | 0 | 4 | 71_82 | -271 | 107 | DNA binding | Note=A.T hook 3 |
| Tgene | >HMGA2 | chr12:58240155 | chr12:66345163 | ENST00000393578 | + | 0 | 4 | 24_34 | -271 | 91 | DNA binding | Note=A.T hook 1 |
| Tgene | >HMGA2 | chr12:58240155 | chr12:66345163 | ENST00000393578 | + | 0 | 4 | 44_54 | -271 | 91 | DNA binding | Note=A.T hook 2 |
| Tgene | >HMGA2 | chr12:58240155 | chr12:66345163 | ENST00000393578 | + | 0 | 4 | 71_82 | -271 | 91 | DNA binding | Note=A.T hook 3 |
| Tgene | >HMGA2 | chr12:58240155 | chr12:66345163 | ENST00000425208 | + | 0 | 4 | 24_34 | -271 | 93 | DNA binding | Note=A.T hook 1 |
| Tgene | >HMGA2 | chr12:58240155 | chr12:66345163 | ENST00000425208 | + | 0 | 4 | 44_54 | -271 | 93 | DNA binding | Note=A.T hook 2 |
| Tgene | >HMGA2 | chr12:58240155 | chr12:66345163 | ENST00000425208 | + | 0 | 4 | 71_82 | -271 | 93 | DNA binding | Note=A.T hook 3 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CTDSP2 | chr12:58240155 | chr12:66345163 | ENST00000398073 | - | 1 | 8 | 97_255 | 21 | 272 | Domain | FCP1 homology |
| Tgene | HMGA2 | chr12:58240155 | chr12:66345163 | ENST00000403681 | + | 2 | 5 | 24_34 | 83 | 110 | DNA binding | Note=A.T hook 1 |
| Tgene | HMGA2 | chr12:58240155 | chr12:66345163 | ENST00000403681 | + | 2 | 5 | 44_54 | 83 | 110 | DNA binding | Note=A.T hook 2 |
| Tgene | HMGA2 | chr12:58240155 | chr12:66345163 | ENST00000403681 | + | 2 | 5 | 71_82 | 83 | 110 | DNA binding | Note=A.T hook 3 |
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FusionGeneSequence for CTDSP2_HMGA2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CTDSP2_ENST00000398073_chr12_58240155_-_HMGA2_ENST00000403681_chr12_66345163_+_48aa >In-frame_CTDSP2_ENST00000398073_chr12_58240155_-_HMGA2_ENST00000393577_chr12_66345163_+_57aa >In-frame_CTDSP2_ENST00000548823_chr12_58240155_-_HMGA2_ENST00000403681_chr12_66345163_+_48aa >In-frame_CTDSP2_ENST00000548823_chr12_58240155_-_HMGA2_ENST00000393577_chr12_66345163_+_57aa |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CTDSP2_ENST00000398073_chr12_58240155_-_HMGA2_ENST00000403681_chr12_66345163_+_145nt ATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCC >In-frame_CTDSP2_ENST00000398073_chr12_58240155_-_HMGA2_ENST00000393577_chr12_66345163_+_172nt ATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCC >In-frame_CTDSP2_ENST00000548823_chr12_58240155_-_HMGA2_ENST00000403681_chr12_66345163_+_145nt ATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCC >In-frame_CTDSP2_ENST00000548823_chr12_58240155_-_HMGA2_ENST00000393577_chr12_66345163_+_172nt ATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CTDSP2_ENST00000398073_chr12_58240155_-_HMGA2_ENST00000403681_chr12_66345163_+_3452nt CCATTTCCTCCTCTTGTTTTCGCTCCGGATTCTCCATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGG GCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCCTTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTG AACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAGCGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTC CCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCAC CAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAGGAGGAAACTGAAGAGACATCCTCACAAGAGTCTGCCGAAGAGGACTAGG GGGCGCCAACGTTCGATTTCTACCTCAGCAGCAGTTGGATCTTTTGAAGGGAGAAGACACTGCAGTGACCACTTATTCTGTATTGCCATG GTCTTTCCACTTTCATCTGGGGTGGGGTGGGGTGGGGTGGGGGAGGGGGGGGTGGGGTGGGGAGAAATCACATAACCTTAAAAAGGACTA TATTAATCACCTTCTTTGTAATCCCTTCACAGTCCCAGGTTTAGTGAAAAACTGCTGTAAACACAGGGGACACAGCTTAACAATGCAACT TTTAATTACTGTTTTCTTTTTTCTTAACCTACTAATAGTTTGTTGATCTGATAAGCAAGAGTGGGCGGGTGAGAAAAACCGAATTGGGTT TAGTCAATCACTGCACTGCATGCAAACAAGAAACGTGTCACACTTGTGACGTCGGGCATTCATATAGGAAGAACGCGGTGTGTAACACTG TGTACACCTCAAATACCACCCCAACCCACTCCCTGTAGTGAATCCTCTGTTTAGAACACCAAAGATAAGGACTAGATACTACTTTCTCTT TTTCGTATAATCTTGTAGACACTTACTTGATGATTTTTAACTTTTTATTTCTAAATGAGACGAAATGCTGATGTATCCTTTCATTCAGCT AACAAACTAGAAAAGGTTATGTTCATTTTTCAAAAAGGGAAGTAAGCAAACAAATATTGCCAACTCTTCTATTTATGGATATCACACATA TCAGCAGGAGTAATAAATTTACTCACAGCACTTGTTTTCAGGACAACACTTCATTTTCAGGAAATCTACTTCCTACAGAGCCAAAATGCC ATTTAGCAATAAATAACACTTGTCAGCCTCAGAGCATTTAAGGAAACTAGACAAGTAAAATTATCCTCTTTGTAATTTAATGAAAAGGTA CAACAGAATAATGCATGATGAACTCACCTAATTATGAGGTGGGAGGAGCGAAATCTAAATTTCTTTTGCTATAGTTATACATCAATTTAA AAAGCAAAAAAAAAAAAGGGGGGGGCAATCTCTCTCTGTGTCTTTCTCTCTCTCTCTTCCTCTCCCTCTCTCTTTTCATTGTGTATCAGT TTCCATGAAAGACCTGAATACCACTTACCTCAAATTAAGCATATGTGTTACTTCAAGTAATACGTTTTGACATAAGATGGTTGACCAAGG TGCTTTTCTTCGGCTTGAGTTCACCATCTCTTCATTCAAACTGCACTTTTAGCCAGAGATGCAATATATCCCCACTACTCAATACTACCT CTGAATGTTACAACGAATTTACAGTCTAGTACTTATTACATGCTGCTATACACAAGCAATGCAAGAAAAAAACTTACTGGGTAGGTGATT CTAATCATCTGCAGTTCTTTTTGTACACTTAATTACAGTTAAAGAAGCAATCTCCTTACTGTGTTTCAGCATGACTATGTATTTTTCTAT GTTTTTTTAATTAAAAATTTTTAAAATACTTGTTTCAGCTTCTCTGCTAGATTTCTACATTAACTTGAAAATTTTTTAACCAAGTCGCTC CTAGGTTCTTAAGGATAATTTTCCTCAATCACACTACACATCACACAAGATTTGACTGTAATATTTAAATATTACCCTCCAAGTCTGTAC CTCAAATGAATTCTTTAAGGAGATGGACTAATTGACTTGCAAAGACCTACCTCCAGACTTCAAAAGGAATGAACTTGTTACTTGCAGCAT TCATTTGTTTTTTCAATGTTTGAAATAGTTCAAACTGCAGCTAACCCTAGTCAAAACTATTTTTGTAAAAGACATTTGATAGAAAGGAAC ACGTTTTTACATACTTTTGCAAAATAAGTAAATAATAAATAAAATAAAAGCCAACCTTCAAAGAAACTTGAAGCTTTGTAGGTGAGATGC AACAAGCCCTGCTTTTGCATAATGCAATCAAAAATATGTGTTTTTAAGATTAGTTGAATATAAGAAAATGCTTGACAAATATTTTCATGT ATTTTACACAAATGTGATTTTTGTAATATGTCTCAACCAGATTTATTTTAAACGCTTCTTATGTAGAGTTTTTATGCCTTTCTCTCCTAG TGAGTGTGCTGACTTTTTAACATGGTATTATCAACTGGGCCAGGAGGTAGTTTCTCATGACGGCTTTTGTCAGTATGGCTTTTAGTACTG AAGCCAAATGAAACTCAAAACCATCTCTCTTCCAGCTGCTTCAGGGAGGTAGTTTCAAAGGCCACATACCTCTCTGAGACTGGCAGATCG CTCACTGTTGTGAATCACCAAAGGAGCTATGGAGAGAATTAAAACTCAACATTACTGTTAACTGTGCGTTAAATAAGCAAATAAACAGTG GCTCATAAAAATAAAAGTCGCATTCCATATCTTTGGATGGGCCTTTTAGAAACCTCATTGGCCAGCTCATAAAATGGAAGCAATTGCTCA TGTTGGCCAAACATGGTGCACCGAGTGATTTCCATCTCTGGTAAAGTTACACTTTTATTTCCTGTATGTTGTACAATCAAAACACACTAC TACCTCTTAAGTCCCAGTATACCTCATTTTTCATACTGAAAAAAAAAGCTTGTGGCCAATGGAACAGTAAGAACATCATAAAATTTTTAT ATATATAGTTTATTTTTGTGGGAGATAAATTTTATAGGACTGTTCTTTGCTGTTGTTGGTCGCAGCTACATAAGACTGGACATTTAACTT TTCTACCATTTCTGCAAGTTAGGTATGTTTGCAGGAGAAAAGTATCAAGACGTTTAACTGCAGTTGACTTTCTCCCTGTTCCTTTGAGTG TCTTCTAACTTTATTCTTTGTTCTTTATGTAGAATTGCTGTCTATGATTGTACTTTGAATCGCTTGCTTGTTGAAAATATTTCTCTAGTG TATTATCACTGTCTGTTCTGCACAATAAACATAACAGCCTCTGTGATCCCCATGTGTTTTGATTCCTGCTCTTTGTTACAGTTCCATTAA >In-frame_CTDSP2_ENST00000398073_chr12_58240155_-_HMGA2_ENST00000393577_chr12_66345163_+_582nt CCATTTCCTCCTCTTGTTTTCGCTCCGGATTCTCCATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGG GCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCCTTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTG AACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAGCGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTC CCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCAC CAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAGGTCAATGTTGCCTTGCCTGGGAAGGACCACCCGGGCAATCTTATATATC TACTGTTCTCTAAAAATGCCACTTAGAAGAGAATTGAAACTTCCAAACACATGAAAGGATCCAAGGAAAGTGTCTTCAAACAATTACATA >In-frame_CTDSP2_ENST00000548823_chr12_58240155_-_HMGA2_ENST00000403681_chr12_66345163_+_3417nt ATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGGGCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCC TTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTGAACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAG CGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTCCCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGA TGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCCT GCTCAGGAGGAAACTGAAGAGACATCCTCACAAGAGTCTGCCGAAGAGGACTAGGGGGCGCCAACGTTCGATTTCTACCTCAGCAGCAGT TGGATCTTTTGAAGGGAGAAGACACTGCAGTGACCACTTATTCTGTATTGCCATGGTCTTTCCACTTTCATCTGGGGTGGGGTGGGGTGG GGTGGGGGAGGGGGGGGTGGGGTGGGGAGAAATCACATAACCTTAAAAAGGACTATATTAATCACCTTCTTTGTAATCCCTTCACAGTCC CAGGTTTAGTGAAAAACTGCTGTAAACACAGGGGACACAGCTTAACAATGCAACTTTTAATTACTGTTTTCTTTTTTCTTAACCTACTAA TAGTTTGTTGATCTGATAAGCAAGAGTGGGCGGGTGAGAAAAACCGAATTGGGTTTAGTCAATCACTGCACTGCATGCAAACAAGAAACG TGTCACACTTGTGACGTCGGGCATTCATATAGGAAGAACGCGGTGTGTAACACTGTGTACACCTCAAATACCACCCCAACCCACTCCCTG TAGTGAATCCTCTGTTTAGAACACCAAAGATAAGGACTAGATACTACTTTCTCTTTTTCGTATAATCTTGTAGACACTTACTTGATGATT TTTAACTTTTTATTTCTAAATGAGACGAAATGCTGATGTATCCTTTCATTCAGCTAACAAACTAGAAAAGGTTATGTTCATTTTTCAAAA AGGGAAGTAAGCAAACAAATATTGCCAACTCTTCTATTTATGGATATCACACATATCAGCAGGAGTAATAAATTTACTCACAGCACTTGT TTTCAGGACAACACTTCATTTTCAGGAAATCTACTTCCTACAGAGCCAAAATGCCATTTAGCAATAAATAACACTTGTCAGCCTCAGAGC ATTTAAGGAAACTAGACAAGTAAAATTATCCTCTTTGTAATTTAATGAAAAGGTACAACAGAATAATGCATGATGAACTCACCTAATTAT GAGGTGGGAGGAGCGAAATCTAAATTTCTTTTGCTATAGTTATACATCAATTTAAAAAGCAAAAAAAAAAAAGGGGGGGGCAATCTCTCT CTGTGTCTTTCTCTCTCTCTCTTCCTCTCCCTCTCTCTTTTCATTGTGTATCAGTTTCCATGAAAGACCTGAATACCACTTACCTCAAAT TAAGCATATGTGTTACTTCAAGTAATACGTTTTGACATAAGATGGTTGACCAAGGTGCTTTTCTTCGGCTTGAGTTCACCATCTCTTCAT TCAAACTGCACTTTTAGCCAGAGATGCAATATATCCCCACTACTCAATACTACCTCTGAATGTTACAACGAATTTACAGTCTAGTACTTA TTACATGCTGCTATACACAAGCAATGCAAGAAAAAAACTTACTGGGTAGGTGATTCTAATCATCTGCAGTTCTTTTTGTACACTTAATTA CAGTTAAAGAAGCAATCTCCTTACTGTGTTTCAGCATGACTATGTATTTTTCTATGTTTTTTTAATTAAAAATTTTTAAAATACTTGTTT CAGCTTCTCTGCTAGATTTCTACATTAACTTGAAAATTTTTTAACCAAGTCGCTCCTAGGTTCTTAAGGATAATTTTCCTCAATCACACT ACACATCACACAAGATTTGACTGTAATATTTAAATATTACCCTCCAAGTCTGTACCTCAAATGAATTCTTTAAGGAGATGGACTAATTGA CTTGCAAAGACCTACCTCCAGACTTCAAAAGGAATGAACTTGTTACTTGCAGCATTCATTTGTTTTTTCAATGTTTGAAATAGTTCAAAC TGCAGCTAACCCTAGTCAAAACTATTTTTGTAAAAGACATTTGATAGAAAGGAACACGTTTTTACATACTTTTGCAAAATAAGTAAATAA TAAATAAAATAAAAGCCAACCTTCAAAGAAACTTGAAGCTTTGTAGGTGAGATGCAACAAGCCCTGCTTTTGCATAATGCAATCAAAAAT ATGTGTTTTTAAGATTAGTTGAATATAAGAAAATGCTTGACAAATATTTTCATGTATTTTACACAAATGTGATTTTTGTAATATGTCTCA ACCAGATTTATTTTAAACGCTTCTTATGTAGAGTTTTTATGCCTTTCTCTCCTAGTGAGTGTGCTGACTTTTTAACATGGTATTATCAAC TGGGCCAGGAGGTAGTTTCTCATGACGGCTTTTGTCAGTATGGCTTTTAGTACTGAAGCCAAATGAAACTCAAAACCATCTCTCTTCCAG CTGCTTCAGGGAGGTAGTTTCAAAGGCCACATACCTCTCTGAGACTGGCAGATCGCTCACTGTTGTGAATCACCAAAGGAGCTATGGAGA GAATTAAAACTCAACATTACTGTTAACTGTGCGTTAAATAAGCAAATAAACAGTGGCTCATAAAAATAAAAGTCGCATTCCATATCTTTG GATGGGCCTTTTAGAAACCTCATTGGCCAGCTCATAAAATGGAAGCAATTGCTCATGTTGGCCAAACATGGTGCACCGAGTGATTTCCAT CTCTGGTAAAGTTACACTTTTATTTCCTGTATGTTGTACAATCAAAACACACTACTACCTCTTAAGTCCCAGTATACCTCATTTTTCATA CTGAAAAAAAAAGCTTGTGGCCAATGGAACAGTAAGAACATCATAAAATTTTTATATATATAGTTTATTTTTGTGGGAGATAAATTTTAT AGGACTGTTCTTTGCTGTTGTTGGTCGCAGCTACATAAGACTGGACATTTAACTTTTCTACCATTTCTGCAAGTTAGGTATGTTTGCAGG AGAAAAGTATCAAGACGTTTAACTGCAGTTGACTTTCTCCCTGTTCCTTTGAGTGTCTTCTAACTTTATTCTTTGTTCTTTATGTAGAAT TGCTGTCTATGATTGTACTTTGAATCGCTTGCTTGTTGAAAATATTTCTCTAGTGTATTATCACTGTCTGTTCTGCACAATAAACATAAC >In-frame_CTDSP2_ENST00000548823_chr12_58240155_-_HMGA2_ENST00000393577_chr12_66345163_+_547nt ATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGGGCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCC TTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTGAACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAG CGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTCCCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGA TGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCCT GCTCAGGTCAATGTTGCCTTGCCTGGGAAGGACCACCCGGGCAATCTTATATATCTACTGTTCTCTAAAAATGCCACTTAGAAGAGAATT GAAACTTCCAAACACATGAAAGGATCCAAGGAAAGTGTCTTCAAACAATTACATATGAGCTTTAAGTGGAATAAAAACAGAGTTACCATG |
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FusionGenePPI for CTDSP2_HMGA2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CTDSP2 | POLR2A, SNAI1, CDCA3, CTDSP1, PLEKHH3, POM121, ZC3H3, ZMYM6, MAP7D1, INTS6, PRR14, ATP2B3, CWC22, SETD1A, UBTF, NEK4, ENDOD1, MAP7, SLC25A20, ATP12A, ANKRD13A, TBC1D4, BSG, DNAJA3, HAX1, P4HA1, RPS27L, TIMM50, TUBB6, ANKRD13D, NEK1, CSF1R, TYRO3, INSRR, PTK7, EPHA3, EPHA1, AKT1 | HMGA2 | RELA, NFKB1, PIAS3, RB1, PRMT6, NPM1, SMAD1, SMAD5, SMAD9, PRKCA, HDGF, PTBP1, APEX1, SYNCRIP, XRCC6, PSIP1, PA2G4, PCBP2, E4F1, OBSL1, HIST1H3A, CREB1, NFATC1, PCGF1, POU5F1, DLST |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | HMGA2 | chr12:58240155 | chr12:66345163 | ENST00000354636 | + | 0 | 4 | 44_63 | -271 | 107 | E4F1 |
| Tgene | HMGA2 | chr12:58240155 | chr12:66345163 | ENST00000393578 | + | 0 | 4 | 44_63 | -271 | 91 | E4F1 |
| Tgene | HMGA2 | chr12:58240155 | chr12:66345163 | ENST00000425208 | + | 0 | 4 | 44_63 | -271 | 93 | E4F1 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | HMGA2 | chr12:58240155 | chr12:66345163 | ENST00000403681 | + | 2 | 5 | 44_63 | 83 | 110 | E4F1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CTDSP2_HMGA2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CTDSP2_HMGA2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | HMGA2 | C0005612 | Birth Weight | 1 | CTD_human |
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