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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8764

FusionGeneSummary for CTDSP2_HMGA2

check button Fusion gene summary
Fusion gene informationFusion gene name: CTDSP2_HMGA2
Fusion gene ID: 8764
HgeneTgene
Gene symbol

CTDSP2

HMGA2

Gene ID

10106

8091

Gene nameCTD small phosphatase 2high mobility group AT-hook 2
SynonymsOS4|PSR2|SCP2BABL|HMGI-C|HMGIC|LIPO|STQTL9
Cytomap

12q14.1

12q14.3

Type of geneprotein-codingprotein-coding
Descriptioncarboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2NLI-interacting factor 2conserved gene amplified in osteosarcomanuclear LIM interactor-interahigh mobility group protein HMGI-CHMGA2/KRT121P fusionhigh-mobility group (nonhistone chromosomal) protein isoform I-C
Modification date2018052320180523
UniProtAcc

O14595

P52926

Ensembl transtripts involved in fusion geneENST00000398073, ENST00000548823, 
ENST00000547701, 
ENST00000403681, 
ENST00000541363, ENST00000393577, 
ENST00000393578, ENST00000425208, 
ENST00000536545, ENST00000354636, 
Fusion gene scores* DoF score26 X 5 X 7=9107 X 4 X 3=84
# samples 226
** MAII scorelog2(22/910*10)=-2.0483630215614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/84*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTDSP2 [Title/Abstract] AND HMGA2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTDSP2

GO:0006470

protein dephosphorylation

12721286

TgeneHMGA2

GO:0000122

negative regulation of transcription by RNA polymerase II

14627817

TgeneHMGA2

GO:0002062

chondrocyte differentiation

21484705

TgeneHMGA2

GO:0006284

base-excision repair

19465398

TgeneHMGA2

GO:0007095

mitotic G2 DNA damage checkpoint

16061642

TgeneHMGA2

GO:0010564

regulation of cell cycle process

14645522

TgeneHMGA2

GO:0010628

positive regulation of gene expression

18832382

TgeneHMGA2

GO:0031052

chromosome breakage

19549901

TgeneHMGA2

GO:0031507

heterochromatin assembly

16901784

TgeneHMGA2

GO:0035978

histone H2A-S139 phosphorylation

16061642

TgeneHMGA2

GO:0035986

senescence-associated heterochromatin focus assembly

16901784

TgeneHMGA2

GO:0035988

chondrocyte proliferation

21484705

TgeneHMGA2

GO:0042769

DNA damage response, detection of DNA damage

19465398

TgeneHMGA2

GO:0043065

positive regulation of apoptotic process

16061642

TgeneHMGA2

GO:0043066

negative regulation of apoptotic process

19465398

TgeneHMGA2

GO:0043392

negative regulation of DNA binding

14645522

TgeneHMGA2

GO:0043922

negative regulation by host of viral transcription

17005673

TgeneHMGA2

GO:0045869

negative regulation of single stranded viral RNA replication via double stranded DNA intermediate

17005673

TgeneHMGA2

GO:0045892

negative regulation of transcription, DNA-templated

18832382

TgeneHMGA2

GO:0045893

positive regulation of transcription, DNA-templated

15225648|15755872|17005673|17324944|17426251

TgeneHMGA2

GO:0045944

positive regulation of transcription by RNA polymerase II

14645522|18832382

TgeneHMGA2

GO:0071158

positive regulation of cell cycle arrest

16061642

TgeneHMGA2

GO:0090402

oncogene-induced cell senescence

16901784

TgeneHMGA2

GO:2000648

positive regulation of stem cell proliferation

21484705

TgeneHMGA2

GO:2000679

positive regulation of transcription regulatory region DNA binding

18832382

TgeneHMGA2

GO:2000685

positive regulation of cellular response to X-ray

16061642

TgeneHMGA2

GO:2001022

positive regulation of response to DNA damage stimulus

16061642|19465398

TgeneHMGA2

GO:2001033

negative regulation of double-strand break repair via nonhomologous end joining

19549901

TgeneHMGA2

GO:2001038

regulation of cellular response to drug

16061642


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-IF-A3RQ-01ACTDSP2chr12

58240155

-HMGA2chr12

66345163

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000398073ENST00000403681CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
Frame-shiftENST00000398073ENST00000541363CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
In-frameENST00000398073ENST00000393577CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
5CDS-intronENST00000398073ENST00000393578CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
5CDS-intronENST00000398073ENST00000425208CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
5CDS-intronENST00000398073ENST00000536545CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
5CDS-intronENST00000398073ENST00000354636CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
In-frameENST00000548823ENST00000403681CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
Frame-shiftENST00000548823ENST00000541363CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
In-frameENST00000548823ENST00000393577CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
5CDS-intronENST00000548823ENST00000393578CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
5CDS-intronENST00000548823ENST00000425208CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
5CDS-intronENST00000548823ENST00000536545CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
5CDS-intronENST00000548823ENST00000354636CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
intron-3CDSENST00000547701ENST00000403681CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
intron-3CDSENST00000547701ENST00000541363CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
intron-3CDSENST00000547701ENST00000393577CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
intron-intronENST00000547701ENST00000393578CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
intron-intronENST00000547701ENST00000425208CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
intron-intronENST00000547701ENST00000536545CTDSP2chr12

58240155

-HMGA2chr12

66345163

+
intron-intronENST00000547701ENST00000354636CTDSP2chr12

58240155

-HMGA2chr12

66345163

+

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FusionProtFeatures for CTDSP2_HMGA2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTDSP2

O14595

HMGA2

P52926

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain(CTD) of the largest RNA polymerase II subunit POLR2A. Negativelyregulates RNA polymerase II transcription, possibly by controllingthe transition from initiation/capping to processive transcriptelongation. Recruited by REST to neuronal genes that contain RE-1elements, leading to neuronal gene silencing in non-neuronalcells. May contribute to the development of sarcomas.{ECO:0000269|PubMed:12721286, ECO:0000269|PubMed:15681389}. Functions as a transcriptional regulator. Functions incell cycle regulation through CCNA2. Plays an important role inchromosome condensation during the meiotic G2/M transition ofspermatocytes. Plays a role in postnatal myogenesis, is involvedin satellite cell activation (By similarity).{ECO:0000250|UniProtKB:P52927, ECO:0000269|PubMed:14645522}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHMGA2chr12:58240155chr12:66345163ENST00000354636+0424_34-271107DNA bindingNote=A.T hook 1
TgeneHMGA2chr12:58240155chr12:66345163ENST00000354636+0444_54-271107DNA bindingNote=A.T hook 2
TgeneHMGA2chr12:58240155chr12:66345163ENST00000354636+0471_82-271107DNA bindingNote=A.T hook 3
TgeneHMGA2chr12:58240155chr12:66345163ENST00000393578+0424_34-27191DNA bindingNote=A.T hook 1
TgeneHMGA2chr12:58240155chr12:66345163ENST00000393578+0444_54-27191DNA bindingNote=A.T hook 2
TgeneHMGA2chr12:58240155chr12:66345163ENST00000393578+0471_82-27191DNA bindingNote=A.T hook 3
TgeneHMGA2chr12:58240155chr12:66345163ENST00000425208+0424_34-27193DNA bindingNote=A.T hook 1
TgeneHMGA2chr12:58240155chr12:66345163ENST00000425208+0444_54-27193DNA bindingNote=A.T hook 2
TgeneHMGA2chr12:58240155chr12:66345163ENST00000425208+0471_82-27193DNA bindingNote=A.T hook 3

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCTDSP2chr12:58240155chr12:66345163ENST00000398073-1897_25521272DomainFCP1 homology
TgeneHMGA2chr12:58240155chr12:66345163ENST00000403681+2524_3483110DNA bindingNote=A.T hook 1
TgeneHMGA2chr12:58240155chr12:66345163ENST00000403681+2544_5483110DNA bindingNote=A.T hook 2
TgeneHMGA2chr12:58240155chr12:66345163ENST00000403681+2571_8283110DNA bindingNote=A.T hook 3


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FusionGeneSequence for CTDSP2_HMGA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CTDSP2_ENST00000398073_chr12_58240155_-_HMGA2_ENST00000403681_chr12_66345163_+_48aa

>In-frame_CTDSP2_ENST00000398073_chr12_58240155_-_HMGA2_ENST00000393577_chr12_66345163_+_57aa

>In-frame_CTDSP2_ENST00000548823_chr12_58240155_-_HMGA2_ENST00000403681_chr12_66345163_+_48aa

>In-frame_CTDSP2_ENST00000548823_chr12_58240155_-_HMGA2_ENST00000393577_chr12_66345163_+_57aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CTDSP2_ENST00000398073_chr12_58240155_-_HMGA2_ENST00000403681_chr12_66345163_+_145nt
ATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCC

>In-frame_CTDSP2_ENST00000398073_chr12_58240155_-_HMGA2_ENST00000393577_chr12_66345163_+_172nt
ATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCC

>In-frame_CTDSP2_ENST00000548823_chr12_58240155_-_HMGA2_ENST00000403681_chr12_66345163_+_145nt
ATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCC

>In-frame_CTDSP2_ENST00000548823_chr12_58240155_-_HMGA2_ENST00000393577_chr12_66345163_+_172nt
ATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_CTDSP2_ENST00000398073_chr12_58240155_-_HMGA2_ENST00000403681_chr12_66345163_+_3452nt
CCATTTCCTCCTCTTGTTTTCGCTCCGGATTCTCCATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGG
GCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCCTTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTG
AACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAGCGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTC
CCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCAC
CAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAGGAGGAAACTGAAGAGACATCCTCACAAGAGTCTGCCGAAGAGGACTAGG
GGGCGCCAACGTTCGATTTCTACCTCAGCAGCAGTTGGATCTTTTGAAGGGAGAAGACACTGCAGTGACCACTTATTCTGTATTGCCATG
GTCTTTCCACTTTCATCTGGGGTGGGGTGGGGTGGGGTGGGGGAGGGGGGGGTGGGGTGGGGAGAAATCACATAACCTTAAAAAGGACTA
TATTAATCACCTTCTTTGTAATCCCTTCACAGTCCCAGGTTTAGTGAAAAACTGCTGTAAACACAGGGGACACAGCTTAACAATGCAACT
TTTAATTACTGTTTTCTTTTTTCTTAACCTACTAATAGTTTGTTGATCTGATAAGCAAGAGTGGGCGGGTGAGAAAAACCGAATTGGGTT
TAGTCAATCACTGCACTGCATGCAAACAAGAAACGTGTCACACTTGTGACGTCGGGCATTCATATAGGAAGAACGCGGTGTGTAACACTG
TGTACACCTCAAATACCACCCCAACCCACTCCCTGTAGTGAATCCTCTGTTTAGAACACCAAAGATAAGGACTAGATACTACTTTCTCTT
TTTCGTATAATCTTGTAGACACTTACTTGATGATTTTTAACTTTTTATTTCTAAATGAGACGAAATGCTGATGTATCCTTTCATTCAGCT
AACAAACTAGAAAAGGTTATGTTCATTTTTCAAAAAGGGAAGTAAGCAAACAAATATTGCCAACTCTTCTATTTATGGATATCACACATA
TCAGCAGGAGTAATAAATTTACTCACAGCACTTGTTTTCAGGACAACACTTCATTTTCAGGAAATCTACTTCCTACAGAGCCAAAATGCC
ATTTAGCAATAAATAACACTTGTCAGCCTCAGAGCATTTAAGGAAACTAGACAAGTAAAATTATCCTCTTTGTAATTTAATGAAAAGGTA
CAACAGAATAATGCATGATGAACTCACCTAATTATGAGGTGGGAGGAGCGAAATCTAAATTTCTTTTGCTATAGTTATACATCAATTTAA
AAAGCAAAAAAAAAAAAGGGGGGGGCAATCTCTCTCTGTGTCTTTCTCTCTCTCTCTTCCTCTCCCTCTCTCTTTTCATTGTGTATCAGT
TTCCATGAAAGACCTGAATACCACTTACCTCAAATTAAGCATATGTGTTACTTCAAGTAATACGTTTTGACATAAGATGGTTGACCAAGG
TGCTTTTCTTCGGCTTGAGTTCACCATCTCTTCATTCAAACTGCACTTTTAGCCAGAGATGCAATATATCCCCACTACTCAATACTACCT
CTGAATGTTACAACGAATTTACAGTCTAGTACTTATTACATGCTGCTATACACAAGCAATGCAAGAAAAAAACTTACTGGGTAGGTGATT
CTAATCATCTGCAGTTCTTTTTGTACACTTAATTACAGTTAAAGAAGCAATCTCCTTACTGTGTTTCAGCATGACTATGTATTTTTCTAT
GTTTTTTTAATTAAAAATTTTTAAAATACTTGTTTCAGCTTCTCTGCTAGATTTCTACATTAACTTGAAAATTTTTTAACCAAGTCGCTC
CTAGGTTCTTAAGGATAATTTTCCTCAATCACACTACACATCACACAAGATTTGACTGTAATATTTAAATATTACCCTCCAAGTCTGTAC
CTCAAATGAATTCTTTAAGGAGATGGACTAATTGACTTGCAAAGACCTACCTCCAGACTTCAAAAGGAATGAACTTGTTACTTGCAGCAT
TCATTTGTTTTTTCAATGTTTGAAATAGTTCAAACTGCAGCTAACCCTAGTCAAAACTATTTTTGTAAAAGACATTTGATAGAAAGGAAC
ACGTTTTTACATACTTTTGCAAAATAAGTAAATAATAAATAAAATAAAAGCCAACCTTCAAAGAAACTTGAAGCTTTGTAGGTGAGATGC
AACAAGCCCTGCTTTTGCATAATGCAATCAAAAATATGTGTTTTTAAGATTAGTTGAATATAAGAAAATGCTTGACAAATATTTTCATGT
ATTTTACACAAATGTGATTTTTGTAATATGTCTCAACCAGATTTATTTTAAACGCTTCTTATGTAGAGTTTTTATGCCTTTCTCTCCTAG
TGAGTGTGCTGACTTTTTAACATGGTATTATCAACTGGGCCAGGAGGTAGTTTCTCATGACGGCTTTTGTCAGTATGGCTTTTAGTACTG
AAGCCAAATGAAACTCAAAACCATCTCTCTTCCAGCTGCTTCAGGGAGGTAGTTTCAAAGGCCACATACCTCTCTGAGACTGGCAGATCG
CTCACTGTTGTGAATCACCAAAGGAGCTATGGAGAGAATTAAAACTCAACATTACTGTTAACTGTGCGTTAAATAAGCAAATAAACAGTG
GCTCATAAAAATAAAAGTCGCATTCCATATCTTTGGATGGGCCTTTTAGAAACCTCATTGGCCAGCTCATAAAATGGAAGCAATTGCTCA
TGTTGGCCAAACATGGTGCACCGAGTGATTTCCATCTCTGGTAAAGTTACACTTTTATTTCCTGTATGTTGTACAATCAAAACACACTAC
TACCTCTTAAGTCCCAGTATACCTCATTTTTCATACTGAAAAAAAAAGCTTGTGGCCAATGGAACAGTAAGAACATCATAAAATTTTTAT
ATATATAGTTTATTTTTGTGGGAGATAAATTTTATAGGACTGTTCTTTGCTGTTGTTGGTCGCAGCTACATAAGACTGGACATTTAACTT
TTCTACCATTTCTGCAAGTTAGGTATGTTTGCAGGAGAAAAGTATCAAGACGTTTAACTGCAGTTGACTTTCTCCCTGTTCCTTTGAGTG
TCTTCTAACTTTATTCTTTGTTCTTTATGTAGAATTGCTGTCTATGATTGTACTTTGAATCGCTTGCTTGTTGAAAATATTTCTCTAGTG
TATTATCACTGTCTGTTCTGCACAATAAACATAACAGCCTCTGTGATCCCCATGTGTTTTGATTCCTGCTCTTTGTTACAGTTCCATTAA

>In-frame_CTDSP2_ENST00000398073_chr12_58240155_-_HMGA2_ENST00000393577_chr12_66345163_+_582nt
CCATTTCCTCCTCTTGTTTTCGCTCCGGATTCTCCATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGG
GCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCCTTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTG
AACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAGCGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTC
CCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCAC
CAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCCTGCTCAGGTCAATGTTGCCTTGCCTGGGAAGGACCACCCGGGCAATCTTATATATC
TACTGTTCTCTAAAAATGCCACTTAGAAGAGAATTGAAACTTCCAAACACATGAAAGGATCCAAGGAAAGTGTCTTCAAACAATTACATA

>In-frame_CTDSP2_ENST00000548823_chr12_58240155_-_HMGA2_ENST00000403681_chr12_66345163_+_3417nt
ATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGGGCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCC
TTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTGAACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAG
CGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTCCCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGA
TGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCCT
GCTCAGGAGGAAACTGAAGAGACATCCTCACAAGAGTCTGCCGAAGAGGACTAGGGGGCGCCAACGTTCGATTTCTACCTCAGCAGCAGT
TGGATCTTTTGAAGGGAGAAGACACTGCAGTGACCACTTATTCTGTATTGCCATGGTCTTTCCACTTTCATCTGGGGTGGGGTGGGGTGG
GGTGGGGGAGGGGGGGGTGGGGTGGGGAGAAATCACATAACCTTAAAAAGGACTATATTAATCACCTTCTTTGTAATCCCTTCACAGTCC
CAGGTTTAGTGAAAAACTGCTGTAAACACAGGGGACACAGCTTAACAATGCAACTTTTAATTACTGTTTTCTTTTTTCTTAACCTACTAA
TAGTTTGTTGATCTGATAAGCAAGAGTGGGCGGGTGAGAAAAACCGAATTGGGTTTAGTCAATCACTGCACTGCATGCAAACAAGAAACG
TGTCACACTTGTGACGTCGGGCATTCATATAGGAAGAACGCGGTGTGTAACACTGTGTACACCTCAAATACCACCCCAACCCACTCCCTG
TAGTGAATCCTCTGTTTAGAACACCAAAGATAAGGACTAGATACTACTTTCTCTTTTTCGTATAATCTTGTAGACACTTACTTGATGATT
TTTAACTTTTTATTTCTAAATGAGACGAAATGCTGATGTATCCTTTCATTCAGCTAACAAACTAGAAAAGGTTATGTTCATTTTTCAAAA
AGGGAAGTAAGCAAACAAATATTGCCAACTCTTCTATTTATGGATATCACACATATCAGCAGGAGTAATAAATTTACTCACAGCACTTGT
TTTCAGGACAACACTTCATTTTCAGGAAATCTACTTCCTACAGAGCCAAAATGCCATTTAGCAATAAATAACACTTGTCAGCCTCAGAGC
ATTTAAGGAAACTAGACAAGTAAAATTATCCTCTTTGTAATTTAATGAAAAGGTACAACAGAATAATGCATGATGAACTCACCTAATTAT
GAGGTGGGAGGAGCGAAATCTAAATTTCTTTTGCTATAGTTATACATCAATTTAAAAAGCAAAAAAAAAAAAGGGGGGGGCAATCTCTCT
CTGTGTCTTTCTCTCTCTCTCTTCCTCTCCCTCTCTCTTTTCATTGTGTATCAGTTTCCATGAAAGACCTGAATACCACTTACCTCAAAT
TAAGCATATGTGTTACTTCAAGTAATACGTTTTGACATAAGATGGTTGACCAAGGTGCTTTTCTTCGGCTTGAGTTCACCATCTCTTCAT
TCAAACTGCACTTTTAGCCAGAGATGCAATATATCCCCACTACTCAATACTACCTCTGAATGTTACAACGAATTTACAGTCTAGTACTTA
TTACATGCTGCTATACACAAGCAATGCAAGAAAAAAACTTACTGGGTAGGTGATTCTAATCATCTGCAGTTCTTTTTGTACACTTAATTA
CAGTTAAAGAAGCAATCTCCTTACTGTGTTTCAGCATGACTATGTATTTTTCTATGTTTTTTTAATTAAAAATTTTTAAAATACTTGTTT
CAGCTTCTCTGCTAGATTTCTACATTAACTTGAAAATTTTTTAACCAAGTCGCTCCTAGGTTCTTAAGGATAATTTTCCTCAATCACACT
ACACATCACACAAGATTTGACTGTAATATTTAAATATTACCCTCCAAGTCTGTACCTCAAATGAATTCTTTAAGGAGATGGACTAATTGA
CTTGCAAAGACCTACCTCCAGACTTCAAAAGGAATGAACTTGTTACTTGCAGCATTCATTTGTTTTTTCAATGTTTGAAATAGTTCAAAC
TGCAGCTAACCCTAGTCAAAACTATTTTTGTAAAAGACATTTGATAGAAAGGAACACGTTTTTACATACTTTTGCAAAATAAGTAAATAA
TAAATAAAATAAAAGCCAACCTTCAAAGAAACTTGAAGCTTTGTAGGTGAGATGCAACAAGCCCTGCTTTTGCATAATGCAATCAAAAAT
ATGTGTTTTTAAGATTAGTTGAATATAAGAAAATGCTTGACAAATATTTTCATGTATTTTACACAAATGTGATTTTTGTAATATGTCTCA
ACCAGATTTATTTTAAACGCTTCTTATGTAGAGTTTTTATGCCTTTCTCTCCTAGTGAGTGTGCTGACTTTTTAACATGGTATTATCAAC
TGGGCCAGGAGGTAGTTTCTCATGACGGCTTTTGTCAGTATGGCTTTTAGTACTGAAGCCAAATGAAACTCAAAACCATCTCTCTTCCAG
CTGCTTCAGGGAGGTAGTTTCAAAGGCCACATACCTCTCTGAGACTGGCAGATCGCTCACTGTTGTGAATCACCAAAGGAGCTATGGAGA
GAATTAAAACTCAACATTACTGTTAACTGTGCGTTAAATAAGCAAATAAACAGTGGCTCATAAAAATAAAAGTCGCATTCCATATCTTTG
GATGGGCCTTTTAGAAACCTCATTGGCCAGCTCATAAAATGGAAGCAATTGCTCATGTTGGCCAAACATGGTGCACCGAGTGATTTCCAT
CTCTGGTAAAGTTACACTTTTATTTCCTGTATGTTGTACAATCAAAACACACTACTACCTCTTAAGTCCCAGTATACCTCATTTTTCATA
CTGAAAAAAAAAGCTTGTGGCCAATGGAACAGTAAGAACATCATAAAATTTTTATATATATAGTTTATTTTTGTGGGAGATAAATTTTAT
AGGACTGTTCTTTGCTGTTGTTGGTCGCAGCTACATAAGACTGGACATTTAACTTTTCTACCATTTCTGCAAGTTAGGTATGTTTGCAGG
AGAAAAGTATCAAGACGTTTAACTGCAGTTGACTTTCTCCCTGTTCCTTTGAGTGTCTTCTAACTTTATTCTTTGTTCTTTATGTAGAAT
TGCTGTCTATGATTGTACTTTGAATCGCTTGCTTGTTGAAAATATTTCTCTAGTGTATTATCACTGTCTGTTCTGCACAATAAACATAAC

>In-frame_CTDSP2_ENST00000548823_chr12_58240155_-_HMGA2_ENST00000393577_chr12_66345163_+_547nt
ATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGGGCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCC
TTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTGAACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAG
CGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTCCCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGA
TGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGCCACAACAAGTTGTTCAGAAGAAGCCT
GCTCAGGTCAATGTTGCCTTGCCTGGGAAGGACCACCCGGGCAATCTTATATATCTACTGTTCTCTAAAAATGCCACTTAGAAGAGAATT
GAAACTTCCAAACACATGAAAGGATCCAAGGAAAGTGTCTTCAAACAATTACATATGAGCTTTAAGTGGAATAAAAACAGAGTTACCATG


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FusionGenePPI for CTDSP2_HMGA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTDSP2POLR2A, SNAI1, CDCA3, CTDSP1, PLEKHH3, POM121, ZC3H3, ZMYM6, MAP7D1, INTS6, PRR14, ATP2B3, CWC22, SETD1A, UBTF, NEK4, ENDOD1, MAP7, SLC25A20, ATP12A, ANKRD13A, TBC1D4, BSG, DNAJA3, HAX1, P4HA1, RPS27L, TIMM50, TUBB6, ANKRD13D, NEK1, CSF1R, TYRO3, INSRR, PTK7, EPHA3, EPHA1, AKT1HMGA2RELA, NFKB1, PIAS3, RB1, PRMT6, NPM1, SMAD1, SMAD5, SMAD9, PRKCA, HDGF, PTBP1, APEX1, SYNCRIP, XRCC6, PSIP1, PA2G4, PCBP2, E4F1, OBSL1, HIST1H3A, CREB1, NFATC1, PCGF1, POU5F1, DLST


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneHMGA2chr12:58240155chr12:66345163ENST00000354636+0444_63-271107E4F1
TgeneHMGA2chr12:58240155chr12:66345163ENST00000393578+0444_63-27191E4F1
TgeneHMGA2chr12:58240155chr12:66345163ENST00000425208+0444_63-27193E4F1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneHMGA2chr12:58240155chr12:66345163ENST00000403681+2544_6383110E4F1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTDSP2_HMGA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTDSP2_HMGA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneHMGA2C0005612Birth Weight1CTD_human