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Fusion gene ID: 8760 |
FusionGeneSummary for CTDSP2_DCUN1D4 |
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Fusion gene information | Fusion gene name: CTDSP2_DCUN1D4 | Fusion gene ID: 8760 | Hgene | Tgene | Gene symbol | CTDSP2 | DCUN1D4 | Gene ID | 10106 | 23142 |
Gene name | CTD small phosphatase 2 | defective in cullin neddylation 1 domain containing 4 | |
Synonyms | OS4|PSR2|SCP2 | - | |
Cytomap | 12q14.1 | 4q12 | |
Type of gene | protein-coding | protein-coding | |
Description | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2NLI-interacting factor 2conserved gene amplified in osteosarcomanuclear LIM interactor-intera | DCN1-like protein 4DCN1, defective in cullin neddylation 1, domain containing 4DCUN1 domain-containing protein 4defective in cullin neddylation protein 1-like protein 4 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O14595 | Q92564 | |
Ensembl transtripts involved in fusion gene | ENST00000398073, ENST00000548823, ENST00000547701, | ENST00000381441, ENST00000334635, ENST00000513800, ENST00000381437, ENST00000451288, | |
Fusion gene scores | * DoF score | 26 X 5 X 7=910 | 3 X 3 X 2=18 |
# samples | 22 | 3 | |
** MAII score | log2(22/910*10)=-2.0483630215614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CTDSP2 [Title/Abstract] AND DCUN1D4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CTDSP2 | GO:0006470 | protein dephosphorylation | 12721286 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | GBM | TCGA-06-2559-01A | CTDSP2 | chr12 | 58240155 | - | DCUN1D4 | chr4 | 52765436 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000398073 | ENST00000381441 | CTDSP2 | chr12 | 58240155 | - | DCUN1D4 | chr4 | 52765436 | + |
Frame-shift | ENST00000398073 | ENST00000334635 | CTDSP2 | chr12 | 58240155 | - | DCUN1D4 | chr4 | 52765436 | + |
5CDS-intron | ENST00000398073 | ENST00000513800 | CTDSP2 | chr12 | 58240155 | - | DCUN1D4 | chr4 | 52765436 | + |
5CDS-intron | ENST00000398073 | ENST00000381437 | CTDSP2 | chr12 | 58240155 | - | DCUN1D4 | chr4 | 52765436 | + |
5CDS-intron | ENST00000398073 | ENST00000451288 | CTDSP2 | chr12 | 58240155 | - | DCUN1D4 | chr4 | 52765436 | + |
Frame-shift | ENST00000548823 | ENST00000381441 | CTDSP2 | chr12 | 58240155 | - | DCUN1D4 | chr4 | 52765436 | + |
Frame-shift | ENST00000548823 | ENST00000334635 | CTDSP2 | chr12 | 58240155 | - | DCUN1D4 | chr4 | 52765436 | + |
5CDS-intron | ENST00000548823 | ENST00000513800 | CTDSP2 | chr12 | 58240155 | - | DCUN1D4 | chr4 | 52765436 | + |
5CDS-intron | ENST00000548823 | ENST00000381437 | CTDSP2 | chr12 | 58240155 | - | DCUN1D4 | chr4 | 52765436 | + |
5CDS-intron | ENST00000548823 | ENST00000451288 | CTDSP2 | chr12 | 58240155 | - | DCUN1D4 | chr4 | 52765436 | + |
intron-3CDS | ENST00000547701 | ENST00000381441 | CTDSP2 | chr12 | 58240155 | - | DCUN1D4 | chr4 | 52765436 | + |
intron-3CDS | ENST00000547701 | ENST00000334635 | CTDSP2 | chr12 | 58240155 | - | DCUN1D4 | chr4 | 52765436 | + |
intron-intron | ENST00000547701 | ENST00000513800 | CTDSP2 | chr12 | 58240155 | - | DCUN1D4 | chr4 | 52765436 | + |
intron-intron | ENST00000547701 | ENST00000381437 | CTDSP2 | chr12 | 58240155 | - | DCUN1D4 | chr4 | 52765436 | + |
intron-intron | ENST00000547701 | ENST00000451288 | CTDSP2 | chr12 | 58240155 | - | DCUN1D4 | chr4 | 52765436 | + |
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FusionProtFeatures for CTDSP2_DCUN1D4 |
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Hgene | Tgene |
CTDSP2 | DCUN1D4 |
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain(CTD) of the largest RNA polymerase II subunit POLR2A. Negativelyregulates RNA polymerase II transcription, possibly by controllingthe transition from initiation/capping to processive transcriptelongation. Recruited by REST to neuronal genes that contain RE-1elements, leading to neuronal gene silencing in non-neuronalcells. May contribute to the development of sarcomas.{ECO:0000269|PubMed:12721286, ECO:0000269|PubMed:15681389}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CTDSP2_DCUN1D4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CTDSP2_DCUN1D4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CTDSP2 | POLR2A, SNAI1, CDCA3, CTDSP1, PLEKHH3, POM121, ZC3H3, ZMYM6, MAP7D1, INTS6, PRR14, ATP2B3, CWC22, SETD1A, UBTF, NEK4, ENDOD1, MAP7, SLC25A20, ATP12A, ANKRD13A, TBC1D4, BSG, DNAJA3, HAX1, P4HA1, RPS27L, TIMM50, TUBB6, ANKRD13D, NEK1, CSF1R, TYRO3, INSRR, PTK7, EPHA3, EPHA1, AKT1 | DCUN1D4 | VAV2, ELAVL1, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, UBE2M, BUD31, TOP3A, CAND1, RBX1, RNF7, ARL4C, MSRB3, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CTDSP2_DCUN1D4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CTDSP2_DCUN1D4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |