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Fusion gene ID: 8758 |
FusionGeneSummary for CTDSP2_COMMD10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CTDSP2_COMMD10 | Fusion gene ID: 8758 | Hgene | Tgene | Gene symbol | CTDSP2 | COMMD10 | Gene ID | 10106 | 51397 |
| Gene name | CTD small phosphatase 2 | COMM domain containing 10 | |
| Synonyms | OS4|PSR2|SCP2 | PTD002 | |
| Cytomap | 12q14.1 | 5q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2NLI-interacting factor 2conserved gene amplified in osteosarcomanuclear LIM interactor-intera | COMM domain-containing protein 10 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O14595 | Q9Y6G5 | |
| Ensembl transtripts involved in fusion gene | ENST00000398073, ENST00000548823, ENST00000547701, | ENST00000274458, ENST00000515539, ENST00000503424, | |
| Fusion gene scores | * DoF score | 26 X 5 X 7=910 | 2 X 2 X 1=4 |
| # samples | 22 | 2 | |
| ** MAII score | log2(22/910*10)=-2.0483630215614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: CTDSP2 [Title/Abstract] AND COMMD10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CTDSP2 | GO:0006470 | protein dephosphorylation | 12721286 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-AB3A-01A | CTDSP2 | chr12 | 58240155 | - | COMMD10 | chr5 | 115426776 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000398073 | ENST00000274458 | CTDSP2 | chr12 | 58240155 | - | COMMD10 | chr5 | 115426776 | + |
| In-frame | ENST00000398073 | ENST00000515539 | CTDSP2 | chr12 | 58240155 | - | COMMD10 | chr5 | 115426776 | + |
| 5CDS-intron | ENST00000398073 | ENST00000503424 | CTDSP2 | chr12 | 58240155 | - | COMMD10 | chr5 | 115426776 | + |
| In-frame | ENST00000548823 | ENST00000274458 | CTDSP2 | chr12 | 58240155 | - | COMMD10 | chr5 | 115426776 | + |
| In-frame | ENST00000548823 | ENST00000515539 | CTDSP2 | chr12 | 58240155 | - | COMMD10 | chr5 | 115426776 | + |
| 5CDS-intron | ENST00000548823 | ENST00000503424 | CTDSP2 | chr12 | 58240155 | - | COMMD10 | chr5 | 115426776 | + |
| intron-3CDS | ENST00000547701 | ENST00000274458 | CTDSP2 | chr12 | 58240155 | - | COMMD10 | chr5 | 115426776 | + |
| intron-3CDS | ENST00000547701 | ENST00000515539 | CTDSP2 | chr12 | 58240155 | - | COMMD10 | chr5 | 115426776 | + |
| intron-intron | ENST00000547701 | ENST00000503424 | CTDSP2 | chr12 | 58240155 | - | COMMD10 | chr5 | 115426776 | + |
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FusionProtFeatures for CTDSP2_COMMD10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CTDSP2 | COMMD10 |
| Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain(CTD) of the largest RNA polymerase II subunit POLR2A. Negativelyregulates RNA polymerase II transcription, possibly by controllingthe transition from initiation/capping to processive transcriptelongation. Recruited by REST to neuronal genes that contain RE-1elements, leading to neuronal gene silencing in non-neuronalcells. May contribute to the development of sarcomas.{ECO:0000269|PubMed:12721286, ECO:0000269|PubMed:15681389}. | May modulate activity of cullin-RING E3 ubiquitin ligase(CRL) complexes (PubMed:21778237). May down-regulate activation ofNF-kappa-B (PubMed:15799966). {ECO:0000269|PubMed:15799966,ECO:0000305|PubMed:21778237}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >COMMD10 | chr12:58240155 | chr5:115426776 | ENST00000274458 | + | 1 | 7 | 133_202 | 44 | 203 | Domain | COMM |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CTDSP2 | chr12:58240155 | chr5:115426776 | ENST00000398073 | - | 1 | 8 | 97_255 | 21 | 272 | Domain | FCP1 homology |
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FusionGeneSequence for CTDSP2_COMMD10 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CTDSP2_ENST00000398073_chr12_58240155_-_COMMD10_ENST00000274458_chr5_115426776_+_180aa MEHGSIITQARREDALVLTKQGXEQFQXRRGRKTSSGIFSRETRSSPSSXNNIIYFRTGSVSQCEASSFAAAIREHSSXTRQSXSICQYV VFYGSRNSXKVPAENSGSLXARDRWMAAXPSDGSLCSSKTKISSSCVTTRSEQXRFKEPGESSCGIQSQGVVXFLXQARDYTSTAGFPYM >In-frame_CTDSP2_ENST00000398073_chr12_58240155_-_COMMD10_ENST00000515539_chr5_115426776_+_180aa MEHGSIITQARREDALVLTKQGXEQFQXRRGRKTSSGIFSRETRSSPSSXNNIIYFRTGSVSQCEASSFAAAIREHSSXTRQSXSICQYV VFYGSRNSXKVPAENSGSLXARDRWMAAXPSDGSLCSSKTKISSSCVTTRSEQXRFKEPGESSCGIQSQGVVXFLXQARDYTSTAGFPYM >In-frame_CTDSP2_ENST00000548823_chr12_58240155_-_COMMD10_ENST00000274458_chr5_115426776_+_180aa MEHGSIITQARREDALVLTKQGXEQFQXRRGRKTSSGIFSRETRSSPSSXNNIIYFRTGSVSQCEASSFAAAIREHSSXTRQSXSICQYV VFYGSRNSXKVPAENSGSLXARDRWMAAXPSDGSLCSSKTKISSSCVTTRSEQXRFKEPGESSCGIQSQGVVXFLXQARDYTSTAGFPYM >In-frame_CTDSP2_ENST00000548823_chr12_58240155_-_COMMD10_ENST00000515539_chr5_115426776_+_180aa MEHGSIITQARREDALVLTKQGXEQFQXRRGRKTSSGIFSRETRSSPSSXNNIIYFRTGSVSQCEASSFAAAIREHSSXTRQSXSICQYV VFYGSRNSXKVPAENSGSLXARDRWMAAXPSDGSLCSSKTKISSSCVTTRSEQXRFKEPGESSCGIQSQGVVXFLXQARDYTSTAGFPYM |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CTDSP2_ENST00000398073_chr12_58240155_-_COMMD10_ENST00000274458_chr5_115426776_+_541nt ATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGGCTGAGAGCAGTTTCAGTGAAGAAGA GGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGT GTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTG GTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGCTAGAGACCGTTGGATGGCAGCTTAACCT TCAGATGGCTCACTCTGCTCAAGCAAAACTAAAATCTCCTCAAGCTGTGTTACAACTCGGAGTGAACAATGAAGATTCAAAGAGCCTGGA GAAAGTTCTTGTGGAATTCAGTCACAAGGAGTTGTTTGATTTCTATAACAAGCTAGAGACTATACAAGCACAGCTGGATTCCCTTACATG >In-frame_CTDSP2_ENST00000398073_chr12_58240155_-_COMMD10_ENST00000515539_chr5_115426776_+_541nt ATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGGCTGAGAGCAGTTTCAGTGAAGAAGA GGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGT GTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTG GTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGCTAGAGACCGTTGGATGGCAGCTTAACCT TCAGATGGCTCACTCTGCTCAAGCAAAACTAAAATCTCCTCAAGCTGTGTTACAACTCGGAGTGAACAATGAAGATTCAAAGAGCCTGGA GAAAGTTCTTGTGGAATTCAGTCACAAGGAGTTGTTTGATTTCTATAACAAGCTAGAGACTATACAAGCACAGCTGGATTCCCTTACATG >In-frame_CTDSP2_ENST00000548823_chr12_58240155_-_COMMD10_ENST00000274458_chr5_115426776_+_541nt ATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGGCTGAGAGCAGTTTCAGTGAAGAAGA GGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGT GTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTG GTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGCTAGAGACCGTTGGATGGCAGCTTAACCT TCAGATGGCTCACTCTGCTCAAGCAAAACTAAAATCTCCTCAAGCTGTGTTACAACTCGGAGTGAACAATGAAGATTCAAAGAGCCTGGA GAAAGTTCTTGTGGAATTCAGTCACAAGGAGTTGTTTGATTTCTATAACAAGCTAGAGACTATACAAGCACAGCTGGATTCCCTTACATG >In-frame_CTDSP2_ENST00000548823_chr12_58240155_-_COMMD10_ENST00000515539_chr5_115426776_+_541nt ATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGGCTGAGAGCAGTTTCAGTGAAGAAGA GGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGT GTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTG GTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGCTAGAGACCGTTGGATGGCAGCTTAACCT TCAGATGGCTCACTCTGCTCAAGCAAAACTAAAATCTCCTCAAGCTGTGTTACAACTCGGAGTGAACAATGAAGATTCAAAGAGCCTGGA GAAAGTTCTTGTGGAATTCAGTCACAAGGAGTTGTTTGATTTCTATAACAAGCTAGAGACTATACAAGCACAGCTGGATTCCCTTACATG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CTDSP2_ENST00000398073_chr12_58240155_-_COMMD10_ENST00000274458_chr5_115426776_+_1643nt CCATTTCCTCCTCTTGTTTTCGCTCCGGATTCTCCATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGG GCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCCTTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTG AACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAGCGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTC CCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCAC CAAGCAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTC TTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTA GACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCT GTAAGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTCAAGCAAAACTAAAATCTCCTCAAGCTGTGTTACAAC TCGGAGTGAACAATGAAGATTCAAAGAGCCTGGAGAAAGTTCTTGTGGAATTCAGTCACAAGGAGTTGTTTGATTTCTATAACAAGCTAG AGACTATACAAGCACAGCTGGATTCCCTTACATGATGTTTTCGAAGACTGTTTTTTTCATCACGCTCCTGCCACCTCATTATTTTGCATT GAAGATACATTGCCAGGTTGTGTTTTCTGAAGGATTCAGTGACTTGCTTTCTGTAAATTATATGGCTTATCACTTCTTAGACAAATAACA ACCAATAGAGATCATTGTTAAGAATACTGAGGTTCTAATATACTTTCTTTAGTTCTGTGAGCCAACAGTAATTATTAAGAACACTTTCCC TTTAAAGGAAACAAAAGTGAATACCATATTGTTTTTACTGTCATAGTGTTGCTTTCTTGCCTGTCCTGCTTAGTTTTTACTTGCTGGATG ATACCATAATGTATCAAGGAGCGTCCATGGATACAAGATAAGATGTGTACCTTAGTAGAATACAGAGCTTTGGTAATTACATGAATAAAA TTAAGAAAATAGCCATATACAATCAAATACACTATGGCATTTTTATTTGAATATGATGAGTATATTTTGCTTCGGAAATAATATAGGAAG GAAATGTAAAATAGTGAGTAGTATGGTATCAGTTAATTCCAGTCTGAGCTTCTCTGTCAACTTCAGTTTCTCTCTCAGTTTAATGATTTA ATAATAGTCCAGGTTTTTGTGTGTTTTTCTTTATACTGCAAATTAATAATGATTCACTTTATAGTTTGGGAGACAGAATCAGGTCTTGAA TAAAATAATTGTAATGAGTGCTAAATGGGCACCATTATTCGAATCAGATACCTTTTATATTCTCTTTCCATAAATACGTTGATTTCTGTC >In-frame_CTDSP2_ENST00000398073_chr12_58240155_-_COMMD10_ENST00000515539_chr5_115426776_+_1013nt CCATTTCCTCCTCTTGTTTTCGCTCCGGATTCTCCATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGG GCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCCTTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTG AACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAGCGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTC CCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGATGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCAC CAAGCAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTC TTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTA GACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCT GTAAGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTCAAGCAAAACTAAAATCTCCTCAAGCTGTGTTACAAC TCGGAGTGAACAATGAAGATTCAAAGAGCCTGGAGAAAGTTCTTGTGGAATTCAGTCACAAGGAGTTGTTTGATTTCTATAACAAGCTAG AGACTATACAAGCACAGCTGGATTCCCTTACATGATGTTTTCGAAGACTGTTTTTTTCATCACGCTCCTGCCACCTCATTATTTTGCATT GAAGATACATTGCCAGGTTGTGTTTTCTGAAGGATTCAGTGACTTGCTTTCTGTAAATTATATGGCTTATCACTTCTTAGACAAATAACA >In-frame_CTDSP2_ENST00000548823_chr12_58240155_-_COMMD10_ENST00000274458_chr5_115426776_+_1608nt ATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGGGCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCC TTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTGAACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAG CGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTCCCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGA TGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGGCTGAGAGCAGTTTCAGTGAAGAAGAG GAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTG TATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGG TCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGCTAGAGACCGTTGGATGGCAGCTTAACCTT CAGATGGCTCACTCTGCTCAAGCAAAACTAAAATCTCCTCAAGCTGTGTTACAACTCGGAGTGAACAATGAAGATTCAAAGAGCCTGGAG AAAGTTCTTGTGGAATTCAGTCACAAGGAGTTGTTTGATTTCTATAACAAGCTAGAGACTATACAAGCACAGCTGGATTCCCTTACATGA TGTTTTCGAAGACTGTTTTTTTCATCACGCTCCTGCCACCTCATTATTTTGCATTGAAGATACATTGCCAGGTTGTGTTTTCTGAAGGAT TCAGTGACTTGCTTTCTGTAAATTATATGGCTTATCACTTCTTAGACAAATAACAACCAATAGAGATCATTGTTAAGAATACTGAGGTTC TAATATACTTTCTTTAGTTCTGTGAGCCAACAGTAATTATTAAGAACACTTTCCCTTTAAAGGAAACAAAAGTGAATACCATATTGTTTT TACTGTCATAGTGTTGCTTTCTTGCCTGTCCTGCTTAGTTTTTACTTGCTGGATGATACCATAATGTATCAAGGAGCGTCCATGGATACA AGATAAGATGTGTACCTTAGTAGAATACAGAGCTTTGGTAATTACATGAATAAAATTAAGAAAATAGCCATATACAATCAAATACACTAT GGCATTTTTATTTGAATATGATGAGTATATTTTGCTTCGGAAATAATATAGGAAGGAAATGTAAAATAGTGAGTAGTATGGTATCAGTTA ATTCCAGTCTGAGCTTCTCTGTCAACTTCAGTTTCTCTCTCAGTTTAATGATTTAATAATAGTCCAGGTTTTTGTGTGTTTTTCTTTATA CTGCAAATTAATAATGATTCACTTTATAGTTTGGGAGACAGAATCAGGTCTTGAATAAAATAATTGTAATGAGTGCTAAATGGGCACCAT >In-frame_CTDSP2_ENST00000548823_chr12_58240155_-_COMMD10_ENST00000515539_chr5_115426776_+_978nt ATGTTGGACCCAAACTGAGGAGCCCGGAGCTGCCGCTGGGGGATCGGGGCCGGGGGCACCCGGGGGAGCCGCTGCCCGGGCCGCCCGCCC TTTGTACAGGCCGCCTCCCTTCCCGGTCCGGGGAGGAAACGAGAGGGGGGATGTGAACAGCTGTGGAAGTCGGAGTCTCGGGAGCCGGAG CGGGCCCCCGCCCAGGCCCCCCAGCCCAGCCCAGCCCGCGCGCCCGCCCGTCCTCCCGCCCAGCCAGCCCGGGCCCGCGGGATTGTTAGA TGGAACACGGCTCCATCATCACCCAGGCGCGGAGGGAAGACGCCCTGGTGCTCACCAAGCAAGGCTGAGAGCAGTTTCAGTGAAGAAGAG GAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTG TATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGG TCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGCTAGAGACCGTTGGATGGCAGCTTAACCTT CAGATGGCTCACTCTGCTCAAGCAAAACTAAAATCTCCTCAAGCTGTGTTACAACTCGGAGTGAACAATGAAGATTCAAAGAGCCTGGAG AAAGTTCTTGTGGAATTCAGTCACAAGGAGTTGTTTGATTTCTATAACAAGCTAGAGACTATACAAGCACAGCTGGATTCCCTTACATGA TGTTTTCGAAGACTGTTTTTTTCATCACGCTCCTGCCACCTCATTATTTTGCATTGAAGATACATTGCCAGGTTGTGTTTTCTGAAGGAT |
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FusionGenePPI for CTDSP2_COMMD10 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CTDSP2 | POLR2A, SNAI1, CDCA3, CTDSP1, PLEKHH3, POM121, ZC3H3, ZMYM6, MAP7D1, INTS6, PRR14, ATP2B3, CWC22, SETD1A, UBTF, NEK4, ENDOD1, MAP7, SLC25A20, ATP12A, ANKRD13A, TBC1D4, BSG, DNAJA3, HAX1, P4HA1, RPS27L, TIMM50, TUBB6, ANKRD13D, NEK1, CSF1R, TYRO3, INSRR, PTK7, EPHA3, EPHA1, AKT1 | COMMD10 | COMMD1, RELA, RELB, NFKB1, COMMD7, COMMD8, CCDC22, COMMD6, COMMD3, COMMD4, CCDC93, COMMD2, COMMD5, FAM45A, VPS29, C16orf62, TRIM13, COMMD9, FKBP15, TCTEX1D2, DSCR3, TRAF7, C11orf73, TP53RK, TPRKB, ACOT9 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CTDSP2_COMMD10 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CTDSP2_COMMD10 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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