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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 875

FusionGeneSummary for ADD3_MYT1L

check button Fusion gene summary
Fusion gene informationFusion gene name: ADD3_MYT1L
Fusion gene ID: 875
HgeneTgene
Gene symbol

ADD3

MYT1L

Gene ID

120

23040

Gene nameadducin 3myelin transcription factor 1 like
SynonymsADDL|CPSQ3MRD39|NZF1|ZC2H2C2|ZC2HC4B|myT1-L
Cytomap

10q25.1-q25.2

2p25.3

Type of geneprotein-codingprotein-coding
Descriptiongamma-adducinadducin 3 (gamma)adducin-like protein 70myelin transcription factor 1-like proteinneural zinc finger transcription factor 1
Modification date2018052320180523
UniProtAcc

Q9UEY8

Q9UL68

Ensembl transtripts involved in fusion geneENST00000360162, ENST00000356080, 
ENST00000277900, ENST00000497125, 
ENST00000399161, ENST00000428368, 
ENST00000407844, ENST00000471668, 
Fusion gene scores* DoF score3 X 3 X 2=185 X 5 X 4=100
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADD3 [Title/Abstract] AND MYT1L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF960116ADD3chr10

111881219

-MYT1Lchr2

2158978

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000360162ENST00000399161ADD3chr10

111881219

-MYT1Lchr2

2158978

+
intron-intronENST00000360162ENST00000428368ADD3chr10

111881219

-MYT1Lchr2

2158978

+
intron-intronENST00000360162ENST00000407844ADD3chr10

111881219

-MYT1Lchr2

2158978

+
intron-intronENST00000360162ENST00000471668ADD3chr10

111881219

-MYT1Lchr2

2158978

+
intron-intronENST00000356080ENST00000399161ADD3chr10

111881219

-MYT1Lchr2

2158978

+
intron-intronENST00000356080ENST00000428368ADD3chr10

111881219

-MYT1Lchr2

2158978

+
intron-intronENST00000356080ENST00000407844ADD3chr10

111881219

-MYT1Lchr2

2158978

+
intron-intronENST00000356080ENST00000471668ADD3chr10

111881219

-MYT1Lchr2

2158978

+
intron-intronENST00000277900ENST00000399161ADD3chr10

111881219

-MYT1Lchr2

2158978

+
intron-intronENST00000277900ENST00000428368ADD3chr10

111881219

-MYT1Lchr2

2158978

+
intron-intronENST00000277900ENST00000407844ADD3chr10

111881219

-MYT1Lchr2

2158978

+
intron-intronENST00000277900ENST00000471668ADD3chr10

111881219

-MYT1Lchr2

2158978

+
intron-intronENST00000497125ENST00000399161ADD3chr10

111881219

-MYT1Lchr2

2158978

+
intron-intronENST00000497125ENST00000428368ADD3chr10

111881219

-MYT1Lchr2

2158978

+
intron-intronENST00000497125ENST00000407844ADD3chr10

111881219

-MYT1Lchr2

2158978

+
intron-intronENST00000497125ENST00000471668ADD3chr10

111881219

-MYT1Lchr2

2158978

+

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FusionProtFeatures for ADD3_MYT1L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADD3

Q9UEY8

MYT1L

Q9UL68

Membrane-cytoskeleton-associated protein that promotesthe assembly of the spectrin-actin network. Plays a role in actinfilament capping (PubMed:23836506). Binds to calmodulin.{ECO:0000269|PubMed:23836506}. Transcription factor that plays a key role in neuronaldifferentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to othertranscription repressors that inhibit specific lineages, mediatesrepression of multiple differentiation programs. Also repressesexpression of negative regulators of neurogenesis, such as membersof the Notch signaling pathway, including HES1. The combination ofthree transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, issufficient to reprogram fibroblasts and other somatic cells intoinduced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes andrepresses transcription by recruiting a multiprotein complexcontaining SIN3B. The 5'-AAGTT-3' core motif is absent from thepromoter of neural genes. {ECO:0000250|UniProtKB:P97500}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADD3_MYT1L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADD3_MYT1L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADD3_MYT1L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ADD3_MYT1L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADD3C0007786Brain Ischemia1CTD_human
HgeneADD3C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneADD3C0235032Neurotoxicity Syndromes1CTD_human
TgeneMYT1LC0036341Schizophrenia3PSYGENET
TgeneMYT1LC0036346Schizophrenia, Childhood1PSYGENET
TgeneMYT1LC0041696Unipolar Depression1PSYGENET
TgeneMYT1LC1269683Major Depressive Disorder1PSYGENET