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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8749

FusionGeneSummary for CTDP1_PQLC1

check button Fusion gene summary
Fusion gene informationFusion gene name: CTDP1_PQLC1
Fusion gene ID: 8749
HgeneTgene
Gene symbol

CTDP1

PQLC1

Gene ID

9150

80148

Gene nameCTD phosphatase subunit 1PQ loop repeat containing 1
SynonymsCCFDN|FCP1-
Cytomap

18q23

18q23

Type of geneprotein-codingprotein-coding
DescriptionRNA polymerase II subunit A C-terminal domain phosphataseCTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1CTD of POLR2A, phosphatase of, subunit 1TFIIF-associating CTD phosphatase 1serine phosphatase FCP1atranscriPQ-loop repeat-containing protein 1
Modification date2018052320180519
UniProtAcc

Q9Y5B0

Q8N2U9

Ensembl transtripts involved in fusion geneENST00000299543, ENST00000075430, 
ENST00000587623, 		ENST00000357575, 
ENST00000397778, ENST00000409073, 
ENST00000590381, ENST00000590895, 
Fusion gene scores* DoF score3 X 4 X 3=363 X 4 X 3=36
# samples 35
** MAII scorelog2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CTDP1 [Title/Abstract] AND PQLC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCTDP1

GO:0006470

protein dephosphorylation

9765293|22692537

HgeneCTDP1

GO:0043923

positive regulation by host of viral transcription

15723517


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLAMLTCGA-AB-2811-03BCTDP1chr18

77464917

+PQLC1chr18

77664183

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000299543ENST00000357575CTDP1chr18

77464917

+PQLC1chr18

77664183

-
Frame-shiftENST00000299543ENST00000397778CTDP1chr18

77464917

+PQLC1chr18

77664183

-
Frame-shiftENST00000299543ENST00000409073CTDP1chr18

77464917

+PQLC1chr18

77664183

-
Frame-shiftENST00000299543ENST00000590381CTDP1chr18

77464917

+PQLC1chr18

77664183

-
5CDS-5UTRENST00000299543ENST00000590895CTDP1chr18

77464917

+PQLC1chr18

77664183

-
In-frameENST00000075430ENST00000357575CTDP1chr18

77464917

+PQLC1chr18

77664183

-
Frame-shiftENST00000075430ENST00000397778CTDP1chr18

77464917

+PQLC1chr18

77664183

-
Frame-shiftENST00000075430ENST00000409073CTDP1chr18

77464917

+PQLC1chr18

77664183

-
Frame-shiftENST00000075430ENST00000590381CTDP1chr18

77464917

+PQLC1chr18

77664183

-
5CDS-5UTRENST00000075430ENST00000590895CTDP1chr18

77464917

+PQLC1chr18

77664183

-
intron-3CDSENST00000587623ENST00000357575CTDP1chr18

77464917

+PQLC1chr18

77664183

-
intron-3CDSENST00000587623ENST00000397778CTDP1chr18

77464917

+PQLC1chr18

77664183

-
intron-3CDSENST00000587623ENST00000409073CTDP1chr18

77464917

+PQLC1chr18

77664183

-
intron-3CDSENST00000587623ENST00000590381CTDP1chr18

77464917

+PQLC1chr18

77664183

-
intron-5UTRENST00000587623ENST00000590895CTDP1chr18

77464917

+PQLC1chr18

77664183

-

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FusionProtFeatures for CTDP1_PQLC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTDP1

Q9Y5B0

PQLC1

Q8N2U9

Processively dephosphorylates 'Ser-2' and 'Ser-5' of theheptad repeats YSPTSPS in the C-terminal domain of the largest RNApolymerase II subunit. This promotes the activity of RNApolymerase II. Plays a role in the exit from mitosis bydephosphorylating crucial mitotic substrates (USP44, CDC20 andWEE1) that are required for M-phase-promoting factor (MPF)/CDK1inactivation. {ECO:0000269|PubMed:22692537}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePQLC1chr18:77464917chr18:77664183ENST00000590381-24178_233112133DomainNote=PQ-loop 2
TgenePQLC1chr18:77464917chr18:77664183ENST00000397778-46232_252202272TransmembraneHelical
TgenePQLC1chr18:77464917chr18:77664183ENST00000590381-24145_165112133TransmembraneHelical
TgenePQLC1chr18:77464917chr18:77664183ENST00000590381-24168_188112133TransmembraneHelical
TgenePQLC1chr18:77464917chr18:77664183ENST00000590381-24232_252112133TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCTDP1chr18:77464917chr18:77664183ENST00000075430+512455_478257868Compositional biasNote=Ser-rich
HgeneCTDP1chr18:77464917chr18:77664183ENST00000075430+512577_582257868Compositional biasNote=Poly-Glu
HgeneCTDP1chr18:77464917chr18:77664183ENST00000299543+513455_478257962Compositional biasNote=Ser-rich
HgeneCTDP1chr18:77464917chr18:77664183ENST00000299543+513577_582257962Compositional biasNote=Poly-Glu
HgeneCTDP1chr18:77464917chr18:77664183ENST00000075430+512178_344257868DomainFCP1 homology
HgeneCTDP1chr18:77464917chr18:77664183ENST00000075430+512629_728257868DomainBRCT
HgeneCTDP1chr18:77464917chr18:77664183ENST00000299543+513178_344257962DomainFCP1 homology
HgeneCTDP1chr18:77464917chr18:77664183ENST00000299543+513629_728257962DomainBRCT
TgenePQLC1chr18:77464917chr18:77664183ENST00000397778-4614_80202272DomainNote=PQ-loop 1
TgenePQLC1chr18:77464917chr18:77664183ENST00000397778-46178_233202272DomainNote=PQ-loop 2
TgenePQLC1chr18:77464917chr18:77664183ENST00000590381-2414_80112133DomainNote=PQ-loop 1
TgenePQLC1chr18:77464917chr18:77664183ENST00000397778-46145_165202272TransmembraneHelical
TgenePQLC1chr18:77464917chr18:77664183ENST00000397778-46168_188202272TransmembraneHelical
TgenePQLC1chr18:77464917chr18:77664183ENST00000397778-4649_69202272TransmembraneHelical
TgenePQLC1chr18:77464917chr18:77664183ENST00000397778-4676_96202272TransmembraneHelical
TgenePQLC1chr18:77464917chr18:77664183ENST00000397778-468_28202272TransmembraneHelical
TgenePQLC1chr18:77464917chr18:77664183ENST00000590381-2449_69112133TransmembraneHelical
TgenePQLC1chr18:77464917chr18:77664183ENST00000590381-2476_96112133TransmembraneHelical
TgenePQLC1chr18:77464917chr18:77664183ENST00000590381-248_28112133TransmembraneHelical


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FusionGeneSequence for CTDP1_PQLC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CTDP1_ENST00000299543_chr18_77464917_+_PQLC1_ENST00000357575_chr18_77664183_-_326aa
MEVPAAGRVPAEGAPTAAVAEVRCPGPAPLRLLEWRVAAGAAVRIGSVLAVFEAAASAQSSGASQSRVASGGCVRPARPERRLRSERAGV
VRELCAQPGQVVAPGAVLVRLEGCSHPVVMKGLCAECGQDLTQLQSKNGKQQVPLSTATVSMVHSVPELMVSSEQAEQLGREDQQRLHRN
RKLVLMVDLDQTLIHTTEQHCQQMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAASRWCSCGPVVTP

>In-frame_CTDP1_ENST00000075430_chr18_77464917_+_PQLC1_ENST00000357575_chr18_77664183_-_326aa
MEVPAAGRVPAEGAPTAAVAEVRCPGPAPLRLLEWRVAAGAAVRIGSVLAVFEAAASAQSSGASQSRVASGGCVRPARPERRLRSERAGV
VRELCAQPGQVVAPGAVLVRLEGCSHPVVMKGLCAECGQDLTQLQSKNGKQQVPLSTATVSMVHSVPELMVSSEQAEQLGREDQQRLHRN
RKLVLMVDLDQTLIHTTEQHCQQMSNKGIFHFQLGRGEPMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAASRWCSCGPVVTP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CTDP1_ENST00000299543_chr18_77464917_+_PQLC1_ENST00000357575_chr18_77664183_-_980nt
ATGGAGGTGCCGGCCGCGGGTCGCGTTCCTGCCGAGGGCGCCCCGACGGCGGCTGTGGCCGAGGTGCGCTGCCCGGGGCCCGCGCCGCTG
CGCCTGCTGGAGTGGAGGGTGGCGGCGGGCGCGGCCGTGCGCATCGGCTCGGTGCTGGCCGTGTTCGAGGCCGCCGCCTCCGCGCAGTCC
TCCGGGGCCTCTCAGTCCCGTGTAGCCTCCGGGGGCTGCGTGCGCCCCGCGCGGCCGGAACGCAGGCTGAGGTCGGAGCGCGCGGGCGTG
GTGCGGGAGCTGTGCGCGCAGCCGGGCCAGGTGGTCGCCCCAGGAGCGGTTCTGGTGAGGTTGGAAGGATGCAGCCACCCGGTTGTCATG
AAAGGCCTGTGTGCTGAATGTGGCCAAGACCTCACCCAGTTGCAGAGTAAGAACGGGAAGCAGCAGGTGCCGCTGTCCACGGCGACCGTG
TCCATGGTGCACAGCGTGCCGGAGTTGATGGTGAGCTCCGAGCAAGCTGAACAGCTGGGAAGAGAAGACCAGCAGCGACTGCACCGAAAC
CGGAAGCTGGTGCTCATGGTGGACTTGGACCAGACGTTGATTCACACAACCGAGCAGCACTGTCAGCAGATGTCGAATAAAGGCATCTTT
CACTTCCAGCTGGGCCGGGGTGAGCCCATGCTGCACACGCGCCTGCGTCCACACTGCAAGGACTTCCTGGAGAAGATCGCCAAGCTGTAC
GAGCTGCACGTCTTCACCTTCGGCAGCCGGCTGTACGCACACACCATCGCAGCATCAAGATGGTGCTCATGTGGACCAGTGGTGACGCCT
TCAAGACGGCCTACTTCCTGCTGAAGGGTGCCCCTCTGCAGTTCTCCGTGTGCGGCCTGCTGCAGGTGCTGGTGGACCTGGCCATCCTGG

>In-frame_CTDP1_ENST00000075430_chr18_77464917_+_PQLC1_ENST00000357575_chr18_77664183_-_980nt
ATGGAGGTGCCGGCCGCGGGTCGCGTTCCTGCCGAGGGCGCCCCGACGGCGGCTGTGGCCGAGGTGCGCTGCCCGGGGCCCGCGCCGCTG
CGCCTGCTGGAGTGGAGGGTGGCGGCGGGCGCGGCCGTGCGCATCGGCTCGGTGCTGGCCGTGTTCGAGGCCGCCGCCTCCGCGCAGTCC
TCCGGGGCCTCTCAGTCCCGTGTAGCCTCCGGGGGCTGCGTGCGCCCCGCGCGGCCGGAACGCAGGCTGAGGTCGGAGCGCGCGGGCGTG
GTGCGGGAGCTGTGCGCGCAGCCGGGCCAGGTGGTCGCCCCAGGAGCGGTTCTGGTGAGGTTGGAAGGATGCAGCCACCCGGTTGTCATG
AAAGGCCTGTGTGCTGAATGTGGCCAAGACCTCACCCAGTTGCAGAGTAAGAACGGGAAGCAGCAGGTGCCGCTGTCCACGGCGACCGTG
TCCATGGTGCACAGCGTGCCGGAGTTGATGGTGAGCTCCGAGCAAGCTGAACAGCTGGGAAGAGAAGACCAGCAGCGACTGCACCGAAAC
CGGAAGCTGGTGCTCATGGTGGACTTGGACCAGACGTTGATTCACACAACCGAGCAGCACTGTCAGCAGATGTCGAATAAAGGCATCTTT
CACTTCCAGCTGGGCCGGGGTGAGCCCATGCTGCACACGCGCCTGCGTCCACACTGCAAGGACTTCCTGGAGAAGATCGCCAAGCTGTAC
GAGCTGCACGTCTTCACCTTCGGCAGCCGGCTGTACGCACACACCATCGCAGCATCAAGATGGTGCTCATGTGGACCAGTGGTGACGCCT
TCAAGACGGCCTACTTCCTGCTGAAGGGTGCCCCTCTGCAGTTCTCCGTGTGCGGCCTGCTGCAGGTGCTGGTGGACCTGGCCATCCTGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_CTDP1_ENST00000299543_chr18_77464917_+_PQLC1_ENST00000357575_chr18_77664183_-_2683nt
GGAAGTCGGCGCGGGCTAGGCGACGGGTGGAAGCCGGTACCGAGAGGAACTACAGCGTCGCCGCCTGGGTTGTGTCGCCGCGGTAGGCGC
TGCGCTCTGAGCGCAGCGCAGGCCCCGTACCGACCGCCCGCCCGCCCTCTGTCCGCGATGGAGGTGCCGGCCGCGGGTCGCGTTCCTGCC
GAGGGCGCCCCGACGGCGGCTGTGGCCGAGGTGCGCTGCCCGGGGCCCGCGCCGCTGCGCCTGCTGGAGTGGAGGGTGGCGGCGGGCGCG
GCCGTGCGCATCGGCTCGGTGCTGGCCGTGTTCGAGGCCGCCGCCTCCGCGCAGTCCTCCGGGGCCTCTCAGTCCCGTGTAGCCTCCGGG
GGCTGCGTGCGCCCCGCGCGGCCGGAACGCAGGCTGAGGTCGGAGCGCGCGGGCGTGGTGCGGGAGCTGTGCGCGCAGCCGGGCCAGGTG
GTCGCCCCAGGAGCGGTTCTGGTGAGGTTGGAAGGATGCAGCCACCCGGTTGTCATGAAAGGCCTGTGTGCTGAATGTGGCCAAGACCTC
ACCCAGTTGCAGAGTAAGAACGGGAAGCAGCAGGTGCCGCTGTCCACGGCGACCGTGTCCATGGTGCACAGCGTGCCGGAGTTGATGGTG
AGCTCCGAGCAAGCTGAACAGCTGGGAAGAGAAGACCAGCAGCGACTGCACCGAAACCGGAAGCTGGTGCTCATGGTGGACTTGGACCAG
ACGTTGATTCACACAACCGAGCAGCACTGTCAGCAGATGTCGAATAAAGGCATCTTTCACTTCCAGCTGGGCCGGGGTGAGCCCATGCTG
CACACGCGCCTGCGTCCACACTGCAAGGACTTCCTGGAGAAGATCGCCAAGCTGTACGAGCTGCACGTCTTCACCTTCGGCAGCCGGCTG
TACGCACACACCATCGCAGCATCAAGATGGTGCTCATGTGGACCAGTGGTGACGCCTTCAAGACGGCCTACTTCCTGCTGAAGGGTGCCC
CTCTGCAGTTCTCCGTGTGCGGCCTGCTGCAGGTGCTGGTGGACCTGGCCATCCTGGGGCAGGCCTACGCCTTCGCCCGCCACCCCCAGA
AGCCGGCGCCCCACGCCGTGCACCCCACTGGCACCAAGGCCCTCTGACAGTGGGGAGGACGAGGATGTGGGACCGCCAGCCGCGGGCACT
GGTGGGCCCTGACCTCCCCGCGGGGAGGGTGGGTGCTGTGGCCCCTGCAGGTGTGGCAGAGATGGGGCATGGGCATTGGGGTCTCCATCA
GCCTCTGTGGGGTGTCTCAGGGTGGGCAGTGGGGGTGGGGCTGGGACGCTGTTTGTGCTCAGCGGGGACAGCCAGGGTTGATCTGGCCCC
GAGGGTTTTGGATGTTTTTAGGATGACATAAAAAGCAAGTGTTTTCCCCATTTCCTCTTATGAAACACCGTCTGAGCCCAAGGTACACAT
TGGGCGGCCTGCAGGAACCTGCTCCAGGTGGACACACGGGCCAGCAGCCGCGAACCTTGAAGCTGGGGTGACCGCAGGAGACCCTGTAAG
GCCTGTGAGCGGAGCCCTCGACCCCGTGACACCCTGGCCAGACACCCTGCTTGGACTGGGGTGGCCTCTGCTACCCAGGGGTCTGGCACG
GGGGAGGGCTGGGGCTTTCTCTGCCTGGTACACACGGAAAGGCGGCTGTGCGGACGCAGGGTCACCGTGCTCCGGGTTTTCTGACAGTCG
GTGTTTCCTGGGCCTTTGGAGTGGCTGCGAGGCCTGAACGCCTTGTGGATCCGCTGTGTCCAGCCCGGCTGAGCATCGCCAGGGCTAGCT
CATGCTGCTCTTGTCAGCCTCTGGTTCTCCTCGAGTCCTTGGGGACGTGGCAGATGCCAGCGACCATCAGACAACGTGGAGGCCCTCATG
GGCAATGGCTGAGGGGGCCGGGCTGAGGCTGTGCACATGCAGTCTGCACGCCACTCTTGGGCTCTGCTGGCGGAGATCCCCTTCCTTCTG
GGTGCAGACTGCACCTCCGGATGCAGTTTTGATGTCCATCTTCCAGGAGAGACGGTCTCGGGTCCAGGGAGTGGAGGGGGCTGCCCCTGC
CGTGCAGGTCCTGGCCGATGGCGCCTTACCCTGCTGCCCTGGGCTTTTGGCCTGAAGCAAATTCCTGAGTGGGGGGTACTGGGGCCTGCC
GCATCCTGTCCTGTCCACTGCCCACCCCCGTGTGCTGGCTCCCTCACTTCTGGCTGCAGTGGGAGCCGCCAGTCTGACCCTTGTCACCGC
ACGCTCTGCCCCCACCCCGTTGCAAGAGGTCACACCATGTCAGCAGCCTTGCACTGACCGCAGCCGGCCCCCAGGCCTCAGAGTTCTGGA
TGCTTCCGTGCGGCTCCAACAGGCATCGTCTTCCCTTCCGCAGGTGGAGGGGCCGCTTCCCGCAGGCATCTGAGCTCTGTGCCGGGGCCG
TGGCCATGGGAAGATGTTCCACGCTGCCTCCTCCTCGAGTTTTCCTCGGAAACACTCTTGAATGTCTGAGTGAGGGTCCTGCTTAGCTCT
TTGGCCTGTGAGATGCTTTGAAAATTTTTATTTTTTTAAGATGAAGCAAGATGTCTGTAGCGGTAATTGCCTCACATTAAACTGTCGCCG

>In-frame_CTDP1_ENST00000075430_chr18_77464917_+_PQLC1_ENST00000357575_chr18_77664183_-_2638nt
GGAACTACAGCGTCGCCGCCTGGGTTGTGTCGCCGCGGTAGGCGCTGCGCTCTGAGCGCAGCGCAGGCCCCGTACCGACCGCCCGCCCGC
CCTCTGTCCGCGATGGAGGTGCCGGCCGCGGGTCGCGTTCCTGCCGAGGGCGCCCCGACGGCGGCTGTGGCCGAGGTGCGCTGCCCGGGG
CCCGCGCCGCTGCGCCTGCTGGAGTGGAGGGTGGCGGCGGGCGCGGCCGTGCGCATCGGCTCGGTGCTGGCCGTGTTCGAGGCCGCCGCC
TCCGCGCAGTCCTCCGGGGCCTCTCAGTCCCGTGTAGCCTCCGGGGGCTGCGTGCGCCCCGCGCGGCCGGAACGCAGGCTGAGGTCGGAG
CGCGCGGGCGTGGTGCGGGAGCTGTGCGCGCAGCCGGGCCAGGTGGTCGCCCCAGGAGCGGTTCTGGTGAGGTTGGAAGGATGCAGCCAC
CCGGTTGTCATGAAAGGCCTGTGTGCTGAATGTGGCCAAGACCTCACCCAGTTGCAGAGTAAGAACGGGAAGCAGCAGGTGCCGCTGTCC
ACGGCGACCGTGTCCATGGTGCACAGCGTGCCGGAGTTGATGGTGAGCTCCGAGCAAGCTGAACAGCTGGGAAGAGAAGACCAGCAGCGA
CTGCACCGAAACCGGAAGCTGGTGCTCATGGTGGACTTGGACCAGACGTTGATTCACACAACCGAGCAGCACTGTCAGCAGATGTCGAAT
AAAGGCATCTTTCACTTCCAGCTGGGCCGGGGTGAGCCCATGCTGCACACGCGCCTGCGTCCACACTGCAAGGACTTCCTGGAGAAGATC
GCCAAGCTGTACGAGCTGCACGTCTTCACCTTCGGCAGCCGGCTGTACGCACACACCATCGCAGCATCAAGATGGTGCTCATGTGGACCA
GTGGTGACGCCTTCAAGACGGCCTACTTCCTGCTGAAGGGTGCCCCTCTGCAGTTCTCCGTGTGCGGCCTGCTGCAGGTGCTGGTGGACC
TGGCCATCCTGGGGCAGGCCTACGCCTTCGCCCGCCACCCCCAGAAGCCGGCGCCCCACGCCGTGCACCCCACTGGCACCAAGGCCCTCT
GACAGTGGGGAGGACGAGGATGTGGGACCGCCAGCCGCGGGCACTGGTGGGCCCTGACCTCCCCGCGGGGAGGGTGGGTGCTGTGGCCCC
TGCAGGTGTGGCAGAGATGGGGCATGGGCATTGGGGTCTCCATCAGCCTCTGTGGGGTGTCTCAGGGTGGGCAGTGGGGGTGGGGCTGGG
ACGCTGTTTGTGCTCAGCGGGGACAGCCAGGGTTGATCTGGCCCCGAGGGTTTTGGATGTTTTTAGGATGACATAAAAAGCAAGTGTTTT
CCCCATTTCCTCTTATGAAACACCGTCTGAGCCCAAGGTACACATTGGGCGGCCTGCAGGAACCTGCTCCAGGTGGACACACGGGCCAGC
AGCCGCGAACCTTGAAGCTGGGGTGACCGCAGGAGACCCTGTAAGGCCTGTGAGCGGAGCCCTCGACCCCGTGACACCCTGGCCAGACAC
CCTGCTTGGACTGGGGTGGCCTCTGCTACCCAGGGGTCTGGCACGGGGGAGGGCTGGGGCTTTCTCTGCCTGGTACACACGGAAAGGCGG
CTGTGCGGACGCAGGGTCACCGTGCTCCGGGTTTTCTGACAGTCGGTGTTTCCTGGGCCTTTGGAGTGGCTGCGAGGCCTGAACGCCTTG
TGGATCCGCTGTGTCCAGCCCGGCTGAGCATCGCCAGGGCTAGCTCATGCTGCTCTTGTCAGCCTCTGGTTCTCCTCGAGTCCTTGGGGA
CGTGGCAGATGCCAGCGACCATCAGACAACGTGGAGGCCCTCATGGGCAATGGCTGAGGGGGCCGGGCTGAGGCTGTGCACATGCAGTCT
GCACGCCACTCTTGGGCTCTGCTGGCGGAGATCCCCTTCCTTCTGGGTGCAGACTGCACCTCCGGATGCAGTTTTGATGTCCATCTTCCA
GGAGAGACGGTCTCGGGTCCAGGGAGTGGAGGGGGCTGCCCCTGCCGTGCAGGTCCTGGCCGATGGCGCCTTACCCTGCTGCCCTGGGCT
TTTGGCCTGAAGCAAATTCCTGAGTGGGGGGTACTGGGGCCTGCCGCATCCTGTCCTGTCCACTGCCCACCCCCGTGTGCTGGCTCCCTC
ACTTCTGGCTGCAGTGGGAGCCGCCAGTCTGACCCTTGTCACCGCACGCTCTGCCCCCACCCCGTTGCAAGAGGTCACACCATGTCAGCA
GCCTTGCACTGACCGCAGCCGGCCCCCAGGCCTCAGAGTTCTGGATGCTTCCGTGCGGCTCCAACAGGCATCGTCTTCCCTTCCGCAGGT
GGAGGGGCCGCTTCCCGCAGGCATCTGAGCTCTGTGCCGGGGCCGTGGCCATGGGAAGATGTTCCACGCTGCCTCCTCCTCGAGTTTTCC
TCGGAAACACTCTTGAATGTCTGAGTGAGGGTCCTGCTTAGCTCTTTGGCCTGTGAGATGCTTTGAAAATTTTTATTTTTTTAAGATGAA
GCAAGATGTCTGTAGCGGTAATTGCCTCACATTAAACTGTCGCCGACTGCAGGCGCAGTGACTGCTGAATGTACCCTGTGTGGCGACTTG


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FusionGenePPI for CTDP1_PQLC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTDP1POLR2A, GTF2F1, TCEA1, WDR77, CHD8, POLR2J, GTF2F2, GTF2B, POLR2B, STK38, ERH, PRMT5, INTS1, INTS3, INTS6, INTS7, INTS8, MED1, MED14, MED23, MED15, MED24, MED16, MED25, MED17, MED26, MED4, MED7, MED6, MED8, CDK9, CDK8, CDK7, PRKDC, ELP2, ELP3, GRK5, POLR2C, UPP1, PPP1CA, PPP2CA, RPRD1B, POLR2G, CSNK2A1, CSNK2A2, HMGB1, CSNK2B, ETS2, POLR2F, LTN1, IWS1, NUF2, DSN1, FBXW7PQLC1ADH5, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTDP1_PQLC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTDP1_PQLC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource