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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8725

FusionGeneSummary for CTBP1_RNF4

check button Fusion gene summary
Fusion gene informationFusion gene name: CTBP1_RNF4
Fusion gene ID: 8725
HgeneTgene
Gene symbol

CTBP1

RNF4

Gene ID

1487

6047

Gene nameC-terminal binding protein 1ring finger protein 4
SynonymsBARS|HADDTSRES4-26|SLX5|SNURF
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
DescriptionC-terminal-binding protein 1brefeldin A-ribosylated substrateE3 ubiquitin-protein ligase RNF4E3 ubiquitin ligase RNF4RING-type E3 ubiquitin transferase RNF4small nuclear RING finger protein
Modification date2018052220180523
UniProtAcc

Q13363

P78317

Ensembl transtripts involved in fusion geneENST00000382952, ENST00000290921, 
ENST00000510568, ENST00000515690, 
ENST00000314289, ENST00000541204, 
ENST00000509258, ENST00000511843, 
ENST00000511859, ENST00000506706, 
ENST00000511600, 
Fusion gene scores* DoF score5 X 4 X 4=802 X 2 X 2=8
# samples 52
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: CTBP1 [Title/Abstract] AND RNF4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRNF4

GO:0045944

positive regulation of transcription by RNA polymerase II

12885770

TgeneRNF4

GO:0046685

response to arsenic-containing substance

20943951


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-P5-A5EZ-01ACTBP1chr4

1231971

-RNF4chr4

2626989

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000382952ENST00000314289CTBP1chr4

1231971

-RNF4chr4

2626989

+
5CDS-intronENST00000382952ENST00000541204CTBP1chr4

1231971

-RNF4chr4

2626989

+
5CDS-intronENST00000382952ENST00000509258CTBP1chr4

1231971

-RNF4chr4

2626989

+
5CDS-intronENST00000382952ENST00000511843CTBP1chr4

1231971

-RNF4chr4

2626989

+
5CDS-intronENST00000382952ENST00000511859CTBP1chr4

1231971

-RNF4chr4

2626989

+
5CDS-intronENST00000382952ENST00000506706CTBP1chr4

1231971

-RNF4chr4

2626989

+
5CDS-intronENST00000382952ENST00000511600CTBP1chr4

1231971

-RNF4chr4

2626989

+
5CDS-intronENST00000290921ENST00000314289CTBP1chr4

1231971

-RNF4chr4

2626989

+
5CDS-intronENST00000290921ENST00000541204CTBP1chr4

1231971

-RNF4chr4

2626989

+
5CDS-intronENST00000290921ENST00000509258CTBP1chr4

1231971

-RNF4chr4

2626989

+
5CDS-intronENST00000290921ENST00000511843CTBP1chr4

1231971

-RNF4chr4

2626989

+
5CDS-intronENST00000290921ENST00000511859CTBP1chr4

1231971

-RNF4chr4

2626989

+
5CDS-intronENST00000290921ENST00000506706CTBP1chr4

1231971

-RNF4chr4

2626989

+
5CDS-intronENST00000290921ENST00000511600CTBP1chr4

1231971

-RNF4chr4

2626989

+
intron-intronENST00000510568ENST00000314289CTBP1chr4

1231971

-RNF4chr4

2626989

+
intron-intronENST00000510568ENST00000541204CTBP1chr4

1231971

-RNF4chr4

2626989

+
intron-intronENST00000510568ENST00000509258CTBP1chr4

1231971

-RNF4chr4

2626989

+
intron-intronENST00000510568ENST00000511843CTBP1chr4

1231971

-RNF4chr4

2626989

+
intron-intronENST00000510568ENST00000511859CTBP1chr4

1231971

-RNF4chr4

2626989

+
intron-intronENST00000510568ENST00000506706CTBP1chr4

1231971

-RNF4chr4

2626989

+
intron-intronENST00000510568ENST00000511600CTBP1chr4

1231971

-RNF4chr4

2626989

+
5UTR-intronENST00000515690ENST00000314289CTBP1chr4

1231971

-RNF4chr4

2626989

+
5UTR-intronENST00000515690ENST00000541204CTBP1chr4

1231971

-RNF4chr4

2626989

+
5UTR-intronENST00000515690ENST00000509258CTBP1chr4

1231971

-RNF4chr4

2626989

+
5UTR-intronENST00000515690ENST00000511843CTBP1chr4

1231971

-RNF4chr4

2626989

+
5UTR-intronENST00000515690ENST00000511859CTBP1chr4

1231971

-RNF4chr4

2626989

+
5UTR-intronENST00000515690ENST00000506706CTBP1chr4

1231971

-RNF4chr4

2626989

+
5UTR-intronENST00000515690ENST00000511600CTBP1chr4

1231971

-RNF4chr4

2626989

+

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FusionProtFeatures for CTBP1_RNF4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTBP1

Q13363

RNF4

P78317

Corepressor targeting diverse transcription regulatorssuch as GLIS2 or BCL6. Has dehydrogenase activity. Involved incontrolling the equilibrium between tubular and stacked structuresin the Golgi complex. Functions in brown adipose tissue (BAT)differentiation. {ECO:0000269|PubMed:12419229,ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:18212045,ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:9858600}. E3 ubiquitin-protein ligase which binds polysumoylatedchains covalently attached to proteins and mediates 'Lys-6'-,'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination ofthose substrates and their subsequent targeting to the proteasomefor degradation. Regulates the degradation of several proteinsincluding PML and the transcriptional activator PEA3. Involved inchromosome alignment and spindle assembly, it regulates thekinetochore CENPH-CENPI-CENPK complex by targeting polysumoylatedCENPI to proteasomal degradation. Regulates the cellular responsesto hypoxia and heat shock through degradation of respectivelyEPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomesand have a more direct role in the regulation of transcription forinstance enhancing basal transcription and steroid receptor-mediated transcriptional activation. {ECO:0000269|PubMed:12885770,ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:19307308,ECO:0000269|PubMed:20026589, ECO:0000269|PubMed:20212317,ECO:0000269|PubMed:20943951}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTBP1_RNF4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTBP1_RNF4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CTBP1PNN, IKZF1, SMAD6, RBBP8, TGIF1, NRIP1, MDM2, HDAC1, HDAC3, HDAC4, HDAC5, HDAC9, BRCA1, HDAC2, KAT2B, GEMIN2, TBP, GTF2B, FOXP1, FOXP2, KMT2A, CBX4, MECOM, IKZF4, CTBP2, ZEB1, ACTL6B, HTT, TBL1X, ZNF217, RCOR1, SATB1, CTBP1, TCF4, LCOR, TP53, HIC1, EHMT2, EHMT1, WIZ, APC, PLK1, TUBG1, HSD11B2, TCF7L2, KDM1A, CREBBP, EP300, KAT2A, SP1, RREB1, CDYL, UBE2I, BCORL1, SERPINH1, BCL3, AKT1, HIST3H3, SPEN, ZBP1, SOBP, ZNF219, LCORL, CHD3, RBBP5, CTNNA1, SOX2, ELAVL1, ZEB2, TERF2IP, TERF2, TFAP4, ATXN1L, BCL6, NCOR2, ECT2, CTNNB1, KLF4, DNMT1, RUNX1, BAG3, THAP11, HEMGN, NME2, ORC4, ARNT2, NOL4L, KLF12, MARCH10, CDC23, FUNDC1, IKZF2, KLF3, LNX1, PIAS2, RAI2, RNF111, ZBTB18, CEP68, NOL4, DGCR6, SNRPN, CRY2, HOXB5, PRKAA1, MAPK9, PLCB1, BCAS3, TSHZ3, DMRTB1, EGFR, HIC2, PRDM2, ZNF516, DYRK1A, TRPS1, C10orf12, BCOR, FBXO11, RCOR2, RCOR3, C2orf44, RBL1, INA, RB1, E2F7, TRMT61B, FOXK1, C15orf39, AMPD2, TOR2A, ADSS, ATIC, CARM1, CTH, ECHS1, FKBP1A, GAPDH, DUT, HYI, SSNA1, WDR1, NTRK1, MED23, OFD1, FBF1, KCNIP3, KLF8, NFATC1, NFATC2, MTMR7, RBM14-RBM4, IGFBP1, CHD4, NISCH, KIAA0430, HELZ, PCGF5, SOWAHA, PAN2, EIF4ENIF1, FANCC, FANCA, FANCF, FANCG, FANCL, FANCE, FANCD2, TRIM25RNF4AR, PATZ1, TCF20, ESR1, PGR, TBP, SP1, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2L6, UBE2T, UBE2W, UEVLD, UBE2E1, UBE2E3, UBE2H, UBE2I, UBE2K, UBE2E2, IKBKG, RNF4, SUMO2, TRIM28, PML, SART1, UHRF1, MDC1, RPA1, SUMO1, TDG, APEX1, TRPS1, SKIL, NFE2L2, TRAIP, HNF4A, SRPK2, UBC, HIST2H3C, ATXN1, TARDBP, MECP2, NCOA1, TERF2, FANCA, UBE2N, MAP3K7, TAB2, TAB3, USP11, MYC, CTNNB1, TRIM25, MIS18BP1, UBE2A, UBE2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTBP1_RNF4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTBP1_RNF4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCTBP1C0009404Colorectal Neoplasms1CTD_human