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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8721

FusionGeneSummary for CTBP1_CTBP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CTBP1_CTBP1
Fusion gene ID: 8721
HgeneTgene
Gene symbol

CTBP1

CTBP1

Gene ID

1487

1487

Gene nameC-terminal binding protein 1C-terminal binding protein 1
SynonymsBARS|HADDTSBARS|HADDTS
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
DescriptionC-terminal-binding protein 1brefeldin A-ribosylated substrateC-terminal-binding protein 1brefeldin A-ribosylated substrate
Modification date2018052220180522
UniProtAcc

Q13363

Q13363

Ensembl transtripts involved in fusion geneENST00000382952, ENST00000290921, 
ENST00000510568, ENST00000515690, 
ENST00000382952, ENST00000290921, 
ENST00000510568, ENST00000515690, 
Fusion gene scores* DoF score5 X 4 X 4=808 X 7 X 8=448
# samples 512
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/448*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CTBP1 [Title/Abstract] AND CTBP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW890211CTBP1chr4

1236541

-CTBP1chr4

1236941

-
ChiTaRS3.1AA506318CTBP1chr4

1235951

+CTBP1chr4

1235256

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000382952ENST00000382952CTBP1chr4

1236541

-CTBP1chr4

1236941

-
intron-intronENST00000382952ENST00000290921CTBP1chr4

1236541

-CTBP1chr4

1236941

-
intron-intronENST00000382952ENST00000510568CTBP1chr4

1236541

-CTBP1chr4

1236941

-
intron-intronENST00000382952ENST00000515690CTBP1chr4

1236541

-CTBP1chr4

1236941

-
intron-intronENST00000290921ENST00000382952CTBP1chr4

1236541

-CTBP1chr4

1236941

-
intron-intronENST00000290921ENST00000290921CTBP1chr4

1236541

-CTBP1chr4

1236941

-
intron-intronENST00000290921ENST00000510568CTBP1chr4

1236541

-CTBP1chr4

1236941

-
intron-intronENST00000290921ENST00000515690CTBP1chr4

1236541

-CTBP1chr4

1236941

-
intron-intronENST00000510568ENST00000382952CTBP1chr4

1236541

-CTBP1chr4

1236941

-
intron-intronENST00000510568ENST00000290921CTBP1chr4

1236541

-CTBP1chr4

1236941

-
intron-intronENST00000510568ENST00000510568CTBP1chr4

1236541

-CTBP1chr4

1236941

-
intron-intronENST00000510568ENST00000515690CTBP1chr4

1236541

-CTBP1chr4

1236941

-
intron-intronENST00000515690ENST00000382952CTBP1chr4

1236541

-CTBP1chr4

1236941

-
intron-intronENST00000515690ENST00000290921CTBP1chr4

1236541

-CTBP1chr4

1236941

-
intron-intronENST00000515690ENST00000510568CTBP1chr4

1236541

-CTBP1chr4

1236941

-
intron-intronENST00000515690ENST00000515690CTBP1chr4

1236541

-CTBP1chr4

1236941

-
intron-5UTRENST00000382952ENST00000382952CTBP1chr4

1235951

+CTBP1chr4

1235256

+
intron-intronENST00000382952ENST00000290921CTBP1chr4

1235951

+CTBP1chr4

1235256

+
intron-5UTRENST00000382952ENST00000510568CTBP1chr4

1235951

+CTBP1chr4

1235256

+
intron-5UTRENST00000382952ENST00000515690CTBP1chr4

1235951

+CTBP1chr4

1235256

+
intron-5UTRENST00000290921ENST00000382952CTBP1chr4

1235951

+CTBP1chr4

1235256

+
intron-intronENST00000290921ENST00000290921CTBP1chr4

1235951

+CTBP1chr4

1235256

+
intron-5UTRENST00000290921ENST00000510568CTBP1chr4

1235951

+CTBP1chr4

1235256

+
intron-5UTRENST00000290921ENST00000515690CTBP1chr4

1235951

+CTBP1chr4

1235256

+
intron-5UTRENST00000510568ENST00000382952CTBP1chr4

1235951

+CTBP1chr4

1235256

+
intron-intronENST00000510568ENST00000290921CTBP1chr4

1235951

+CTBP1chr4

1235256

+
intron-5UTRENST00000510568ENST00000510568CTBP1chr4

1235951

+CTBP1chr4

1235256

+
intron-5UTRENST00000510568ENST00000515690CTBP1chr4

1235951

+CTBP1chr4

1235256

+
intron-5UTRENST00000515690ENST00000382952CTBP1chr4

1235951

+CTBP1chr4

1235256

+
intron-intronENST00000515690ENST00000290921CTBP1chr4

1235951

+CTBP1chr4

1235256

+
intron-5UTRENST00000515690ENST00000510568CTBP1chr4

1235951

+CTBP1chr4

1235256

+
intron-5UTRENST00000515690ENST00000515690CTBP1chr4

1235951

+CTBP1chr4

1235256

+

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FusionProtFeatures for CTBP1_CTBP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CTBP1

Q13363

CTBP1

Q13363

Corepressor targeting diverse transcription regulatorssuch as GLIS2 or BCL6. Has dehydrogenase activity. Involved incontrolling the equilibrium between tubular and stacked structuresin the Golgi complex. Functions in brown adipose tissue (BAT)differentiation. {ECO:0000269|PubMed:12419229,ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:18212045,ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:9858600}. Corepressor targeting diverse transcription regulatorssuch as GLIS2 or BCL6. Has dehydrogenase activity. Involved incontrolling the equilibrium between tubular and stacked structuresin the Golgi complex. Functions in brown adipose tissue (BAT)differentiation. {ECO:0000269|PubMed:12419229,ECO:0000269|PubMed:15542832, ECO:0000269|PubMed:18212045,ECO:0000269|PubMed:19103759, ECO:0000269|PubMed:9858600}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CTBP1_CTBP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CTBP1_CTBP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CTBP1_CTBP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CTBP1_CTBP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCTBP1C0009404Colorectal Neoplasms1CTD_human
TgeneCTBP1C0009404Colorectal Neoplasms1CTD_human