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Fusion gene ID: 8700 |
FusionGeneSummary for CSTB_CSTB |
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Fusion gene information | Fusion gene name: CSTB_CSTB | Fusion gene ID: 8700 | Hgene | Tgene | Gene symbol | CSTB | CSTB | Gene ID | 1476 | 1476 |
Gene name | cystatin B | cystatin B | |
Synonyms | CPI-B|CST6|EPM1|EPM1A|PME|STFB|ULD | CPI-B|CST6|EPM1|EPM1A|PME|STFB|ULD | |
Cytomap | 21q22.3 | 21q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | cystatin-Bcystatin B (stefin B)liver thiol proteinase inhibitor | cystatin-Bcystatin B (stefin B)liver thiol proteinase inhibitor | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P04080 | P04080 | |
Ensembl transtripts involved in fusion gene | ENST00000291568, | ENST00000291568, | |
Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 3 X 3 X 1=9 |
# samples | 4 | 3 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CSTB [Title/Abstract] AND CSTB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CSTB | GO:0010466 | negative regulation of peptidase activity | 6203523 |
Hgene | CSTB | GO:0045861 | negative regulation of proteolysis | 3488317 |
Tgene | CSTB | GO:0010466 | negative regulation of peptidase activity | 6203523 |
Tgene | CSTB | GO:0045861 | negative regulation of proteolysis | 3488317 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW265426 | CSTB | chr21 | 45194579 | + | CSTB | chr21 | 45194143 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000291568 | ENST00000291568 | CSTB | chr21 | 45194579 | + | CSTB | chr21 | 45194143 | - |
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FusionProtFeatures for CSTB_CSTB |
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Hgene | Tgene |
CSTB | CSTB |
This is an intracellular thiol proteinase inhibitor.Tightly binding reversible inhibitor of cathepsins L, H and B. | This is an intracellular thiol proteinase inhibitor.Tightly binding reversible inhibitor of cathepsins L, H and B. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CSTB_CSTB |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CSTB_CSTB |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CSTB_CSTB |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CSTB_CSTB |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CSTB | C0751785 | Unverricht-Lundborg Syndrome | 3 | CTD_human;ORPHANET;UNIPROT |
Hgene | CSTB | C0027626 | Neoplasm Invasiveness | 2 | CTD_human |
Hgene | CSTB | C0017636 | Glioblastoma | 1 | CTD_human |
Hgene | CSTB | C0025286 | Meningioma | 1 | CTD_human |
Hgene | CSTB | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Tgene | CSTB | C0751785 | Unverricht-Lundborg Syndrome | 3 | CTD_human;ORPHANET;UNIPROT |
Tgene | CSTB | C0027626 | Neoplasm Invasiveness | 2 | CTD_human |
Tgene | CSTB | C0017636 | Glioblastoma | 1 | CTD_human |
Tgene | CSTB | C0025286 | Meningioma | 1 | CTD_human |
Tgene | CSTB | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |