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Fusion gene ID: 8687 |
FusionGeneSummary for CSRP1_RASGEF1B |
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Fusion gene information | Fusion gene name: CSRP1_RASGEF1B | Fusion gene ID: 8687 | Hgene | Tgene | Gene symbol | CSRP1 | RASGEF1B | Gene ID | 1465 | 153020 |
Gene name | cysteine and glycine rich protein 1 | RasGEF domain family member 1B | |
Synonyms | CRP|CRP1|CSRP|CYRP|D1S181E|HEL-141|HEL-S-286 | GPIG4 | |
Cytomap | 1q32.1 | 4q21.21 | |
Type of gene | protein-coding | protein-coding | |
Description | cysteine and glycine-rich protein 1LIM-domain proteincysteine-rich protein 1epididymis luminal protein 141epididymis secretory protein Li 286 | ras-GEF domain-containing family member 1BGPI gamma-4 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | P21291 | Q0VAM2 | |
Ensembl transtripts involved in fusion gene | ENST00000367306, ENST00000340006, ENST00000531916, ENST00000532460, ENST00000533432, ENST00000526723, ENST00000458271, | ENST00000509081, ENST00000264400, ENST00000335927, ENST00000436139, ENST00000514889, | |
Fusion gene scores | * DoF score | 5 X 7 X 3=105 | 6 X 4 X 5=120 |
# samples | 7 | 6 | |
** MAII score | log2(7/105*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CSRP1 [Title/Abstract] AND RASGEF1B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-A7-A6VV-01A | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-intron | ENST00000367306 | ENST00000509081 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000367306 | ENST00000264400 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000367306 | ENST00000335927 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000367306 | ENST00000436139 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000367306 | ENST00000514889 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000340006 | ENST00000509081 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000340006 | ENST00000264400 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000340006 | ENST00000335927 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000340006 | ENST00000436139 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000340006 | ENST00000514889 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000531916 | ENST00000509081 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000531916 | ENST00000264400 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000531916 | ENST00000335927 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000531916 | ENST00000436139 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000531916 | ENST00000514889 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
intron-intron | ENST00000532460 | ENST00000509081 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
intron-intron | ENST00000532460 | ENST00000264400 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
intron-intron | ENST00000532460 | ENST00000335927 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
intron-intron | ENST00000532460 | ENST00000436139 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
intron-intron | ENST00000532460 | ENST00000514889 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
intron-intron | ENST00000533432 | ENST00000509081 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
intron-intron | ENST00000533432 | ENST00000264400 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
intron-intron | ENST00000533432 | ENST00000335927 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
intron-intron | ENST00000533432 | ENST00000436139 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
intron-intron | ENST00000533432 | ENST00000514889 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000526723 | ENST00000509081 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000526723 | ENST00000264400 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000526723 | ENST00000335927 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000526723 | ENST00000436139 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000526723 | ENST00000514889 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000458271 | ENST00000509081 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000458271 | ENST00000264400 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000458271 | ENST00000335927 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000458271 | ENST00000436139 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
5UTR-intron | ENST00000458271 | ENST00000514889 | CSRP1 | chr1 | 201476198 | - | RASGEF1B | chr4 | 82524076 | - |
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FusionProtFeatures for CSRP1_RASGEF1B |
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Hgene | Tgene |
CSRP1 | RASGEF1B |
Could play a role in neuronal development. | Guanine nucleotide exchange factor (GEF) withspecificity for RAP2A, it doesn't seems to activate other Rasfamily proteins (in vitro). {ECO:0000269|PubMed:19645719,ECO:0000269|PubMed:23894443}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CSRP1_RASGEF1B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CSRP1_RASGEF1B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CSRP1 | CSRP1, EGFR, APP, GRB2, ACTN1, BAG3, YBX3, MACF1, PRKAR2A, SUZ12, RNF2, BMI1, ACAA2, CFL1, HSPB1, NUP214, UFM1, FUBP3, TALDO1, ESR1, CNTRL, ASCC2, ASCC1, TRIP4, TES | RASGEF1B | EGFR, COL1A1, GAPDHS |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CSRP1_RASGEF1B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | CSRP1 | P21291 | DB11638 | Artenimol | Cysteine and glycine-rich protein 1 | small molecule | approved|investigational |
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RelatedDiseases for CSRP1_RASGEF1B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CSRP1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Hgene | CSRP1 | C0014173 | Endometrial Hyperplasia | 1 | CTD_human |
Hgene | CSRP1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | CSRP1 | C0746402 | manic symptom | 1 | PSYGENET |
Tgene | RASGEF1B | C3495559 | Juvenile arthritis | 1 | CTD_human |