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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8686

FusionGeneSummary for CSRP1_PALLD

check button Fusion gene summary
Fusion gene informationFusion gene name: CSRP1_PALLD
Fusion gene ID: 8686
HgeneTgene
Gene symbol

CSRP1

PALLD

Gene ID

1465

23022

Gene namecysteine and glycine rich protein 1palladin, cytoskeletal associated protein
SynonymsCRP|CRP1|CSRP|CYRP|D1S181E|HEL-141|HEL-S-286CGI-151|CGI151|MYN|PNCA1|SIH002
Cytomap

1q32.1

4q32.3

Type of geneprotein-codingprotein-coding
Descriptioncysteine and glycine-rich protein 1LIM-domain proteincysteine-rich protein 1epididymis luminal protein 141epididymis secretory protein Li 286palladinmyoneurinsarcoma antigen NY-SAR-77
Modification date2018051920180523
UniProtAcc

P21291

Q8WX93

Ensembl transtripts involved in fusion geneENST00000367306, ENST00000340006, 
ENST00000531916, ENST00000532460, 
ENST00000533432, ENST00000526723, 
ENST00000458271, 		ENST00000335742, 
ENST00000261509, ENST00000505667, 
ENST00000333488, ENST00000512127, 
ENST00000507735, 
Fusion gene scores* DoF score5 X 7 X 3=1057 X 6 X 3=126
# samples 77
** MAII scorelog2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CSRP1 [Title/Abstract] AND PALLD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A48J-01ACSRP1chr1

201452662

-PALLDchr4

169418275

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000367306ENST00000335742CSRP1chr1

201452662

-PALLDchr4

169418275

+
5CDS-5UTRENST00000367306ENST00000261509CSRP1chr1

201452662

-PALLDchr4

169418275

+
5CDS-5UTRENST00000367306ENST00000505667CSRP1chr1

201452662

-PALLDchr4

169418275

+
5CDS-intronENST00000367306ENST00000333488CSRP1chr1

201452662

-PALLDchr4

169418275

+
5CDS-intronENST00000367306ENST00000512127CSRP1chr1

201452662

-PALLDchr4

169418275

+
5CDS-intronENST00000367306ENST00000507735CSRP1chr1

201452662

-PALLDchr4

169418275

+
5CDS-5UTRENST00000340006ENST00000335742CSRP1chr1

201452662

-PALLDchr4

169418275

+
5CDS-5UTRENST00000340006ENST00000261509CSRP1chr1

201452662

-PALLDchr4

169418275

+
5CDS-5UTRENST00000340006ENST00000505667CSRP1chr1

201452662

-PALLDchr4

169418275

+
5CDS-intronENST00000340006ENST00000333488CSRP1chr1

201452662

-PALLDchr4

169418275

+
5CDS-intronENST00000340006ENST00000512127CSRP1chr1

201452662

-PALLDchr4

169418275

+
5CDS-intronENST00000340006ENST00000507735CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-5UTRENST00000531916ENST00000335742CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-5UTRENST00000531916ENST00000261509CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-5UTRENST00000531916ENST00000505667CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-intronENST00000531916ENST00000333488CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-intronENST00000531916ENST00000512127CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-intronENST00000531916ENST00000507735CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-5UTRENST00000532460ENST00000335742CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-5UTRENST00000532460ENST00000261509CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-5UTRENST00000532460ENST00000505667CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-intronENST00000532460ENST00000333488CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-intronENST00000532460ENST00000512127CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-intronENST00000532460ENST00000507735CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-5UTRENST00000533432ENST00000335742CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-5UTRENST00000533432ENST00000261509CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-5UTRENST00000533432ENST00000505667CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-intronENST00000533432ENST00000333488CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-intronENST00000533432ENST00000512127CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-intronENST00000533432ENST00000507735CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-5UTRENST00000526723ENST00000335742CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-5UTRENST00000526723ENST00000261509CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-5UTRENST00000526723ENST00000505667CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-intronENST00000526723ENST00000333488CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-intronENST00000526723ENST00000512127CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-intronENST00000526723ENST00000507735CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-5UTRENST00000458271ENST00000335742CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-5UTRENST00000458271ENST00000261509CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-5UTRENST00000458271ENST00000505667CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-intronENST00000458271ENST00000333488CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-intronENST00000458271ENST00000512127CSRP1chr1

201452662

-PALLDchr4

169418275

+
intron-intronENST00000458271ENST00000507735CSRP1chr1

201452662

-PALLDchr4

169418275

+

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FusionProtFeatures for CSRP1_PALLD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CSRP1

P21291

PALLD

Q8WX93

Could play a role in neuronal development.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CSRP1_PALLD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CSRP1_PALLD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CSRP1CSRP1, EGFR, APP, GRB2, ACTN1, BAG3, YBX3, MACF1, PRKAR2A, SUZ12, RNF2, BMI1, ACAA2, CFL1, HSPB1, NUP214, UFM1, FUBP3, TALDO1, ESR1, CNTRL, ASCC2, ASCC1, TRIP4, TESPALLDEZR, ISG15, SORBS2, ACTN1, ACOX1, SARS, HSP90AA4P, IGBP1, DSTN, HSPB1, NDUFV1, LIG4, SIRT6, GRPEL1, WDFY2, TSG101, NTRK1, SRPK2, CEP162, CEP152, CNTROB, CEP128, NINL, NIN, ODF2, SCLT1, CEP83, CENPJ, FLNA, HSPA5, KDR, LLGL2, MYH9, MYO1C, PDLIM7, MYO19, SKA3, MCM2, NCKIPSD, PFN2, BCHE, TRIM25, G3BP1, BRCA1, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CSRP1_PALLD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCSRP1P21291DB11638ArtenimolCysteine and glycine-rich protein 1small moleculeapproved|investigational

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RelatedDiseases for CSRP1_PALLD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCSRP1C0005586Bipolar Disorder1PSYGENET
HgeneCSRP1C0014173Endometrial Hyperplasia1CTD_human
HgeneCSRP1C0033578Prostatic Neoplasms1CTD_human
HgeneCSRP1C0746402manic symptom1PSYGENET
TgenePALLDC0043094Weight Gain1CTD_human