	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 866

FusionGeneSummary for ADD1_CAST

Fusion gene summary

Fusion gene information	Fusion gene name: ADD1_CAST
	Fusion gene ID: 866
		Hgene	Tgene
	Gene symbol	ADD1	CAST
	Gene ID	118	26059
	Gene name	adducin 1	ELKS/RAB6-interacting/CAST family member 2
	Synonyms	ADDA	CAST\|CAST1\|ELKSL\|SPBC110\|Spc110
	Cytomap	4p16.3	3p14.3
	Type of gene	protein-coding	protein-coding
	Description	alpha-adducinadducin 1 (alpha)erythrocyte adducin alpha subunit	ERC protein 2CAZ-associated structural proteincytomatrix protein p110
	Modification date	20180523	20180519
	UniProtAcc	P35611	P20810
	Ensembl transtripts involved in fusion gene	ENST00000446856, ENST00000264758, ENST00000398125, ENST00000513328, ENST00000503455, ENST00000355842, ENST00000398123, ENST00000398129, ENST00000538860,	ENST00000338252, ENST00000508830, ENST00000359176, ENST00000395812, ENST00000325674, ENST00000395813, ENST00000510756, ENST00000508608, ENST00000341926, ENST00000511049, ENST00000309190, ENST00000509903, ENST00000511782, ENST00000504465, ENST00000348386, ENST00000508579, ENST00000515663,
Fusion gene scores	* DoF score	11 X 8 X 7=616	10 X 9 X 6=540
	# samples	13	12
	** MAII score	log2(13/616*10)=-2.24441872766645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/540*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ADD1 [Title/Abstract] AND CAST [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ADD1	GO:0032092	positive regulation of protein binding	3693401\|7642559
Hgene	ADD1	GO:0051016	barbed-end actin filament capping	8626479
Hgene	ADD1	GO:0051017	actin filament bundle assembly	3693401
Hgene	ADD1	GO:0071277	cellular response to calcium ion	25978380
Hgene	ADD1	GO:1903142	positive regulation of establishment of endothelial barrier	25978380
Hgene	ADD1	GO:1903393	positive regulation of adherens junction organization	25978380

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BE000093	ADD1	chr4	2900815	-	CAST	chr5	96084251	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000446856	ENST00000338252	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000446856	ENST00000508830	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000446856	ENST00000359176	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000446856	ENST00000395812	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000446856	ENST00000325674	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000446856	ENST00000395813	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000446856	ENST00000510756	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000446856	ENST00000508608	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000446856	ENST00000341926	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000446856	ENST00000511049	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000446856	ENST00000309190	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000446856	ENST00000509903	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000446856	ENST00000511782	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000446856	ENST00000504465	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000446856	ENST00000348386	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000446856	ENST00000508579	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000446856	ENST00000515663	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000264758	ENST00000338252	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000264758	ENST00000508830	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000264758	ENST00000359176	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000264758	ENST00000395812	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000264758	ENST00000325674	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000264758	ENST00000395813	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000264758	ENST00000510756	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000264758	ENST00000508608	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000264758	ENST00000341926	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000264758	ENST00000511049	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000264758	ENST00000309190	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000264758	ENST00000509903	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000264758	ENST00000511782	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000264758	ENST00000504465	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000264758	ENST00000348386	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000264758	ENST00000508579	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000264758	ENST00000515663	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398125	ENST00000338252	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398125	ENST00000508830	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398125	ENST00000359176	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398125	ENST00000395812	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398125	ENST00000325674	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398125	ENST00000395813	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398125	ENST00000510756	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398125	ENST00000508608	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398125	ENST00000341926	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398125	ENST00000511049	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398125	ENST00000309190	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398125	ENST00000509903	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398125	ENST00000511782	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398125	ENST00000504465	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000398125	ENST00000348386	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000398125	ENST00000508579	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000398125	ENST00000515663	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000513328	ENST00000338252	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000513328	ENST00000508830	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000513328	ENST00000359176	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000513328	ENST00000395812	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000513328	ENST00000325674	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000513328	ENST00000395813	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000513328	ENST00000510756	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000513328	ENST00000508608	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000513328	ENST00000341926	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000513328	ENST00000511049	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000513328	ENST00000309190	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000513328	ENST00000509903	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000513328	ENST00000511782	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000513328	ENST00000504465	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000513328	ENST00000348386	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000513328	ENST00000508579	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000513328	ENST00000515663	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000503455	ENST00000338252	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000503455	ENST00000508830	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000503455	ENST00000359176	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000503455	ENST00000395812	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000503455	ENST00000325674	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000503455	ENST00000395813	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000503455	ENST00000510756	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000503455	ENST00000508608	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000503455	ENST00000341926	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000503455	ENST00000511049	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000503455	ENST00000309190	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000503455	ENST00000509903	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000503455	ENST00000511782	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000503455	ENST00000504465	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000503455	ENST00000348386	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000503455	ENST00000508579	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000503455	ENST00000515663	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000355842	ENST00000338252	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000355842	ENST00000508830	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000355842	ENST00000359176	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000355842	ENST00000395812	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000355842	ENST00000325674	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000355842	ENST00000395813	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000355842	ENST00000510756	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000355842	ENST00000508608	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000355842	ENST00000341926	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000355842	ENST00000511049	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000355842	ENST00000309190	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000355842	ENST00000509903	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000355842	ENST00000511782	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000355842	ENST00000504465	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000355842	ENST00000348386	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000355842	ENST00000508579	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000355842	ENST00000515663	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398123	ENST00000338252	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398123	ENST00000508830	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398123	ENST00000359176	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398123	ENST00000395812	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398123	ENST00000325674	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398123	ENST00000395813	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398123	ENST00000510756	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398123	ENST00000508608	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398123	ENST00000341926	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398123	ENST00000511049	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398123	ENST00000309190	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398123	ENST00000509903	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398123	ENST00000511782	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398123	ENST00000504465	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000398123	ENST00000348386	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000398123	ENST00000508579	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000398123	ENST00000515663	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398129	ENST00000338252	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398129	ENST00000508830	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398129	ENST00000359176	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398129	ENST00000395812	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398129	ENST00000325674	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398129	ENST00000395813	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398129	ENST00000510756	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398129	ENST00000508608	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398129	ENST00000341926	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398129	ENST00000511049	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398129	ENST00000309190	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398129	ENST00000509903	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398129	ENST00000511782	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000398129	ENST00000504465	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000398129	ENST00000348386	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000398129	ENST00000508579	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000398129	ENST00000515663	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000538860	ENST00000338252	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000538860	ENST00000508830	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000538860	ENST00000359176	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000538860	ENST00000395812	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000538860	ENST00000325674	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000538860	ENST00000395813	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000538860	ENST00000510756	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000538860	ENST00000508608	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000538860	ENST00000341926	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000538860	ENST00000511049	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000538860	ENST00000309190	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000538860	ENST00000509903	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000538860	ENST00000511782	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3CDS	ENST00000538860	ENST00000504465	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000538860	ENST00000348386	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000538860	ENST00000508579	ADD1	chr4	2900815	-	CAST	chr5	96084251	+
intron-3UTR	ENST00000538860	ENST00000515663	ADD1	chr4	2900815	-	CAST	chr5	96084251	+

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FusionProtFeatures for ADD1_CAST

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ADD1 P35611	CAST P20810

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for ADD1_CAST

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADD1_CAST

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for ADD1_CAST

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	CAST	P20810	DB11638	Artenimol	Calpastatin	small molecule	approved\|investigational
Tgene	CAST	P20810	DB01373	Calcium	Calpastatin	small molecule	approved\|nutraceutical

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RelatedDiseases for ADD1_CAST

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ADD1	C0020538	Hypertensive disease	2	CTD_human
Hgene	ADD1	C2239176	Liver carcinoma	1	CTD_human
Tgene	CAST	C0027540	Necrosis	1	CTD_human
Tgene	CAST	C0162557	Liver Failure, Acute	1	CTD_human

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Fusion gene ID: 866

FusionGeneSummary for ADD1_CAST

FusionProtFeatures for ADD1_CAST

FusionGeneSequence for ADD1_CAST

FusionGenePPI for ADD1_CAST

RelatedDrugs for ADD1_CAST

RelatedDiseases for ADD1_CAST