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Fusion gene ID: 8641 |
FusionGeneSummary for CSNK1E_DMC1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CSNK1E_DMC1 | Fusion gene ID: 8641 | Hgene | Tgene | Gene symbol | CSNK1E | DMC1 | Gene ID | 1454 | 283987 |
| Gene name | casein kinase 1 epsilon | HID1 domain containing | |
| Synonyms | CKIe|CKIepsilon|HCKIE | 17orf28|C17orf28|DMC1|HID-1 | |
| Cytomap | 22q13.1 | 17q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | casein kinase I isoform epsilon | protein HID1HID1 domain-containing proteinUPF0663 transmembrane protein C17orf28down-regulated in multiple cancers 1downregulated in multiple cancer 1protein hid-1 homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P49674 | Q14565 | |
| Ensembl transtripts involved in fusion gene | ENST00000359867, ENST00000396832, ENST00000400206, ENST00000403904, ENST00000413574, ENST00000405675, ENST00000498529, | ENST00000216024, ENST00000428462, ENST00000464842, | |
| Fusion gene scores | * DoF score | 11 X 8 X 10=880 | 3 X 3 X 3=27 |
| # samples | 11 | 3 | |
| ** MAII score | log2(11/880*10)=-3 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CSNK1E [Title/Abstract] AND DMC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CSNK1E | GO:0006468 | protein phosphorylation | 15917222|17244647 |
| Hgene | CSNK1E | GO:0018105 | peptidyl-serine phosphorylation | 25500533 |
| Hgene | CSNK1E | GO:0032091 | negative regulation of protein binding | 23109420 |
| Hgene | CSNK1E | GO:0060070 | canonical Wnt signaling pathway | 14722104 |
| Hgene | CSNK1E | GO:1903827 | regulation of cellular protein localization | 17244647 |
| Tgene | DMC1 | GO:0006886 | intracellular protein transport | 21337012 |
| Tgene | DMC1 | GO:0031001 | response to brefeldin A | 21337012 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCEC | TCGA-AX-A2H4-01A | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000359867 | ENST00000216024 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| Frame-shift | ENST00000359867 | ENST00000428462 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| 5CDS-intron | ENST00000359867 | ENST00000464842 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| Frame-shift | ENST00000396832 | ENST00000216024 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| Frame-shift | ENST00000396832 | ENST00000428462 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| 5CDS-intron | ENST00000396832 | ENST00000464842 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| In-frame | ENST00000400206 | ENST00000216024 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| In-frame | ENST00000400206 | ENST00000428462 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| 5CDS-intron | ENST00000400206 | ENST00000464842 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| Frame-shift | ENST00000403904 | ENST00000216024 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| Frame-shift | ENST00000403904 | ENST00000428462 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| 5CDS-intron | ENST00000403904 | ENST00000464842 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| Frame-shift | ENST00000413574 | ENST00000216024 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| Frame-shift | ENST00000413574 | ENST00000428462 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| 5CDS-intron | ENST00000413574 | ENST00000464842 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| Frame-shift | ENST00000405675 | ENST00000216024 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| Frame-shift | ENST00000405675 | ENST00000428462 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| 5CDS-intron | ENST00000405675 | ENST00000464842 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| 5UTR-3CDS | ENST00000498529 | ENST00000216024 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| 5UTR-3CDS | ENST00000498529 | ENST00000428462 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
| 5UTR-intron | ENST00000498529 | ENST00000464842 | CSNK1E | chr22 | 38694791 | - | DMC1 | chr22 | 38958374 | - |
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FusionProtFeatures for CSNK1E_DMC1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CSNK1E | DMC1 |
| Casein kinases are operationally defined by theirpreferential utilization of acidic proteins such as caseins assubstrates. Can phosphorylate a large number of proteins.Participates in Wnt signaling. Phosphorylates DVL1 and DVL2.Central component of the circadian clock. In balance with PP1,determines the circadian period length, through the regulation ofthe speed and rhythmicity of PER1 and PER2 phosphorylation.Controls PER1 and PER2 nuclear transport and degradation. Inhibitscytokine-induced granuloytic differentiation.{ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676,ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549,ECO:0000269|PubMed:23413191}. | May participate in meiotic recombination, specificallyin homologous strand assimilation, which is required for theresolution of meiotic double-strand breaks. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CSNK1E_DMC1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CSNK1E_ENST00000400206_chr22_38694791_-_DMC1_ENST00000216024_chr22_38958374_-_260aa EPGFLTAFEYSEKRKMVFHITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLCVTAQLPGAGGYPGGKIIFIDTENTFRPDRLR DIADRFNVDHDAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYN >In-frame_CSNK1E_ENST00000400206_chr22_38694791_-_DMC1_ENST00000428462_chr22_38958374_-_205aa EPGFLTAFEYSEKRKMVFHITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLCGEHQMELLDYVAAKFHEEAGIFKLLIIDSIM ALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIY |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CSNK1E_ENST00000400206_chr22_38694791_-_DMC1_ENST00000216024_chr22_38958374_-_780nt GAACCAGGATTCTTGACTGCATTTGAGTATAGTGAAAAGAGGAAAATGGTTTTCCATATCACCACCGGGAGCCAGGAATTTGATAAGTTA CTAGGAGGTGGAATTGAAAGTATGGCAATTACAGAAGCTTTTGGAGAATTTCGTACTGGAAAAACCCAGCTTTCTCATACCCTCTGTGTG ACAGCTCAACTTCCAGGAGCTGGTGGCTACCCAGGAGGAAAGATTATCTTCATTGATACAGAAAATACTTTCCGTCCAGATCGCCTTAGG GACATTGCTGATCGCTTTAATGTAGACCATGATGCAGTACTGGACAACGTACTTTATGCACGTGCATATACTAGTGAACATCAGATGGAG CTACTTGATTATGTAGCAGCAAAGTTCCATGAAGAAGCTGGCATCTTCAAGCTATTGATTATCGATTCAATAATGGCACTTTTTCGAGTG GATTTCAGTGGCCGTGGGGAGTTGGCCGAACGGCAGCAAAAATTGGCCCAGATGTTGTCACGACTCCAAAAAATCTCAGAAGAATATAAC GTGGCTGTTTTTGTGACCAATCAAATGACTGCCGATCCAGGAGCAACTATGACCTTTCAGGCAGATCCCAAAAAACCCATTGGGGGACAC ATTCTGGCTCATGCTTCAACAACAAGAATAAGCTTGCGAAAGGGAAGAGGAGAGCTCAGAATTGCCAAGATTTATGACAGTCCTGAGATG >In-frame_CSNK1E_ENST00000400206_chr22_38694791_-_DMC1_ENST00000428462_chr22_38958374_-_615nt GAACCAGGATTCTTGACTGCATTTGAGTATAGTGAAAAGAGGAAAATGGTTTTCCATATCACCACCGGGAGCCAGGAATTTGATAAGTTA CTAGGAGGTGGAATTGAAAGTATGGCAATTACAGAAGCTTTTGGAGAATTTCGTACTGGAAAAACCCAGCTTTCTCATACCCTCTGTGGT GAACATCAGATGGAGCTACTTGATTATGTAGCAGCAAAGTTCCATGAAGAAGCTGGCATCTTCAAGCTATTGATTATCGATTCAATAATG GCACTTTTTCGAGTGGATTTCAGTGGCCGTGGGGAGTTGGCCGAACGGCAGCAAAAATTGGCCCAGATGTTGTCACGACTCCAAAAAATC TCAGAAGAATATAACGTGGCTGTTTTTGTGACCAATCAAATGACTGCCGATCCAGGAGCAACTATGACCTTTCAGGCAGATCCCAAAAAA CCCATTGGGGGACACATTCTGGCTCATGCTTCAACAACAAGAATAAGCTTGCGAAAGGGAAGAGGAGAGCTCAGAATTGCCAAGATTTAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CSNK1E_ENST00000400206_chr22_38694791_-_DMC1_ENST00000216024_chr22_38958374_-_3202nt CTTTCAAACCCGGCCGGCCCGAGTGGAGTCAGCTCAGTCCCGGCAGCCGCCGCGCGAGGAAATGGCCGAGGGGCCGGAGCCACAGTCCAC AGACAAACGAATTTAAAGGAGCAACCGAGGAGGCACCTGCGAAAGAAAGCCCACACACAGGTGAATTTAAAGGAGCAGCCCTGGTGTCAC CTATCAGTAAAAGACTATTTGGAGTTTTCCTCGTCTTACTGGATGTCACTCTCGTCCTTGCCGACCTAATTTTCACTGACAGCAAACTTT ATATTCCTTTGGAGTATCGTTCTATTTCTCTAGCTATTGCCTTATTTTTTCTCATGGATGTTCTTCTTCGAGTATTTGTAGAAGGGTGTT GGAGCGGGCCGGAGAGAAGTAGAGTGGGCTGCGAGGAGAAGGAAACAGGCCTTTCGGAGGCTCCTCATCCCTCGGAGGTCATCCCTTACT CCAGCAAGAGTGAGCCATGGAGCTACGTGTGGGGAACAAGTACCGCCTGGGACGGAAGATCGGGAGCGGGTCCTTCGGAGATATCTACCT GGGTGCCAACATCGCCTCTGGTGAGGAAGTCGCCATCAAGCTGGAGTGTGTGAAGACAAAGCACCCCCAGCTGCACATCGAGAGCAAGTT CTACAAGATGATGCAGGGTGGCGTGGGGATCCCGTCCATCAAGTGGTGCGGAGCTGAGGGCGACTACAACGTGATGGTCATGGAGCTGCT GGGGCCTAGCCTCGAGGACCTGTTCAACTTCTGTTCCCGCAAATTCAGCCTCAAGACGGTGCTGCTCTTGGCCGACCAGATGATCAGCCG CATCGAGTATATCCACTCCAAGAACTTCATCCACCGGGACGTCAAGCCCGACAACTTCCTCATGGGGCTGGGGAAGAAGGGCAACCTGGT CTACATCATCGACTTCGGCCTGGCCAAGAAGTACCGGGACGCCCGCACCCACCAGCACATTCCCTACCGGGAAAACAAGAACCTGACCGG CACGGCCCGCTACGCTTCCATCAACACGCACCTGGGCATTGAGCAAAGCCGTCGAGATGACCTGGAGAGCCTGGGCTACGTGCTCATGTA CTTCAACCTGGGCTCCCTGCCCTGGCAGGGGCTCAAAGCAGCCACCAAGCGCCAGAAGTATGAACGGATCAGCGAGAAGAAGATGTCAAC GCCCATCGAGGTCCTCTGCAAAGGCTATCCCTCCGAATTCTCAACATACCTCAACTTCTGCCGCTCCCTGCGGTTTGACGACAAGCCCGA CTACTCTTACCTACGTCAGCTCTTCCGCAACCTCTTCCACCGGCAGGGCTTCTCCTATGACTACGTCTTTGACTGGAACATGCTGAAATT CGAACCAGGATTCTTGACTGCATTTGAGTATAGTGAAAAGAGGAAAATGGTTTTCCATATCACCACCGGGAGCCAGGAATTTGATAAGTT ACTAGGAGGTGGAATTGAAAGTATGGCAATTACAGAAGCTTTTGGAGAATTTCGTACTGGAAAAACCCAGCTTTCTCATACCCTCTGTGT GACAGCTCAACTTCCAGGAGCTGGTGGCTACCCAGGAGGAAAGATTATCTTCATTGATACAGAAAATACTTTCCGTCCAGATCGCCTTAG GGACATTGCTGATCGCTTTAATGTAGACCATGATGCAGTACTGGACAACGTACTTTATGCACGTGCATATACTAGTGAACATCAGATGGA GCTACTTGATTATGTAGCAGCAAAGTTCCATGAAGAAGCTGGCATCTTCAAGCTATTGATTATCGATTCAATAATGGCACTTTTTCGAGT GGATTTCAGTGGCCGTGGGGAGTTGGCCGAACGGCAGCAAAAATTGGCCCAGATGTTGTCACGACTCCAAAAAATCTCAGAAGAATATAA CGTGGCTGTTTTTGTGACCAATCAAATGACTGCCGATCCAGGAGCAACTATGACCTTTCAGGCAGATCCCAAAAAACCCATTGGGGGACA CATTCTGGCTCATGCTTCAACAACAAGAATAAGCTTGCGAAAGGGAAGAGGAGAGCTCAGAATTGCCAAGATTTATGACAGTCCTGAGAT GCCTGAAAATGAAGCCACCTTCGCAATAACTGCTGGAGGAATTGGGGATGCCAAGGAGTAGGTGGTGAATTGATGCAAATTGCTTCTTAG TGCTTATTAGGAGCTGAAGAAATGGAAAAGCAGTCTCCAATTTCACATCTTGAAATAGAGGTTTTTTCCCACATGTTACTAAAGAAAAGT CAGCAAAGAGATTTAAATCTTATATTTATCTTAAAAGTCCCTGATTTATGATAACTATACATTGTATGTAAATTCAGGGATATGTATATG TATGTTTGTGTGTGTGTGTGTTTGTGTGTGTATACCTGACATATATAGTAGATATATATACCTATTGAAATTCTCTCACTCTGTGTATGT ATATATACCTATGGAAAACTAGTTGTTGGGAAAGGAGTACGTGATTCCCTCCCTTTCACTTTTCAAAGTGAGCCACTAAACAGAAAGTCT AAGAGTTCAGAAATGTCCCATTCTCCTAAGGACTTTCCCTTCACCATTTTTCTAGGGTATAGTGCCACTGACTTACATAGCTAGATGTTT TTCCACAAGAGGATTTAAGGGAGGAATGTTTATAGGACACACACACAAAAGCTCTTTCTATTTATAATATCAAACTGCATATTCACCTTT ATAGCAACAGAAAACAGACATTAAATTAAGCCAAATTTTAAATCATTTGACTTTGACAAGCAGAAATTACTTTTAAAAAATGTATTTATG GCTGGGCGTGGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACTTGAGGTCAGGAGTTCAAGACCAGCCT GGCCAACATGGAGAAACCCCATCTCTACTAAAAATACAAAAATTAGCCAAGTGCAGTGGCATGTGCTTGTAATCCCAGCTACTCTGGAGG CTGAGGCAGGAGAATTGCTTGAACCCAGGAGGCAGAGATTGCGGTGAGCCAAGATGGCACCACTGCACTCCAGCCTAGGTGACAGAGTGA GACTCCGTCTCAAAAAAAAAAAAAAAACTTTTTTAAAATGTTAAAATTAATTTAAATGTAAAATTTCTGAATACTAATCTTAGAAATGTG >In-frame_CSNK1E_ENST00000400206_chr22_38694791_-_DMC1_ENST00000428462_chr22_38958374_-_2011nt CTTTCAAACCCGGCCGGCCCGAGTGGAGTCAGCTCAGTCCCGGCAGCCGCCGCGCGAGGAAATGGCCGAGGGGCCGGAGCCACAGTCCAC AGACAAACGAATTTAAAGGAGCAACCGAGGAGGCACCTGCGAAAGAAAGCCCACACACAGGTGAATTTAAAGGAGCAGCCCTGGTGTCAC CTATCAGTAAAAGACTATTTGGAGTTTTCCTCGTCTTACTGGATGTCACTCTCGTCCTTGCCGACCTAATTTTCACTGACAGCAAACTTT ATATTCCTTTGGAGTATCGTTCTATTTCTCTAGCTATTGCCTTATTTTTTCTCATGGATGTTCTTCTTCGAGTATTTGTAGAAGGGTGTT GGAGCGGGCCGGAGAGAAGTAGAGTGGGCTGCGAGGAGAAGGAAACAGGCCTTTCGGAGGCTCCTCATCCCTCGGAGGTCATCCCTTACT CCAGCAAGAGTGAGCCATGGAGCTACGTGTGGGGAACAAGTACCGCCTGGGACGGAAGATCGGGAGCGGGTCCTTCGGAGATATCTACCT GGGTGCCAACATCGCCTCTGGTGAGGAAGTCGCCATCAAGCTGGAGTGTGTGAAGACAAAGCACCCCCAGCTGCACATCGAGAGCAAGTT CTACAAGATGATGCAGGGTGGCGTGGGGATCCCGTCCATCAAGTGGTGCGGAGCTGAGGGCGACTACAACGTGATGGTCATGGAGCTGCT GGGGCCTAGCCTCGAGGACCTGTTCAACTTCTGTTCCCGCAAATTCAGCCTCAAGACGGTGCTGCTCTTGGCCGACCAGATGATCAGCCG CATCGAGTATATCCACTCCAAGAACTTCATCCACCGGGACGTCAAGCCCGACAACTTCCTCATGGGGCTGGGGAAGAAGGGCAACCTGGT CTACATCATCGACTTCGGCCTGGCCAAGAAGTACCGGGACGCCCGCACCCACCAGCACATTCCCTACCGGGAAAACAAGAACCTGACCGG CACGGCCCGCTACGCTTCCATCAACACGCACCTGGGCATTGAGCAAAGCCGTCGAGATGACCTGGAGAGCCTGGGCTACGTGCTCATGTA CTTCAACCTGGGCTCCCTGCCCTGGCAGGGGCTCAAAGCAGCCACCAAGCGCCAGAAGTATGAACGGATCAGCGAGAAGAAGATGTCAAC GCCCATCGAGGTCCTCTGCAAAGGCTATCCCTCCGAATTCTCAACATACCTCAACTTCTGCCGCTCCCTGCGGTTTGACGACAAGCCCGA CTACTCTTACCTACGTCAGCTCTTCCGCAACCTCTTCCACCGGCAGGGCTTCTCCTATGACTACGTCTTTGACTGGAACATGCTGAAATT CGAACCAGGATTCTTGACTGCATTTGAGTATAGTGAAAAGAGGAAAATGGTTTTCCATATCACCACCGGGAGCCAGGAATTTGATAAGTT ACTAGGAGGTGGAATTGAAAGTATGGCAATTACAGAAGCTTTTGGAGAATTTCGTACTGGAAAAACCCAGCTTTCTCATACCCTCTGTGG TGAACATCAGATGGAGCTACTTGATTATGTAGCAGCAAAGTTCCATGAAGAAGCTGGCATCTTCAAGCTATTGATTATCGATTCAATAAT GGCACTTTTTCGAGTGGATTTCAGTGGCCGTGGGGAGTTGGCCGAACGGCAGCAAAAATTGGCCCAGATGTTGTCACGACTCCAAAAAAT CTCAGAAGAATATAACGTGGCTGTTTTTGTGACCAATCAAATGACTGCCGATCCAGGAGCAACTATGACCTTTCAGGCAGATCCCAAAAA ACCCATTGGGGGACACATTCTGGCTCATGCTTCAACAACAAGAATAAGCTTGCGAAAGGGAAGAGGAGAGCTCAGAATTGCCAAGATTTA TGACAGTCCTGAGATGCCTGAAAATGAAGCCACCTTCGCAATAACTGCTGGAGGAATTGGGGATGCCAAGGAGTAGGTGGTGAATTGATG |
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FusionGenePPI for CSNK1E_DMC1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CSNK1E | DVL2, RAD54B, MCC, PER3, PER1, ARNTL, AXIN1, DVL1, ANKRD6, NCOA3, CADM4, HES1, GTF3C1, RBX1, KAT7, TAOK1, BBS10, ZNF227, PNO1, C2orf44, FAM110A, FBP1, ARHGEF1, FAM83D, ZMYND8, ELAVL1, MYC, MYCN, TAZ, CTNND1, DBNDD2, APP, BYSL, PPP1R14A, PPP1CA, SDCCAG3, TENC1, FAM110C, SAV1, REST, CSNK1A1, ZSWIM8, USP9Y, PRMT5, SEC16A, AHCYL1, HMMR, MTA2, FARP2, CSNK1D, SEC13, WDR5, ACACA, PRDX4, STK3, CUL2, TCEB2, CRY1, PPP6R3, FAM83B, FAM199X, FAM83H, VPS13B, FAM110B, USP9X, AHCYL2, SNX22, KLHDC3, UNC45A, ADAM22, STOX2, RASAL2, SNX24, TIAM1, DVL3, OCLN, CSNK1E, DEC1, BHLHE41, PER2, PPP1CC, PPP2R5E, RORC, CSNK2B, FBXW11, NR1D2, CLOCK, PPP2R5D, RORA, UBE2S, DRICH1, CACNG2, TRA2A, TEX264, MRPL4, CACNG4, RP2, SGOL2, MAPK9, MICU2, LTBR, PCMT1, SMARCD1, LDLRAD4, NTRK1, ALYREF, DHX16, DTD1, NLRP1, NSUN2, USP39, NOB1, PPM1B, CEP290, CEP162, PCM1, CEP128, XPO1, CRY2, CLTC, JAK3, KIF2A, BAIAP2, GTSE1, CAMKK1, PRKAR2A, OFD1, KIAA0753, TRIM3, CEP131, GAPVD1, CEP72, MIER1, FOPNL, SPICE1, WDR90, CCDC61, APC, BID, TP53, UBXN7, TRAF3, MAVS, ATOH1, LPIN1, ZNF618, PDE4DIP, ANKRD49, SSMEM1, NXF2, RPS4Y2, FKBPL, UQCC1, POTEF, ARHGAP22, HSPA8, KLHL42, CACNG5, RNF43, TNFRSF1A, BTBD1, C7orf60, PRKAR2B, MTMR4, FOXP2, WWC1 | DMC1 | RAD51, DNAJA3, BRCA2, TRIM23, PSMA3, SDCBP, DMC1, GORASP2, NIF3L1, KCTD17, POTEF, ACTA1, RFWD2, SVIP, SIRT3, ZNF302 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CSNK1E_DMC1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CSNK1E_DMC1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CSNK1E | C0005586 | Bipolar Disorder | 5 | PSYGENET |
| Hgene | CSNK1E | C0036341 | Schizophrenia | 2 | PSYGENET |
| Hgene | CSNK1E | C0033975 | Psychotic Disorders | 1 | PSYGENET |
| Hgene | CSNK1E | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
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