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Fusion gene ID: 8625 |
FusionGeneSummary for CSNK1A1_PDE6A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CSNK1A1_PDE6A | Fusion gene ID: 8625 | Hgene | Tgene | Gene symbol | CSNK1A1 | PDE6A | Gene ID | 1452 | 5145 |
| Gene name | casein kinase 1 alpha 1 | phosphodiesterase 6A | |
| Synonyms | CK1|CK1a|CKIa|HEL-S-77p|HLCDGP1|PRO2975 | CGPR-A|PDEA|RP43 | |
| Cytomap | 5q32 | 5q32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | casein kinase I isoform alphaCKI-alphaclock regulator kinasedown-regulated in lung cancerepididymis secretory sperm binding protein Li 77p | rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alphaGMP-PDE alphaPDE V-B1cGMP phosphodiesterase alpha subunitphosphodiesterase 6A, cGMP-specific, rod, alpharod photoreceptor cGMP phosphodiesterase alpha subunit | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P48729 | P16499 | |
| Ensembl transtripts involved in fusion gene | ENST00000261798, ENST00000377843, ENST00000515435, ENST00000504676, ENST00000515768, ENST00000606719, ENST00000606299, ENST00000515748, | ENST00000255266, | |
| Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 2 X 4 X 4=32 |
| # samples | 9 | 4 | |
| ** MAII score | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CSNK1A1 [Title/Abstract] AND PDE6A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CSNK1A1 | GO:0006468 | protein phosphorylation | 18305108 |
| Hgene | CSNK1A1 | GO:0018105 | peptidyl-serine phosphorylation | 25500533 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-L5-A43M-01A | CSNK1A1 | chr5 | 148885010 | - | PDE6A | chr5 | 149264430 | - |
| TCGA | LD | OV | TCGA-13-1506-01A | CSNK1A1 | chr5 | 148899853 | - | PDE6A | chr5 | 149242829 | - |
| TCGA | LD | UCEC | TCGA-EO-A1Y7-01A | CSNK1A1 | chr5 | 148929638 | - | PDE6A | chr5 | 149279087 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000261798 | ENST00000255266 | CSNK1A1 | chr5 | 148885010 | - | PDE6A | chr5 | 149264430 | - |
| Frame-shift | ENST00000377843 | ENST00000255266 | CSNK1A1 | chr5 | 148885010 | - | PDE6A | chr5 | 149264430 | - |
| intron-3CDS | ENST00000515435 | ENST00000255266 | CSNK1A1 | chr5 | 148885010 | - | PDE6A | chr5 | 149264430 | - |
| intron-3CDS | ENST00000504676 | ENST00000255266 | CSNK1A1 | chr5 | 148885010 | - | PDE6A | chr5 | 149264430 | - |
| Frame-shift | ENST00000515768 | ENST00000255266 | CSNK1A1 | chr5 | 148885010 | - | PDE6A | chr5 | 149264430 | - |
| Frame-shift | ENST00000606719 | ENST00000255266 | CSNK1A1 | chr5 | 148885010 | - | PDE6A | chr5 | 149264430 | - |
| intron-3CDS | ENST00000606299 | ENST00000255266 | CSNK1A1 | chr5 | 148885010 | - | PDE6A | chr5 | 149264430 | - |
| intron-3CDS | ENST00000515748 | ENST00000255266 | CSNK1A1 | chr5 | 148885010 | - | PDE6A | chr5 | 149264430 | - |
| In-frame | ENST00000261798 | ENST00000255266 | CSNK1A1 | chr5 | 148899853 | - | PDE6A | chr5 | 149242829 | - |
| In-frame | ENST00000377843 | ENST00000255266 | CSNK1A1 | chr5 | 148899853 | - | PDE6A | chr5 | 149242829 | - |
| In-frame | ENST00000515435 | ENST00000255266 | CSNK1A1 | chr5 | 148899853 | - | PDE6A | chr5 | 149242829 | - |
| In-frame | ENST00000504676 | ENST00000255266 | CSNK1A1 | chr5 | 148899853 | - | PDE6A | chr5 | 149242829 | - |
| In-frame | ENST00000515768 | ENST00000255266 | CSNK1A1 | chr5 | 148899853 | - | PDE6A | chr5 | 149242829 | - |
| intron-3CDS | ENST00000606719 | ENST00000255266 | CSNK1A1 | chr5 | 148899853 | - | PDE6A | chr5 | 149242829 | - |
| intron-3CDS | ENST00000606299 | ENST00000255266 | CSNK1A1 | chr5 | 148899853 | - | PDE6A | chr5 | 149242829 | - |
| intron-3CDS | ENST00000515748 | ENST00000255266 | CSNK1A1 | chr5 | 148899853 | - | PDE6A | chr5 | 149242829 | - |
| Frame-shift | ENST00000261798 | ENST00000255266 | CSNK1A1 | chr5 | 148929638 | - | PDE6A | chr5 | 149279087 | - |
| Frame-shift | ENST00000377843 | ENST00000255266 | CSNK1A1 | chr5 | 148929638 | - | PDE6A | chr5 | 149279087 | - |
| 5UTR-3CDS | ENST00000515435 | ENST00000255266 | CSNK1A1 | chr5 | 148929638 | - | PDE6A | chr5 | 149279087 | - |
| 5UTR-3CDS | ENST00000504676 | ENST00000255266 | CSNK1A1 | chr5 | 148929638 | - | PDE6A | chr5 | 149279087 | - |
| Frame-shift | ENST00000515768 | ENST00000255266 | CSNK1A1 | chr5 | 148929638 | - | PDE6A | chr5 | 149279087 | - |
| intron-3CDS | ENST00000606719 | ENST00000255266 | CSNK1A1 | chr5 | 148929638 | - | PDE6A | chr5 | 149279087 | - |
| intron-3CDS | ENST00000606299 | ENST00000255266 | CSNK1A1 | chr5 | 148929638 | - | PDE6A | chr5 | 149279087 | - |
| Frame-shift | ENST00000515748 | ENST00000255266 | CSNK1A1 | chr5 | 148929638 | - | PDE6A | chr5 | 149279087 | - |
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FusionProtFeatures for CSNK1A1_PDE6A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CSNK1A1 | PDE6A |
| This protein participates in processes of transmissionand amplification of the visual signal. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CSNK1A1 | chr5:148899853 | chr5:149242829 | ENST00000377843 | - | 4 | 10 | 23_31 | 152 | 338 | Nucleotide binding | ATP |
| Hgene | CSNK1A1 | chr5:148899853 | chr5:149242829 | ENST00000515768 | - | 4 | 11 | 23_31 | 152 | 366 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CSNK1A1 | chr5:148899853 | chr5:149242829 | ENST00000377843 | - | 4 | 10 | 17_285 | 152 | 338 | Domain | Protein kinase |
| Hgene | >CSNK1A1 | chr5:148899853 | chr5:149242829 | ENST00000515768 | - | 4 | 11 | 17_285 | 152 | 366 | Domain | Protein kinase |
| Tgene | PDE6A | chr5:148899853 | chr5:149242829 | ENST00000255266 | - | 19 | 22 | 254_431 | 786 | 861 | Domain | Note=GAF 2 |
| Tgene | PDE6A | chr5:148899853 | chr5:149242829 | ENST00000255266 | - | 19 | 22 | 483_816 | 786 | 861 | Domain | PDEase |
| Tgene | PDE6A | chr5:148899853 | chr5:149242829 | ENST00000255266 | - | 19 | 22 | 73_222 | 786 | 861 | Domain | Note=GAF 1 |
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FusionGeneSequence for CSNK1A1_PDE6A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CSNK1A1_ENST00000261798_chr5_148899853_-_PDE6A_ENST00000255266_chr5_149242829_-_227aa MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVM DLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKEFSRFHEEITPMLDGITNNRKEWKALAD >In-frame_CSNK1A1_ENST00000377843_chr5_148899853_-_PDE6A_ENST00000255266_chr5_149242829_-_227aa MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVM DLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKEFSRFHEEITPMLDGITNNRKEWKALAD >In-frame_CSNK1A1_ENST00000515435_chr5_148899853_-_PDE6A_ENST00000255266_chr5_149242829_-_138aa MDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKEFSRFHEEITPMLDGITNNRKEWKALA >In-frame_CSNK1A1_ENST00000504676_chr5_148899853_-_PDE6A_ENST00000255266_chr5_149242829_-_138aa MDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKEFSRFHEEITPMLDGITNNRKEWKALA >In-frame_CSNK1A1_ENST00000515768_chr5_148899853_-_PDE6A_ENST00000255266_chr5_149242829_-_227aa MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVM DLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKEFSRFHEEITPMLDGITNNRKEWKALAD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CSNK1A1_ENST00000261798_chr5_148899853_-_PDE6A_ENST00000255266_chr5_149242829_-_681nt ATGGCGAGTAGCAGCGGCTCCAAGGCTGAATTCATTGTCGGAGGGAAATATAAACTGGTACGGAAGATCGGGTCTGGCTCCTTCGGGGAC ATCTATTTGGCGATCAACATCACCAACGGCGAGGAAGTGGCAGTGAAGCTAGAATCTCAGAAGGCCAGGCATCCCCAGTTGCTGTACGAG AGCAAGCTCTATAAGATTCTTCAAGGTGGGGTTGGCATCCCCCACATACGGTGGTATGGTCAGGAAAAAGACTACAATGTACTAGTCATG GATCTTCTGGGACCTAGCCTCGAAGACCTCTTCAATTTCTGTTCAAGAAGGTTCACAATGAAAACTGTACTTATGTTAGCTGACCAGATG ATCAGTAGAATTGAATATGTGCATACAAAGAATTTTATACACAGAGACATTAAACCAGATAACTTCCTAATGGGTATTGGGCGTCACTGT AATAAGGAATTCTCCCGTTTCCACGAGGAGATCACCCCAATGTTGGACGGGATCACCAACAATCGCAAGGAGTGGAAGGCGCTTGCTGAT GAGTACGATGCCAAGATGAAGGTGCAGGAGGAGAAGAAGCAGAAACAGCAGTCGGCCAAGTCAGCAGCCGCAGGAAATCAGCCGGGGGGA >In-frame_CSNK1A1_ENST00000377843_chr5_148899853_-_PDE6A_ENST00000255266_chr5_149242829_-_681nt ATGGCGAGTAGCAGCGGCTCCAAGGCTGAATTCATTGTCGGAGGGAAATATAAACTGGTACGGAAGATCGGGTCTGGCTCCTTCGGGGAC ATCTATTTGGCGATCAACATCACCAACGGCGAGGAAGTGGCAGTGAAGCTAGAATCTCAGAAGGCCAGGCATCCCCAGTTGCTGTACGAG AGCAAGCTCTATAAGATTCTTCAAGGTGGGGTTGGCATCCCCCACATACGGTGGTATGGTCAGGAAAAAGACTACAATGTACTAGTCATG GATCTTCTGGGACCTAGCCTCGAAGACCTCTTCAATTTCTGTTCAAGAAGGTTCACAATGAAAACTGTACTTATGTTAGCTGACCAGATG ATCAGTAGAATTGAATATGTGCATACAAAGAATTTTATACACAGAGACATTAAACCAGATAACTTCCTAATGGGTATTGGGCGTCACTGT AATAAGGAATTCTCCCGTTTCCACGAGGAGATCACCCCAATGTTGGACGGGATCACCAACAATCGCAAGGAGTGGAAGGCGCTTGCTGAT GAGTACGATGCCAAGATGAAGGTGCAGGAGGAGAAGAAGCAGAAACAGCAGTCGGCCAAGTCAGCAGCCGCAGGAAATCAGCCGGGGGGA >In-frame_CSNK1A1_ENST00000515435_chr5_148899853_-_PDE6A_ENST00000255266_chr5_149242829_-_414nt ATGGATCTTCTGGGACCTAGCCTCGAAGACCTCTTCAATTTCTGTTCAAGAAGGTTCACAATGAAAACTGTACTTATGTTAGCTGACCAG ATGATCAGTAGAATTGAATATGTGCATACAAAGAATTTTATACACAGAGACATTAAACCAGATAACTTCCTAATGGGTATTGGGCGTCAC TGTAATAAGGAATTCTCCCGTTTCCACGAGGAGATCACCCCAATGTTGGACGGGATCACCAACAATCGCAAGGAGTGGAAGGCGCTTGCT GATGAGTACGATGCCAAGATGAAGGTGCAGGAGGAGAAGAAGCAGAAACAGCAGTCGGCCAAGTCAGCAGCCGCAGGAAATCAGCCGGGG >In-frame_CSNK1A1_ENST00000504676_chr5_148899853_-_PDE6A_ENST00000255266_chr5_149242829_-_414nt ATGGATCTTCTGGGACCTAGCCTCGAAGACCTCTTCAATTTCTGTTCAAGAAGGTTCACAATGAAAACTGTACTTATGTTAGCTGACCAG ATGATCAGTAGAATTGAATATGTGCATACAAAGAATTTTATACACAGAGACATTAAACCAGATAACTTCCTAATGGGTATTGGGCGTCAC TGTAATAAGGAATTCTCCCGTTTCCACGAGGAGATCACCCCAATGTTGGACGGGATCACCAACAATCGCAAGGAGTGGAAGGCGCTTGCT GATGAGTACGATGCCAAGATGAAGGTGCAGGAGGAGAAGAAGCAGAAACAGCAGTCGGCCAAGTCAGCAGCCGCAGGAAATCAGCCGGGG >In-frame_CSNK1A1_ENST00000515768_chr5_148899853_-_PDE6A_ENST00000255266_chr5_149242829_-_681nt ATGGCGAGTAGCAGCGGCTCCAAGGCTGAATTCATTGTCGGAGGGAAATATAAACTGGTACGGAAGATCGGGTCTGGCTCCTTCGGGGAC ATCTATTTGGCGATCAACATCACCAACGGCGAGGAAGTGGCAGTGAAGCTAGAATCTCAGAAGGCCAGGCATCCCCAGTTGCTGTACGAG AGCAAGCTCTATAAGATTCTTCAAGGTGGGGTTGGCATCCCCCACATACGGTGGTATGGTCAGGAAAAAGACTACAATGTACTAGTCATG GATCTTCTGGGACCTAGCCTCGAAGACCTCTTCAATTTCTGTTCAAGAAGGTTCACAATGAAAACTGTACTTATGTTAGCTGACCAGATG ATCAGTAGAATTGAATATGTGCATACAAAGAATTTTATACACAGAGACATTAAACCAGATAACTTCCTAATGGGTATTGGGCGTCACTGT AATAAGGAATTCTCCCGTTTCCACGAGGAGATCACCCCAATGTTGGACGGGATCACCAACAATCGCAAGGAGTGGAAGGCGCTTGCTGAT GAGTACGATGCCAAGATGAAGGTGCAGGAGGAGAAGAAGCAGAAACAGCAGTCGGCCAAGTCAGCAGCCGCAGGAAATCAGCCGGGGGGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CSNK1A1_ENST00000261798_chr5_148899853_-_PDE6A_ENST00000255266_chr5_149242829_-_4053nt GGGGGCATTTTGTGTTGGCTGGAGCTGGAGTAACAAGATGGCGTCGTCCGCGGAGTGACAGGGGTCCCTCTGGGCCGGAGCCGGCGGCAG TGGTGGCAGCGGTATCGCCGCCCTAGCTCACCGCGCCCCTTTTCCAGCCCGCGACGTCGCCGCGCAAGCGAGGCAGCGGCGGCCGCCGAG AAACAAGTGGCCCAGCCTGGTAACCGCCGAGAAGCCCTTCACAAACTGCGGCCTGGCAAAAAGAAACCTGACTGAGCGGCGGTGATCAGG TTCCCCTCTGCTGATTCTGGGCCCCGAACCCCGGTAAAGGCCTCCGTGTTCCGTTTCCTGCCGCCCTCCTCCGTAGCCTTGCCTAGTGTA GGAGCCCCGAGGCCTCCGTCCTCTTCCCAGAGGTGTCGGGGCTTGGCCCCAGCCTCCATCTTCGTCTCTCAGGATGGCGAGTAGCAGCGG CTCCAAGGCTGAATTCATTGTCGGAGGGAAATATAAACTGGTACGGAAGATCGGGTCTGGCTCCTTCGGGGACATCTATTTGGCGATCAA CATCACCAACGGCGAGGAAGTGGCAGTGAAGCTAGAATCTCAGAAGGCCAGGCATCCCCAGTTGCTGTACGAGAGCAAGCTCTATAAGAT TCTTCAAGGTGGGGTTGGCATCCCCCACATACGGTGGTATGGTCAGGAAAAAGACTACAATGTACTAGTCATGGATCTTCTGGGACCTAG CCTCGAAGACCTCTTCAATTTCTGTTCAAGAAGGTTCACAATGAAAACTGTACTTATGTTAGCTGACCAGATGATCAGTAGAATTGAATA TGTGCATACAAAGAATTTTATACACAGAGACATTAAACCAGATAACTTCCTAATGGGTATTGGGCGTCACTGTAATAAGGAATTCTCCCG TTTCCACGAGGAGATCACCCCAATGTTGGACGGGATCACCAACAATCGCAAGGAGTGGAAGGCGCTTGCTGATGAGTACGATGCCAAGAT GAAGGTGCAGGAGGAGAAGAAGCAGAAACAGCAGTCGGCCAAGTCAGCAGCCGCAGGAAATCAGCCGGGGGGAAACCCCAGCCCAGGGGG TGCAACTACATCCAAGTCCTGCTGCATCCAGTAACACCACTGGGGATGTGCTGGCTGGACGGCACCACCCTTTCCTGGGAAGAGATGACT CAAGCCAGTGGAAGACCACACACCTTGAGAAGTAGAAGAGTCATAGGATTTGAAAGCTGTTAGAGAATTTAGCTTCCAGGACTGTTCAAT CTTTTGGCTTCCCTGGGCCACATTGGAAGAATTGTCTTGGGTCACACATAAAATACAGTAACACTAATGATAGCTGTTGAACTTAAAAAA AAAAATCGCCAAAAAAAAAAATTTCATAATGTTTTAAGAAAGTTTATGAATTTGTGTTGGGCCGCATTCAAAGCCGTCCTGGGCTGCATG TGGCCCACGGGCCGTGGGTTGAACAAGCTTGGCTTATACCTTATCCAGTGGCTTTTAAACATTCTTTTAGTCTTGAGAACTGCCTATTGA GCTAAAACCAATATTCTAGCTTTCATAGACATCAGTTAAACATTTAATTACATTTAATTAATGCCAGATTCACTGGCTTGCTTAGAATCA TTTTTGTTCTTATACTTTCAGTTAATGTATTGTAAAAATTTTCAATCATTTTCAAAAGTAGAGAATTGTACGTTGAATCCCCACATACCC ATCACCCAGATTCCAATATCAAGATTTTGCTACATGCATTTCGTCTGTCCTTTTTACATTTTCTTTTCAATTTTTTTTCTTACCTGAAGT GTTTAAAGGCAAATCCTGGCCAGGCGTGGTGGCTCACACCTGTAATCCCAGCACTTCAGGAGGCTGAGGTGGGCAGACTGCATGAGCCCA GGAGTCTGAGACCAACCTGAGCAAAATGGCAAAACCCTGTCTCTACAAAAAATACAAAAATTAGCACTCACCTGTAGTCTCAGCTACCTG GGAGGCAGAGGTGAGAGGATCTCTTGAACCCAGGAGGCGGAAGTTGCAGTGAGCTGAGATCATGCTACTGCACTCCAGCTTGGGCGACCG AGCGAGACTCTGACTCAAACAAAAGCAAAAGAAAAGGCAAATCCCAAACATATCATTTCACACCTCTACTATCTCATCTTTAAAGAAATA AGTATGTTTTCTAACATAACCACATCACTGGCCCATGCAACCAATGCCTGCCTAATACCCAGCTGTGATCTATGCTTTGATGGGCTGCAC AGACCCCAAGCTTCAGCAAAGGACTTGGGACCCCACCAGCTTTGAGTGCTGTTGACAGACCCTTAGTATCAACCCCATCAGGTGTTACTG CAGCCTTCCCCAGGGTGGCCTACACCCAATGACTGATCCATGCCAGGTGGAGAGGCCTGGCCATCTTGGCTGAGCATGGGATAACTGTGC AGGGCTGTTCCAGCTCCACGACTCCTCGTGGGGTCCACTAAGGCTGTCGCTGGGCTCACATCCCAACTCGACTTCTCCCTCTGCCCACTC CTATTTCCTTCCCTTCCCCAAGCATCGGTCCCCAGGGCACTGCTTAATAAGCATCCTGCAGACTAAGTCCATTTTAGAGTCTGCTTTCTG GGACACCCAACTTGTGATGCCAGCCCTTAATCAACCTTCCTTCATTCTCATGAACGTTTTCAATGGTTGGCTTGCCTGAATCTGATCCAA ACAAATTCACATATTGAATTTAGTTGTTTCTTTTTGTTGGTTTTTAGAAAAAAGAAGATGTACTTTTTATTCTTGGATTTTTCATTGATT TCACAGAGTATAAATTAAGTCAGATTATTCTCAATTCCAGAACTTCTGTTTCTTAAATTAGCAGGCATTCTGTTGGTTTAAAAAGATAGA TGTTGGCCGGGCGCGGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGAGTTCAAGACC AGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGTGTGCACCTGTAATCCCAGCTACTCA GGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCGAAGGTTGCAGTGAGCTGAGATCATGCCACTGCACTCCAGCCTGGGCAACAA GAGCAAGACTCCGTCTCAAAAAAAAAAAAAAGAAAAAAAAAAGATGTGGCAGATAGAATTTCTCTCTTTCTCTATCTTTCATGACGAGGT CTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGTATGACCATAGCTCACTGGAGCCCCAGCTGCCCGGGCTCAAGCAATCCTCCATCTCAG CTTACCAAGCAGCGGTGACCACAGGCATGCACCACCATGCCCAGCTAATTTTTTAAAACCTATCTTTGTAGACATGGGGTCTCATTCTGT TGCCCAGGCTGGCCTCAAACTCCTGACTTCAAGCAATCCTCCTGCCTCAGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACTGCAC CTGGCCAGGACTTATTTCTTTTAAACCGAATCTAAGTATGTTCTGGCAAGTATGCAATACCTAGCGGAATGCACTGGCCTGATCAGCATT CATACCATAGTAACTGATGTTGAAAACAGCACAAATAAACCAGAAGTTGAAAATGGCAATAACATGCTAAAAATTTGCAAGTCAATTTGT TACACTTGTCCAAATCTTGATTTTTTTTCCTTCTCTATCGTTCCCCCCCCACCACCAGCTTTATGGAGGTATAATTAGCAAATAAAAAGT ATACATATTTAAGGTATACACTGTGATGTTTTGATATACATTGTGAAATGGTTACCATAATTAAGCTAATTAATATATCCATCACCTCAC ATAGCCATGGTTAAGTTTCTGAAGTCTCTTTTAATCTACAAAGTACTCCTTCCTTTTTTCCATTGTCATCACCTTGCAGAAACAGAGTCA GTTTTCCCACATTCTGTATTTATCTGTTTGTTTCTTTGTGGCCGCATGTAACACATTCCTCTGTCTCATTCTAATAAATGGACATTAGCT >In-frame_CSNK1A1_ENST00000377843_chr5_148899853_-_PDE6A_ENST00000255266_chr5_149242829_-_4100nt CCTTTCCCAGAGTGCTCTGCGCCGTGAAGAAGCGGCTCCCGGGGACTGGGGGCATTTTGTGTTGGCTGGAGCTGGAGTAACAAGATGGCG TCGTCCGCGGAGTGACAGGGGTCCCTCTGGGCCGGAGCCGGCGGCAGTGGTGGCAGCGGTATCGCCGCCCTAGCTCACCGCGCCCCTTTT CCAGCCCGCGACGTCGCCGCGCAAGCGAGGCAGCGGCGGCCGCCGAGAAACAAGTGGCCCAGCCTGGTAACCGCCGAGAAGCCCTTCACA AACTGCGGCCTGGCAAAAAGAAACCTGACTGAGCGGCGGTGATCAGGTTCCCCTCTGCTGATTCTGGGCCCCGAACCCCGGTAAAGGCCT CCGTGTTCCGTTTCCTGCCGCCCTCCTCCGTAGCCTTGCCTAGTGTAGGAGCCCCGAGGCCTCCGTCCTCTTCCCAGAGGTGTCGGGGCT TGGCCCCAGCCTCCATCTTCGTCTCTCAGGATGGCGAGTAGCAGCGGCTCCAAGGCTGAATTCATTGTCGGAGGGAAATATAAACTGGTA CGGAAGATCGGGTCTGGCTCCTTCGGGGACATCTATTTGGCGATCAACATCACCAACGGCGAGGAAGTGGCAGTGAAGCTAGAATCTCAG AAGGCCAGGCATCCCCAGTTGCTGTACGAGAGCAAGCTCTATAAGATTCTTCAAGGTGGGGTTGGCATCCCCCACATACGGTGGTATGGT CAGGAAAAAGACTACAATGTACTAGTCATGGATCTTCTGGGACCTAGCCTCGAAGACCTCTTCAATTTCTGTTCAAGAAGGTTCACAATG AAAACTGTACTTATGTTAGCTGACCAGATGATCAGTAGAATTGAATATGTGCATACAAAGAATTTTATACACAGAGACATTAAACCAGAT AACTTCCTAATGGGTATTGGGCGTCACTGTAATAAGGAATTCTCCCGTTTCCACGAGGAGATCACCCCAATGTTGGACGGGATCACCAAC AATCGCAAGGAGTGGAAGGCGCTTGCTGATGAGTACGATGCCAAGATGAAGGTGCAGGAGGAGAAGAAGCAGAAACAGCAGTCGGCCAAG TCAGCAGCCGCAGGAAATCAGCCGGGGGGAAACCCCAGCCCAGGGGGTGCAACTACATCCAAGTCCTGCTGCATCCAGTAACACCACTGG GGATGTGCTGGCTGGACGGCACCACCCTTTCCTGGGAAGAGATGACTCAAGCCAGTGGAAGACCACACACCTTGAGAAGTAGAAGAGTCA TAGGATTTGAAAGCTGTTAGAGAATTTAGCTTCCAGGACTGTTCAATCTTTTGGCTTCCCTGGGCCACATTGGAAGAATTGTCTTGGGTC ACACATAAAATACAGTAACACTAATGATAGCTGTTGAACTTAAAAAAAAAAATCGCCAAAAAAAAAAATTTCATAATGTTTTAAGAAAGT TTATGAATTTGTGTTGGGCCGCATTCAAAGCCGTCCTGGGCTGCATGTGGCCCACGGGCCGTGGGTTGAACAAGCTTGGCTTATACCTTA TCCAGTGGCTTTTAAACATTCTTTTAGTCTTGAGAACTGCCTATTGAGCTAAAACCAATATTCTAGCTTTCATAGACATCAGTTAAACAT TTAATTACATTTAATTAATGCCAGATTCACTGGCTTGCTTAGAATCATTTTTGTTCTTATACTTTCAGTTAATGTATTGTAAAAATTTTC AATCATTTTCAAAAGTAGAGAATTGTACGTTGAATCCCCACATACCCATCACCCAGATTCCAATATCAAGATTTTGCTACATGCATTTCG TCTGTCCTTTTTACATTTTCTTTTCAATTTTTTTTCTTACCTGAAGTGTTTAAAGGCAAATCCTGGCCAGGCGTGGTGGCTCACACCTGT AATCCCAGCACTTCAGGAGGCTGAGGTGGGCAGACTGCATGAGCCCAGGAGTCTGAGACCAACCTGAGCAAAATGGCAAAACCCTGTCTC TACAAAAAATACAAAAATTAGCACTCACCTGTAGTCTCAGCTACCTGGGAGGCAGAGGTGAGAGGATCTCTTGAACCCAGGAGGCGGAAG TTGCAGTGAGCTGAGATCATGCTACTGCACTCCAGCTTGGGCGACCGAGCGAGACTCTGACTCAAACAAAAGCAAAAGAAAAGGCAAATC CCAAACATATCATTTCACACCTCTACTATCTCATCTTTAAAGAAATAAGTATGTTTTCTAACATAACCACATCACTGGCCCATGCAACCA ATGCCTGCCTAATACCCAGCTGTGATCTATGCTTTGATGGGCTGCACAGACCCCAAGCTTCAGCAAAGGACTTGGGACCCCACCAGCTTT GAGTGCTGTTGACAGACCCTTAGTATCAACCCCATCAGGTGTTACTGCAGCCTTCCCCAGGGTGGCCTACACCCAATGACTGATCCATGC CAGGTGGAGAGGCCTGGCCATCTTGGCTGAGCATGGGATAACTGTGCAGGGCTGTTCCAGCTCCACGACTCCTCGTGGGGTCCACTAAGG CTGTCGCTGGGCTCACATCCCAACTCGACTTCTCCCTCTGCCCACTCCTATTTCCTTCCCTTCCCCAAGCATCGGTCCCCAGGGCACTGC TTAATAAGCATCCTGCAGACTAAGTCCATTTTAGAGTCTGCTTTCTGGGACACCCAACTTGTGATGCCAGCCCTTAATCAACCTTCCTTC ATTCTCATGAACGTTTTCAATGGTTGGCTTGCCTGAATCTGATCCAAACAAATTCACATATTGAATTTAGTTGTTTCTTTTTGTTGGTTT TTAGAAAAAAGAAGATGTACTTTTTATTCTTGGATTTTTCATTGATTTCACAGAGTATAAATTAAGTCAGATTATTCTCAATTCCAGAAC TTCTGTTTCTTAAATTAGCAGGCATTCTGTTGGTTTAAAAAGATAGATGTTGGCCGGGCGCGGTGGCTCACGCCTGTAATTCCAGCACTT TGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACA AAAATTAGCTGGGTGTGGTGGTGTGCACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCGAAGG TTGCAGTGAGCTGAGATCATGCCACTGCACTCCAGCCTGGGCAACAAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAGAAAAAAAAAAG ATGTGGCAGATAGAATTTCTCTCTTTCTCTATCTTTCATGACGAGGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGTATGACCATAG CTCACTGGAGCCCCAGCTGCCCGGGCTCAAGCAATCCTCCATCTCAGCTTACCAAGCAGCGGTGACCACAGGCATGCACCACCATGCCCA GCTAATTTTTTAAAACCTATCTTTGTAGACATGGGGTCTCATTCTGTTGCCCAGGCTGGCCTCAAACTCCTGACTTCAAGCAATCCTCCT GCCTCAGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGCCACTGCACCTGGCCAGGACTTATTTCTTTTAAACCGAATCTAAGTATGTTC TGGCAAGTATGCAATACCTAGCGGAATGCACTGGCCTGATCAGCATTCATACCATAGTAACTGATGTTGAAAACAGCACAAATAAACCAG AAGTTGAAAATGGCAATAACATGCTAAAAATTTGCAAGTCAATTTGTTACACTTGTCCAAATCTTGATTTTTTTTCCTTCTCTATCGTTC CCCCCCCACCACCAGCTTTATGGAGGTATAATTAGCAAATAAAAAGTATACATATTTAAGGTATACACTGTGATGTTTTGATATACATTG TGAAATGGTTACCATAATTAAGCTAATTAATATATCCATCACCTCACATAGCCATGGTTAAGTTTCTGAAGTCTCTTTTAATCTACAAAG TACTCCTTCCTTTTTTCCATTGTCATCACCTTGCAGAAACAGAGTCAGTTTTCCCACATTCTGTATTTATCTGTTTGTTTCTTTGTGGCC >In-frame_CSNK1A1_ENST00000515435_chr5_148899853_-_PDE6A_ENST00000255266_chr5_149242829_-_3615nt CAGCTTTTCACTTCTTCTTGTAGTCGCGACTTGGAGTTTTGCTAATGTCTCCCTCCTTTCCTAAGTGACATTGAATCCGTAGGGATGTTG ATGCCATCATCCCCTCTTTCCCCTGCAGGAAGTGGCAGTGAAGCTAGAATCTCAGAAGGCCAGGCATCCCCAGTTGCTGTACGAGAGCAA GCTCTATAAGATTCTTCAAGGTGGGGTTGGCATCCCCCACATACGGTGGTATGGTCAGGAAAAAGACTACAATGTACTAGTCATGGATCT TCTGGGACCTAGCCTCGAAGACCTCTTCAATTTCTGTTCAAGAAGGTTCACAATGAAAACTGTACTTATGTTAGCTGACCAGATGATCAG TAGAATTGAATATGTGCATACAAAGAATTTTATACACAGAGACATTAAACCAGATAACTTCCTAATGGGTATTGGGCGTCACTGTAATAA GGAATTCTCCCGTTTCCACGAGGAGATCACCCCAATGTTGGACGGGATCACCAACAATCGCAAGGAGTGGAAGGCGCTTGCTGATGAGTA CGATGCCAAGATGAAGGTGCAGGAGGAGAAGAAGCAGAAACAGCAGTCGGCCAAGTCAGCAGCCGCAGGAAATCAGCCGGGGGGAAACCC CAGCCCAGGGGGTGCAACTACATCCAAGTCCTGCTGCATCCAGTAACACCACTGGGGATGTGCTGGCTGGACGGCACCACCCTTTCCTGG GAAGAGATGACTCAAGCCAGTGGAAGACCACACACCTTGAGAAGTAGAAGAGTCATAGGATTTGAAAGCTGTTAGAGAATTTAGCTTCCA GGACTGTTCAATCTTTTGGCTTCCCTGGGCCACATTGGAAGAATTGTCTTGGGTCACACATAAAATACAGTAACACTAATGATAGCTGTT GAACTTAAAAAAAAAAATCGCCAAAAAAAAAAATTTCATAATGTTTTAAGAAAGTTTATGAATTTGTGTTGGGCCGCATTCAAAGCCGTC CTGGGCTGCATGTGGCCCACGGGCCGTGGGTTGAACAAGCTTGGCTTATACCTTATCCAGTGGCTTTTAAACATTCTTTTAGTCTTGAGA ACTGCCTATTGAGCTAAAACCAATATTCTAGCTTTCATAGACATCAGTTAAACATTTAATTACATTTAATTAATGCCAGATTCACTGGCT TGCTTAGAATCATTTTTGTTCTTATACTTTCAGTTAATGTATTGTAAAAATTTTCAATCATTTTCAAAAGTAGAGAATTGTACGTTGAAT CCCCACATACCCATCACCCAGATTCCAATATCAAGATTTTGCTACATGCATTTCGTCTGTCCTTTTTACATTTTCTTTTCAATTTTTTTT CTTACCTGAAGTGTTTAAAGGCAAATCCTGGCCAGGCGTGGTGGCTCACACCTGTAATCCCAGCACTTCAGGAGGCTGAGGTGGGCAGAC TGCATGAGCCCAGGAGTCTGAGACCAACCTGAGCAAAATGGCAAAACCCTGTCTCTACAAAAAATACAAAAATTAGCACTCACCTGTAGT CTCAGCTACCTGGGAGGCAGAGGTGAGAGGATCTCTTGAACCCAGGAGGCGGAAGTTGCAGTGAGCTGAGATCATGCTACTGCACTCCAG CTTGGGCGACCGAGCGAGACTCTGACTCAAACAAAAGCAAAAGAAAAGGCAAATCCCAAACATATCATTTCACACCTCTACTATCTCATC TTTAAAGAAATAAGTATGTTTTCTAACATAACCACATCACTGGCCCATGCAACCAATGCCTGCCTAATACCCAGCTGTGATCTATGCTTT GATGGGCTGCACAGACCCCAAGCTTCAGCAAAGGACTTGGGACCCCACCAGCTTTGAGTGCTGTTGACAGACCCTTAGTATCAACCCCAT CAGGTGTTACTGCAGCCTTCCCCAGGGTGGCCTACACCCAATGACTGATCCATGCCAGGTGGAGAGGCCTGGCCATCTTGGCTGAGCATG GGATAACTGTGCAGGGCTGTTCCAGCTCCACGACTCCTCGTGGGGTCCACTAAGGCTGTCGCTGGGCTCACATCCCAACTCGACTTCTCC CTCTGCCCACTCCTATTTCCTTCCCTTCCCCAAGCATCGGTCCCCAGGGCACTGCTTAATAAGCATCCTGCAGACTAAGTCCATTTTAGA GTCTGCTTTCTGGGACACCCAACTTGTGATGCCAGCCCTTAATCAACCTTCCTTCATTCTCATGAACGTTTTCAATGGTTGGCTTGCCTG AATCTGATCCAAACAAATTCACATATTGAATTTAGTTGTTTCTTTTTGTTGGTTTTTAGAAAAAAGAAGATGTACTTTTTATTCTTGGAT TTTTCATTGATTTCACAGAGTATAAATTAAGTCAGATTATTCTCAATTCCAGAACTTCTGTTTCTTAAATTAGCAGGCATTCTGTTGGTT TAAAAAGATAGATGTTGGCCGGGCGCGGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAG GAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGTGTGCACCTGTAAT CCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCGAAGGTTGCAGTGAGCTGAGATCATGCCACTGCACTCCAG CCTGGGCAACAAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAGAAAAAAAAAAGATGTGGCAGATAGAATTTCTCTCTTTCTCTATCTT TCATGACGAGGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGTATGACCATAGCTCACTGGAGCCCCAGCTGCCCGGGCTCAAGCAAT CCTCCATCTCAGCTTACCAAGCAGCGGTGACCACAGGCATGCACCACCATGCCCAGCTAATTTTTTAAAACCTATCTTTGTAGACATGGG GTCTCATTCTGTTGCCCAGGCTGGCCTCAAACTCCTGACTTCAAGCAATCCTCCTGCCTCAGCCTCCCAAAGTGTTGGGATTACAGGCGT GAGCCACTGCACCTGGCCAGGACTTATTTCTTTTAAACCGAATCTAAGTATGTTCTGGCAAGTATGCAATACCTAGCGGAATGCACTGGC CTGATCAGCATTCATACCATAGTAACTGATGTTGAAAACAGCACAAATAAACCAGAAGTTGAAAATGGCAATAACATGCTAAAAATTTGC AAGTCAATTTGTTACACTTGTCCAAATCTTGATTTTTTTTCCTTCTCTATCGTTCCCCCCCCACCACCAGCTTTATGGAGGTATAATTAG CAAATAAAAAGTATACATATTTAAGGTATACACTGTGATGTTTTGATATACATTGTGAAATGGTTACCATAATTAAGCTAATTAATATAT CCATCACCTCACATAGCCATGGTTAAGTTTCTGAAGTCTCTTTTAATCTACAAAGTACTCCTTCCTTTTTTCCATTGTCATCACCTTGCA GAAACAGAGTCAGTTTTCCCACATTCTGTATTTATCTGTTTGTTTCTTTGTGGCCGCATGTAACACATTCCTCTGTCTCATTCTAATAAA >In-frame_CSNK1A1_ENST00000504676_chr5_148899853_-_PDE6A_ENST00000255266_chr5_149242829_-_3615nt CAGCTTTTCACTTCTTCTTGTAGTCGCGACTTGGAGTTTTGCTAATGTCTCCCTCCTTTCCTAAGTGACATTGAATCCGTAGGGATGTTG ATGCCATCATCCCCTCTTTCCCCTGCAGGAAGTGGCAGTGAAGCTAGAATCTCAGAAGGCCAGGCATCCCCAGTTGCTGTACGAGAGCAA GCTCTATAAGATTCTTCAAGGTGGGGTTGGCATCCCCCACATACGGTGGTATGGTCAGGAAAAAGACTACAATGTACTAGTCATGGATCT TCTGGGACCTAGCCTCGAAGACCTCTTCAATTTCTGTTCAAGAAGGTTCACAATGAAAACTGTACTTATGTTAGCTGACCAGATGATCAG TAGAATTGAATATGTGCATACAAAGAATTTTATACACAGAGACATTAAACCAGATAACTTCCTAATGGGTATTGGGCGTCACTGTAATAA GGAATTCTCCCGTTTCCACGAGGAGATCACCCCAATGTTGGACGGGATCACCAACAATCGCAAGGAGTGGAAGGCGCTTGCTGATGAGTA CGATGCCAAGATGAAGGTGCAGGAGGAGAAGAAGCAGAAACAGCAGTCGGCCAAGTCAGCAGCCGCAGGAAATCAGCCGGGGGGAAACCC CAGCCCAGGGGGTGCAACTACATCCAAGTCCTGCTGCATCCAGTAACACCACTGGGGATGTGCTGGCTGGACGGCACCACCCTTTCCTGG GAAGAGATGACTCAAGCCAGTGGAAGACCACACACCTTGAGAAGTAGAAGAGTCATAGGATTTGAAAGCTGTTAGAGAATTTAGCTTCCA GGACTGTTCAATCTTTTGGCTTCCCTGGGCCACATTGGAAGAATTGTCTTGGGTCACACATAAAATACAGTAACACTAATGATAGCTGTT GAACTTAAAAAAAAAAATCGCCAAAAAAAAAAATTTCATAATGTTTTAAGAAAGTTTATGAATTTGTGTTGGGCCGCATTCAAAGCCGTC CTGGGCTGCATGTGGCCCACGGGCCGTGGGTTGAACAAGCTTGGCTTATACCTTATCCAGTGGCTTTTAAACATTCTTTTAGTCTTGAGA ACTGCCTATTGAGCTAAAACCAATATTCTAGCTTTCATAGACATCAGTTAAACATTTAATTACATTTAATTAATGCCAGATTCACTGGCT TGCTTAGAATCATTTTTGTTCTTATACTTTCAGTTAATGTATTGTAAAAATTTTCAATCATTTTCAAAAGTAGAGAATTGTACGTTGAAT CCCCACATACCCATCACCCAGATTCCAATATCAAGATTTTGCTACATGCATTTCGTCTGTCCTTTTTACATTTTCTTTTCAATTTTTTTT CTTACCTGAAGTGTTTAAAGGCAAATCCTGGCCAGGCGTGGTGGCTCACACCTGTAATCCCAGCACTTCAGGAGGCTGAGGTGGGCAGAC TGCATGAGCCCAGGAGTCTGAGACCAACCTGAGCAAAATGGCAAAACCCTGTCTCTACAAAAAATACAAAAATTAGCACTCACCTGTAGT CTCAGCTACCTGGGAGGCAGAGGTGAGAGGATCTCTTGAACCCAGGAGGCGGAAGTTGCAGTGAGCTGAGATCATGCTACTGCACTCCAG CTTGGGCGACCGAGCGAGACTCTGACTCAAACAAAAGCAAAAGAAAAGGCAAATCCCAAACATATCATTTCACACCTCTACTATCTCATC TTTAAAGAAATAAGTATGTTTTCTAACATAACCACATCACTGGCCCATGCAACCAATGCCTGCCTAATACCCAGCTGTGATCTATGCTTT GATGGGCTGCACAGACCCCAAGCTTCAGCAAAGGACTTGGGACCCCACCAGCTTTGAGTGCTGTTGACAGACCCTTAGTATCAACCCCAT CAGGTGTTACTGCAGCCTTCCCCAGGGTGGCCTACACCCAATGACTGATCCATGCCAGGTGGAGAGGCCTGGCCATCTTGGCTGAGCATG GGATAACTGTGCAGGGCTGTTCCAGCTCCACGACTCCTCGTGGGGTCCACTAAGGCTGTCGCTGGGCTCACATCCCAACTCGACTTCTCC CTCTGCCCACTCCTATTTCCTTCCCTTCCCCAAGCATCGGTCCCCAGGGCACTGCTTAATAAGCATCCTGCAGACTAAGTCCATTTTAGA GTCTGCTTTCTGGGACACCCAACTTGTGATGCCAGCCCTTAATCAACCTTCCTTCATTCTCATGAACGTTTTCAATGGTTGGCTTGCCTG AATCTGATCCAAACAAATTCACATATTGAATTTAGTTGTTTCTTTTTGTTGGTTTTTAGAAAAAAGAAGATGTACTTTTTATTCTTGGAT TTTTCATTGATTTCACAGAGTATAAATTAAGTCAGATTATTCTCAATTCCAGAACTTCTGTTTCTTAAATTAGCAGGCATTCTGTTGGTT TAAAAAGATAGATGTTGGCCGGGCGCGGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAGGTCAG GAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGTGTGCACCTGTAAT CCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCGAAGGTTGCAGTGAGCTGAGATCATGCCACTGCACTCCAG CCTGGGCAACAAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAGAAAAAAAAAAGATGTGGCAGATAGAATTTCTCTCTTTCTCTATCTT TCATGACGAGGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGTATGACCATAGCTCACTGGAGCCCCAGCTGCCCGGGCTCAAGCAAT CCTCCATCTCAGCTTACCAAGCAGCGGTGACCACAGGCATGCACCACCATGCCCAGCTAATTTTTTAAAACCTATCTTTGTAGACATGGG GTCTCATTCTGTTGCCCAGGCTGGCCTCAAACTCCTGACTTCAAGCAATCCTCCTGCCTCAGCCTCCCAAAGTGTTGGGATTACAGGCGT GAGCCACTGCACCTGGCCAGGACTTATTTCTTTTAAACCGAATCTAAGTATGTTCTGGCAAGTATGCAATACCTAGCGGAATGCACTGGC CTGATCAGCATTCATACCATAGTAACTGATGTTGAAAACAGCACAAATAAACCAGAAGTTGAAAATGGCAATAACATGCTAAAAATTTGC AAGTCAATTTGTTACACTTGTCCAAATCTTGATTTTTTTTCCTTCTCTATCGTTCCCCCCCCACCACCAGCTTTATGGAGGTATAATTAG CAAATAAAAAGTATACATATTTAAGGTATACACTGTGATGTTTTGATATACATTGTGAAATGGTTACCATAATTAAGCTAATTAATATAT CCATCACCTCACATAGCCATGGTTAAGTTTCTGAAGTCTCTTTTAATCTACAAAGTACTCCTTCCTTTTTTCCATTGTCATCACCTTGCA GAAACAGAGTCAGTTTTCCCACATTCTGTATTTATCTGTTTGTTTCTTTGTGGCCGCATGTAACACATTCCTCTGTCTCATTCTAATAAA >In-frame_CSNK1A1_ENST00000515768_chr5_148899853_-_PDE6A_ENST00000255266_chr5_149242829_-_3620nt ATGGCGAGTAGCAGCGGCTCCAAGGCTGAATTCATTGTCGGAGGGAAATATAAACTGGTACGGAAGATCGGGTCTGGCTCCTTCGGGGAC ATCTATTTGGCGATCAACATCACCAACGGCGAGGAAGTGGCAGTGAAGCTAGAATCTCAGAAGGCCAGGCATCCCCAGTTGCTGTACGAG AGCAAGCTCTATAAGATTCTTCAAGGTGGGGTTGGCATCCCCCACATACGGTGGTATGGTCAGGAAAAAGACTACAATGTACTAGTCATG GATCTTCTGGGACCTAGCCTCGAAGACCTCTTCAATTTCTGTTCAAGAAGGTTCACAATGAAAACTGTACTTATGTTAGCTGACCAGATG ATCAGTAGAATTGAATATGTGCATACAAAGAATTTTATACACAGAGACATTAAACCAGATAACTTCCTAATGGGTATTGGGCGTCACTGT AATAAGGAATTCTCCCGTTTCCACGAGGAGATCACCCCAATGTTGGACGGGATCACCAACAATCGCAAGGAGTGGAAGGCGCTTGCTGAT GAGTACGATGCCAAGATGAAGGTGCAGGAGGAGAAGAAGCAGAAACAGCAGTCGGCCAAGTCAGCAGCCGCAGGAAATCAGCCGGGGGGA AACCCCAGCCCAGGGGGTGCAACTACATCCAAGTCCTGCTGCATCCAGTAACACCACTGGGGATGTGCTGGCTGGACGGCACCACCCTTT CCTGGGAAGAGATGACTCAAGCCAGTGGAAGACCACACACCTTGAGAAGTAGAAGAGTCATAGGATTTGAAAGCTGTTAGAGAATTTAGC TTCCAGGACTGTTCAATCTTTTGGCTTCCCTGGGCCACATTGGAAGAATTGTCTTGGGTCACACATAAAATACAGTAACACTAATGATAG CTGTTGAACTTAAAAAAAAAAATCGCCAAAAAAAAAAATTTCATAATGTTTTAAGAAAGTTTATGAATTTGTGTTGGGCCGCATTCAAAG CCGTCCTGGGCTGCATGTGGCCCACGGGCCGTGGGTTGAACAAGCTTGGCTTATACCTTATCCAGTGGCTTTTAAACATTCTTTTAGTCT TGAGAACTGCCTATTGAGCTAAAACCAATATTCTAGCTTTCATAGACATCAGTTAAACATTTAATTACATTTAATTAATGCCAGATTCAC TGGCTTGCTTAGAATCATTTTTGTTCTTATACTTTCAGTTAATGTATTGTAAAAATTTTCAATCATTTTCAAAAGTAGAGAATTGTACGT TGAATCCCCACATACCCATCACCCAGATTCCAATATCAAGATTTTGCTACATGCATTTCGTCTGTCCTTTTTACATTTTCTTTTCAATTT TTTTTCTTACCTGAAGTGTTTAAAGGCAAATCCTGGCCAGGCGTGGTGGCTCACACCTGTAATCCCAGCACTTCAGGAGGCTGAGGTGGG CAGACTGCATGAGCCCAGGAGTCTGAGACCAACCTGAGCAAAATGGCAAAACCCTGTCTCTACAAAAAATACAAAAATTAGCACTCACCT GTAGTCTCAGCTACCTGGGAGGCAGAGGTGAGAGGATCTCTTGAACCCAGGAGGCGGAAGTTGCAGTGAGCTGAGATCATGCTACTGCAC TCCAGCTTGGGCGACCGAGCGAGACTCTGACTCAAACAAAAGCAAAAGAAAAGGCAAATCCCAAACATATCATTTCACACCTCTACTATC TCATCTTTAAAGAAATAAGTATGTTTTCTAACATAACCACATCACTGGCCCATGCAACCAATGCCTGCCTAATACCCAGCTGTGATCTAT GCTTTGATGGGCTGCACAGACCCCAAGCTTCAGCAAAGGACTTGGGACCCCACCAGCTTTGAGTGCTGTTGACAGACCCTTAGTATCAAC CCCATCAGGTGTTACTGCAGCCTTCCCCAGGGTGGCCTACACCCAATGACTGATCCATGCCAGGTGGAGAGGCCTGGCCATCTTGGCTGA GCATGGGATAACTGTGCAGGGCTGTTCCAGCTCCACGACTCCTCGTGGGGTCCACTAAGGCTGTCGCTGGGCTCACATCCCAACTCGACT TCTCCCTCTGCCCACTCCTATTTCCTTCCCTTCCCCAAGCATCGGTCCCCAGGGCACTGCTTAATAAGCATCCTGCAGACTAAGTCCATT TTAGAGTCTGCTTTCTGGGACACCCAACTTGTGATGCCAGCCCTTAATCAACCTTCCTTCATTCTCATGAACGTTTTCAATGGTTGGCTT GCCTGAATCTGATCCAAACAAATTCACATATTGAATTTAGTTGTTTCTTTTTGTTGGTTTTTAGAAAAAAGAAGATGTACTTTTTATTCT TGGATTTTTCATTGATTTCACAGAGTATAAATTAAGTCAGATTATTCTCAATTCCAGAACTTCTGTTTCTTAAATTAGCAGGCATTCTGT TGGTTTAAAAAGATAGATGTTGGCCGGGCGCGGTGGCTCACGCCTGTAATTCCAGCACTTTGGGAGGCCAAGGTGGGTGGATCACCTGAG GTCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGTGGTGGTGTGCACCT GTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGCGAAGGTTGCAGTGAGCTGAGATCATGCCACTGCAC TCCAGCCTGGGCAACAAGAGCAAGACTCCGTCTCAAAAAAAAAAAAAAGAAAAAAAAAAGATGTGGCAGATAGAATTTCTCTCTTTCTCT ATCTTTCATGACGAGGTCTCACTCTGTCGCCCAGGCTGGAGTGCAGTGGTATGACCATAGCTCACTGGAGCCCCAGCTGCCCGGGCTCAA GCAATCCTCCATCTCAGCTTACCAAGCAGCGGTGACCACAGGCATGCACCACCATGCCCAGCTAATTTTTTAAAACCTATCTTTGTAGAC ATGGGGTCTCATTCTGTTGCCCAGGCTGGCCTCAAACTCCTGACTTCAAGCAATCCTCCTGCCTCAGCCTCCCAAAGTGTTGGGATTACA GGCGTGAGCCACTGCACCTGGCCAGGACTTATTTCTTTTAAACCGAATCTAAGTATGTTCTGGCAAGTATGCAATACCTAGCGGAATGCA CTGGCCTGATCAGCATTCATACCATAGTAACTGATGTTGAAAACAGCACAAATAAACCAGAAGTTGAAAATGGCAATAACATGCTAAAAA TTTGCAAGTCAATTTGTTACACTTGTCCAAATCTTGATTTTTTTTCCTTCTCTATCGTTCCCCCCCCACCACCAGCTTTATGGAGGTATA ATTAGCAAATAAAAAGTATACATATTTAAGGTATACACTGTGATGTTTTGATATACATTGTGAAATGGTTACCATAATTAAGCTAATTAA TATATCCATCACCTCACATAGCCATGGTTAAGTTTCTGAAGTCTCTTTTAATCTACAAAGTACTCCTTCCTTTTTTCCATTGTCATCACC TTGCAGAAACAGAGTCAGTTTTCCCACATTCTGTATTTATCTGTTTGTTTCTTTGTGGCCGCATGTAACACATTCCTCTGTCTCATTCTA 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FusionGenePPI for CSNK1A1_PDE6A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CSNK1A1 | HMGB1, HMGB2, RCC1, PPP1R14A, SYT9, ERF, ADAP1, KPNA2, PPP2CA, ACTA1, AXIN1, TNFRSF1B, CHRM3, APC, PHLPP1, MDM4, MALT1, BCL10, NFKBIA, MDM2, TP53, E2F1, COPS5, ELAVL1, SH3KBP1, CDC25A, PDE4D, HSPA4, HSP90AA1, GLI3, MAPT, SNCA, PIP5K1A, CPSF6, PPP1CC, VCAM1, YWHAE, ITGA4, HNRNPC, GNB2, RPA3, RPA2, RPA1, FAM83G, BACH1, SEC16A, HMMR, CSNK1D, CSNK1E, SEC13, DYNLL1, ACACA, SEC23B, FAM83B, ZNF618, MZT2B, MZT2A, FAM83H, USP34, EPM2AIP1, DYNLL2, SNX22, UNC45A, FAM83D, RASAL2, DBR1, SNX24, EGFR, TIAM1, OCLN, SIK2, BTRC, C1orf111, NFATC3, TEX264, FAM170A, NTRK1, PCM1, CEP170, CEP128, CEP135, NIN, XPO1, CLTC, XRCC6, GTSE1, MYO18A, CARD11, NFATC1, SQSTM1, ATOH1, CRBN, CDH1, ZDBF2, SSMEM1, GAPVD1, POTEC, LRP5, HERC1, POTEB3, ARHGAP22, LRP6, TTC9C, NCKIPSD, WEE1, KCTD3, KIF13B, BCR, CGN, ZBTB21, DENND4C, KSR1, GIGYF1, CBY1, WDR92, FOXA1, TRIM25 | PDE6A | CHERP, DPPA4, NANOG, POU5F1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CSNK1A1_PDE6A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CSNK1A1_PDE6A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CSNK1A1 | C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | CTD_human |
| Hgene | CSNK1A1 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| Tgene | PDE6A | C0035334 | Retinitis Pigmentosa | 2 | CTD_human;HPO;ORPHANET |
| Tgene | PDE6A | C3151139 | RETINITIS PIGMENTOSA 43 | 2 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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