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Fusion gene ID: 8618 |
FusionGeneSummary for CSN1S1_CSN2 |
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Fusion gene information | Fusion gene name: CSN1S1_CSN2 | Fusion gene ID: 8618 | Hgene | Tgene | Gene symbol | CSN1S1 | CSN2 | Gene ID | 1446 | 9318 |
Gene name | casein alpha s1 | COP9 signalosome subunit 2 | |
Synonyms | CASA|CSN1 | ALIEN|CSN2|SGN2|TRIP15 | |
Cytomap | 4q13.3 | 15q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | alpha-S1-caseincasein, alpha | COP9 signalosome complex subunit 2COP9 constitutive photomorphogenic homolog subunit 2JAB1-containing signalosome subunit 2TR-interacting protein 15TRIP-15alien homologsignalosome subunit 2thyroid receptor-interacting protein 15 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P47710 | P05814 | |
Ensembl transtripts involved in fusion gene | ENST00000444405, ENST00000246891, ENST00000507763, ENST00000507772, ENST00000505782, | ENST00000353151, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 14 X 11 X 2=308 |
# samples | 2 | 3 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/308*10)=-3.35989594508638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CSN1S1 [Title/Abstract] AND CSN2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CSN2 | GO:0000338 | protein deneddylation | 19141280 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AO-A1KO-01A | CSN1S1 | chr4 | 70798324 | + | CSN2 | chr4 | 70823522 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000444405 | ENST00000353151 | CSN1S1 | chr4 | 70798324 | + | CSN2 | chr4 | 70823522 | - |
In-frame | ENST00000246891 | ENST00000353151 | CSN1S1 | chr4 | 70798324 | + | CSN2 | chr4 | 70823522 | - |
In-frame | ENST00000507763 | ENST00000353151 | CSN1S1 | chr4 | 70798324 | + | CSN2 | chr4 | 70823522 | - |
In-frame | ENST00000507772 | ENST00000353151 | CSN1S1 | chr4 | 70798324 | + | CSN2 | chr4 | 70823522 | - |
In-frame | ENST00000505782 | ENST00000353151 | CSN1S1 | chr4 | 70798324 | + | CSN2 | chr4 | 70823522 | - |
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FusionProtFeatures for CSN1S1_CSN2 |
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Hgene | Tgene |
CSN1S1 | CSN2 |
Important role in the capacity of milk to transportcalcium phosphate. Casoxin D acts as opioid antagonist and has vasorelaxingactivity mediated by bradykinin B1 receptors. | Important role in determination of the surfaceproperties of the casein micelles. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CSN1S1_CSN2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CSN1S1_CSN2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CSN1S1 | TOLLIP, COPS5, CSNK2A1, CSNK2B, CUL1, CUL4A, COPS7A, PLK1, PARK7, PRSS2, PDE10A, B4GALNT4, LTBP1, EMILIN3, KLHL15, HSPA5, TIMP3, ERF, BCOR, CDKN2AIP, FAM120A, ETV3 | CSN2 | CDC42, GRB2, NFYC, RAC1, TOLLIP, PLK1, ARRB1, ARRB2, CUL1, CUL4B, COPS7A, CSNK2A1, CDK1, HTRA2, NEK2, AURKA, CSNK2B, FHL2, NEK9, CORO2A, PPP3CC |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CSN1S1_CSN2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CSN1S1_CSN2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CSN2 | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
Tgene | CSN2 | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |