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Fusion gene ID: 8562 |
FusionGeneSummary for CRYL1_SPACA7 |
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Fusion gene information | Fusion gene name: CRYL1_SPACA7 | Fusion gene ID: 8562 | Hgene | Tgene | Gene symbol | CRYL1 | SPACA7 | Gene ID | 51084 | 122258 |
Gene name | crystallin lambda 1 | sperm acrosome associated 7 | |
Synonyms | GDH|HEL30|gul3DH|lambda-CRY | C13orf28 | |
Cytomap | 13q12.11 | 13q34 | |
Type of gene | protein-coding | protein-coding | |
Description | lambda-crystallin homologL-gulonate 3-dehydrogenasecrystallin, lamda 1epididymis luminal protein 30testicular tissue protein Li 44 | sperm acrosome-associated protein 7protein SPACA7 | |
Modification date | 20180524 | 20180522 | |
UniProtAcc | Q9Y2S2 | Q96KW9 | |
Ensembl transtripts involved in fusion gene | ENST00000298248, ENST00000382812, ENST00000480748, | ENST00000283550, ENST00000375699, | |
Fusion gene scores | * DoF score | 9 X 8 X 5=360 | 3 X 3 X 3=27 |
# samples | 10 | 3 | |
** MAII score | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CRYL1 [Title/Abstract] AND SPACA7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | KIRC | TCGA-B0-5117-01A | CRYL1 | chr13 | 21063509 | - | SPACA7 | chr13 | 113088799 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000298248 | ENST00000283550 | CRYL1 | chr13 | 21063509 | - | SPACA7 | chr13 | 113088799 | + |
Frame-shift | ENST00000298248 | ENST00000375699 | CRYL1 | chr13 | 21063509 | - | SPACA7 | chr13 | 113088799 | + |
In-frame | ENST00000382812 | ENST00000283550 | CRYL1 | chr13 | 21063509 | - | SPACA7 | chr13 | 113088799 | + |
In-frame | ENST00000382812 | ENST00000375699 | CRYL1 | chr13 | 21063509 | - | SPACA7 | chr13 | 113088799 | + |
5UTR-3CDS | ENST00000480748 | ENST00000283550 | CRYL1 | chr13 | 21063509 | - | SPACA7 | chr13 | 113088799 | + |
5UTR-3CDS | ENST00000480748 | ENST00000375699 | CRYL1 | chr13 | 21063509 | - | SPACA7 | chr13 | 113088799 | + |
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FusionProtFeatures for CRYL1_SPACA7 |
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Hgene | Tgene |
CRYL1 | SPACA7 |
Involved in fertilization. Seems not to play a directrole in sperm-egg binding or gamete fusion.{ECO:0000250|UniProtKB:Q9D2S4}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CRYL1_SPACA7 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_CRYL1_ENST00000382812_chr13_21063509_-_SPACA7_ENST00000283550_chr13_113088799_+_91aa MLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQETFSIKSSRGPAHRGGAKAV >In-frame_CRYL1_ENST00000382812_chr13_21063509_-_SPACA7_ENST00000375699_chr13_113088799_+_91aa MLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQETFSIKSSRGPAHRGGAKAV |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_CRYL1_ENST00000382812_chr13_21063509_-_SPACA7_ENST00000283550_chr13_113088799_+_275nt ATGCTGTTTGCCAGTGGAGGCTTCCAGGTGAAACTCTATGACATTGAGCAACAGCAGATAAGGAACGCCCTGGAAAACATCAGAAAGGAG ATGAAGTTGCTGGAGCAGGCAGGTTCTCTGAAAGGCTCCCTGAGTGTGGAAGAGCAGCTGTCACTCATCAGTGGTTGTCCCAATATCCAA GAAGCAGTAGAGGGTGCCATGCACATTCAGGAAACATTTTCCATAAAGAGCAGCAGAGGACCAGCGCACAGAGGAGGAGCCAAGGCAGTC >In-frame_CRYL1_ENST00000382812_chr13_21063509_-_SPACA7_ENST00000375699_chr13_113088799_+_275nt ATGCTGTTTGCCAGTGGAGGCTTCCAGGTGAAACTCTATGACATTGAGCAACAGCAGATAAGGAACGCCCTGGAAAACATCAGAAAGGAG ATGAAGTTGCTGGAGCAGGCAGGTTCTCTGAAAGGCTCCCTGAGTGTGGAAGAGCAGCTGTCACTCATCAGTGGTTGTCCCAATATCCAA GAAGCAGTAGAGGGTGCCATGCACATTCAGGAAACATTTTCCATAAAGAGCAGCAGAGGACCAGCGCACAGAGGAGGAGCCAAGGCAGTC |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_CRYL1_ENST00000382812_chr13_21063509_-_SPACA7_ENST00000283550_chr13_113088799_+_644nt AGAGCTCGCAGCTCCGCCGGCGCCTGGTCCCAGCGCCCGCGGCGCCGCGTCCCCGGCCCAACCATGGCGTCCTCCGCGGCCGGCTGCGTG GTGATCGTTGGCAGAATTAAAACTCTGTACCCATTGAACAACAGCTGCTCATTTCCCCCAGCCCCAGCCCCTGGCATCCACCCTTCTAGC TTTCTGTCTCTATGGGTACCTCAGTGGAGTCATTGGGCGAAGCTGGGCCATGCTGTTTGCCAGTGGAGGCTTCCAGGTGAAACTCTATGA CATTGAGCAACAGCAGATAAGGAACGCCCTGGAAAACATCAGAAAGGAGATGAAGTTGCTGGAGCAGGCAGGTTCTCTGAAAGGCTCCCT GAGTGTGGAAGAGCAGCTGTCACTCATCAGTGGTTGTCCCAATATCCAAGAAGCAGTAGAGGGTGCCATGCACATTCAGGAAACATTTTC CATAAAGAGCAGCAGAGGACCAGCGCACAGAGGAGGAGCCAAGGCAGTCAGTGAGGCCGCAGCCCCAGACCCCCTGCGCAGGAGAGGAGC CTGCTAGAACCCCCACCCACCAGCCTCCGGAACAGGGCACTTGTGTGCACACGCCCACGTTCTCTGAACCATTCCACATAAAGGAAAATC >In-frame_CRYL1_ENST00000382812_chr13_21063509_-_SPACA7_ENST00000375699_chr13_113088799_+_644nt AGAGCTCGCAGCTCCGCCGGCGCCTGGTCCCAGCGCCCGCGGCGCCGCGTCCCCGGCCCAACCATGGCGTCCTCCGCGGCCGGCTGCGTG GTGATCGTTGGCAGAATTAAAACTCTGTACCCATTGAACAACAGCTGCTCATTTCCCCCAGCCCCAGCCCCTGGCATCCACCCTTCTAGC TTTCTGTCTCTATGGGTACCTCAGTGGAGTCATTGGGCGAAGCTGGGCCATGCTGTTTGCCAGTGGAGGCTTCCAGGTGAAACTCTATGA CATTGAGCAACAGCAGATAAGGAACGCCCTGGAAAACATCAGAAAGGAGATGAAGTTGCTGGAGCAGGCAGGTTCTCTGAAAGGCTCCCT GAGTGTGGAAGAGCAGCTGTCACTCATCAGTGGTTGTCCCAATATCCAAGAAGCAGTAGAGGGTGCCATGCACATTCAGGAAACATTTTC CATAAAGAGCAGCAGAGGACCAGCGCACAGAGGAGGAGCCAAGGCAGTCAGTGAGGCCGCAGCCCCAGACCCCCTGCGCAGGAGAGGAGC CTGCTAGAACCCCCACCCACCAGCCTCCGGAACAGGGCACTTGTGTGCACACGCCCACGTTCTCTGAACCATTCCACATAAAGGAAAATC |
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FusionGenePPI for CRYL1_SPACA7 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CRYL1 | ELAVL1, ABCC6, F2R, PKD2, TRIM65, HTT, SPG11, ANAPC5, C5orf34, DYNC2H1, SMG7, HAUS5, USP19, CEP164, PIK3C2A, IFT122, CDC23, TBCD, STIL, IFT140, UBR4, SMG8, ALMS1, HAUS3, MYO9A, WDR59, TTC37, WRAP53, HOOK1, ANAPC1, BRIP1, USP54, PLD2, TRIM32, MYO5C, EIF2AK4 | SPACA7 | HSPB1, KRAS |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CRYL1_SPACA7 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CRYL1_SPACA7 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CRYL1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | CRYL1 | C0520459 | Necrotizing Enterocolitis | 1 | CTD_human |