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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8562

FusionGeneSummary for CRYL1_SPACA7

check button Fusion gene summary
Fusion gene informationFusion gene name: CRYL1_SPACA7
Fusion gene ID: 8562
HgeneTgene
Gene symbol

CRYL1

SPACA7

Gene ID

51084

122258

Gene namecrystallin lambda 1sperm acrosome associated 7
SynonymsGDH|HEL30|gul3DH|lambda-CRYC13orf28
Cytomap

13q12.11

13q34

Type of geneprotein-codingprotein-coding
Descriptionlambda-crystallin homologL-gulonate 3-dehydrogenasecrystallin, lamda 1epididymis luminal protein 30testicular tissue protein Li 44sperm acrosome-associated protein 7protein SPACA7
Modification date2018052420180522
UniProtAcc

Q9Y2S2

Q96KW9

Ensembl transtripts involved in fusion geneENST00000298248, ENST00000382812, 
ENST00000480748, 
ENST00000283550, 
ENST00000375699, 
Fusion gene scores* DoF score9 X 8 X 5=3603 X 3 X 3=27
# samples 103
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CRYL1 [Title/Abstract] AND SPACA7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDKIRCTCGA-B0-5117-01ACRYL1chr13

21063509

-SPACA7chr13

113088799

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000298248ENST00000283550CRYL1chr13

21063509

-SPACA7chr13

113088799

+
Frame-shiftENST00000298248ENST00000375699CRYL1chr13

21063509

-SPACA7chr13

113088799

+
In-frameENST00000382812ENST00000283550CRYL1chr13

21063509

-SPACA7chr13

113088799

+
In-frameENST00000382812ENST00000375699CRYL1chr13

21063509

-SPACA7chr13

113088799

+
5UTR-3CDSENST00000480748ENST00000283550CRYL1chr13

21063509

-SPACA7chr13

113088799

+
5UTR-3CDSENST00000480748ENST00000375699CRYL1chr13

21063509

-SPACA7chr13

113088799

+

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FusionProtFeatures for CRYL1_SPACA7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRYL1

Q9Y2S2

SPACA7

Q96KW9

Involved in fertilization. Seems not to play a directrole in sperm-egg binding or gamete fusion.{ECO:0000250|UniProtKB:Q9D2S4}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CRYL1_SPACA7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CRYL1_ENST00000382812_chr13_21063509_-_SPACA7_ENST00000283550_chr13_113088799_+_91aa
MLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQETFSIKSSRGPAHRGGAKAV

>In-frame_CRYL1_ENST00000382812_chr13_21063509_-_SPACA7_ENST00000375699_chr13_113088799_+_91aa
MLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQETFSIKSSRGPAHRGGAKAV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CRYL1_ENST00000382812_chr13_21063509_-_SPACA7_ENST00000283550_chr13_113088799_+_275nt
ATGCTGTTTGCCAGTGGAGGCTTCCAGGTGAAACTCTATGACATTGAGCAACAGCAGATAAGGAACGCCCTGGAAAACATCAGAAAGGAG
ATGAAGTTGCTGGAGCAGGCAGGTTCTCTGAAAGGCTCCCTGAGTGTGGAAGAGCAGCTGTCACTCATCAGTGGTTGTCCCAATATCCAA
GAAGCAGTAGAGGGTGCCATGCACATTCAGGAAACATTTTCCATAAAGAGCAGCAGAGGACCAGCGCACAGAGGAGGAGCCAAGGCAGTC

>In-frame_CRYL1_ENST00000382812_chr13_21063509_-_SPACA7_ENST00000375699_chr13_113088799_+_275nt
ATGCTGTTTGCCAGTGGAGGCTTCCAGGTGAAACTCTATGACATTGAGCAACAGCAGATAAGGAACGCCCTGGAAAACATCAGAAAGGAG
ATGAAGTTGCTGGAGCAGGCAGGTTCTCTGAAAGGCTCCCTGAGTGTGGAAGAGCAGCTGTCACTCATCAGTGGTTGTCCCAATATCCAA
GAAGCAGTAGAGGGTGCCATGCACATTCAGGAAACATTTTCCATAAAGAGCAGCAGAGGACCAGCGCACAGAGGAGGAGCCAAGGCAGTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_CRYL1_ENST00000382812_chr13_21063509_-_SPACA7_ENST00000283550_chr13_113088799_+_644nt
AGAGCTCGCAGCTCCGCCGGCGCCTGGTCCCAGCGCCCGCGGCGCCGCGTCCCCGGCCCAACCATGGCGTCCTCCGCGGCCGGCTGCGTG
GTGATCGTTGGCAGAATTAAAACTCTGTACCCATTGAACAACAGCTGCTCATTTCCCCCAGCCCCAGCCCCTGGCATCCACCCTTCTAGC
TTTCTGTCTCTATGGGTACCTCAGTGGAGTCATTGGGCGAAGCTGGGCCATGCTGTTTGCCAGTGGAGGCTTCCAGGTGAAACTCTATGA
CATTGAGCAACAGCAGATAAGGAACGCCCTGGAAAACATCAGAAAGGAGATGAAGTTGCTGGAGCAGGCAGGTTCTCTGAAAGGCTCCCT
GAGTGTGGAAGAGCAGCTGTCACTCATCAGTGGTTGTCCCAATATCCAAGAAGCAGTAGAGGGTGCCATGCACATTCAGGAAACATTTTC
CATAAAGAGCAGCAGAGGACCAGCGCACAGAGGAGGAGCCAAGGCAGTCAGTGAGGCCGCAGCCCCAGACCCCCTGCGCAGGAGAGGAGC
CTGCTAGAACCCCCACCCACCAGCCTCCGGAACAGGGCACTTGTGTGCACACGCCCACGTTCTCTGAACCATTCCACATAAAGGAAAATC

>In-frame_CRYL1_ENST00000382812_chr13_21063509_-_SPACA7_ENST00000375699_chr13_113088799_+_644nt
AGAGCTCGCAGCTCCGCCGGCGCCTGGTCCCAGCGCCCGCGGCGCCGCGTCCCCGGCCCAACCATGGCGTCCTCCGCGGCCGGCTGCGTG
GTGATCGTTGGCAGAATTAAAACTCTGTACCCATTGAACAACAGCTGCTCATTTCCCCCAGCCCCAGCCCCTGGCATCCACCCTTCTAGC
TTTCTGTCTCTATGGGTACCTCAGTGGAGTCATTGGGCGAAGCTGGGCCATGCTGTTTGCCAGTGGAGGCTTCCAGGTGAAACTCTATGA
CATTGAGCAACAGCAGATAAGGAACGCCCTGGAAAACATCAGAAAGGAGATGAAGTTGCTGGAGCAGGCAGGTTCTCTGAAAGGCTCCCT
GAGTGTGGAAGAGCAGCTGTCACTCATCAGTGGTTGTCCCAATATCCAAGAAGCAGTAGAGGGTGCCATGCACATTCAGGAAACATTTTC
CATAAAGAGCAGCAGAGGACCAGCGCACAGAGGAGGAGCCAAGGCAGTCAGTGAGGCCGCAGCCCCAGACCCCCTGCGCAGGAGAGGAGC
CTGCTAGAACCCCCACCCACCAGCCTCCGGAACAGGGCACTTGTGTGCACACGCCCACGTTCTCTGAACCATTCCACATAAAGGAAAATC


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FusionGenePPI for CRYL1_SPACA7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CRYL1ELAVL1, ABCC6, F2R, PKD2, TRIM65, HTT, SPG11, ANAPC5, C5orf34, DYNC2H1, SMG7, HAUS5, USP19, CEP164, PIK3C2A, IFT122, CDC23, TBCD, STIL, IFT140, UBR4, SMG8, ALMS1, HAUS3, MYO9A, WDR59, TTC37, WRAP53, HOOK1, ANAPC1, BRIP1, USP54, PLD2, TRIM32, MYO5C, EIF2AK4SPACA7HSPB1, KRAS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CRYL1_SPACA7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CRYL1_SPACA7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCRYL1C0033578Prostatic Neoplasms1CTD_human
HgeneCRYL1C0520459Necrotizing Enterocolitis1CTD_human