FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 8555

FusionGeneSummary for CRYL1_ATPAF1

check button Fusion gene summary
Fusion gene informationFusion gene name: CRYL1_ATPAF1
Fusion gene ID: 8555
HgeneTgene
Gene symbol

CRYL1

ATPAF1

Gene ID

51084

64756

Gene namecrystallin lambda 1ATP synthase mitochondrial F1 complex assembly factor 1
SynonymsGDH|HEL30|gul3DH|lambda-CRYATP11|ATP11p
Cytomap

13q12.11

1p33

Type of geneprotein-codingprotein-coding
Descriptionlambda-crystallin homologL-gulonate 3-dehydrogenasecrystallin, lamda 1epididymis luminal protein 30testicular tissue protein Li 44ATP synthase mitochondrial F1 complex assembly factor 1homolog of yeast ATP11
Modification date2018052420180523
UniProtAcc

Q9Y2S2

Q5TC12

Ensembl transtripts involved in fusion geneENST00000298248, ENST00000382812, 
ENST00000480748, 
ENST00000576409, 
ENST00000574428, ENST00000371937, 
ENST00000542495, ENST00000329231, 
ENST00000532925, ENST00000525633, 
Fusion gene scores* DoF score9 X 8 X 5=3603 X 3 X 2=18
# samples 103
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CRYL1 [Title/Abstract] AND ATPAF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP276779CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000298248ENST00000576409CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-3CDSENST00000298248ENST00000574428CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-3CDSENST00000298248ENST00000371937CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-intronENST00000298248ENST00000542495CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-intronENST00000298248ENST00000329231CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-intronENST00000298248ENST00000532925CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-intronENST00000298248ENST00000525633CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-3CDSENST00000382812ENST00000576409CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-3CDSENST00000382812ENST00000574428CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-3CDSENST00000382812ENST00000371937CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-intronENST00000382812ENST00000542495CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-intronENST00000382812ENST00000329231CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-intronENST00000382812ENST00000532925CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-intronENST00000382812ENST00000525633CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-3CDSENST00000480748ENST00000576409CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-3CDSENST00000480748ENST00000574428CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-3CDSENST00000480748ENST00000371937CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-intronENST00000480748ENST00000542495CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-intronENST00000480748ENST00000329231CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-intronENST00000480748ENST00000532925CRYL1chr13

21006251

-ATPAF1chr1

47133965

-
intron-intronENST00000480748ENST00000525633CRYL1chr13

21006251

-ATPAF1chr1

47133965

-

Top

FusionProtFeatures for CRYL1_ATPAF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRYL1

Q9Y2S2

ATPAF1

Q5TC12

May play an essential role for the assembly of themitochondrial F1-F0 complex. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CRYL1_ATPAF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CRYL1_ATPAF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CRYL1_ATPAF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CRYL1_ATPAF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCRYL1C0033578Prostatic Neoplasms1CTD_human
HgeneCRYL1C0520459Necrotizing Enterocolitis1CTD_human
TgeneATPAF1C0028754Obesity1CTD_human