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Fusion gene ID: 8555 |
FusionGeneSummary for CRYL1_ATPAF1 |
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Fusion gene information | Fusion gene name: CRYL1_ATPAF1 | Fusion gene ID: 8555 | Hgene | Tgene | Gene symbol | CRYL1 | ATPAF1 | Gene ID | 51084 | 64756 |
Gene name | crystallin lambda 1 | ATP synthase mitochondrial F1 complex assembly factor 1 | |
Synonyms | GDH|HEL30|gul3DH|lambda-CRY | ATP11|ATP11p | |
Cytomap | 13q12.11 | 1p33 | |
Type of gene | protein-coding | protein-coding | |
Description | lambda-crystallin homologL-gulonate 3-dehydrogenasecrystallin, lamda 1epididymis luminal protein 30testicular tissue protein Li 44 | ATP synthase mitochondrial F1 complex assembly factor 1homolog of yeast ATP11 | |
Modification date | 20180524 | 20180523 | |
UniProtAcc | Q9Y2S2 | Q5TC12 | |
Ensembl transtripts involved in fusion gene | ENST00000298248, ENST00000382812, ENST00000480748, | ENST00000576409, ENST00000574428, ENST00000371937, ENST00000542495, ENST00000329231, ENST00000532925, ENST00000525633, | |
Fusion gene scores | * DoF score | 9 X 8 X 5=360 | 3 X 3 X 2=18 |
# samples | 10 | 3 | |
** MAII score | log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CRYL1 [Title/Abstract] AND ATPAF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BP276779 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000298248 | ENST00000576409 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-3CDS | ENST00000298248 | ENST00000574428 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-3CDS | ENST00000298248 | ENST00000371937 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-intron | ENST00000298248 | ENST00000542495 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-intron | ENST00000298248 | ENST00000329231 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-intron | ENST00000298248 | ENST00000532925 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-intron | ENST00000298248 | ENST00000525633 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-3CDS | ENST00000382812 | ENST00000576409 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-3CDS | ENST00000382812 | ENST00000574428 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-3CDS | ENST00000382812 | ENST00000371937 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-intron | ENST00000382812 | ENST00000542495 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-intron | ENST00000382812 | ENST00000329231 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-intron | ENST00000382812 | ENST00000532925 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-intron | ENST00000382812 | ENST00000525633 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-3CDS | ENST00000480748 | ENST00000576409 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-3CDS | ENST00000480748 | ENST00000574428 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-3CDS | ENST00000480748 | ENST00000371937 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-intron | ENST00000480748 | ENST00000542495 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-intron | ENST00000480748 | ENST00000329231 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-intron | ENST00000480748 | ENST00000532925 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
intron-intron | ENST00000480748 | ENST00000525633 | CRYL1 | chr13 | 21006251 | - | ATPAF1 | chr1 | 47133965 | - |
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FusionProtFeatures for CRYL1_ATPAF1 |
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Hgene | Tgene |
CRYL1 | ATPAF1 |
May play an essential role for the assembly of themitochondrial F1-F0 complex. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CRYL1_ATPAF1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CRYL1_ATPAF1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CRYL1_ATPAF1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CRYL1_ATPAF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CRYL1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | CRYL1 | C0520459 | Necrotizing Enterocolitis | 1 | CTD_human |
Tgene | ATPAF1 | C0028754 | Obesity | 1 | CTD_human |