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Fusion gene ID: 8539 |
FusionGeneSummary for CRY1_HPSE2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CRY1_HPSE2 | Fusion gene ID: 8539 | Hgene | Tgene | Gene symbol | CRY1 | HPSE2 | Gene ID | 1407 | 60495 |
| Gene name | cryptochrome circadian regulator 1 | heparanase 2 (inactive) | |
| Synonyms | DSPD|PHLL1 | HPA2|HPR2|UFS|UFS1 | |
| Cytomap | 12q23.3 | 10q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cryptochrome-1cryptochrome 1 (photolyase-like)cryptochrome circadian clock 1 | inactive heparanase-2heparanase 3heparanase-like protein | |
| Modification date | 20180520 | 20180523 | |
| UniProtAcc | Q16526 | Q8WWQ2 | |
| Ensembl transtripts involved in fusion gene | ENST00000008527, ENST00000550633, | ENST00000370549, ENST00000370552, ENST00000370546, ENST00000404542, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 2 X 2=12 |
| # samples | 1 | 3 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: CRY1 [Title/Abstract] AND HPSE2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CRY1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12397359|14672706|15147242 |
| Hgene | CRY1 | GO:0045892 | negative regulation of transcription, DNA-templated | 12397359|23133559 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-EJ-5527-01A | CRY1 | chr12 | 107486582 | - | HPSE2 | chr10 | 100249953 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000008527 | ENST00000370549 | CRY1 | chr12 | 107486582 | - | HPSE2 | chr10 | 100249953 | - |
| In-frame | ENST00000008527 | ENST00000370552 | CRY1 | chr12 | 107486582 | - | HPSE2 | chr10 | 100249953 | - |
| In-frame | ENST00000008527 | ENST00000370546 | CRY1 | chr12 | 107486582 | - | HPSE2 | chr10 | 100249953 | - |
| In-frame | ENST00000008527 | ENST00000404542 | CRY1 | chr12 | 107486582 | - | HPSE2 | chr10 | 100249953 | - |
| 5UTR-3CDS | ENST00000550633 | ENST00000370549 | CRY1 | chr12 | 107486582 | - | HPSE2 | chr10 | 100249953 | - |
| 5UTR-3CDS | ENST00000550633 | ENST00000370552 | CRY1 | chr12 | 107486582 | - | HPSE2 | chr10 | 100249953 | - |
| 5UTR-3CDS | ENST00000550633 | ENST00000370546 | CRY1 | chr12 | 107486582 | - | HPSE2 | chr10 | 100249953 | - |
| 5UTR-3CDS | ENST00000550633 | ENST00000404542 | CRY1 | chr12 | 107486582 | - | HPSE2 | chr10 | 100249953 | - |
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FusionProtFeatures for CRY1_HPSE2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CRY1 | HPSE2 |
| Transcriptional repressor which forms a core componentof the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes throughthe generation of approximately 24 hour circadian rhythms in geneexpression, which are translated into rhythms in metabolism andbehavior. It is derived from the Latin roots 'circa' (about) and'diem' (day) and acts as an important regulator of a wide array ofphysiological functions including metabolism, sleep, bodytemperature, blood pressure, endocrine, immune, cardiovascular,and renal function. Consists of two major components: the centralclock, residing in the suprachiasmatic nucleus (SCN) of the brain,and the peripheral clocks that are present in nearly every tissueand organ system. Both the central and peripheral clocks can bereset by environmental cues, also known as Zeitgebers (German for'timegivers'). The predominant Zeitgeber for the central clock islight, which is sensed by retina and signals directly to the SCN.The central clock entrains the peripheral clocks through neuronaland hormonal signals, body temperature and feeding-related cues,aligning all clocks with the external light/dark cycle. Circadianrhythms allow an organism to achieve temporal homeostasis with itsenvironment at the molecular level by regulating gene expressionto create a peak of protein expression once every 24 hours tocontrol when a particular physiological process is most activewith respect to the solar day. Transcription and translation ofcore clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2,PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythmgeneration, whereas delays imposed by post-translationalmodifications (PTMs) are important for determining the period(tau) of the rhythms (tau refers to the period of a rhythm and isthe length, in time, of one complete cycle). A diurnal rhythm issynchronized with the day/night cycle, while the ultradian andinfradian rhythms have a period shorter and longer than 24 hours,respectively. Disruptions in the circadian rhythms contribute tothe pathology of cardiovascular diseases, cancer, metabolicsyndromes and aging. A transcription/translation feedback loop(TTFL) forms the core of the molecular circadian clock mechanism.Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 orARNTL2/BMAL2, form the positive limb of the feedback loop, act inthe form of a heterodimer and activate the transcription of coreclock genes and clock-controlled genes (involved in key metabolicprocesses), harboring E-box elements (5'-CACGTG-3') within theirpromoters. The core clock genes: PER1/2/3 and CRY1/2 which aretranscriptional repressors form the negative limb of the feedbackloop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2heterodimer inhibiting its activity and thereby negativelyregulating their own expression. This heterodimer also activatesnuclear receptors NR1D1/2 and RORA/B/G, which form a secondfeedback loop and which activate and repress ARNTL/BMAL1transcription, respectively. CRY1 and CRY2 have redundantfunctions but also differential and selective contributions atleast in defining the pace of the SCN circadian clock and itscircadian transcriptional outputs. More potent transcriptionalrepressor in cerebellum and liver than CRY2, though more effectivein lengthening the period of the SCN oscillator. On its side, CRY2seems to play a critical role in tuning SCN circadian period byopposing the action of CRY1. With CRY2, is dispensable forcircadian rhythm generation but necessary for the development ofintercellular networks for rhythm synchrony. Capable oftranslocating circadian clock core proteins such as PER proteinsto the nucleus. Interacts with CLOCK-ARNTL/BMAL1 independently ofPER proteins and is found at CLOCK-ARNTL/BMAL1-bound sites,suggesting that CRY may act as a molecular gatekeeper to maintainCLOCK-ARNTL/BMAL1 in a poised and repressed state until the propertime for transcriptional activation. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1. Represses theCLOCK-ARNTL/BMAL1 induced transcription of ATF4, MTA1, KLF10 andNAMPT (By similarity). May repress circadian target genesexpression in collaboration with HDAC1 and HDAC2 through histonedeacetylation. Mediates the clock-control activation of ATR andmodulates ATR-mediated DNA damage checkpoint. In liver, mediatescircadian regulation of cAMP signaling and gluconeogenesis bybinding to membrane-coupled G proteins and blocking glucagon-mediated increases in intracellular cAMP concentrations and CREB1phosphorylation. Besides its role in the maintenance of thecircadian clock, is also involved in the regulation of otherprocesses. Represses glucocorticoid receptor NR3C1/GR-inducedtranscriptional activity by binding to glucocorticoid responseelements (GREs). Plays a key role in glucose and lipid metabolismmodulation, in part, through the transcriptional regulation ofgenes involved in these pathways, such as LEP or ACSL4.{ECO:0000250|UniProtKB:P97784, ECO:0000269|PubMed:10531061,ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:22170608,ECO:0000269|PubMed:23133559, ECO:0000269|PubMed:28388406}. | Binds heparin and heparan sulfate with high affinity,but lacks heparanase activity. Inhibits HPSE, possibly bycompeting for its substrates (in vitro).{ECO:0000269|PubMed:20576607}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CRY1 | chr12:107486582 | chr10:100249953 | ENST00000008527 | - | 1 | 13 | 3_132 | 52 | 456 | Domain | Note=Photolyase/cryptochrome alpha/beta |
| Hgene | >CRY1 | chr12:107486582 | chr10:100249953 | ENST00000008527 | - | 1 | 13 | 387_389 | 52 | 456 | Nucleotide binding | FAD |
| Hgene | >CRY1 | chr12:107486582 | chr10:100249953 | ENST00000008527 | - | 1 | 13 | 371_470 | 52 | 456 | Region | Required for inhibition of CLOCK-ARNTL/BMAL1-mediated transcription |
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FusionGeneSequence for CRY1_HPSE2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CRY1_ENST00000008527_chr12_107486582_-_HPSE2_ENST00000370549_chr10_100249953_-_205aa MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWRTTGSLSSTSAXSAPKSWLCMWLGSSGSHGLAEXSGTN XGFMLTAQTTTTTTTFVGPLHFLSSTCIDQERKSSWLGLSETSWFTSTCCSPMGRRAXSPSQCNXMASPXXWWTTGPSQNXSPAPFGPAG >In-frame_CRY1_ENST00000008527_chr12_107486582_-_HPSE2_ENST00000370552_chr10_100249953_-_205aa MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWRTTGSLSSTSAXSAPKSWLCMWLGSSGSHGLAEXSGTN XGFMLTAQTTTTTTTFVGPLHFLSSTCIDQERKSSWLGLSETSWFTSTCCSPMGRRAXSPSQCNXMASPXXWWTTGPSQNXSPAPFGPAG >In-frame_CRY1_ENST00000008527_chr12_107486582_-_HPSE2_ENST00000370546_chr10_100249953_-_161aa MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWRTTGSLSSTSAXSAPKSWLCMWLGSSGSHGLAEXSGTN >In-frame_CRY1_ENST00000008527_chr12_107486582_-_HPSE2_ENST00000404542_chr10_100249953_-_205aa MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGSSNVGINRWRTTGSLSSTSAXSAPKSWLCMWLGSSGSHGLAEXSGTN XGFMLTAQTTTTTTTFVGPLHFLSSTCIDQERKSSWLGLSETSWFTSTCCSPMGRRAXSPSQCNXMASPXXWWTTGPSQNXSPAPFGPAG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CRY1_ENST00000008527_chr12_107486582_-_HPSE2_ENST00000370549_chr10_100249953_-_617nt ATGGGGGTGAACGCCGTGCACTGGTTCCGAAAGGGGCTCCGGCTCCACGACAACCCCGCCCTGAAGGAGTGCATTCAGGGCGCCGACACC ATCCGCTGCGTCTACATCCTGGACCCCTGGTTCGCCGGCTCCTCCAATGTGGGCATCAACAGGTGGCGGACTACTGGCTCTCTCTCCTCT ACAAGCGCCTGATCGGCCCCAAAGTCTTGGCTGTGCATGTGGCTGGGCTCCAGCGGAAGCCACGGCCTGGCCGAGTGATCCGGGACAAAC TAAGGATTTATGCTCACTGCACAAACCACCACAACCACAACTACGTTCGTGGGTCCATTACACTTTTTATCATCAACTTGCATCGATCAA GAAAGAAAATCAAGCTGGCTGGGACTCTCAGAGACAAGCTGGTTCACCAGTACCTGCTGCAGCCCTATGGGCAGGAGGGCCTAAAGTCCA AGTCAGTGCAACTGAATGGCCAGCCCTTAGTGATGGTGGACGACGGGACCCTCCCAGAATTGAAGCCCCGCCCCCTTCGGGCCGGCCGGA >In-frame_CRY1_ENST00000008527_chr12_107486582_-_HPSE2_ENST00000370552_chr10_100249953_-_617nt ATGGGGGTGAACGCCGTGCACTGGTTCCGAAAGGGGCTCCGGCTCCACGACAACCCCGCCCTGAAGGAGTGCATTCAGGGCGCCGACACC ATCCGCTGCGTCTACATCCTGGACCCCTGGTTCGCCGGCTCCTCCAATGTGGGCATCAACAGGTGGCGGACTACTGGCTCTCTCTCCTCT ACAAGCGCCTGATCGGCCCCAAAGTCTTGGCTGTGCATGTGGCTGGGCTCCAGCGGAAGCCACGGCCTGGCCGAGTGATCCGGGACAAAC TAAGGATTTATGCTCACTGCACAAACCACCACAACCACAACTACGTTCGTGGGTCCATTACACTTTTTATCATCAACTTGCATCGATCAA GAAAGAAAATCAAGCTGGCTGGGACTCTCAGAGACAAGCTGGTTCACCAGTACCTGCTGCAGCCCTATGGGCAGGAGGGCCTAAAGTCCA AGTCAGTGCAACTGAATGGCCAGCCCTTAGTGATGGTGGACGACGGGACCCTCCCAGAATTGAAGCCCCGCCCCCTTCGGGCCGGCCGGA >In-frame_CRY1_ENST00000008527_chr12_107486582_-_HPSE2_ENST00000370546_chr10_100249953_-_485nt ATGGGGGTGAACGCCGTGCACTGGTTCCGAAAGGGGCTCCGGCTCCACGACAACCCCGCCCTGAAGGAGTGCATTCAGGGCGCCGACACC ATCCGCTGCGTCTACATCCTGGACCCCTGGTTCGCCGGCTCCTCCAATGTGGGCATCAACAGGTGGCGGACTACTGGCTCTCTCTCCTCT ACAAGCGCCTGATCGGCCCCAAAGTCTTGGCTGTGCATGTGGCTGGGCTCCAGCGGAAGCCACGGCCTGGCCGAGTGATCCGGGACAAAC TAAGGATTTATGCTCACTGCACAAACCACCACAACCACAACTACGTTCGTGGGTCCATTACACTTTTTATCATCAACTTGCATCGATCAA GAAAGAAAATCAAGCTGGCTGGGACTCTCAGAGACAAGCTGGTTCACCAGTACCTGCTGCAGCCCTATGGGCAGGAGGGCCTAAAGTCCA >In-frame_CRY1_ENST00000008527_chr12_107486582_-_HPSE2_ENST00000404542_chr10_100249953_-_617nt ATGGGGGTGAACGCCGTGCACTGGTTCCGAAAGGGGCTCCGGCTCCACGACAACCCCGCCCTGAAGGAGTGCATTCAGGGCGCCGACACC ATCCGCTGCGTCTACATCCTGGACCCCTGGTTCGCCGGCTCCTCCAATGTGGGCATCAACAGGTGGCGGACTACTGGCTCTCTCTCCTCT ACAAGCGCCTGATCGGCCCCAAAGTCTTGGCTGTGCATGTGGCTGGGCTCCAGCGGAAGCCACGGCCTGGCCGAGTGATCCGGGACAAAC TAAGGATTTATGCTCACTGCACAAACCACCACAACCACAACTACGTTCGTGGGTCCATTACACTTTTTATCATCAACTTGCATCGATCAA GAAAGAAAATCAAGCTGGCTGGGACTCTCAGAGACAAGCTGGTTCACCAGTACCTGCTGCAGCCCTATGGGCAGGAGGGCCTAAAGTCCA AGTCAGTGCAACTGAATGGCCAGCCCTTAGTGATGGTGGACGACGGGACCCTCCCAGAATTGAAGCCCCGCCCCCTTCGGGCCGGCCGGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CRY1_ENST00000008527_chr12_107486582_-_HPSE2_ENST00000370549_chr10_100249953_-_1941nt GGGGCCTGTGGTCAACGCGATTTGCTTCCAAGGGACGGCCACCAGTCGGCACAGGAAAGGGGCAGAGGCAGTGAGTTCAGCGTGTGGACG AGGGTCAACAAGTTTGGGATCAAGCGGCTGCCGCTCCTCCAAAAGCGACCGAAGCGCGAGCAGATTACCCCTCCGAGCCAGTGTAGTAAA CACACTTCAGAAACGTGAGGTGCCGGTGGTCACGAGGGGAGCGCGCCCTCCAATGAGGAGCCGGGGGCGGGGCCGAGGCCGCTGACGCGG CGGCGGCGGCAGAGTCACCCGGGCAGCCTCGGGACCGGTCACCGGCCGGCAACCGTCCAGCGGCCTCGACCACCGCCTCTAGCCTCCGTT CCCGGTCCTTTCTCCCGGGCCGAGAGACAGCGTCGCCGACAGGGGCTCATTCCCCTCCGGTTCTCCTCGGTGACTCACCTCGGGCGGGCC GTTTTGTCTTTAGGGGCCGCCTTGGTGGGGCGAGGTTTCCGTGACGAATCTCCTGGGGCCGTCCGTGCCGGCTCGGGCCGTCGTGGCGGC TCGAGCTCCTGGAACTTGCTCAGGCTCCGGAGGTCCGAGGCCCTCGAAGTTATGCGTCGCCTCCAGGCGGTTGCGGCGGGCGCGGGCTCC TAAAGGGCGTCACACCCGGACTCCGCCGACTAGGCAACCTCCATTCATCTTTCCACTGCGCCTCCGGCGCCCCCGCCTTCTCCGGTCCCC TCCTCGGAGTCATTTTTTCCTGTTCCCCCTCTGCCGCCCTTTCCTCACGCCCCGGGTGAGGCAATTCTCTTGGAAGCGAAGGTGTCGGCT ATGAGCCGGAGCCTCCTTCCTTGAATTTCTCCGTGGAGGACCCGCCGCGCCCCCCGGCATGGGGGTGAACGCCGTGCACTGGTTCCGAAA GGGGCTCCGGCTCCACGACAACCCCGCCCTGAAGGAGTGCATTCAGGGCGCCGACACCATCCGCTGCGTCTACATCCTGGACCCCTGGTT CGCCGGCTCCTCCAATGTGGGCATCAACAGGTGGCGGACTACTGGCTCTCTCTCCTCTACAAGCGCCTGATCGGCCCCAAAGTCTTGGCT GTGCATGTGGCTGGGCTCCAGCGGAAGCCACGGCCTGGCCGAGTGATCCGGGACAAACTAAGGATTTATGCTCACTGCACAAACCACCAC AACCACAACTACGTTCGTGGGTCCATTACACTTTTTATCATCAACTTGCATCGATCAAGAAAGAAAATCAAGCTGGCTGGGACTCTCAGA GACAAGCTGGTTCACCAGTACCTGCTGCAGCCCTATGGGCAGGAGGGCCTAAAGTCCAAGTCAGTGCAACTGAATGGCCAGCCCTTAGTG ATGGTGGACGACGGGACCCTCCCAGAATTGAAGCCCCGCCCCCTTCGGGCCGGCCGGACATTGGTCATCCCTCCAGTCACCATGGGCTTT TATGTGGTCAAGAATGTCAATGCTTTGGCCTGCCGCTACCGATAAGCTATCCTCACACTCACGGCTACCAGTGGGCCTGCTGGGCTGCTT CCACTCCTCCACTCCAGTAGTATCCTCTGTTTTCAGACATCCTAGCAACCAGCCCCTGCTGCCCCATCCTGCTGGAATCAACACAGACTT GCTCTCCAAAGAGACTAAATGTCATAGCGTGATCTTAGCCTAGGTAGGCCACATCCATCCCAAAGGAAAATGTAGACATCACCTGTACCT ATATAAGGATAAAGGCATGTGTATAGAGCAGAATGTTTCCCTTCATGTGCACTATGAAAACGAGCTGACAGCACACTCCCAGGAGAAATG TTTCCAGACAACTCCCCATGATCCTGTCACACAGCATTATAACCACAAATCCAAACCTTAGCCTGCTGCTGCTGCTGCCCTCAGAGGAAG >In-frame_CRY1_ENST00000008527_chr12_107486582_-_HPSE2_ENST00000370552_chr10_100249953_-_1941nt GGGGCCTGTGGTCAACGCGATTTGCTTCCAAGGGACGGCCACCAGTCGGCACAGGAAAGGGGCAGAGGCAGTGAGTTCAGCGTGTGGACG AGGGTCAACAAGTTTGGGATCAAGCGGCTGCCGCTCCTCCAAAAGCGACCGAAGCGCGAGCAGATTACCCCTCCGAGCCAGTGTAGTAAA CACACTTCAGAAACGTGAGGTGCCGGTGGTCACGAGGGGAGCGCGCCCTCCAATGAGGAGCCGGGGGCGGGGCCGAGGCCGCTGACGCGG CGGCGGCGGCAGAGTCACCCGGGCAGCCTCGGGACCGGTCACCGGCCGGCAACCGTCCAGCGGCCTCGACCACCGCCTCTAGCCTCCGTT CCCGGTCCTTTCTCCCGGGCCGAGAGACAGCGTCGCCGACAGGGGCTCATTCCCCTCCGGTTCTCCTCGGTGACTCACCTCGGGCGGGCC GTTTTGTCTTTAGGGGCCGCCTTGGTGGGGCGAGGTTTCCGTGACGAATCTCCTGGGGCCGTCCGTGCCGGCTCGGGCCGTCGTGGCGGC TCGAGCTCCTGGAACTTGCTCAGGCTCCGGAGGTCCGAGGCCCTCGAAGTTATGCGTCGCCTCCAGGCGGTTGCGGCGGGCGCGGGCTCC TAAAGGGCGTCACACCCGGACTCCGCCGACTAGGCAACCTCCATTCATCTTTCCACTGCGCCTCCGGCGCCCCCGCCTTCTCCGGTCCCC TCCTCGGAGTCATTTTTTCCTGTTCCCCCTCTGCCGCCCTTTCCTCACGCCCCGGGTGAGGCAATTCTCTTGGAAGCGAAGGTGTCGGCT ATGAGCCGGAGCCTCCTTCCTTGAATTTCTCCGTGGAGGACCCGCCGCGCCCCCCGGCATGGGGGTGAACGCCGTGCACTGGTTCCGAAA GGGGCTCCGGCTCCACGACAACCCCGCCCTGAAGGAGTGCATTCAGGGCGCCGACACCATCCGCTGCGTCTACATCCTGGACCCCTGGTT CGCCGGCTCCTCCAATGTGGGCATCAACAGGTGGCGGACTACTGGCTCTCTCTCCTCTACAAGCGCCTGATCGGCCCCAAAGTCTTGGCT GTGCATGTGGCTGGGCTCCAGCGGAAGCCACGGCCTGGCCGAGTGATCCGGGACAAACTAAGGATTTATGCTCACTGCACAAACCACCAC AACCACAACTACGTTCGTGGGTCCATTACACTTTTTATCATCAACTTGCATCGATCAAGAAAGAAAATCAAGCTGGCTGGGACTCTCAGA GACAAGCTGGTTCACCAGTACCTGCTGCAGCCCTATGGGCAGGAGGGCCTAAAGTCCAAGTCAGTGCAACTGAATGGCCAGCCCTTAGTG ATGGTGGACGACGGGACCCTCCCAGAATTGAAGCCCCGCCCCCTTCGGGCCGGCCGGACATTGGTCATCCCTCCAGTCACCATGGGCTTT TATGTGGTCAAGAATGTCAATGCTTTGGCCTGCCGCTACCGATAAGCTATCCTCACACTCACGGCTACCAGTGGGCCTGCTGGGCTGCTT CCACTCCTCCACTCCAGTAGTATCCTCTGTTTTCAGACATCCTAGCAACCAGCCCCTGCTGCCCCATCCTGCTGGAATCAACACAGACTT GCTCTCCAAAGAGACTAAATGTCATAGCGTGATCTTAGCCTAGGTAGGCCACATCCATCCCAAAGGAAAATGTAGACATCACCTGTACCT ATATAAGGATAAAGGCATGTGTATAGAGCAGAATGTTTCCCTTCATGTGCACTATGAAAACGAGCTGACAGCACACTCCCAGGAGAAATG TTTCCAGACAACTCCCCATGATCCTGTCACACAGCATTATAACCACAAATCCAAACCTTAGCCTGCTGCTGCTGCTGCCCTCAGAGGAAG >In-frame_CRY1_ENST00000008527_chr12_107486582_-_HPSE2_ENST00000370546_chr10_100249953_-_1555nt GGGGCCTGTGGTCAACGCGATTTGCTTCCAAGGGACGGCCACCAGTCGGCACAGGAAAGGGGCAGAGGCAGTGAGTTCAGCGTGTGGACG AGGGTCAACAAGTTTGGGATCAAGCGGCTGCCGCTCCTCCAAAAGCGACCGAAGCGCGAGCAGATTACCCCTCCGAGCCAGTGTAGTAAA CACACTTCAGAAACGTGAGGTGCCGGTGGTCACGAGGGGAGCGCGCCCTCCAATGAGGAGCCGGGGGCGGGGCCGAGGCCGCTGACGCGG CGGCGGCGGCAGAGTCACCCGGGCAGCCTCGGGACCGGTCACCGGCCGGCAACCGTCCAGCGGCCTCGACCACCGCCTCTAGCCTCCGTT CCCGGTCCTTTCTCCCGGGCCGAGAGACAGCGTCGCCGACAGGGGCTCATTCCCCTCCGGTTCTCCTCGGTGACTCACCTCGGGCGGGCC GTTTTGTCTTTAGGGGCCGCCTTGGTGGGGCGAGGTTTCCGTGACGAATCTCCTGGGGCCGTCCGTGCCGGCTCGGGCCGTCGTGGCGGC TCGAGCTCCTGGAACTTGCTCAGGCTCCGGAGGTCCGAGGCCCTCGAAGTTATGCGTCGCCTCCAGGCGGTTGCGGCGGGCGCGGGCTCC TAAAGGGCGTCACACCCGGACTCCGCCGACTAGGCAACCTCCATTCATCTTTCCACTGCGCCTCCGGCGCCCCCGCCTTCTCCGGTCCCC TCCTCGGAGTCATTTTTTCCTGTTCCCCCTCTGCCGCCCTTTCCTCACGCCCCGGGTGAGGCAATTCTCTTGGAAGCGAAGGTGTCGGCT ATGAGCCGGAGCCTCCTTCCTTGAATTTCTCCGTGGAGGACCCGCCGCGCCCCCCGGCATGGGGGTGAACGCCGTGCACTGGTTCCGAAA GGGGCTCCGGCTCCACGACAACCCCGCCCTGAAGGAGTGCATTCAGGGCGCCGACACCATCCGCTGCGTCTACATCCTGGACCCCTGGTT CGCCGGCTCCTCCAATGTGGGCATCAACAGGTGGCGGACTACTGGCTCTCTCTCCTCTACAAGCGCCTGATCGGCCCCAAAGTCTTGGCT GTGCATGTGGCTGGGCTCCAGCGGAAGCCACGGCCTGGCCGAGTGATCCGGGACAAACTAAGGATTTATGCTCACTGCACAAACCACCAC AACCACAACTACGTTCGTGGGTCCATTACACTTTTTATCATCAACTTGCATCGATCAAGAAAGAAAATCAAGCTGGCTGGGACTCTCAGA GACAAGCTGGTTCACCAGTACCTGCTGCAGCCCTATGGGCAGGAGGGCCTAAAGTCCAAAACCCAAAGATGTCAATACTGTGGGATCATC TGAATCTAAAAGGGCATTACCTAATTCTTCAGAAGAAAGGTCAGTGCAACTGAATGGCCAGCCCTTAGTGATGGTGGACGACGGGACCCT CCCAGAATTGAAGCCCCGCCCCCTTCGGGCCGGCCGGACATTGGTCATCCCTCCAGTCACCATGGGCTTTTATGTGGTCAAGAATGTCAA >In-frame_CRY1_ENST00000008527_chr12_107486582_-_HPSE2_ENST00000404542_chr10_100249953_-_1485nt GGGGCCTGTGGTCAACGCGATTTGCTTCCAAGGGACGGCCACCAGTCGGCACAGGAAAGGGGCAGAGGCAGTGAGTTCAGCGTGTGGACG AGGGTCAACAAGTTTGGGATCAAGCGGCTGCCGCTCCTCCAAAAGCGACCGAAGCGCGAGCAGATTACCCCTCCGAGCCAGTGTAGTAAA CACACTTCAGAAACGTGAGGTGCCGGTGGTCACGAGGGGAGCGCGCCCTCCAATGAGGAGCCGGGGGCGGGGCCGAGGCCGCTGACGCGG CGGCGGCGGCAGAGTCACCCGGGCAGCCTCGGGACCGGTCACCGGCCGGCAACCGTCCAGCGGCCTCGACCACCGCCTCTAGCCTCCGTT CCCGGTCCTTTCTCCCGGGCCGAGAGACAGCGTCGCCGACAGGGGCTCATTCCCCTCCGGTTCTCCTCGGTGACTCACCTCGGGCGGGCC GTTTTGTCTTTAGGGGCCGCCTTGGTGGGGCGAGGTTTCCGTGACGAATCTCCTGGGGCCGTCCGTGCCGGCTCGGGCCGTCGTGGCGGC TCGAGCTCCTGGAACTTGCTCAGGCTCCGGAGGTCCGAGGCCCTCGAAGTTATGCGTCGCCTCCAGGCGGTTGCGGCGGGCGCGGGCTCC TAAAGGGCGTCACACCCGGACTCCGCCGACTAGGCAACCTCCATTCATCTTTCCACTGCGCCTCCGGCGCCCCCGCCTTCTCCGGTCCCC TCCTCGGAGTCATTTTTTCCTGTTCCCCCTCTGCCGCCCTTTCCTCACGCCCCGGGTGAGGCAATTCTCTTGGAAGCGAAGGTGTCGGCT ATGAGCCGGAGCCTCCTTCCTTGAATTTCTCCGTGGAGGACCCGCCGCGCCCCCCGGCATGGGGGTGAACGCCGTGCACTGGTTCCGAAA GGGGCTCCGGCTCCACGACAACCCCGCCCTGAAGGAGTGCATTCAGGGCGCCGACACCATCCGCTGCGTCTACATCCTGGACCCCTGGTT CGCCGGCTCCTCCAATGTGGGCATCAACAGGTGGCGGACTACTGGCTCTCTCTCCTCTACAAGCGCCTGATCGGCCCCAAAGTCTTGGCT GTGCATGTGGCTGGGCTCCAGCGGAAGCCACGGCCTGGCCGAGTGATCCGGGACAAACTAAGGATTTATGCTCACTGCACAAACCACCAC AACCACAACTACGTTCGTGGGTCCATTACACTTTTTATCATCAACTTGCATCGATCAAGAAAGAAAATCAAGCTGGCTGGGACTCTCAGA GACAAGCTGGTTCACCAGTACCTGCTGCAGCCCTATGGGCAGGAGGGCCTAAAGTCCAAGTCAGTGCAACTGAATGGCCAGCCCTTAGTG ATGGTGGACGACGGGACCCTCCCAGAATTGAAGCCCCGCCCCCTTCGGGCCGGCCGGACATTGGTCATCCCTCCAGTCACCATGGGCTTT |
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FusionGenePPI for CRY1_HPSE2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CRY1 | PER1, PER2, ARNTL, PLSCR1, CBLB, MDFI, KRTAP4-12, TRAF2, CRY1, USP2, FBXL3, BTRC, SKP1, CUL1, GRN, SNRPD3, LTBP4, FBXL21, CSNK1E, CLOCK, CSNK2B, DEC1, BHLHE41, NPAS2, PPP2R5E, PPP2R1B, PPP2R5D, NR1D2, QPRT, TEKT4, AP2M1, XPO1, JAK3, KIF20B, BAIAP2, SYNCRIP, TGS1, NEDD1, BAG6, USP7, HNRNPH1, PTBP1, PRKDC, EEF1A1, EEF2, HNRNPK, YWHAE, HNRNPH2, HNRNPF, SDHA, LRPPRC, EIF4A1, PRDX1, PPP2R1A, YWHAZ, HUWE1, CRY2, TUBB, EPRS, KHDRBS1, NPM1, FLNA, RPS27A, PABPC1, IMMT, EIF4A2, YWHAQ, TCP1, NASP, CCT8, USP9X, ATP5A1, PSMC4, PPP2CB, PCBP1, ALDH9A1, YWHAB, SLC25A5, PSMC6, CCT4, MATR3, MYCBP2, RUVBL1, PSMC5, MTHFD1, DNAJA1, RPS14, ILF3, HNRNPU, UBA1, HSPA5, UBB, ACLY, IMPDH2, RARS, PAICS, FASN, IARS, USP11, PRDX4, RUVBL2, KRT10, CCT6A, PSMC1, PSMD3, MCM7, HSPA1A, KRT2, PKM, EFTUD2, HSPA1B, TRIM28, HNRNPL, MCM3, SCYL2, HNRNPA3, NDUFS3, GMPS, SFPQ, KPNB1, DARS, GARS, PPAT, PRMT5, RPS3, RPL10, MARS, C1QBP, MCM4, TXN, PSMD11, XRCC5, WDR77, PABPC4, YWHAH, PABPC3, FOXO1, RGS20, CSNK1D | HPSE2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | CRY1 | chr12:107486582 | chr10:100249953 | ENST00000008527 | - | 1 | 13 | 471_493 | 52 | 456 | TIMELESS |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CRY1_HPSE2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CRY1_HPSE2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CRY1 | C0005586 | Bipolar Disorder | 3 | PSYGENET |
| Hgene | CRY1 | C0011581 | Depressive disorder | 2 | PSYGENET |
| Hgene | CRY1 | C0011570 | Mental Depression | 1 | PSYGENET |
| Hgene | CRY1 | C0023473 | Myeloid Leukemia, Chronic | 1 | CTD_human |
| Hgene | CRY1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | CRY1 | C0085159 | Seasonal Affective Disorder | 1 | PSYGENET |
| Tgene | HPSE2 | C0403555 | Ochoa syndrome | 1 | CTD_human;ORPHANET |
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