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Fusion gene ID: 8537 |
FusionGeneSummary for CRTC3_MAML2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CRTC3_MAML2 | Fusion gene ID: 8537 | Hgene | Tgene | Gene symbol | CRTC3 | MAML2 | Gene ID | 64784 | 84441 |
| Gene name | CREB regulated transcription coactivator 3 | mastermind like transcriptional coactivator 2 | |
| Synonyms | TORC-3|TORC3 | MAM-3|MAM2|MAM3|MLL-MAML2 | |
| Cytomap | 15q26.1 | 11q21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CREB-regulated transcription coactivator 3transducer of regulated CREB protein 3transducer of regulated cAMP response element-binding protein (CREB) 3 | mastermind-like protein 2mam-2mastermind-like 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q6UUV7 | Q8IZL2 | |
| Ensembl transtripts involved in fusion gene | ENST00000420329, ENST00000560098, ENST00000268184, ENST00000558619, | ENST00000524717, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 10 X 12 X 4=480 |
| # samples | 4 | 16 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/480*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CRTC3 [Title/Abstract] AND MAML2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MAML2 | GO:0007219 | Notch signaling pathway | 12370315 |
| Tgene | MAML2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12370315 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | EU048224 | CRTC3 | chr15 | 91073435 | + | MAML2 | chr11 | 95826682 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000420329 | ENST00000524717 | CRTC3 | chr15 | 91073435 | + | MAML2 | chr11 | 95826682 | - |
| In-frame | ENST00000560098 | ENST00000524717 | CRTC3 | chr15 | 91073435 | + | MAML2 | chr11 | 95826682 | - |
| In-frame | ENST00000268184 | ENST00000524717 | CRTC3 | chr15 | 91073435 | + | MAML2 | chr11 | 95826682 | - |
| intron-3CDS | ENST00000558619 | ENST00000524717 | CRTC3 | chr15 | 91073435 | + | MAML2 | chr11 | 95826682 | - |
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FusionProtFeatures for CRTC3_MAML2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CRTC3 | MAML2 |
| Transcriptional coactivator for CREB1 which activatestranscription through both consensus and variant cAMP responseelement (CRE) sites. Acts as a coactivator, in the SIK/TORCsignaling pathway, being active when dephosphorylated and actsindependently of CREB1 'Ser-133' phosphorylation. Enhances theinteraction of CREB1 with TAF4. Regulates the expression ofspecific CREB-activated genes such as the steroidogenic gene,StAR. Potent coactivator of PPARGC1A and inducer of mitochondrialbiogenesis in muscle cells. Also coactivator for TAX activation ofthe human T-cell leukemia virus type 1 (HTLV-1) long terminalrepeats (LTR). {ECO:0000269|PubMed:14506290,ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468,ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408,ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}. | Acts as a transcriptional coactivator for NOTCHproteins. Has been shown to amplify NOTCH-induced transcription ofHES1. Potentiates activation by NOTCH3 and NOTCH4 more efficientlythan MAML1 or MAML3. {ECO:0000269|PubMed:12370315,ECO:0000269|PubMed:12386158, ECO:0000269|PubMed:12539049}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CRTC3 | chr15:91073435 | chr11:95826682 | ENST00000268184 | + | 1 | 15 | 180_183 | 44 | 620 | Compositional bias | Note=Poly-Gly |
| Hgene | >CRTC3 | chr15:91073435 | chr11:95826682 | ENST00000268184 | + | 1 | 15 | 444_451 | 44 | 620 | Compositional bias | Note=Poly-Pro |
| Hgene | >CRTC3 | chr15:91073435 | chr11:95826682 | ENST00000420329 | + | 1 | 15 | 180_183 | 44 | 619 | Compositional bias | Note=Poly-Gly |
| Hgene | >CRTC3 | chr15:91073435 | chr11:95826682 | ENST00000420329 | + | 1 | 15 | 444_451 | 44 | 619 | Compositional bias | Note=Poly-Pro |
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FusionGeneSequence for CRTC3_MAML2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CRTC3_ENST00000420329_chr15_91073435_+_MAML2_ENST00000524717_chr11_95826682_-_1030aa MAASPGSGSANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRLQGSLKRKQVVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQG GLQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGLFNMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQ ELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSA LSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQ QTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPS QNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPS SQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKK QTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSS LLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLR PNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMR PMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTDHSSDLAFDFLSQQNDN >In-frame_CRTC3_ENST00000560098_chr15_91073435_+_MAML2_ENST00000524717_chr11_95826682_-_1030aa MAASPGSGSANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRLQGSLKRKQVVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQG GLQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGLFNMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQ ELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSA LSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQ QTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPS QNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPS SQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKK QTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSS LLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLR PNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMR PMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTDHSSDLAFDFLSQQNDN >In-frame_CRTC3_ENST00000268184_chr15_91073435_+_MAML2_ENST00000524717_chr11_95826682_-_1030aa MAASPGSGSANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRLQGSLKRKQVVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQG GLQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGLFNMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQ ELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSA LSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQ QTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPS QNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPS SQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKK QTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSS LLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLR PNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMR PMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTDHSSDLAFDFLSQQNDN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CRTC3_ENST00000420329_chr15_91073435_+_MAML2_ENST00000524717_chr11_95826682_-_3090nt ATGGCCGCCTCGCCGGGCTCGGGCAGCGCCAACCCGCGGAAGTTCAGTGAGAAGATCGCGCTGCACACGCAGAGACAGGCCGAGGAGACG CGGGCCTTCGAGCAGCTCATGACCGACCTCACCCTGTCGCGGCTCCAGGGTTCCTTGAAAAGAAAACAGGTAGTTAACCTATCTCCTGCC AACAGCAAGCGACCCAATGGCTTTGTGGACAACTCATTTCTTGATATCAAAAGAATTCGTGTTGGGGAGAATCTCTCTGCAGGACAAGGT GGCCTCCAAATAAACAATGGACAAAGTCAGATTATGTCAGGGACCTTGCCTATGAGCCAAGCACCCCTGCGAAAGACTAACACTCTGCCA TCCCATACACATTCTCCTGGCAATGGCCTGTTTAACATGGGCTTAAAGGAGGTAAAGAAGGAGCCAGGAGAGACTCTGTCTTGCAGTAAG CACATGGATGGCCAAATGACCCAAGAGAATATTTTTCCTAATAGGTACGGAGACGACCCTGGAGAACAACTGATGGATCCTGAGCTGCAG GAACTGTTCAATGAACTGACCAACATATCTGTGCCTCCCATGAGTGACCTTGAACTGGAGAACATGATCAATGCCACCATAAAGCAGGAT GACCCATTTAACATTGACTTGGGTCAGCAAAGCCAGAGGAGCACACCTAGGCCCTCCTTACCCATGGAGAAAATAGTGATCAAAAGTGAA TACTCACCGGGCTTGACTCAGGGCCCCTCAGGCTCTCCTCAGCTGAGGCCCCCATCAGCTGGCCCCGCATTCTCCATGGCCAACTCTGCC CTCTCCACTTCGTCTCCAATCCCTTCAGTCCCTCAGAGCCAGGCTCAGCCTCAGACAGGCTCCGGAGCAAGCCGGGCCTTGCCAAGCTGG CAGGAAGTATCCCATGCCCAGCAGCTCAAACAGATAGCTGCTAATCGTCAGCAGCATGCCCGGATGCAGCAGCACCAGCAGCAGCACCAG CCTACCAACTGGTCAGCCTTGCCCTCTTCTGCTGGACCATCACCAGGTCCATTTGGGCAGGAGAAAATCCCCAGCCCTTCTTTTGGTCAG CAGACATTCAGCCCACAGAGCTCCCCCATGCCTGGGGTAGCTGGCGGCAGCGGCCAGTCGAAAGTAATGGCTAACTACATGTACAAGGCC GGCCCCTCAGCCCAGGGTGGGCACCTAGATGTCCTCATGCAGCAAAAGCCTCAGGATCTCAGTCGAAGTTTTATTAACAACCCGCACCCA GCCATGGAGCCCCGTCAGGGCAACACCAAGCCTTTGTTTCATTTTAACTCAGATCAAGCGAACCAGCAGATGCCTTCTGTTTTGCCTTCC CAGAACAAGCCTTCTCTCCTACACTACACCCAACAGCAACAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAA CAGCAGCAGCAGCAGCAACAGCAACAGCAACAGCAACAGCAGAGTTCAATTTCAGCTCAACAACAGCAACAGCAGCAGAGCTCAATTTCA GCCCAACAGCAGCAGCAGCAGCAACAACAGCAGCAGCAGCAGCAACAACAACAGCAACAACAGCAGCAGCAGCAGCAGCAACAACCATCT TCTCAGCCTGCCCAATCTCTACCAAGCCAGCCTTTGCTAAGGTCACCTTTGCCACTTCAGCAAAAGCTCCTACTTCAGCAAATGCAGAAT CAGCCCATTGCAGGAATGGGATACCAAGTCTCCCAACAACAGAGACAGGATCAACACTCTGTGGTAGGCCAGAACACAGGCCCCAGTCCA AGTCCTAACCCCTGCTCAAATCCAAACACTGGAAGTGGTTACATGAACTCCCAGCAATCACTGTTGAATCAGCAATTGATGGGAAAGAAG CAGACTCTACAGAGGCAGATCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGCAGATGCTGGCTGACGCGGAGAAAATTGCTCCACAA GATCAGATAAACCGACATTTGTCAAGGCCACCTCCAGATTATAAAGACCAAAGAAGAAATGTGGGCAATATGCAACCAACTGCTCAGTAT TCTGGTGGCTCATCCACAATAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAGTTTCAACACACACCATTTTAACTCCCAATTCCAGC CTCCTGTCTACTTCTCACGGGACAAGAATGCCATCATTATCTACAGCAGTTCAGAATATGGGGATGTATGGAAATCTGCCTTGTAATCAA CCTAACACATACAGTGTCACTTCAGGAATGAATCAATTGACCCAACAGAGAAACCCAAAGCAATTGTTAGCAAATCAAAACAACCCTATG ATGCCACGGCCACCTACCTTAGGGCCAAGTAATAATAACAATGTAGCCACTTTTGGAGCTGGATCTGTTGGTAATTCACAACAATTGAGA CCAAATTTAACCCATAGTATGGCAAGCATGCCACCACAGAGAACATCAAACGTAATGATCACATCCAACACAACTGCACCAAACTGGGCC TCTCAAGAAGGAACAAGCAAACAGCAAGAAGCCCTGACGTCTGCAGGAGTCCGCTTCCCCACAGGTACACCTGCAGCCTATACCCCAAAT CAGTCACTGCAACAGGCAGTAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTCCTCCTAACCAGTTAACACCAGCAGTGCAAATGAGA CCCATGAACCAAATGAGCCAAACACTAAATGGGCAAACCATGGGTCCCCTCAGGGGTCTGAATCTCAGACCCAATCAGCTAAGCACACAG ATTTTGCCTAATTTGAATCAGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCATCAACCAGCCACCATCCCTGACGCCCAGCAATTTT CCTTCACCCAACCAAAGTTCCAGGGCTTTTCAAGGAACTGACCACAGCAGTGACTTAGCTTTTGACTTCCTCAGCCAACAAAATGATAAC ATGGGCCCTGCCCTAAACAGTGATGCTGATTTCATTGATTCTTTATTGAAGACAGAGCCTGGTAATGATGACTGGATGAAAGACATCAAT >In-frame_CRTC3_ENST00000560098_chr15_91073435_+_MAML2_ENST00000524717_chr11_95826682_-_3090nt ATGGCCGCCTCGCCGGGCTCGGGCAGCGCCAACCCGCGGAAGTTCAGTGAGAAGATCGCGCTGCACACGCAGAGACAGGCCGAGGAGACG CGGGCCTTCGAGCAGCTCATGACCGACCTCACCCTGTCGCGGCTCCAGGGTTCCTTGAAAAGAAAACAGGTAGTTAACCTATCTCCTGCC AACAGCAAGCGACCCAATGGCTTTGTGGACAACTCATTTCTTGATATCAAAAGAATTCGTGTTGGGGAGAATCTCTCTGCAGGACAAGGT GGCCTCCAAATAAACAATGGACAAAGTCAGATTATGTCAGGGACCTTGCCTATGAGCCAAGCACCCCTGCGAAAGACTAACACTCTGCCA TCCCATACACATTCTCCTGGCAATGGCCTGTTTAACATGGGCTTAAAGGAGGTAAAGAAGGAGCCAGGAGAGACTCTGTCTTGCAGTAAG CACATGGATGGCCAAATGACCCAAGAGAATATTTTTCCTAATAGGTACGGAGACGACCCTGGAGAACAACTGATGGATCCTGAGCTGCAG GAACTGTTCAATGAACTGACCAACATATCTGTGCCTCCCATGAGTGACCTTGAACTGGAGAACATGATCAATGCCACCATAAAGCAGGAT GACCCATTTAACATTGACTTGGGTCAGCAAAGCCAGAGGAGCACACCTAGGCCCTCCTTACCCATGGAGAAAATAGTGATCAAAAGTGAA TACTCACCGGGCTTGACTCAGGGCCCCTCAGGCTCTCCTCAGCTGAGGCCCCCATCAGCTGGCCCCGCATTCTCCATGGCCAACTCTGCC CTCTCCACTTCGTCTCCAATCCCTTCAGTCCCTCAGAGCCAGGCTCAGCCTCAGACAGGCTCCGGAGCAAGCCGGGCCTTGCCAAGCTGG CAGGAAGTATCCCATGCCCAGCAGCTCAAACAGATAGCTGCTAATCGTCAGCAGCATGCCCGGATGCAGCAGCACCAGCAGCAGCACCAG CCTACCAACTGGTCAGCCTTGCCCTCTTCTGCTGGACCATCACCAGGTCCATTTGGGCAGGAGAAAATCCCCAGCCCTTCTTTTGGTCAG CAGACATTCAGCCCACAGAGCTCCCCCATGCCTGGGGTAGCTGGCGGCAGCGGCCAGTCGAAAGTAATGGCTAACTACATGTACAAGGCC GGCCCCTCAGCCCAGGGTGGGCACCTAGATGTCCTCATGCAGCAAAAGCCTCAGGATCTCAGTCGAAGTTTTATTAACAACCCGCACCCA GCCATGGAGCCCCGTCAGGGCAACACCAAGCCTTTGTTTCATTTTAACTCAGATCAAGCGAACCAGCAGATGCCTTCTGTTTTGCCTTCC CAGAACAAGCCTTCTCTCCTACACTACACCCAACAGCAACAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAA CAGCAGCAGCAGCAGCAACAGCAACAGCAACAGCAACAGCAGAGTTCAATTTCAGCTCAACAACAGCAACAGCAGCAGAGCTCAATTTCA GCCCAACAGCAGCAGCAGCAGCAACAACAGCAGCAGCAGCAGCAACAACAACAGCAACAACAGCAGCAGCAGCAGCAGCAACAACCATCT TCTCAGCCTGCCCAATCTCTACCAAGCCAGCCTTTGCTAAGGTCACCTTTGCCACTTCAGCAAAAGCTCCTACTTCAGCAAATGCAGAAT CAGCCCATTGCAGGAATGGGATACCAAGTCTCCCAACAACAGAGACAGGATCAACACTCTGTGGTAGGCCAGAACACAGGCCCCAGTCCA AGTCCTAACCCCTGCTCAAATCCAAACACTGGAAGTGGTTACATGAACTCCCAGCAATCACTGTTGAATCAGCAATTGATGGGAAAGAAG CAGACTCTACAGAGGCAGATCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGCAGATGCTGGCTGACGCGGAGAAAATTGCTCCACAA GATCAGATAAACCGACATTTGTCAAGGCCACCTCCAGATTATAAAGACCAAAGAAGAAATGTGGGCAATATGCAACCAACTGCTCAGTAT TCTGGTGGCTCATCCACAATAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAGTTTCAACACACACCATTTTAACTCCCAATTCCAGC CTCCTGTCTACTTCTCACGGGACAAGAATGCCATCATTATCTACAGCAGTTCAGAATATGGGGATGTATGGAAATCTGCCTTGTAATCAA CCTAACACATACAGTGTCACTTCAGGAATGAATCAATTGACCCAACAGAGAAACCCAAAGCAATTGTTAGCAAATCAAAACAACCCTATG ATGCCACGGCCACCTACCTTAGGGCCAAGTAATAATAACAATGTAGCCACTTTTGGAGCTGGATCTGTTGGTAATTCACAACAATTGAGA CCAAATTTAACCCATAGTATGGCAAGCATGCCACCACAGAGAACATCAAACGTAATGATCACATCCAACACAACTGCACCAAACTGGGCC TCTCAAGAAGGAACAAGCAAACAGCAAGAAGCCCTGACGTCTGCAGGAGTCCGCTTCCCCACAGGTACACCTGCAGCCTATACCCCAAAT CAGTCACTGCAACAGGCAGTAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTCCTCCTAACCAGTTAACACCAGCAGTGCAAATGAGA CCCATGAACCAAATGAGCCAAACACTAAATGGGCAAACCATGGGTCCCCTCAGGGGTCTGAATCTCAGACCCAATCAGCTAAGCACACAG ATTTTGCCTAATTTGAATCAGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCATCAACCAGCCACCATCCCTGACGCCCAGCAATTTT CCTTCACCCAACCAAAGTTCCAGGGCTTTTCAAGGAACTGACCACAGCAGTGACTTAGCTTTTGACTTCCTCAGCCAACAAAATGATAAC ATGGGCCCTGCCCTAAACAGTGATGCTGATTTCATTGATTCTTTATTGAAGACAGAGCCTGGTAATGATGACTGGATGAAAGACATCAAT >In-frame_CRTC3_ENST00000268184_chr15_91073435_+_MAML2_ENST00000524717_chr11_95826682_-_3090nt ATGGCCGCCTCGCCGGGCTCGGGCAGCGCCAACCCGCGGAAGTTCAGTGAGAAGATCGCGCTGCACACGCAGAGACAGGCCGAGGAGACG CGGGCCTTCGAGCAGCTCATGACCGACCTCACCCTGTCGCGGCTCCAGGGTTCCTTGAAAAGAAAACAGGTAGTTAACCTATCTCCTGCC AACAGCAAGCGACCCAATGGCTTTGTGGACAACTCATTTCTTGATATCAAAAGAATTCGTGTTGGGGAGAATCTCTCTGCAGGACAAGGT GGCCTCCAAATAAACAATGGACAAAGTCAGATTATGTCAGGGACCTTGCCTATGAGCCAAGCACCCCTGCGAAAGACTAACACTCTGCCA TCCCATACACATTCTCCTGGCAATGGCCTGTTTAACATGGGCTTAAAGGAGGTAAAGAAGGAGCCAGGAGAGACTCTGTCTTGCAGTAAG CACATGGATGGCCAAATGACCCAAGAGAATATTTTTCCTAATAGGTACGGAGACGACCCTGGAGAACAACTGATGGATCCTGAGCTGCAG GAACTGTTCAATGAACTGACCAACATATCTGTGCCTCCCATGAGTGACCTTGAACTGGAGAACATGATCAATGCCACCATAAAGCAGGAT GACCCATTTAACATTGACTTGGGTCAGCAAAGCCAGAGGAGCACACCTAGGCCCTCCTTACCCATGGAGAAAATAGTGATCAAAAGTGAA TACTCACCGGGCTTGACTCAGGGCCCCTCAGGCTCTCCTCAGCTGAGGCCCCCATCAGCTGGCCCCGCATTCTCCATGGCCAACTCTGCC CTCTCCACTTCGTCTCCAATCCCTTCAGTCCCTCAGAGCCAGGCTCAGCCTCAGACAGGCTCCGGAGCAAGCCGGGCCTTGCCAAGCTGG CAGGAAGTATCCCATGCCCAGCAGCTCAAACAGATAGCTGCTAATCGTCAGCAGCATGCCCGGATGCAGCAGCACCAGCAGCAGCACCAG CCTACCAACTGGTCAGCCTTGCCCTCTTCTGCTGGACCATCACCAGGTCCATTTGGGCAGGAGAAAATCCCCAGCCCTTCTTTTGGTCAG CAGACATTCAGCCCACAGAGCTCCCCCATGCCTGGGGTAGCTGGCGGCAGCGGCCAGTCGAAAGTAATGGCTAACTACATGTACAAGGCC GGCCCCTCAGCCCAGGGTGGGCACCTAGATGTCCTCATGCAGCAAAAGCCTCAGGATCTCAGTCGAAGTTTTATTAACAACCCGCACCCA GCCATGGAGCCCCGTCAGGGCAACACCAAGCCTTTGTTTCATTTTAACTCAGATCAAGCGAACCAGCAGATGCCTTCTGTTTTGCCTTCC CAGAACAAGCCTTCTCTCCTACACTACACCCAACAGCAACAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAA CAGCAGCAGCAGCAGCAACAGCAACAGCAACAGCAACAGCAGAGTTCAATTTCAGCTCAACAACAGCAACAGCAGCAGAGCTCAATTTCA GCCCAACAGCAGCAGCAGCAGCAACAACAGCAGCAGCAGCAGCAACAACAACAGCAACAACAGCAGCAGCAGCAGCAGCAACAACCATCT TCTCAGCCTGCCCAATCTCTACCAAGCCAGCCTTTGCTAAGGTCACCTTTGCCACTTCAGCAAAAGCTCCTACTTCAGCAAATGCAGAAT CAGCCCATTGCAGGAATGGGATACCAAGTCTCCCAACAACAGAGACAGGATCAACACTCTGTGGTAGGCCAGAACACAGGCCCCAGTCCA AGTCCTAACCCCTGCTCAAATCCAAACACTGGAAGTGGTTACATGAACTCCCAGCAATCACTGTTGAATCAGCAATTGATGGGAAAGAAG CAGACTCTACAGAGGCAGATCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGCAGATGCTGGCTGACGCGGAGAAAATTGCTCCACAA GATCAGATAAACCGACATTTGTCAAGGCCACCTCCAGATTATAAAGACCAAAGAAGAAATGTGGGCAATATGCAACCAACTGCTCAGTAT TCTGGTGGCTCATCCACAATAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAGTTTCAACACACACCATTTTAACTCCCAATTCCAGC CTCCTGTCTACTTCTCACGGGACAAGAATGCCATCATTATCTACAGCAGTTCAGAATATGGGGATGTATGGAAATCTGCCTTGTAATCAA CCTAACACATACAGTGTCACTTCAGGAATGAATCAATTGACCCAACAGAGAAACCCAAAGCAATTGTTAGCAAATCAAAACAACCCTATG ATGCCACGGCCACCTACCTTAGGGCCAAGTAATAATAACAATGTAGCCACTTTTGGAGCTGGATCTGTTGGTAATTCACAACAATTGAGA CCAAATTTAACCCATAGTATGGCAAGCATGCCACCACAGAGAACATCAAACGTAATGATCACATCCAACACAACTGCACCAAACTGGGCC TCTCAAGAAGGAACAAGCAAACAGCAAGAAGCCCTGACGTCTGCAGGAGTCCGCTTCCCCACAGGTACACCTGCAGCCTATACCCCAAAT CAGTCACTGCAACAGGCAGTAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTCCTCCTAACCAGTTAACACCAGCAGTGCAAATGAGA CCCATGAACCAAATGAGCCAAACACTAAATGGGCAAACCATGGGTCCCCTCAGGGGTCTGAATCTCAGACCCAATCAGCTAAGCACACAG ATTTTGCCTAATTTGAATCAGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCATCAACCAGCCACCATCCCTGACGCCCAGCAATTTT CCTTCACCCAACCAAAGTTCCAGGGCTTTTCAAGGAACTGACCACAGCAGTGACTTAGCTTTTGACTTCCTCAGCCAACAAAATGATAAC ATGGGCCCTGCCCTAAACAGTGATGCTGATTTCATTGATTCTTTATTGAAGACAGAGCCTGGTAATGATGACTGGATGAAAGACATCAAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CRTC3_ENST00000420329_chr15_91073435_+_MAML2_ENST00000524717_chr11_95826682_-_5587nt CTCCGGGGCCGCGGCGGCTCCTCTGCCGGGTCGCGCCGGACGACTGGCTTCGGGCGGCGGCCCCGGCGGCCTGTGGACGGACGGGTGGGC CGAGGTACAGGCCCCACGGCCGCCGTCTCCCGCTTCTGCCCGCGCAGAGTCCGCGCCATGGCCGCCTCGCCGGGCTCGGGCAGCGCCAAC CCGCGGAAGTTCAGTGAGAAGATCGCGCTGCACACGCAGAGACAGGCCGAGGAGACGCGGGCCTTCGAGCAGCTCATGACCGACCTCACC CTGTCGCGGCTCCAGGGTTCCTTGAAAAGAAAACAGGTAGTTAACCTATCTCCTGCCAACAGCAAGCGACCCAATGGCTTTGTGGACAAC TCATTTCTTGATATCAAAAGAATTCGTGTTGGGGAGAATCTCTCTGCAGGACAAGGTGGCCTCCAAATAAACAATGGACAAAGTCAGATT ATGTCAGGGACCTTGCCTATGAGCCAAGCACCCCTGCGAAAGACTAACACTCTGCCATCCCATACACATTCTCCTGGCAATGGCCTGTTT AACATGGGCTTAAAGGAGGTAAAGAAGGAGCCAGGAGAGACTCTGTCTTGCAGTAAGCACATGGATGGCCAAATGACCCAAGAGAATATT TTTCCTAATAGGTACGGAGACGACCCTGGAGAACAACTGATGGATCCTGAGCTGCAGGAACTGTTCAATGAACTGACCAACATATCTGTG CCTCCCATGAGTGACCTTGAACTGGAGAACATGATCAATGCCACCATAAAGCAGGATGACCCATTTAACATTGACTTGGGTCAGCAAAGC CAGAGGAGCACACCTAGGCCCTCCTTACCCATGGAGAAAATAGTGATCAAAAGTGAATACTCACCGGGCTTGACTCAGGGCCCCTCAGGC TCTCCTCAGCTGAGGCCCCCATCAGCTGGCCCCGCATTCTCCATGGCCAACTCTGCCCTCTCCACTTCGTCTCCAATCCCTTCAGTCCCT CAGAGCCAGGCTCAGCCTCAGACAGGCTCCGGAGCAAGCCGGGCCTTGCCAAGCTGGCAGGAAGTATCCCATGCCCAGCAGCTCAAACAG ATAGCTGCTAATCGTCAGCAGCATGCCCGGATGCAGCAGCACCAGCAGCAGCACCAGCCTACCAACTGGTCAGCCTTGCCCTCTTCTGCT GGACCATCACCAGGTCCATTTGGGCAGGAGAAAATCCCCAGCCCTTCTTTTGGTCAGCAGACATTCAGCCCACAGAGCTCCCCCATGCCT GGGGTAGCTGGCGGCAGCGGCCAGTCGAAAGTAATGGCTAACTACATGTACAAGGCCGGCCCCTCAGCCCAGGGTGGGCACCTAGATGTC CTCATGCAGCAAAAGCCTCAGGATCTCAGTCGAAGTTTTATTAACAACCCGCACCCAGCCATGGAGCCCCGTCAGGGCAACACCAAGCCT TTGTTTCATTTTAACTCAGATCAAGCGAACCAGCAGATGCCTTCTGTTTTGCCTTCCCAGAACAAGCCTTCTCTCCTACACTACACCCAA CAGCAACAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAGCAGCAACAGCAACAGCAACAG CAACAGCAGAGTTCAATTTCAGCTCAACAACAGCAACAGCAGCAGAGCTCAATTTCAGCCCAACAGCAGCAGCAGCAGCAACAACAGCAG CAGCAGCAGCAACAACAACAGCAACAACAGCAGCAGCAGCAGCAGCAACAACCATCTTCTCAGCCTGCCCAATCTCTACCAAGCCAGCCT TTGCTAAGGTCACCTTTGCCACTTCAGCAAAAGCTCCTACTTCAGCAAATGCAGAATCAGCCCATTGCAGGAATGGGATACCAAGTCTCC CAACAACAGAGACAGGATCAACACTCTGTGGTAGGCCAGAACACAGGCCCCAGTCCAAGTCCTAACCCCTGCTCAAATCCAAACACTGGA AGTGGTTACATGAACTCCCAGCAATCACTGTTGAATCAGCAATTGATGGGAAAGAAGCAGACTCTACAGAGGCAGATCATGGAGCAGAAA CAGCAACTTCTTCTCCAGCAGCAGATGCTGGCTGACGCGGAGAAAATTGCTCCACAAGATCAGATAAACCGACATTTGTCAAGGCCACCT CCAGATTATAAAGACCAAAGAAGAAATGTGGGCAATATGCAACCAACTGCTCAGTATTCTGGTGGCTCATCCACAATAAGCTTAAACTCT AACCAGGCTTTGGCAAACCCAGTTTCAACACACACCATTTTAACTCCCAATTCCAGCCTCCTGTCTACTTCTCACGGGACAAGAATGCCA TCATTATCTACAGCAGTTCAGAATATGGGGATGTATGGAAATCTGCCTTGTAATCAACCTAACACATACAGTGTCACTTCAGGAATGAAT CAATTGACCCAACAGAGAAACCCAAAGCAATTGTTAGCAAATCAAAACAACCCTATGATGCCACGGCCACCTACCTTAGGGCCAAGTAAT AATAACAATGTAGCCACTTTTGGAGCTGGATCTGTTGGTAATTCACAACAATTGAGACCAAATTTAACCCATAGTATGGCAAGCATGCCA CCACAGAGAACATCAAACGTAATGATCACATCCAACACAACTGCACCAAACTGGGCCTCTCAAGAAGGAACAAGCAAACAGCAAGAAGCC CTGACGTCTGCAGGAGTCCGCTTCCCCACAGGTACACCTGCAGCCTATACCCCAAATCAGTCACTGCAACAGGCAGTAGGTAGCCAGCAA TTTTCCCAGAGGGCAGTGGCTCCTCCTAACCAGTTAACACCAGCAGTGCAAATGAGACCCATGAACCAAATGAGCCAAACACTAAATGGG CAAACCATGGGTCCCCTCAGGGGTCTGAATCTCAGACCCAATCAGCTAAGCACACAGATTTTGCCTAATTTGAATCAGTCAGGAACAGGG TTGAATCAGTCGAGGACGGGCATCAACCAGCCACCATCCCTGACGCCCAGCAATTTTCCTTCACCCAACCAAAGTTCCAGGGCTTTTCAA GGAACTGACCACAGCAGTGACTTAGCTTTTGACTTCCTCAGCCAACAAAATGATAACATGGGCCCTGCCCTAAACAGTGATGCTGATTTC ATTGATTCTTTATTGAAGACAGAGCCTGGTAATGATGACTGGATGAAAGACATCAATCTTGATGAAATCTTGGGGAACAATTCCTAAAGA AGAAAGGGAAGACAATTTACAAACTCCAAGCACTAAAAGGCAGTATATTACAGAAACTCTGTAGAGGCTGAACTGTTGATGTTCAGGTGG ACTACATGAAGATAACATGCTTAAAAATGGAAAGCAGAAAGTAACTGCAGTGATGAACATTTTGGTCCAAATTCTTGTTTTAAATCTTAC ACCTGAAAGTAAAATATTGGGATCACTTTTCCCTGTCTAAACTCCAGGATACAGTATCCAATTTATCCAAACAGAACTGTGGTGTCAATG TGTAATTAATTGTGTAAAATAGCCTTCCCAAGTTTCTTTTTCCCTGGAAAATAAAAAAGGTAATAGAACTTGTAGTTTATTTAAACCCCA TGTCATGAGGAGGTACTAGTTCCAAGCAACAAACTCCTTAATTTGCTCTAATAGATAGGTATGGTTTAATCTTTCCATTGTGTCTTTTCA TTTAATTTTCCTGAAGCTTGCAGGATAGATTGAAATGTTATAGGTTTGTTTGGAGTAACCAAACAGTATGCAAATTAAGAAAAAGCCAGA GAACCTAGAAAACATCCAGTGGATTACAGAATTTCTTCCCCATATTCACTCCTCACTTTTACAATTTTCCCACAATCCTCTACTTCAGTG GGATGCTGTGTCTAGTGATTAAACAAAAATATAGAGCTGTGCAATTTGATTTTGGCTTCCACAACGAATATCTGAATCCATTCCAAATGA AATTTTAGATATAACAAAGACTTGTCCTAATCATACTGAAATATTGGTGCACACCTCTCTGCATTAGATTTCACTTTTTTAAAAAACCCA GTGGACATTGCTATAAATAAGATTTATTTGGCTACAAATAACCTGGGATGTTGCTTATTATGATTGATGCCTGCTGGTTTGTTCCCAAGC TGAGTGAAATTGAACCTCGTCCTCCCTACTCATTTTGATGACTGAGGCTGGTTTATAAGAAAAGGAAGTTTGGAGAAGAAAACCGAGATT AGAAAATATCATGTTTTGGTTGGAGATAAGAACCAGGGATGGCAAGTACCAGTGTGTACAAATGTATTTCACGGAGTTTGAAGGAACGCA TAATCAAGAGGGAAAACAATTTGTCCTTCATTGGACGTATTATTTGGATTTGGGTGAGCAACAAAATGGAATGTGGTCTGTTAGGAGCAT TCTGTTTGTTCTTTTGTCCCTGATGTGATGAATCATTGCCACATGCTAGATGGACTCTTCATATCCAGGTTTTGTCCCTCAGGGCTGAGC ACTGTATTAAAGAGTTTTTGTTGAGTCATTTAACCTTAGTGTCCACATCCAGATCAGCTGTAAAATGGGGAAGACGTGTGCTGATTTGGA ATGAATGCAAAATATCACTATCATTTTCCTAATTACAGAGGAGCAAAGGTTATCTTCAGCCCTTTCAGTTCTATGCTCACATATTCAAAT ATCAAATGTAATTTAGCTGAAGTTATTTAATAATCAAGTCTTTCAATATCTGTTCAAAGAAAAAGAACACACTTTGAAAATTCTGCAAAG CTGTCTCCCAGTCTTTAAAATGTCTGGAAGCACTCTCCTTCTTTACAATACCAACATCACTGGCCCAGAATCTTCCCTGTGCTAGTTTGT AAATATAAATAAATTACTTGTTTTGTAAACTTTTGTAAAGAATATTTTGGTAGAAATACTTCAAACATATTCTTTGGGTTATATTTATAC ATATGTGAAATAAATATACTATCAAAAGGTTATATTTTATACAAAAAGTAAATTGCTACCTTTTGTATGCTAATATGCAAAGTTTTGTAT AATATGATGGTTTATTTTTAGCTCTACACTTAAACCATAGGTGGTTGAGTGGGAACTTTTGAAAACTATCAAGAGGCTTGTTAGACAAAT TTATATTCTGAAACCTCAATAAGAAAGCATTCCAGGTTTCAATCCTTGTTTTTTGTCCTGCTCCCAAATTCTTTTTTAAACCCATAGTTC TTGTGTCTTATTTGATTCTTCTGCTGTGCACATTGTATTGGTCCTTGTTGCATGTAGTCTACTGTGTGTTTTCCGATTTTATAAGGCAGC ATTTCTCCATACAAAAAGAAAAAAAATGATGTACATATAAACGCTTTTGTTGTATGGCTCCTCCATGTTACTGTATATATCTGCCAGCAC TTCCCAGTTACACTCCTGTGAGTCAGCTTATTTTTACCCTAACATAAATAGTATGTTTTGTAGTAGTTATCAAATTTAAGAGATAAAGCA ATCAGAATGTTTGGATTTTCTTCTATCTTAATGTGAATTTCATAATTAATGTCTATTTATTCAGCTATTCATTAAAATACAGGATTCTTT >In-frame_CRTC3_ENST00000560098_chr15_91073435_+_MAML2_ENST00000524717_chr11_95826682_-_5544nt CTGGCTTCGGGCGGCGGCCCCGGCGGCCTGTGGACGGACGGGTGGGCCGAGGTACAGGCCCCACGGCCGCCGTCTCCCGCTTCTGCCCGC GCAGAGTCCGCGCCATGGCCGCCTCGCCGGGCTCGGGCAGCGCCAACCCGCGGAAGTTCAGTGAGAAGATCGCGCTGCACACGCAGAGAC AGGCCGAGGAGACGCGGGCCTTCGAGCAGCTCATGACCGACCTCACCCTGTCGCGGCTCCAGGGTTCCTTGAAAAGAAAACAGGTAGTTA ACCTATCTCCTGCCAACAGCAAGCGACCCAATGGCTTTGTGGACAACTCATTTCTTGATATCAAAAGAATTCGTGTTGGGGAGAATCTCT CTGCAGGACAAGGTGGCCTCCAAATAAACAATGGACAAAGTCAGATTATGTCAGGGACCTTGCCTATGAGCCAAGCACCCCTGCGAAAGA CTAACACTCTGCCATCCCATACACATTCTCCTGGCAATGGCCTGTTTAACATGGGCTTAAAGGAGGTAAAGAAGGAGCCAGGAGAGACTC TGTCTTGCAGTAAGCACATGGATGGCCAAATGACCCAAGAGAATATTTTTCCTAATAGGTACGGAGACGACCCTGGAGAACAACTGATGG ATCCTGAGCTGCAGGAACTGTTCAATGAACTGACCAACATATCTGTGCCTCCCATGAGTGACCTTGAACTGGAGAACATGATCAATGCCA CCATAAAGCAGGATGACCCATTTAACATTGACTTGGGTCAGCAAAGCCAGAGGAGCACACCTAGGCCCTCCTTACCCATGGAGAAAATAG TGATCAAAAGTGAATACTCACCGGGCTTGACTCAGGGCCCCTCAGGCTCTCCTCAGCTGAGGCCCCCATCAGCTGGCCCCGCATTCTCCA TGGCCAACTCTGCCCTCTCCACTTCGTCTCCAATCCCTTCAGTCCCTCAGAGCCAGGCTCAGCCTCAGACAGGCTCCGGAGCAAGCCGGG CCTTGCCAAGCTGGCAGGAAGTATCCCATGCCCAGCAGCTCAAACAGATAGCTGCTAATCGTCAGCAGCATGCCCGGATGCAGCAGCACC AGCAGCAGCACCAGCCTACCAACTGGTCAGCCTTGCCCTCTTCTGCTGGACCATCACCAGGTCCATTTGGGCAGGAGAAAATCCCCAGCC CTTCTTTTGGTCAGCAGACATTCAGCCCACAGAGCTCCCCCATGCCTGGGGTAGCTGGCGGCAGCGGCCAGTCGAAAGTAATGGCTAACT ACATGTACAAGGCCGGCCCCTCAGCCCAGGGTGGGCACCTAGATGTCCTCATGCAGCAAAAGCCTCAGGATCTCAGTCGAAGTTTTATTA ACAACCCGCACCCAGCCATGGAGCCCCGTCAGGGCAACACCAAGCCTTTGTTTCATTTTAACTCAGATCAAGCGAACCAGCAGATGCCTT CTGTTTTGCCTTCCCAGAACAAGCCTTCTCTCCTACACTACACCCAACAGCAACAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGC AGCAGCAGCAGCAACAGCAGCAGCAGCAGCAACAGCAACAGCAACAGCAACAGCAGAGTTCAATTTCAGCTCAACAACAGCAACAGCAGC AGAGCTCAATTTCAGCCCAACAGCAGCAGCAGCAGCAACAACAGCAGCAGCAGCAGCAACAACAACAGCAACAACAGCAGCAGCAGCAGC AGCAACAACCATCTTCTCAGCCTGCCCAATCTCTACCAAGCCAGCCTTTGCTAAGGTCACCTTTGCCACTTCAGCAAAAGCTCCTACTTC AGCAAATGCAGAATCAGCCCATTGCAGGAATGGGATACCAAGTCTCCCAACAACAGAGACAGGATCAACACTCTGTGGTAGGCCAGAACA CAGGCCCCAGTCCAAGTCCTAACCCCTGCTCAAATCCAAACACTGGAAGTGGTTACATGAACTCCCAGCAATCACTGTTGAATCAGCAAT TGATGGGAAAGAAGCAGACTCTACAGAGGCAGATCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGCAGATGCTGGCTGACGCGGAGA AAATTGCTCCACAAGATCAGATAAACCGACATTTGTCAAGGCCACCTCCAGATTATAAAGACCAAAGAAGAAATGTGGGCAATATGCAAC CAACTGCTCAGTATTCTGGTGGCTCATCCACAATAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAGTTTCAACACACACCATTTTAA CTCCCAATTCCAGCCTCCTGTCTACTTCTCACGGGACAAGAATGCCATCATTATCTACAGCAGTTCAGAATATGGGGATGTATGGAAATC TGCCTTGTAATCAACCTAACACATACAGTGTCACTTCAGGAATGAATCAATTGACCCAACAGAGAAACCCAAAGCAATTGTTAGCAAATC AAAACAACCCTATGATGCCACGGCCACCTACCTTAGGGCCAAGTAATAATAACAATGTAGCCACTTTTGGAGCTGGATCTGTTGGTAATT CACAACAATTGAGACCAAATTTAACCCATAGTATGGCAAGCATGCCACCACAGAGAACATCAAACGTAATGATCACATCCAACACAACTG CACCAAACTGGGCCTCTCAAGAAGGAACAAGCAAACAGCAAGAAGCCCTGACGTCTGCAGGAGTCCGCTTCCCCACAGGTACACCTGCAG CCTATACCCCAAATCAGTCACTGCAACAGGCAGTAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTCCTCCTAACCAGTTAACACCAG CAGTGCAAATGAGACCCATGAACCAAATGAGCCAAACACTAAATGGGCAAACCATGGGTCCCCTCAGGGGTCTGAATCTCAGACCCAATC AGCTAAGCACACAGATTTTGCCTAATTTGAATCAGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCATCAACCAGCCACCATCCCTGA CGCCCAGCAATTTTCCTTCACCCAACCAAAGTTCCAGGGCTTTTCAAGGAACTGACCACAGCAGTGACTTAGCTTTTGACTTCCTCAGCC AACAAAATGATAACATGGGCCCTGCCCTAAACAGTGATGCTGATTTCATTGATTCTTTATTGAAGACAGAGCCTGGTAATGATGACTGGA TGAAAGACATCAATCTTGATGAAATCTTGGGGAACAATTCCTAAAGAAGAAAGGGAAGACAATTTACAAACTCCAAGCACTAAAAGGCAG TATATTACAGAAACTCTGTAGAGGCTGAACTGTTGATGTTCAGGTGGACTACATGAAGATAACATGCTTAAAAATGGAAAGCAGAAAGTA ACTGCAGTGATGAACATTTTGGTCCAAATTCTTGTTTTAAATCTTACACCTGAAAGTAAAATATTGGGATCACTTTTCCCTGTCTAAACT CCAGGATACAGTATCCAATTTATCCAAACAGAACTGTGGTGTCAATGTGTAATTAATTGTGTAAAATAGCCTTCCCAAGTTTCTTTTTCC CTGGAAAATAAAAAAGGTAATAGAACTTGTAGTTTATTTAAACCCCATGTCATGAGGAGGTACTAGTTCCAAGCAACAAACTCCTTAATT TGCTCTAATAGATAGGTATGGTTTAATCTTTCCATTGTGTCTTTTCATTTAATTTTCCTGAAGCTTGCAGGATAGATTGAAATGTTATAG GTTTGTTTGGAGTAACCAAACAGTATGCAAATTAAGAAAAAGCCAGAGAACCTAGAAAACATCCAGTGGATTACAGAATTTCTTCCCCAT ATTCACTCCTCACTTTTACAATTTTCCCACAATCCTCTACTTCAGTGGGATGCTGTGTCTAGTGATTAAACAAAAATATAGAGCTGTGCA ATTTGATTTTGGCTTCCACAACGAATATCTGAATCCATTCCAAATGAAATTTTAGATATAACAAAGACTTGTCCTAATCATACTGAAATA TTGGTGCACACCTCTCTGCATTAGATTTCACTTTTTTAAAAAACCCAGTGGACATTGCTATAAATAAGATTTATTTGGCTACAAATAACC TGGGATGTTGCTTATTATGATTGATGCCTGCTGGTTTGTTCCCAAGCTGAGTGAAATTGAACCTCGTCCTCCCTACTCATTTTGATGACT GAGGCTGGTTTATAAGAAAAGGAAGTTTGGAGAAGAAAACCGAGATTAGAAAATATCATGTTTTGGTTGGAGATAAGAACCAGGGATGGC AAGTACCAGTGTGTACAAATGTATTTCACGGAGTTTGAAGGAACGCATAATCAAGAGGGAAAACAATTTGTCCTTCATTGGACGTATTAT TTGGATTTGGGTGAGCAACAAAATGGAATGTGGTCTGTTAGGAGCATTCTGTTTGTTCTTTTGTCCCTGATGTGATGAATCATTGCCACA TGCTAGATGGACTCTTCATATCCAGGTTTTGTCCCTCAGGGCTGAGCACTGTATTAAAGAGTTTTTGTTGAGTCATTTAACCTTAGTGTC CACATCCAGATCAGCTGTAAAATGGGGAAGACGTGTGCTGATTTGGAATGAATGCAAAATATCACTATCATTTTCCTAATTACAGAGGAG CAAAGGTTATCTTCAGCCCTTTCAGTTCTATGCTCACATATTCAAATATCAAATGTAATTTAGCTGAAGTTATTTAATAATCAAGTCTTT CAATATCTGTTCAAAGAAAAAGAACACACTTTGAAAATTCTGCAAAGCTGTCTCCCAGTCTTTAAAATGTCTGGAAGCACTCTCCTTCTT TACAATACCAACATCACTGGCCCAGAATCTTCCCTGTGCTAGTTTGTAAATATAAATAAATTACTTGTTTTGTAAACTTTTGTAAAGAAT ATTTTGGTAGAAATACTTCAAACATATTCTTTGGGTTATATTTATACATATGTGAAATAAATATACTATCAAAAGGTTATATTTTATACA AAAAGTAAATTGCTACCTTTTGTATGCTAATATGCAAAGTTTTGTATAATATGATGGTTTATTTTTAGCTCTACACTTAAACCATAGGTG GTTGAGTGGGAACTTTTGAAAACTATCAAGAGGCTTGTTAGACAAATTTATATTCTGAAACCTCAATAAGAAAGCATTCCAGGTTTCAAT CCTTGTTTTTTGTCCTGCTCCCAAATTCTTTTTTAAACCCATAGTTCTTGTGTCTTATTTGATTCTTCTGCTGTGCACATTGTATTGGTC CTTGTTGCATGTAGTCTACTGTGTGTTTTCCGATTTTATAAGGCAGCATTTCTCCATACAAAAAGAAAAAAAATGATGTACATATAAACG CTTTTGTTGTATGGCTCCTCCATGTTACTGTATATATCTGCCAGCACTTCCCAGTTACACTCCTGTGAGTCAGCTTATTTTTACCCTAAC ATAAATAGTATGTTTTGTAGTAGTTATCAAATTTAAGAGATAAAGCAATCAGAATGTTTGGATTTTCTTCTATCTTAATGTGAATTTCAT >In-frame_CRTC3_ENST00000268184_chr15_91073435_+_MAML2_ENST00000524717_chr11_95826682_-_5444nt CGCCATGGCCGCCTCGCCGGGCTCGGGCAGCGCCAACCCGCGGAAGTTCAGTGAGAAGATCGCGCTGCACACGCAGAGACAGGCCGAGGA GACGCGGGCCTTCGAGCAGCTCATGACCGACCTCACCCTGTCGCGGCTCCAGGGTTCCTTGAAAAGAAAACAGGTAGTTAACCTATCTCC TGCCAACAGCAAGCGACCCAATGGCTTTGTGGACAACTCATTTCTTGATATCAAAAGAATTCGTGTTGGGGAGAATCTCTCTGCAGGACA AGGTGGCCTCCAAATAAACAATGGACAAAGTCAGATTATGTCAGGGACCTTGCCTATGAGCCAAGCACCCCTGCGAAAGACTAACACTCT GCCATCCCATACACATTCTCCTGGCAATGGCCTGTTTAACATGGGCTTAAAGGAGGTAAAGAAGGAGCCAGGAGAGACTCTGTCTTGCAG TAAGCACATGGATGGCCAAATGACCCAAGAGAATATTTTTCCTAATAGGTACGGAGACGACCCTGGAGAACAACTGATGGATCCTGAGCT GCAGGAACTGTTCAATGAACTGACCAACATATCTGTGCCTCCCATGAGTGACCTTGAACTGGAGAACATGATCAATGCCACCATAAAGCA GGATGACCCATTTAACATTGACTTGGGTCAGCAAAGCCAGAGGAGCACACCTAGGCCCTCCTTACCCATGGAGAAAATAGTGATCAAAAG TGAATACTCACCGGGCTTGACTCAGGGCCCCTCAGGCTCTCCTCAGCTGAGGCCCCCATCAGCTGGCCCCGCATTCTCCATGGCCAACTC TGCCCTCTCCACTTCGTCTCCAATCCCTTCAGTCCCTCAGAGCCAGGCTCAGCCTCAGACAGGCTCCGGAGCAAGCCGGGCCTTGCCAAG CTGGCAGGAAGTATCCCATGCCCAGCAGCTCAAACAGATAGCTGCTAATCGTCAGCAGCATGCCCGGATGCAGCAGCACCAGCAGCAGCA CCAGCCTACCAACTGGTCAGCCTTGCCCTCTTCTGCTGGACCATCACCAGGTCCATTTGGGCAGGAGAAAATCCCCAGCCCTTCTTTTGG TCAGCAGACATTCAGCCCACAGAGCTCCCCCATGCCTGGGGTAGCTGGCGGCAGCGGCCAGTCGAAAGTAATGGCTAACTACATGTACAA GGCCGGCCCCTCAGCCCAGGGTGGGCACCTAGATGTCCTCATGCAGCAAAAGCCTCAGGATCTCAGTCGAAGTTTTATTAACAACCCGCA CCCAGCCATGGAGCCCCGTCAGGGCAACACCAAGCCTTTGTTTCATTTTAACTCAGATCAAGCGAACCAGCAGATGCCTTCTGTTTTGCC TTCCCAGAACAAGCCTTCTCTCCTACACTACACCCAACAGCAACAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCA GCAACAGCAGCAGCAGCAGCAACAGCAACAGCAACAGCAACAGCAGAGTTCAATTTCAGCTCAACAACAGCAACAGCAGCAGAGCTCAAT TTCAGCCCAACAGCAGCAGCAGCAGCAACAACAGCAGCAGCAGCAGCAACAACAACAGCAACAACAGCAGCAGCAGCAGCAGCAACAACC ATCTTCTCAGCCTGCCCAATCTCTACCAAGCCAGCCTTTGCTAAGGTCACCTTTGCCACTTCAGCAAAAGCTCCTACTTCAGCAAATGCA GAATCAGCCCATTGCAGGAATGGGATACCAAGTCTCCCAACAACAGAGACAGGATCAACACTCTGTGGTAGGCCAGAACACAGGCCCCAG TCCAAGTCCTAACCCCTGCTCAAATCCAAACACTGGAAGTGGTTACATGAACTCCCAGCAATCACTGTTGAATCAGCAATTGATGGGAAA GAAGCAGACTCTACAGAGGCAGATCATGGAGCAGAAACAGCAACTTCTTCTCCAGCAGCAGATGCTGGCTGACGCGGAGAAAATTGCTCC ACAAGATCAGATAAACCGACATTTGTCAAGGCCACCTCCAGATTATAAAGACCAAAGAAGAAATGTGGGCAATATGCAACCAACTGCTCA GTATTCTGGTGGCTCATCCACAATAAGCTTAAACTCTAACCAGGCTTTGGCAAACCCAGTTTCAACACACACCATTTTAACTCCCAATTC CAGCCTCCTGTCTACTTCTCACGGGACAAGAATGCCATCATTATCTACAGCAGTTCAGAATATGGGGATGTATGGAAATCTGCCTTGTAA TCAACCTAACACATACAGTGTCACTTCAGGAATGAATCAATTGACCCAACAGAGAAACCCAAAGCAATTGTTAGCAAATCAAAACAACCC TATGATGCCACGGCCACCTACCTTAGGGCCAAGTAATAATAACAATGTAGCCACTTTTGGAGCTGGATCTGTTGGTAATTCACAACAATT GAGACCAAATTTAACCCATAGTATGGCAAGCATGCCACCACAGAGAACATCAAACGTAATGATCACATCCAACACAACTGCACCAAACTG GGCCTCTCAAGAAGGAACAAGCAAACAGCAAGAAGCCCTGACGTCTGCAGGAGTCCGCTTCCCCACAGGTACACCTGCAGCCTATACCCC AAATCAGTCACTGCAACAGGCAGTAGGTAGCCAGCAATTTTCCCAGAGGGCAGTGGCTCCTCCTAACCAGTTAACACCAGCAGTGCAAAT GAGACCCATGAACCAAATGAGCCAAACACTAAATGGGCAAACCATGGGTCCCCTCAGGGGTCTGAATCTCAGACCCAATCAGCTAAGCAC ACAGATTTTGCCTAATTTGAATCAGTCAGGAACAGGGTTGAATCAGTCGAGGACGGGCATCAACCAGCCACCATCCCTGACGCCCAGCAA TTTTCCTTCACCCAACCAAAGTTCCAGGGCTTTTCAAGGAACTGACCACAGCAGTGACTTAGCTTTTGACTTCCTCAGCCAACAAAATGA TAACATGGGCCCTGCCCTAAACAGTGATGCTGATTTCATTGATTCTTTATTGAAGACAGAGCCTGGTAATGATGACTGGATGAAAGACAT CAATCTTGATGAAATCTTGGGGAACAATTCCTAAAGAAGAAAGGGAAGACAATTTACAAACTCCAAGCACTAAAAGGCAGTATATTACAG AAACTCTGTAGAGGCTGAACTGTTGATGTTCAGGTGGACTACATGAAGATAACATGCTTAAAAATGGAAAGCAGAAAGTAACTGCAGTGA TGAACATTTTGGTCCAAATTCTTGTTTTAAATCTTACACCTGAAAGTAAAATATTGGGATCACTTTTCCCTGTCTAAACTCCAGGATACA GTATCCAATTTATCCAAACAGAACTGTGGTGTCAATGTGTAATTAATTGTGTAAAATAGCCTTCCCAAGTTTCTTTTTCCCTGGAAAATA AAAAAGGTAATAGAACTTGTAGTTTATTTAAACCCCATGTCATGAGGAGGTACTAGTTCCAAGCAACAAACTCCTTAATTTGCTCTAATA GATAGGTATGGTTTAATCTTTCCATTGTGTCTTTTCATTTAATTTTCCTGAAGCTTGCAGGATAGATTGAAATGTTATAGGTTTGTTTGG AGTAACCAAACAGTATGCAAATTAAGAAAAAGCCAGAGAACCTAGAAAACATCCAGTGGATTACAGAATTTCTTCCCCATATTCACTCCT CACTTTTACAATTTTCCCACAATCCTCTACTTCAGTGGGATGCTGTGTCTAGTGATTAAACAAAAATATAGAGCTGTGCAATTTGATTTT GGCTTCCACAACGAATATCTGAATCCATTCCAAATGAAATTTTAGATATAACAAAGACTTGTCCTAATCATACTGAAATATTGGTGCACA CCTCTCTGCATTAGATTTCACTTTTTTAAAAAACCCAGTGGACATTGCTATAAATAAGATTTATTTGGCTACAAATAACCTGGGATGTTG CTTATTATGATTGATGCCTGCTGGTTTGTTCCCAAGCTGAGTGAAATTGAACCTCGTCCTCCCTACTCATTTTGATGACTGAGGCTGGTT TATAAGAAAAGGAAGTTTGGAGAAGAAAACCGAGATTAGAAAATATCATGTTTTGGTTGGAGATAAGAACCAGGGATGGCAAGTACCAGT GTGTACAAATGTATTTCACGGAGTTTGAAGGAACGCATAATCAAGAGGGAAAACAATTTGTCCTTCATTGGACGTATTATTTGGATTTGG GTGAGCAACAAAATGGAATGTGGTCTGTTAGGAGCATTCTGTTTGTTCTTTTGTCCCTGATGTGATGAATCATTGCCACATGCTAGATGG ACTCTTCATATCCAGGTTTTGTCCCTCAGGGCTGAGCACTGTATTAAAGAGTTTTTGTTGAGTCATTTAACCTTAGTGTCCACATCCAGA TCAGCTGTAAAATGGGGAAGACGTGTGCTGATTTGGAATGAATGCAAAATATCACTATCATTTTCCTAATTACAGAGGAGCAAAGGTTAT CTTCAGCCCTTTCAGTTCTATGCTCACATATTCAAATATCAAATGTAATTTAGCTGAAGTTATTTAATAATCAAGTCTTTCAATATCTGT TCAAAGAAAAAGAACACACTTTGAAAATTCTGCAAAGCTGTCTCCCAGTCTTTAAAATGTCTGGAAGCACTCTCCTTCTTTACAATACCA ACATCACTGGCCCAGAATCTTCCCTGTGCTAGTTTGTAAATATAAATAAATTACTTGTTTTGTAAACTTTTGTAAAGAATATTTTGGTAG AAATACTTCAAACATATTCTTTGGGTTATATTTATACATATGTGAAATAAATATACTATCAAAAGGTTATATTTTATACAAAAAGTAAAT TGCTACCTTTTGTATGCTAATATGCAAAGTTTTGTATAATATGATGGTTTATTTTTAGCTCTACACTTAAACCATAGGTGGTTGAGTGGG AACTTTTGAAAACTATCAAGAGGCTTGTTAGACAAATTTATATTCTGAAACCTCAATAAGAAAGCATTCCAGGTTTCAATCCTTGTTTTT TGTCCTGCTCCCAAATTCTTTTTTAAACCCATAGTTCTTGTGTCTTATTTGATTCTTCTGCTGTGCACATTGTATTGGTCCTTGTTGCAT GTAGTCTACTGTGTGTTTTCCGATTTTATAAGGCAGCATTTCTCCATACAAAAAGAAAAAAAATGATGTACATATAAACGCTTTTGTTGT ATGGCTCCTCCATGTTACTGTATATATCTGCCAGCACTTCCCAGTTACACTCCTGTGAGTCAGCTTATTTTTACCCTAACATAAATAGTA TGTTTTGTAGTAGTTATCAAATTTAAGAGATAAAGCAATCAGAATGTTTGGATTTTCTTCTATCTTAATGTGAATTTCATAATTAATGTC |
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FusionGenePPI for CRTC3_MAML2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CRTC3 | YWHAG, YWHAB, SCYL1, NEDD1, MAGEA10, EWSR1, CENPJ, XPO1, CLTC, HCCS, HSPA5, POLD1, MAPK8, LRP8, GTSE1, PCDHB15, CFAP97, MCM2, DCAF7, KCTD3, KIF13B, CGN, ZBTB21, KSR1, CBY1, MDM2, TRIM25 | MAML2 | MAML1, NOTCH1, DIABLO, CREBBP, EP300, RBPJ |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CRTC3_MAML2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CRTC3_MAML2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | MAML2 | C3495559 | Juvenile arthritis | 1 | CTD_human |
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