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Fusion gene ID: 8531 |
FusionGeneSummary for CRTC1_SORCS2 |
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Fusion gene information | Fusion gene name: CRTC1_SORCS2 | Fusion gene ID: 8531 | Hgene | Tgene | Gene symbol | CRTC1 | SORCS2 | Gene ID | 23373 | 57537 |
Gene name | CREB regulated transcription coactivator 1 | sortilin related VPS10 domain containing receptor 2 | |
Synonyms | MECT1|TORC-1|TORC1|WAMTP1 | - | |
Cytomap | 19p13.11 | 4p16.1 | |
Type of gene | protein-coding | protein-coding | |
Description | CREB-regulated transcription coactivator 1mucoepidermoid carcinoma translocated protein 1transducer of regulated cAMP response element-binding protein (CREB) 1 | VPS10 domain-containing receptor SorCS2VPS10 domain receptor protein | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q6UUV9 | Q96PQ0 | |
Ensembl transtripts involved in fusion gene | ENST00000321949, ENST00000338797, ENST00000594658, ENST00000601916, | ENST00000507866, ENST00000511199, ENST00000329016, | |
Fusion gene scores | * DoF score | 7 X 4 X 4=112 | 3 X 2 X 3=18 |
# samples | 9 | 3 | |
** MAII score | log2(9/112*10)=-0.315501825727929 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CRTC1 [Title/Abstract] AND SORCS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CRTC1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 14536081 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AC003107 | CRTC1 | chr19 | 18910251 | + | SORCS2 | chr4 | 7558763 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000321949 | ENST00000507866 | CRTC1 | chr19 | 18910251 | + | SORCS2 | chr4 | 7558763 | - |
intron-intron | ENST00000321949 | ENST00000511199 | CRTC1 | chr19 | 18910251 | + | SORCS2 | chr4 | 7558763 | - |
intron-intron | ENST00000321949 | ENST00000329016 | CRTC1 | chr19 | 18910251 | + | SORCS2 | chr4 | 7558763 | - |
intron-intron | ENST00000338797 | ENST00000507866 | CRTC1 | chr19 | 18910251 | + | SORCS2 | chr4 | 7558763 | - |
intron-intron | ENST00000338797 | ENST00000511199 | CRTC1 | chr19 | 18910251 | + | SORCS2 | chr4 | 7558763 | - |
intron-intron | ENST00000338797 | ENST00000329016 | CRTC1 | chr19 | 18910251 | + | SORCS2 | chr4 | 7558763 | - |
intron-intron | ENST00000594658 | ENST00000507866 | CRTC1 | chr19 | 18910251 | + | SORCS2 | chr4 | 7558763 | - |
intron-intron | ENST00000594658 | ENST00000511199 | CRTC1 | chr19 | 18910251 | + | SORCS2 | chr4 | 7558763 | - |
intron-intron | ENST00000594658 | ENST00000329016 | CRTC1 | chr19 | 18910251 | + | SORCS2 | chr4 | 7558763 | - |
intron-intron | ENST00000601916 | ENST00000507866 | CRTC1 | chr19 | 18910251 | + | SORCS2 | chr4 | 7558763 | - |
intron-intron | ENST00000601916 | ENST00000511199 | CRTC1 | chr19 | 18910251 | + | SORCS2 | chr4 | 7558763 | - |
intron-intron | ENST00000601916 | ENST00000329016 | CRTC1 | chr19 | 18910251 | + | SORCS2 | chr4 | 7558763 | - |
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FusionProtFeatures for CRTC1_SORCS2 |
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Hgene | Tgene |
CRTC1 | SORCS2 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CRTC1_SORCS2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CRTC1_SORCS2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CRTC1_SORCS2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CRTC1_SORCS2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CRTC1 | C0279628 | Adenocarcinoma Of Esophagus | 1 | CTD_human |
Hgene | CRTC1 | C0525045 | Mood Disorders | 1 | PSYGENET |
Tgene | SORCS2 | C0005586 | Bipolar Disorder | 1 | PSYGENET |