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Fusion gene ID: 85 |
FusionGeneSummary for ABCA11P_CRLS1 |
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Fusion gene information | Fusion gene name: ABCA11P_CRLS1 | Fusion gene ID: 85 | Hgene | Tgene | Gene symbol | ABCA11P | CRLS1 | Gene ID | 79963 | 54675 |
Gene name | ATP binding cassette subfamily A member 11, pseudogene | cardiolipin synthase 1 | |
Synonyms | ABCA11|EST1133530 | C20orf155|CLS|CLS1|GCD10|dJ967N21.6 | |
Cytomap | 4p16.3 | 20p12.3 | |
Type of gene | pseudo | protein-coding | |
Description | ATP-binding cassette, sub-family A (ABC1), member 11 (pseudogene) | cardiolipin synthase (CMP-forming) | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UJA2 | ||
Ensembl transtripts involved in fusion gene | ENST00000451020, | ENST00000378863, ENST00000452938, ENST00000378868, ENST00000464921, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 2 X 2 X 2=8 |
# samples | 2 | 2 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: ABCA11P [Title/Abstract] AND CRLS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CB163082 | ABCA11P | chr4 | 431791 | + | CRLS1 | chr20 | 5989691 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000451020 | ENST00000378863 | ABCA11P | chr4 | 431791 | + | CRLS1 | chr20 | 5989691 | - |
intron-intron | ENST00000451020 | ENST00000452938 | ABCA11P | chr4 | 431791 | + | CRLS1 | chr20 | 5989691 | - |
intron-intron | ENST00000451020 | ENST00000378868 | ABCA11P | chr4 | 431791 | + | CRLS1 | chr20 | 5989691 | - |
intron-intron | ENST00000451020 | ENST00000464921 | ABCA11P | chr4 | 431791 | + | CRLS1 | chr20 | 5989691 | - |
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FusionProtFeatures for ABCA11P_CRLS1 |
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Hgene | Tgene |
ABCA11P | CRLS1 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Catalyzes the synthesis of cardiolipin (CL)(diphosphatidylglycerol) by specifically transferring aphosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol(PG). CL is a key phospholipid in mitochondrial membranes andplays important roles in maintaining the functional integrity anddynamics of mitochondria under both optimal and stress conditions.{ECO:0000269|PubMed:16547353, ECO:0000269|PubMed:16678169}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ABCA11P_CRLS1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ABCA11P_CRLS1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ABCA11P_CRLS1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ABCA11P_CRLS1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |