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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 8496

FusionGeneSummary for CRK_SMG6

check button Fusion gene summary
Fusion gene informationFusion gene name: CRK_SMG6
Fusion gene ID: 8496
HgeneTgene
Gene symbol

CRK

SMG6

Gene ID

1398

23293

Gene nameCRK proto-oncogene, adaptor proteinSMG6, nonsense mediated mRNA decay factor
SynonymsCRKII|p38C17orf31|EST1A|SMG-6|hSMG5/7a
Cytomap

17p13.3

17p13.3

Type of geneprotein-codingprotein-coding
Descriptionadapter molecule crkproto-oncogene c-Crkv-crk avian sarcoma virus CT10 oncogene homologv-crk sarcoma virus CT10 oncogene-like proteintelomerase-binding protein EST1AEST1 telomerase component homolog Aever shorter telomeres 1Asmg-6 homolog, nonsense mediated mRNA decay factortelomerase subunit EST1A
Modification date2018052220180523
UniProtAcc

P46108

Q86US8

Ensembl transtripts involved in fusion geneENST00000398970, ENST00000300574, 
ENST00000574295, ENST00000572145, 
ENST00000544865, ENST00000263073, 
ENST00000354901, ENST00000536871, 
ENST00000573166, 
Fusion gene scores* DoF score10 X 5 X 6=3008 X 6 X 5=240
# samples 108
** MAII scorelog2(10/300*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CRK [Title/Abstract] AND SMG6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCRK

GO:0009966

regulation of signal transduction

17515907

HgeneCRK

GO:0032956

regulation of actin cytoskeleton organization

11870224

HgeneCRK

GO:0043087

regulation of GTPase activity

11870224

HgeneCRK

GO:0048013

ephrin receptor signaling pathway

11870224

HgeneCRK

GO:0061045

negative regulation of wound healing

17515907

HgeneCRK

GO:0071538

SH2 domain-mediated complex assembly

12384576

HgeneCRK

GO:2000146

negative regulation of cell motility

17515907

TgeneSMG6

GO:1904354

negative regulation of telomere capping

12676087


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-24-1842-01ACRKchr17

1359171

-SMG6chr17

1964916

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000398970ENST00000544865CRKchr17

1359171

-SMG6chr17

1964916

-
In-frameENST00000398970ENST00000263073CRKchr17

1359171

-SMG6chr17

1964916

-
In-frameENST00000398970ENST00000354901CRKchr17

1359171

-SMG6chr17

1964916

-
Frame-shitENST00000398970ENST00000536871CRKchr17

1359171

-SMG6chr17

1964916

-
5CDS-5UTRENST00000398970ENST00000573166CRKchr17

1359171

-SMG6chr17

1964916

-
In-frameENST00000300574ENST00000544865CRKchr17

1359171

-SMG6chr17

1964916

-
In-frameENST00000300574ENST00000263073CRKchr17

1359171

-SMG6chr17

1964916

-
In-frameENST00000300574ENST00000354901CRKchr17

1359171

-SMG6chr17

1964916

-
Frame-shitENST00000300574ENST00000536871CRKchr17

1359171

-SMG6chr17

1964916

-
5CDS-5UTRENST00000300574ENST00000573166CRKchr17

1359171

-SMG6chr17

1964916

-
In-frameENST00000574295ENST00000544865CRKchr17

1359171

-SMG6chr17

1964916

-
In-frameENST00000574295ENST00000263073CRKchr17

1359171

-SMG6chr17

1964916

-
In-frameENST00000574295ENST00000354901CRKchr17

1359171

-SMG6chr17

1964916

-
Frame-shitENST00000574295ENST00000536871CRKchr17

1359171

-SMG6chr17

1964916

-
5CDS-5UTRENST00000574295ENST00000573166CRKchr17

1359171

-SMG6chr17

1964916

-
intron-3CDSENST00000572145ENST00000544865CRKchr17

1359171

-SMG6chr17

1964916

-
intron-3CDSENST00000572145ENST00000263073CRKchr17

1359171

-SMG6chr17

1964916

-
intron-3CDSENST00000572145ENST00000354901CRKchr17

1359171

-SMG6chr17

1964916

-
intron-3CDSENST00000572145ENST00000536871CRKchr17

1359171

-SMG6chr17

1964916

-
intron-5UTRENST00000572145ENST00000573166CRKchr17

1359171

-SMG6chr17

1964916

-

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FusionProtFeatures for CRK_SMG6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRK

P46108

SMG6

Q86US8

Isoform Crk-II: Regulates cell adhesion, spreading andmigration. Mediates attachment-induced MAPK8 activation, membraneruffling and cell motility in a Rac-dependent manner. Involved inphagocytosis of apoptotic cells and cell motility via itsinteraction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3signaling. {ECO:0000269|PubMed:11870224,ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907,ECO:0000269|PubMed:19004829}. Component of the telomerase ribonucleoprotein (RNP)complex that is essential for the replication of chromosometermini. May have a general role in telomere regulation. Promotesin vitro the ability of TERT to elongate telomeres. Overexpressioninduces telomere uncapping, chromosomal end-to-end fusions(telomeric DNA persists at the fusion points) and did not perturbTRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNAtemplate component (TER). Plays a role in nonsense-mediated mRNA decay. Is thoughtto provide a link to the mRNA degradation machinery as it hasendonuclease activity required to initiate NMD, and to serve as anadapter for UPF1 to protein phosphatase 2A (PP2A), therebytriggering UPF1 dephosphorylation. Degrades single-stranded RNA(ssRNA), but not ssDNA or dsRNA.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSMG6chr17:1359171chr17:1964916ENST00000354901-10121197_1239468512Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST00000354901-1012567_625468512Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST00000536871-9111197_1239468512Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST00000536871-911567_625468512Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST00000354901-10121246_1397468512DomainNote=PINc
TgeneSMG6chr17:1359171chr17:1964916ENST00000536871-9111246_1397468512DomainNote=PINc

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCRKchr17:1359171chr17:1964916ENST00000300574-13132_19280305DomainSH3 1
HgeneCRKchr17:1359171chr17:1964916ENST00000300574-1313_11880305DomainSH2
HgeneCRKchr17:1359171chr17:1964916ENST00000300574-13235_29680305DomainSH3 2
HgeneCRKchr17:1359171chr17:1964916ENST00000398970-13132_19280205DomainSH3 1
HgeneCRKchr17:1359171chr17:1964916ENST00000398970-1313_11880205DomainSH2
HgeneCRKchr17:1359171chr17:1964916ENST00000398970-13235_29680205DomainSH3 2
TgeneSMG6chr17:1359171chr17:1964916ENST00000263073-17191197_123913761420Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST00000263073-1719163_19313761420Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST00000263073-1719567_62513761420Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST00000354901-1012163_193468512Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST00000536871-911163_193468512Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST00000544865-17191197_123913451389Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST00000544865-1719163_19313451389Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST00000544865-1719567_62513451389Coiled coilOntology_term=ECO:0000255
TgeneSMG6chr17:1359171chr17:1964916ENST00000263073-17191246_139713761420DomainNote=PINc
TgeneSMG6chr17:1359171chr17:1964916ENST00000544865-17191246_139713451389DomainNote=PINc


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FusionGeneSequence for CRK_SMG6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CRK_ENST00000398970_chr17_1359171_-_SMG6_ENST00000544865_chr17_1964916_-_124aa
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDTVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPEEPIRLLREV

>In-frame_CRK_ENST00000398970_chr17_1359171_-_SMG6_ENST00000263073_chr17_1964916_-_124aa
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDTVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPEEPIRLLREV

>In-frame_CRK_ENST00000398970_chr17_1359171_-_SMG6_ENST00000354901_chr17_1964916_-_124aa
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDTVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPEEPIRLLREV

>In-frame_CRK_ENST00000300574_chr17_1359171_-_SMG6_ENST00000544865_chr17_1964916_-_124aa
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDTVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPEEPIRLLREV

>In-frame_CRK_ENST00000300574_chr17_1359171_-_SMG6_ENST00000263073_chr17_1964916_-_124aa
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDTVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPEEPIRLLREV

>In-frame_CRK_ENST00000300574_chr17_1359171_-_SMG6_ENST00000354901_chr17_1964916_-_124aa
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDTVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPEEPIRLLREV

>In-frame_CRK_ENST00000574295_chr17_1359171_-_SMG6_ENST00000544865_chr17_1964916_-_124aa
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDTVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPEEPIRLLREV

>In-frame_CRK_ENST00000574295_chr17_1359171_-_SMG6_ENST00000263073_chr17_1964916_-_124aa
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDTVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPEEPIRLLREV

>In-frame_CRK_ENST00000574295_chr17_1359171_-_SMG6_ENST00000354901_chr17_1964916_-_124aa
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDTVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPEEPIRLLREV


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CRK_ENST00000398970_chr17_1359171_-_SMG6_ENST00000544865_chr17_1964916_-_372nt
ATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAG
CGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTAC
ATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCGGCTACTGCGGGAGGTG
GTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGACATCCCAGCCTTCCTCACGTGGGCC

>In-frame_CRK_ENST00000398970_chr17_1359171_-_SMG6_ENST00000263073_chr17_1964916_-_372nt
ATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAG
CGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTAC
ATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCGGCTACTGCGGGAGGTG
GTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGACATCCCAGCCTTCCTCACGTGGGCC

>In-frame_CRK_ENST00000398970_chr17_1359171_-_SMG6_ENST00000354901_chr17_1964916_-_372nt
ATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAG
CGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTAC
ATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCGGCTACTGCGGGAGGTG
GTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGACATCCCAGCCTTCCTCACGTGGGCC

>In-frame_CRK_ENST00000300574_chr17_1359171_-_SMG6_ENST00000544865_chr17_1964916_-_372nt
ATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAG
CGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTAC
ATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCGGCTACTGCGGGAGGTG
GTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGACATCCCAGCCTTCCTCACGTGGGCC

>In-frame_CRK_ENST00000300574_chr17_1359171_-_SMG6_ENST00000263073_chr17_1964916_-_372nt
ATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAG
CGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTAC
ATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCGGCTACTGCGGGAGGTG
GTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGACATCCCAGCCTTCCTCACGTGGGCC

>In-frame_CRK_ENST00000300574_chr17_1359171_-_SMG6_ENST00000354901_chr17_1964916_-_372nt
ATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAG
CGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTAC
ATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCGGCTACTGCGGGAGGTG
GTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGACATCCCAGCCTTCCTCACGTGGGCC

>In-frame_CRK_ENST00000574295_chr17_1359171_-_SMG6_ENST00000544865_chr17_1964916_-_372nt
ATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAG
CGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTAC
ATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCGGCTACTGCGGGAGGTG
GTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGACATCCCAGCCTTCCTCACGTGGGCC

>In-frame_CRK_ENST00000574295_chr17_1359171_-_SMG6_ENST00000263073_chr17_1964916_-_372nt
ATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAG
CGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTAC
ATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCGGCTACTGCGGGAGGTG
GTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGACATCCCAGCCTTCCTCACGTGGGCC

>In-frame_CRK_ENST00000574295_chr17_1359171_-_SMG6_ENST00000354901_chr17_1964916_-_372nt
ATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAG
CGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTAC
ATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCGGCTACTGCGGGAGGTG
GTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGACATCCCAGCCTTCCTCACGTGGGCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_CRK_ENST00000398970_chr17_1359171_-_SMG6_ENST00000544865_chr17_1964916_-_2131nt
GCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCCGGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTT
AGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGC
GCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTC
GCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCG
GCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGACATCCCAGC
CTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCGTGGAACCGTTCCTGAAAGGCCACCAGGCGCCCAGT
GTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACCATCCTCTTCCAACCCACGCCACGGCCATGCTGTGG
GGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACCCTCCTGGGCTGCCAGGATTTAGCAGGGAGGTGGCT
GGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTTTCTCCCTCCCCCGTCTCATTCCAAGGCTGAGGGAG
GGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTTCTGAGTTTCCGTCAGATGCAGTGAAATCACAGTTC
CCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTCAGGAAGAAGTGCCCAGGGTGTGTGTCCCCAGTCTC
CCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCTAACAGCAGCCCTGGGCCCCCACCTCTTCTACCATC
CACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAACCTGGGTCCCTCACACTTCGCCAGTTGCGTCCCCGT
GGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGGGTGGCCTCCACCTGCTCCCTCTCTCCTCACTGGCC
TTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCCCTTCACCCCTCCTTGCCCGCCTACCCTCCCTCCAG
AATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCCCCTTCATTTCTTCACCGCGGTTCCTCGTCATAGGG
GTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGTCTCCCACCCAGGGCCTTCCACCCTCGGCTCCTGTG
CTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGGCACCGTCGCCTAACCTGGTTTCTAGCTTTGCCCTC
ACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTGGTACCTCAGTGGGGAGGCTTCCTTACCAAGAATGA
GTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTCGGTGGAGCCAGGGGCAAATCTTAATGGGACCAGTG
GGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGCGCAGCTCTGCCCTCCCTGAGGCCCAGGACTATGCC
AGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAGTCCCCTAGAGTCTCAGAAGACTGGGCTCTTTGGAG
TACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGACTGGGTGGTCGGGAGGGAGACCCAGCTCTCCTTTC

>In-frame_CRK_ENST00000398970_chr17_1359171_-_SMG6_ENST00000263073_chr17_1964916_-_2127nt
GCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCCGGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTT
AGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGC
GCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTC
GCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCG
GCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGACATCCCAGC
CTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCGTGGAACCGTTCCTGAAAGGCCACCAGGCGCCCAGT
GTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACCATCCTCTTCCAACCCACGCCACGGCCATGCTGTGG
GGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACCCTCCTGGGCTGCCAGGATTTAGCAGGGAGGTGGCT
GGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTTTCTCCCTCCCCCGTCTCATTCCAAGGCTGAGGGAG
GGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTTCTGAGTTTCCGTCAGATGCAGTGAAATCACAGTTC
CCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTCAGGAAGAAGTGCCCAGGGTGTGTGTCCCCAGTCTC
CCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCTAACAGCAGCCCTGGGCCCCCACCTCTTCTACCATC
CACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAACCTGGGTCCCTCACACTTCGCCAGTTGCGTCCCCGT
GGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGGGTGGCCTCCACCTGCTCCCTCTCTCCTCACTGGCC
TTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCCCTTCACCCCTCCTTGCCCGCCTACCCTCCCTCCAG
AATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCCCCTTCATTTCTTCACCGCGGTTCCTCGTCATAGGG
GTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGTCTCCCACCCAGGGCCTTCCACCCTCGGCTCCTGTG
CTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGGCACCGTCGCCTAACCTGGTTTCTAGCTTTGCCCTC
ACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTGGTACCTCAGTGGGGAGGCTTCCTTACCAAGAATGA
GTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTCGGTGGAGCCAGGGGCAAATCTTAATGGGACCAGTG
GGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGCGCAGCTCTGCCCTCCCTGAGGCCCAGGACTATGCC
AGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAGTCCCCTAGAGTCTCAGAAGACTGGGCTCTTTGGAG
TACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGACTGGGTGGTCGGGAGGGAGACCCAGCTCTCCTTTC

>In-frame_CRK_ENST00000398970_chr17_1359171_-_SMG6_ENST00000354901_chr17_1964916_-_2120nt
GCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCCGGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTT
AGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGC
GCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTC
GCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCG
GCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTGTACGGGACATCCCAGC
CTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCGTGGAACCGTTCCTGAAAGGCCACCAGGCGCCCAGT
GTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACCATCCTCTTCCAACCCACGCCACGGCCATGCTGTGG
GGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACCCTCCTGGGCTGCCAGGATTTAGCAGGGAGGTGGCT
GGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTTTCTCCCTCCCCCGTCTCATTCCAAGGCTGAGGGAG
GGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTTCTGAGTTTCCGTCAGATGCAGTGAAATCACAGTTC
CCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTCAGGAAGAAGTGCCCAGGGTGTGTGTCCCCAGTCTC
CCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCTAACAGCAGCCCTGGGCCCCCACCTCTTCTACCATC
CACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAACCTGGGTCCCTCACACTTCGCCAGTTGCGTCCCCGT
GGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGGGTGGCCTCCACCTGCTCCCTCTCTCCTCACTGGCC
TTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCCCTTCACCCCTCCTTGCCCGCCTACCCTCCCTCCAG
AATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCCCCTTCATTTCTTCACCGCGGTTCCTCGTCATAGGG
GTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGTCTCCCACCCAGGGCCTTCCACCCTCGGCTCCTGTG
CTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGGCACCGTCGCCTAACCTGGTTTCTAGCTTTGCCCTC
ACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTGGTACCTCAGTGGGGAGGCTTCCTTACCAAGAATGA
GTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTCGGTGGAGCCAGGGGCAAATCTTAATGGGACCAGTG
GGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGCGCAGCTCTGCCCTCCCTGAGGCCCAGGACTATGCC
AGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAGTCCCCTAGAGTCTCAGAAGACTGGGCTCTTTGGAG
TACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGACTGGGTGGTCGGGAGGGAGACCCAGCTCTCCTTTC

>In-frame_CRK_ENST00000300574_chr17_1359171_-_SMG6_ENST00000544865_chr17_1964916_-_2166nt
GGGGGAGGCCCGCGGCTGCCGCCGCCATTTCGGGCGCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCC
GGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTTAGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGG
TACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGC
CCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCG
TCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCGGCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCG
CTCACAAGGAATGTTCCTGTACGGGACATCCCAGCCTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCG
TGGAACCGTTCCTGAAAGGCCACCAGGCGCCCAGTGTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACC
ATCCTCTTCCAACCCACGCCACGGCCATGCTGTGGGGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACC
CTCCTGGGCTGCCAGGATTTAGCAGGGAGGTGGCTGGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTT
TCTCCCTCCCCCGTCTCATTCCAAGGCTGAGGGAGGGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTT
CTGAGTTTCCGTCAGATGCAGTGAAATCACAGTTCCCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTC
AGGAAGAAGTGCCCAGGGTGTGTGTCCCCAGTCTCCCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCT
AACAGCAGCCCTGGGCCCCCACCTCTTCTACCATCCACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAAC
CTGGGTCCCTCACACTTCGCCAGTTGCGTCCCCGTGGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGG
GTGGCCTCCACCTGCTCCCTCTCTCCTCACTGGCCTTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCC
CTTCACCCCTCCTTGCCCGCCTACCCTCCCTCCAGAATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCC
CCTTCATTTCTTCACCGCGGTTCCTCGTCATAGGGGTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGT
CTCCCACCCAGGGCCTTCCACCCTCGGCTCCTGTGCTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGG
CACCGTCGCCTAACCTGGTTTCTAGCTTTGCCCTCACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTG
GTACCTCAGTGGGGAGGCTTCCTTACCAAGAATGAGTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTC
GGTGGAGCCAGGGGCAAATCTTAATGGGACCAGTGGGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGC
GCAGCTCTGCCCTCCCTGAGGCCCAGGACTATGCCAGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAG
TCCCCTAGAGTCTCAGAAGACTGGGCTCTTTGGAGTACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGA
CTGGGTGGTCGGGAGGGAGACCCAGCTCTCCTTTCTGTCCCGTTTGCAGCACTGGTTTTGTTTCCTTAATAAATTTTTAGTTATGAAACA

>In-frame_CRK_ENST00000300574_chr17_1359171_-_SMG6_ENST00000263073_chr17_1964916_-_2162nt
GGGGGAGGCCCGCGGCTGCCGCCGCCATTTCGGGCGCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCC
GGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTTAGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGG
TACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGC
CCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCG
TCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCGGCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCG
CTCACAAGGAATGTTCCTGTACGGGACATCCCAGCCTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCG
TGGAACCGTTCCTGAAAGGCCACCAGGCGCCCAGTGTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACC
ATCCTCTTCCAACCCACGCCACGGCCATGCTGTGGGGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACC
CTCCTGGGCTGCCAGGATTTAGCAGGGAGGTGGCTGGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTT
TCTCCCTCCCCCGTCTCATTCCAAGGCTGAGGGAGGGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTT
CTGAGTTTCCGTCAGATGCAGTGAAATCACAGTTCCCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTC
AGGAAGAAGTGCCCAGGGTGTGTGTCCCCAGTCTCCCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCT
AACAGCAGCCCTGGGCCCCCACCTCTTCTACCATCCACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAAC
CTGGGTCCCTCACACTTCGCCAGTTGCGTCCCCGTGGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGG
GTGGCCTCCACCTGCTCCCTCTCTCCTCACTGGCCTTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCC
CTTCACCCCTCCTTGCCCGCCTACCCTCCCTCCAGAATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCC
CCTTCATTTCTTCACCGCGGTTCCTCGTCATAGGGGTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGT
CTCCCACCCAGGGCCTTCCACCCTCGGCTCCTGTGCTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGG
CACCGTCGCCTAACCTGGTTTCTAGCTTTGCCCTCACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTG
GTACCTCAGTGGGGAGGCTTCCTTACCAAGAATGAGTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTC
GGTGGAGCCAGGGGCAAATCTTAATGGGACCAGTGGGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGC
GCAGCTCTGCCCTCCCTGAGGCCCAGGACTATGCCAGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAG
TCCCCTAGAGTCTCAGAAGACTGGGCTCTTTGGAGTACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGA
CTGGGTGGTCGGGAGGGAGACCCAGCTCTCCTTTCTGTCCCGTTTGCAGCACTGGTTTTGTTTCCTTAATAAATTTTTAGTTATGAAACA

>In-frame_CRK_ENST00000300574_chr17_1359171_-_SMG6_ENST00000354901_chr17_1964916_-_2155nt
GGGGGAGGCCCGCGGCTGCCGCCGCCATTTCGGGCGCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCC
GGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTTAGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGG
TACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGC
CCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCG
TCGCCCGCCCAGCCTCCGCCCGAGGAGCCAATCCGGCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCG
CTCACAAGGAATGTTCCTGTACGGGACATCCCAGCCTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCG
TGGAACCGTTCCTGAAAGGCCACCAGGCGCCCAGTGTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACC
ATCCTCTTCCAACCCACGCCACGGCCATGCTGTGGGGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACC
CTCCTGGGCTGCCAGGATTTAGCAGGGAGGTGGCTGGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTT
TCTCCCTCCCCCGTCTCATTCCAAGGCTGAGGGAGGGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTT
CTGAGTTTCCGTCAGATGCAGTGAAATCACAGTTCCCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTC
AGGAAGAAGTGCCCAGGGTGTGTGTCCCCAGTCTCCCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCT
AACAGCAGCCCTGGGCCCCCACCTCTTCTACCATCCACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAAC
CTGGGTCCCTCACACTTCGCCAGTTGCGTCCCCGTGGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGG
GTGGCCTCCACCTGCTCCCTCTCTCCTCACTGGCCTTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCC
CTTCACCCCTCCTTGCCCGCCTACCCTCCCTCCAGAATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCC
CCTTCATTTCTTCACCGCGGTTCCTCGTCATAGGGGTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGT
CTCCCACCCAGGGCCTTCCACCCTCGGCTCCTGTGCTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGG
CACCGTCGCCTAACCTGGTTTCTAGCTTTGCCCTCACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTG
GTACCTCAGTGGGGAGGCTTCCTTACCAAGAATGAGTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTC
GGTGGAGCCAGGGGCAAATCTTAATGGGACCAGTGGGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGC
GCAGCTCTGCCCTCCCTGAGGCCCAGGACTATGCCAGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAG
TCCCCTAGAGTCTCAGAAGACTGGGCTCTTTGGAGTACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGA

>In-frame_CRK_ENST00000574295_chr17_1359171_-_SMG6_ENST00000544865_chr17_1964916_-_2057nt
CGGCACCCCAGCGTTTAGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTC
GGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCA
GCGTCTCAGAGAACTCGCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGC
CCGAGGAGCCAATCCGGCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTG
TACGGGACATCCCAGCCTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCGTGGAACCGTTCCTGAAAGG
CCACCAGGCGCCCAGTGTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACCATCCTCTTCCAACCCACGC
CACGGCCATGCTGTGGGGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACCCTCCTGGGCTGCCAGGATT
TAGCAGGGAGGTGGCTGGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTTTCTCCCTCCCCCGTCTCAT
TCCAAGGCTGAGGGAGGGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTTCTGAGTTTCCGTCAGATGC
AGTGAAATCACAGTTCCCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTCAGGAAGAAGTGCCCAGGGT
GTGTGTCCCCAGTCTCCCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCTAACAGCAGCCCTGGGCCCC
CACCTCTTCTACCATCCACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAACCTGGGTCCCTCACACTTCG
CCAGTTGCGTCCCCGTGGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGGGTGGCCTCCACCTGCTCCC
TCTCTCCTCACTGGCCTTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCCCTTCACCCCTCCTTGCCCG
CCTACCCTCCCTCCAGAATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCCCCTTCATTTCTTCACCGCG
GTTCCTCGTCATAGGGGTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGTCTCCCACCCAGGGCCTTCC
ACCCTCGGCTCCTGTGCTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGGCACCGTCGCCTAACCTGGT
TTCTAGCTTTGCCCTCACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTGGTACCTCAGTGGGGAGGCT
TCCTTACCAAGAATGAGTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTCGGTGGAGCCAGGGGCAAAT
CTTAATGGGACCAGTGGGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGCGCAGCTCTGCCCTCCCTGA
GGCCCAGGACTATGCCAGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAGTCCCCTAGAGTCTCAGAAG
ACTGGGCTCTTTGGAGTACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGACTGGGTGGTCGGGAGGGAG

>In-frame_CRK_ENST00000574295_chr17_1359171_-_SMG6_ENST00000263073_chr17_1964916_-_2053nt
CGGCACCCCAGCGTTTAGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTC
GGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCA
GCGTCTCAGAGAACTCGCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGC
CCGAGGAGCCAATCCGGCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTG
TACGGGACATCCCAGCCTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCGTGGAACCGTTCCTGAAAGG
CCACCAGGCGCCCAGTGTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACCATCCTCTTCCAACCCACGC
CACGGCCATGCTGTGGGGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACCCTCCTGGGCTGCCAGGATT
TAGCAGGGAGGTGGCTGGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTTTCTCCCTCCCCCGTCTCAT
TCCAAGGCTGAGGGAGGGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTTCTGAGTTTCCGTCAGATGC
AGTGAAATCACAGTTCCCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTCAGGAAGAAGTGCCCAGGGT
GTGTGTCCCCAGTCTCCCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCTAACAGCAGCCCTGGGCCCC
CACCTCTTCTACCATCCACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAACCTGGGTCCCTCACACTTCG
CCAGTTGCGTCCCCGTGGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGGGTGGCCTCCACCTGCTCCC
TCTCTCCTCACTGGCCTTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCCCTTCACCCCTCCTTGCCCG
CCTACCCTCCCTCCAGAATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCCCCTTCATTTCTTCACCGCG
GTTCCTCGTCATAGGGGTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGTCTCCCACCCAGGGCCTTCC
ACCCTCGGCTCCTGTGCTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGGCACCGTCGCCTAACCTGGT
TTCTAGCTTTGCCCTCACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTGGTACCTCAGTGGGGAGGCT
TCCTTACCAAGAATGAGTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTCGGTGGAGCCAGGGGCAAAT
CTTAATGGGACCAGTGGGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGCGCAGCTCTGCCCTCCCTGA
GGCCCAGGACTATGCCAGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAGTCCCCTAGAGTCTCAGAAG
ACTGGGCTCTTTGGAGTACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGACTGGGTGGTCGGGAGGGAG

>In-frame_CRK_ENST00000574295_chr17_1359171_-_SMG6_ENST00000354901_chr17_1964916_-_2046nt
CGGCACCCCAGCGTTTAGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTC
GGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCA
GCGTCTCAGAGAACTCGCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGC
CCGAGGAGCCAATCCGGCTACTGCGGGAGGTGGTGCTGTTGACGGATGACCGGAACCTGCGTGTGAAGGCGCTCACAAGGAATGTTCCTG
TACGGGACATCCCAGCCTTCCTCACGTGGGCCCAGGTGGGCTGAGGGAGCCACACTGGGGCCCCCCCCCCGTGGAACCGTTCCTGAAAGG
CCACCAGGCGCCCAGTGTAGCACGGAAGATGCCCACGTGCCTGAGCCACCAATCCACCCAGACAATAAACCATCCTCTTCCAACCCACGC
CACGGCCATGCTGTGGGGGACCTGCTCCTCACAGAGCCCCTCCCAAGGATCGGGCGGAAGCTGCTGGGACCCTCCTGGGCTGCCAGGATT
TAGCAGGGAGGTGGCTGGCTACAGCAACAGCAGCTGGGCAAGCCAGATAGGCCGCCCATGCTCTCAGCCTTTCTCCCTCCCCCGTCTCAT
TCCAAGGCTGAGGGAGGGCCTTCTCGCCTGGGGACGCAGCCACTTTCTCCAGTGGAGACAGGGCAGGGGTTCTGAGTTTCCGTCAGATGC
AGTGAAATCACAGTTCCCTTTCATCTTCAGAACCTCTGTCGTGAATGTGTTCAAGAGGCTTTGGTTAAGTCAGGAAGAAGTGCCCAGGGT
GTGTGTCCCCAGTCTCCCTGAGGCCTGGACTCGCCCATGAACCCAAGTCGGCTTCTAGACAGCATGTCCCTAACAGCAGCCCTGGGCCCC
CACCTCTTCTACCATCCACCCCAGACTTACCACACACCCTTCCTGCTGCTCCTCTTCCTGCCCTTATCAACCTGGGTCCCTCACACTTCG
CCAGTTGCGTCCCCGTGGACAGTCATGAGTCTAGAGGAAAGGGGCATCTGGTCTCAGGCCCGTGCTCTCGGGTGGCCTCCACCTGCTCCC
TCTCTCCTCACTGGCCTTTCTTTCCGTCTAGCTTCCTCTTCAGGAAATGTCCTGACTCCCCTCAGCTCCCCCTTCACCCCTCCTTGCCCG
CCTACCCTCCCTCCAGAATAGCCCCTCACCCTTCTTCCCCTTCTAGTTGATCCTTTTCACCTCCCTGATCCCCTTCATTTCTTCACCGCG
GTTCCTCGTCATAGGGGTTCTCACTCTGAACTTTCCCTCTCTACTACCCATGGCAGGAACCTAGTACAGGTCTCCCACCCAGGGCCTTCC
ACCCTCGGCTCCTGTGCTGGGAGAAACTTCCAGGCGTGGACAGCCCAGCCTGAGGCATTCCAGTGCTGGGGCACCGTCGCCTAACCTGGT
TTCTAGCTTTGCCCTCACTCCCCGGAAAAACTGACACTGACACAGGGGCCCTTTCCTTGCCCCTTTAGCTGGTACCTCAGTGGGGAGGCT
TCCTTACCAAGAATGAGTTCCTGAAACCCAGGGCCAGAGACAAGGACAACTTAGGGGAAGACGGGGTTTTCGGTGGAGCCAGGGGCAAAT
CTTAATGGGACCAGTGGGGGATACCCCAGAGCCCATGGCCTGACTGCACAGCCTGCCTGGAGGATGGGTGCGCAGCTCTGCCCTCCCTGA
GGCCCAGGACTATGCCAGAAGCGATGGGGTACCGTGTAGGGGAGCCAAGGCCAGTAGTTTGGGGGTAGGAGTCCCCTAGAGTCTCAGAAG
ACTGGGCTCTTTGGAGTACAGGGTCCCCGGCCTCTCCTTTAAGATTCTCTCCCCAGCTGGAAGGCCGATGACTGGGTGGTCGGGAGGGAG


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FusionGenePPI for CRK_SMG6


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check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CRKPLSCR1, DPPA4, BUB1, PSMC6, EGFR, ERBB4, BCAR1, SRCIN1, ARHGAP32, DOCK1, SRC, PTK2, MAP4K1, EPHA3, SH3KBP1, SOCS1, IRS4, MAPK8, KHDRBS1, ASAP1, PDGFRA, AVIL, GRB2, ARHGAP17, RET, PXN, PDGFRB, NEDD9, EPHB3, FRS2, MAP4K5, EPHB2, RAPGEF1, SH3BP1, SOS1, XPO1, WEE1, SHB, ZAP70, EPS15, CBL, PTPN1, CBLC, MICAL1, SYN1, PPP1CA, BCR, CSE1L, PIK3R1, TERF2IP, POT1, FASLG, EFS, ATXN1, KIT, ABL1, UBASH3B, PIK3R2, SHC1, PIK3CB, KRT1, PIK3CA, KRT2, KRT9, KRT10, HSPA8, KRT14, KRT5, KRT16, KRT6A, HSPA1B, KRT6B, PIK3C2B, TUBB, TUBB4B, CASS4, PTPN11, INPPL1, KRT17, ACTB, TUBB2A, SOS2, NCKIPSD, EDC4, HSPA1L, TUBB3, TUBA1A, CBLB, ABL2, HSPA9, RPS19, PIK3R3, PEAK1, GAB2, HSPA6, KRT3, KRT19, KRT15, HSPA5, AP2A1, KRT76, KRT77, PIK3CD, GAB1, KRT73, KRT8, AGO2, YWHAG, KRT79, KRT78, UBC, EEF1A1, YWHAQ, CORO1C, AP2B1, RPS5, DDX3X, DDX6, UBASH3A, KRT24, RPS25, SFN, ASAP3, KRT12, KRT4, AGO1, DNAJA3, RNGTT, RPL23, HSP90AB1, TUBA4B, LYZ, DDX5, RPS3, SERPINB6, HSPBP1, DSC1, AP2M1, GGA3, FUBP1, ATIC, SERPINH1, NANS, DHX9, HSPB1, SPR, DOK1, ERBB2, ERBB3, PPFIBP2, LMNA, BAG3, PTPN4, MAPK4, MET, SPRR2A, HUWE1, FAM154A, CAST, GFPT1, SRM, BEX5, RTCB, CHTF18, CNDP2, DOK2, DOK3, DOK7, ELK1, EPYC, EYA3, GAREM, FSTL1, GABPB2, HSH2D, KCTD13, KLHL20, LASP1, MAGEC3, MPG, MYLIP, MYOZ2, NUFIP2, OFCC1, PAFAH1B2, PHC2, PRKACA, PRRG2, RAB2B, SEMA4D, SH2D2A, SOCS6, STAT4, TCAP, TM4SF19, VAC14, ANKZF1, ANLN, ASB9, ASCL4, PRRC2B, BATF3, C4orf17, SETD9, C6orf141, CORO6, ESD, HABP4, IFT140, INO80E, ISL1, KCTD17, KLF15, LHX8, MNDA, PSMC1, PTTG1, RYBP, SEPT6, STRN4, TDG, TP53, TUBA1C, TWIST2, WDR83, ZKSCAN7, ZNF557, ATF3, FER, CLNK, RIN3, CCP110, CEP128, CEP89, ODF2, CEP19, COX6C, HIST1H1D, PPP1R12A, NUMA1, KAT6A, MPDZ, ARPC1B, SLC25A13, C10orf12, MRPL48, INF2, FLNA, STAT5A, FGFR1, TRIM15, TSG101, CDH1SMG6TERT, HDAC8, UPF1, HBB, PPP1CC, SOX2, RBM8A, MAGOH, PABPC1, SMG6, UPF3B, SMG5, SMG7, PSG1, C2orf68, FAM221B, SPATA1, HAO2, LPIN3, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneSMG6chr17:1359171chr17:1964916ENST00000263073-1719114_50313761420telomeric DNA
TgeneSMG6chr17:1359171chr17:1964916ENST00000354901-1012114_503468512telomeric DNA
TgeneSMG6chr17:1359171chr17:1964916ENST00000536871-911114_503468512telomeric DNA
TgeneSMG6chr17:1359171chr17:1964916ENST00000544865-1719114_50313451389telomeric DNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CRK_SMG6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CRK_SMG6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCRKC0151744Myocardial Ischemia1CTD_human