|
Fusion gene ID: 8489 |
FusionGeneSummary for CRK_ABR |
Fusion gene summary |
Fusion gene information | Fusion gene name: CRK_ABR | Fusion gene ID: 8489 | Hgene | Tgene | Gene symbol | CRK | ABR | Gene ID | 1398 | 29 |
Gene name | CRK proto-oncogene, adaptor protein | ABR, RhoGEF and GTPase activating protein | |
Synonyms | CRKII|p38 | MDB | |
Cytomap | 17p13.3 | 17p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | adapter molecule crkproto-oncogene c-Crkv-crk avian sarcoma virus CT10 oncogene homologv-crk sarcoma virus CT10 oncogene-like protein | active breakpoint cluster region-related proteinactive BCR-related | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P46108 | Q12979 | |
Ensembl transtripts involved in fusion gene | ENST00000398970, ENST00000300574, ENST00000574295, ENST00000572145, | ENST00000302538, ENST00000544583, ENST00000572441, ENST00000574437, ENST00000291107, ENST00000543210, ENST00000536794, ENST00000573895, | |
Fusion gene scores | * DoF score | 10 X 5 X 6=300 | 14 X 13 X 8=1456 |
# samples | 10 | 18 | |
** MAII score | log2(10/300*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/1456*10)=-3.01594154386902 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CRK [Title/Abstract] AND ABR [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CRK | GO:0009966 | regulation of signal transduction | 17515907 |
Hgene | CRK | GO:0032956 | regulation of actin cytoskeleton organization | 11870224 |
Hgene | CRK | GO:0043087 | regulation of GTPase activity | 11870224 |
Hgene | CRK | GO:0048013 | ephrin receptor signaling pathway | 11870224 |
Hgene | CRK | GO:0061045 | negative regulation of wound healing | 17515907 |
Hgene | CRK | GO:0071538 | SH2 domain-mediated complex assembly | 12384576 |
Hgene | CRK | GO:2000146 | negative regulation of cell motility | 17515907 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | SARC | TCGA-DX-A1KY-01A | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000398970 | ENST00000302538 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
5CDS-5UTR | ENST00000398970 | ENST00000544583 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
5CDS-intron | ENST00000398970 | ENST00000572441 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
5CDS-5UTR | ENST00000398970 | ENST00000574437 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
5CDS-intron | ENST00000398970 | ENST00000291107 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
5CDS-intron | ENST00000398970 | ENST00000543210 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
5CDS-intron | ENST00000398970 | ENST00000536794 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
5CDS-intron | ENST00000398970 | ENST00000573895 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
intron-3CDS | ENST00000300574 | ENST00000302538 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
intron-5UTR | ENST00000300574 | ENST00000544583 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
intron-intron | ENST00000300574 | ENST00000572441 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
intron-5UTR | ENST00000300574 | ENST00000574437 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
intron-intron | ENST00000300574 | ENST00000291107 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
intron-intron | ENST00000300574 | ENST00000543210 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
intron-intron | ENST00000300574 | ENST00000536794 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
intron-intron | ENST00000300574 | ENST00000573895 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
intron-3CDS | ENST00000574295 | ENST00000302538 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
intron-5UTR | ENST00000574295 | ENST00000544583 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
intron-intron | ENST00000574295 | ENST00000572441 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
intron-5UTR | ENST00000574295 | ENST00000574437 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
intron-intron | ENST00000574295 | ENST00000291107 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
intron-intron | ENST00000574295 | ENST00000543210 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
intron-intron | ENST00000574295 | ENST00000536794 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
intron-intron | ENST00000574295 | ENST00000573895 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
5UTR-3CDS | ENST00000572145 | ENST00000302538 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
5UTR-5UTR | ENST00000572145 | ENST00000544583 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
5UTR-intron | ENST00000572145 | ENST00000572441 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
5UTR-5UTR | ENST00000572145 | ENST00000574437 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
5UTR-intron | ENST00000572145 | ENST00000291107 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
5UTR-intron | ENST00000572145 | ENST00000543210 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
5UTR-intron | ENST00000572145 | ENST00000536794 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
5UTR-intron | ENST00000572145 | ENST00000573895 | CRK | chr17 | 1340084 | - | ABR | chr17 | 1028702 | - |
Top |
FusionProtFeatures for CRK_ABR |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
CRK | ABR |
Isoform Crk-II: Regulates cell adhesion, spreading andmigration. Mediates attachment-induced MAPK8 activation, membraneruffling and cell motility in a Rac-dependent manner. Involved inphagocytosis of apoptotic cells and cell motility via itsinteraction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3signaling. {ECO:0000269|PubMed:11870224,ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907,ECO:0000269|PubMed:19004829}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CRK | chr17:1340084 | chr17:1028702 | ENST00000398970 | - | 2 | 3 | 132_192 | 202 | 205 | Domain | SH3 1 |
Hgene | CRK | chr17:1340084 | chr17:1028702 | ENST00000398970 | - | 2 | 3 | 13_118 | 202 | 205 | Domain | SH2 |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000291107 | - | 0 | 22 | 417_420 | -11 | 823 | Compositional bias | Note=Poly-Leu |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000302538 | - | 0 | 23 | 417_420 | 20 | 860 | Compositional bias | Note=Poly-Leu |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000543210 | - | 0 | 8 | 417_420 | -33 | 311 | Compositional bias | Note=Poly-Leu |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000544583 | - | 0 | 23 | 417_420 | -26 | 814 | Compositional bias | Note=Poly-Leu |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000574437 | - | 0 | 22 | 417_420 | -155 | 814 | Compositional bias | Note=Poly-Leu |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000291107 | - | 0 | 22 | 301_459 | -11 | 823 | Domain | PH |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000291107 | - | 0 | 22 | 463_595 | -11 | 823 | Domain | C2 |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000291107 | - | 0 | 22 | 647_845 | -11 | 823 | Domain | Rho-GAP |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000291107 | - | 0 | 22 | 91_284 | -11 | 823 | Domain | DH |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000302538 | - | 0 | 23 | 301_459 | 20 | 860 | Domain | PH |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000302538 | - | 0 | 23 | 463_595 | 20 | 860 | Domain | C2 |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000302538 | - | 0 | 23 | 647_845 | 20 | 860 | Domain | Rho-GAP |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000302538 | - | 0 | 23 | 91_284 | 20 | 860 | Domain | DH |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000543210 | - | 0 | 8 | 301_459 | -33 | 311 | Domain | PH |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000543210 | - | 0 | 8 | 463_595 | -33 | 311 | Domain | C2 |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000543210 | - | 0 | 8 | 647_845 | -33 | 311 | Domain | Rho-GAP |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000543210 | - | 0 | 8 | 91_284 | -33 | 311 | Domain | DH |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000544583 | - | 0 | 23 | 301_459 | -26 | 814 | Domain | PH |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000544583 | - | 0 | 23 | 463_595 | -26 | 814 | Domain | C2 |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000544583 | - | 0 | 23 | 647_845 | -26 | 814 | Domain | Rho-GAP |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000544583 | - | 0 | 23 | 91_284 | -26 | 814 | Domain | DH |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000574437 | - | 0 | 22 | 301_459 | -155 | 814 | Domain | PH |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000574437 | - | 0 | 22 | 463_595 | -155 | 814 | Domain | C2 |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000574437 | - | 0 | 22 | 647_845 | -155 | 814 | Domain | Rho-GAP |
Tgene | >ABR | chr17:1340084 | chr17:1028702 | ENST00000574437 | - | 0 | 22 | 91_284 | -155 | 814 | Domain | DH |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >CRK | chr17:1340084 | chr17:1028702 | ENST00000300574 | - | 1 | 3 | 132_192 | -47 | 305 | Domain | SH3 1 |
Hgene | >CRK | chr17:1340084 | chr17:1028702 | ENST00000300574 | - | 1 | 3 | 13_118 | -47 | 305 | Domain | SH2 |
Hgene | >CRK | chr17:1340084 | chr17:1028702 | ENST00000300574 | - | 1 | 3 | 235_296 | -47 | 305 | Domain | SH3 2 |
Hgene | >CRK | chr17:1340084 | chr17:1028702 | ENST00000398970 | - | 2 | 3 | 235_296 | 202 | 205 | Domain | SH3 2 |
Top |
FusionGeneSequence for CRK_ABR |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_CRK_ENST00000398970_chr17_1340084_-_ABR_ENST00000302538_chr17_1028702_-_1042aa MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIG DQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG MIPVPYVEKYRPASASVSALIGDFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKG LEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLA SQLGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQ DALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFP SPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERS EWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLYGFLHVIVHSAKGFKQSANLYCTLEVDSFGYFVSKA KTRVFRDTAEPKWDEEFEIELEGSQSLRILCYEKCYDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTS RDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIA GTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPS |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_CRK_ENST00000398970_chr17_1340084_-_ABR_ENST00000302538_chr17_1028702_-_3126nt ATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAG CGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTAC ATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGGGGTGAGCCCCTCCAGACTCCGAATAGGA GATCAAGAGTTTGATTCATTGCCTGCTTTACTGGAATTCTACAAAATACACTATTTGGACACTACAACGTTGATAGAACCAGTTTCCAGA TCCAGGCAGGGTAGTGGAGTGATTCTCAGGCAGGAGGAGGCGGAGTATGTGCGAGCCCTCTTTGACTTTAATGGGAATGATGAGGAAGAT CTTCCCTTTAAGAAAGGAGACATCTTGAGAATCCGGGACAAGCCTGAAGAGCAGTGGTGGAATGCGGAGGACAGCGAAGGCAAGAGAGGG ATGATTCCAGTCCCTTACGTCGAGAAGTATAGACCTGCCTCCGCCTCAGTATCGGCTCTGATTGGAGACTTCAGCTACGGGACGGACGAG TACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCGGAGGGCTCAGAGACCATGCCGTACATCGATGAGTCGCCCACCATGTCCCCG CAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTCTCCCCGACTCCACCTGAGGGACTGGCTCCTGGGGTGGAAGCAGGGAAAGGC CTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCCAGCGAAGAGATCTACATTAACCAGCTGGAAGCCCTGTTGCTGCCCATGAAA CCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTCACCATCCAGCAGATCGAGACCATCTTCTACAAGATCCAGGACATCTATGAG ATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTGCAACAGTGGGACAGCCAGGTCACCATGGGCCACCTCTTCCAGAAGCTGGCC AGCCAGCTCGGTGTGTACAAAGCGTTTGTCGATAACTATAAAGTCGCTCTGGAGACAGCTGAGAAGTGCAGCCAGTCCAACAACCAGTTC CAGAAGATCTCAGAGGAACTCAAAGTGAAAGGTCCCAAGGACTCCAAGGACAGCCACACGTCTGTCACCATGGAAGCTCTGCTCTACAAG CCCATTGACCGGGTCACTCGGAGCACCCTAGTCCTACACGACCTGCTGAAGCACACACCTGTGGACCACCCCGACTACCCGCTGCTGCAG GATGCCCTCCGCATCTCCCAGAACTTCCTGTCCAGCATCAACGAGGACATCGACCCCCGCCGGACTGCAGTGACAACGCCCAAGGGGGAG ACGCGACAGCTGGTGAAGGACGGCTTCCTGGTGGAAGTGTCAGAGAGCTCCCGGAAGCTGCGGCACGTCTTCCTCTTTACAGATGTCCTA CTGTGTGCCAAGCTGAAGAAGACCTCTGCAGGGAAGCACCAGCAGTATGACTGTAAGTGGTACATCCCCCTGGCCGACCTGGTGTTTCCA TCCCCCGAGGAGTCTGAGGCCAGCCCCCAGGTGCACCCCTTCCCAGACCATGAGCTGGAGGACATGAAGATGAAGATCTCTGCCCTCAAG AGTGAAATCCAGAAGGAGAAAGCCAACAAAGGCCAGAGCCGGGCCATCGAGCGCCTGAAGAAGAAGATGTTTGAGAATGAGTTCCTGCTG CTGCTCAACTCCCCCACAATCCCGTTCAGGATCCACAATCGGAATGGAAAGAGTTACCTGTTCCTACTGTCCTCGGACTACGAGAGGTCA GAGTGGAGAGAAGCAATTCAGAAACTACAGAAGAAGGATCTCCAGGCCTTTGTCCTGAGCTCAGTGGAGCTCCAGGTGCTCACAGGATCC TGTTTCAAGCTTAGGACTGTACACAACATTCCTGTCACCAGCAATAAAGACGACGATGAGTCTCCAGGACTCTATGGCTTCCTTCATGTC ATCGTCCACTCTGCCAAGGGATTTAAGCAATCAGCCAACCTGTACTGTACCCTGGAGGTGGATTCCTTCGGCTATTTTGTCAGCAAAGCC AAAACCAGGGTGTTCCGGGACACAGCGGAGCCCAAGTGGGATGAGGAGTTTGAGATCGAGCTGGAGGGCTCCCAGTCCCTGAGGATCCTG TGCTATGAGAAGTGCTATGACAAGACCAAGGTCAACAAGGACAACAATGAGATCGTGGACAAGATCATGGGCAAAGGACAGATCCAGCTG GACCCACAAACCGTGGAGACCAAGAACTGGCACACGGACGTGATTGAGATGAACGGGATCAAAGTGGAATTTTCCATGAAATTCACCAGC CGAGATATGAGCCTGAAGAGGACCCCGTCCAAAAAGCAGACCGGCGTCTTCGGTGTGAAGATCAGCGTGGTGACGAAGCGGGAGCGCTCC AAGGTGCCCTACATCGTCCGGCAGTGTGTGGAGGAGGTGGAGAAGAGGGGTATCGAGGAGGTTGGCATCTACAGGATATCGGGCGTGGCC ACGGACATCCAGGCGCTCAAGGCCGTCTTCGATGCCAATAACAAGGACATCCTGCTGATGCTGAGTGACATGGACATCAACGCCATCGCC GGGACGCTCAAGCTGTACTTCCGGGAACTGCCCGAGCCGCTCCTCACGGACCGACTCTACCCAGCCTTCATGGAGGGCATCGCCCTGTCA GACCCTGCTGCCAAGGAAAACTGCATGATGCACCTGCTCCGCTCCCTGCCCGACCCCAACCTCATCACCTTCCTCTTCCTGCTGGAACAC TTGAAAAGGGTTGCCGAGAAGGAGCCCATCAACAAAATGTCACTTCACAACCTGGCTACCGTGTTTGGACCCACGTTACTGAGACCCTCA GAAGTGGAGAGCAAAGCACACCTCACCTCGGCTGCGGACATCTGGTCCCATGACGTCATGGCGCAGGTCCAGGTCCTCCTCTACTACCTG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_CRK_ENST00000398970_chr17_1340084_-_ABR_ENST00000302538_chr17_1028702_-_5794nt GCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCCGGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTT AGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGC GCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTC GCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGGGGTGAGCCCCTC CAGACTCCGAATAGGAGATCAAGAGTTTGATTCATTGCCTGCTTTACTGGAATTCTACAAAATACACTATTTGGACACTACAACGTTGAT AGAACCAGTTTCCAGATCCAGGCAGGGTAGTGGAGTGATTCTCAGGCAGGAGGAGGCGGAGTATGTGCGAGCCCTCTTTGACTTTAATGG GAATGATGAGGAAGATCTTCCCTTTAAGAAAGGAGACATCTTGAGAATCCGGGACAAGCCTGAAGAGCAGTGGTGGAATGCGGAGGACAG CGAAGGCAAGAGAGGGATGATTCCAGTCCCTTACGTCGAGAAGTATAGACCTGCCTCCGCCTCAGTATCGGCTCTGATTGGAGACTTCAG CTACGGGACGGACGAGTACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCGGAGGGCTCAGAGACCATGCCGTACATCGATGAGTC GCCCACCATGTCCCCGCAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTCTCCCCGACTCCACCTGAGGGACTGGCTCCTGGGGT GGAAGCAGGGAAAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCCAGCGAAGAGATCTACATTAACCAGCTGGAAGCCCT GTTGCTGCCCATGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTCACCATCCAGCAGATCGAGACCATCTTCTACAAGAT CCAGGACATCTATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTGCAACAGTGGGACAGCCAGGTCACCATGGGCCACCT CTTCCAGAAGCTGGCCAGCCAGCTCGGTGTGTACAAAGCGTTTGTCGATAACTATAAAGTCGCTCTGGAGACAGCTGAGAAGTGCAGCCA GTCCAACAACCAGTTCCAGAAGATCTCAGAGGAACTCAAAGTGAAAGGTCCCAAGGACTCCAAGGACAGCCACACGTCTGTCACCATGGA AGCTCTGCTCTACAAGCCCATTGACCGGGTCACTCGGAGCACCCTAGTCCTACACGACCTGCTGAAGCACACACCTGTGGACCACCCCGA CTACCCGCTGCTGCAGGATGCCCTCCGCATCTCCCAGAACTTCCTGTCCAGCATCAACGAGGACATCGACCCCCGCCGGACTGCAGTGAC AACGCCCAAGGGGGAGACGCGACAGCTGGTGAAGGACGGCTTCCTGGTGGAAGTGTCAGAGAGCTCCCGGAAGCTGCGGCACGTCTTCCT CTTTACAGATGTCCTACTGTGTGCCAAGCTGAAGAAGACCTCTGCAGGGAAGCACCAGCAGTATGACTGTAAGTGGTACATCCCCCTGGC CGACCTGGTGTTTCCATCCCCCGAGGAGTCTGAGGCCAGCCCCCAGGTGCACCCCTTCCCAGACCATGAGCTGGAGGACATGAAGATGAA GATCTCTGCCCTCAAGAGTGAAATCCAGAAGGAGAAAGCCAACAAAGGCCAGAGCCGGGCCATCGAGCGCCTGAAGAAGAAGATGTTTGA GAATGAGTTCCTGCTGCTGCTCAACTCCCCCACAATCCCGTTCAGGATCCACAATCGGAATGGAAAGAGTTACCTGTTCCTACTGTCCTC GGACTACGAGAGGTCAGAGTGGAGAGAAGCAATTCAGAAACTACAGAAGAAGGATCTCCAGGCCTTTGTCCTGAGCTCAGTGGAGCTCCA GGTGCTCACAGGATCCTGTTTCAAGCTTAGGACTGTACACAACATTCCTGTCACCAGCAATAAAGACGACGATGAGTCTCCAGGACTCTA TGGCTTCCTTCATGTCATCGTCCACTCTGCCAAGGGATTTAAGCAATCAGCCAACCTGTACTGTACCCTGGAGGTGGATTCCTTCGGCTA TTTTGTCAGCAAAGCCAAAACCAGGGTGTTCCGGGACACAGCGGAGCCCAAGTGGGATGAGGAGTTTGAGATCGAGCTGGAGGGCTCCCA GTCCCTGAGGATCCTGTGCTATGAGAAGTGCTATGACAAGACCAAGGTCAACAAGGACAACAATGAGATCGTGGACAAGATCATGGGCAA AGGACAGATCCAGCTGGACCCACAAACCGTGGAGACCAAGAACTGGCACACGGACGTGATTGAGATGAACGGGATCAAAGTGGAATTTTC CATGAAATTCACCAGCCGAGATATGAGCCTGAAGAGGACCCCGTCCAAAAAGCAGACCGGCGTCTTCGGTGTGAAGATCAGCGTGGTGAC GAAGCGGGAGCGCTCCAAGGTGCCCTACATCGTCCGGCAGTGTGTGGAGGAGGTGGAGAAGAGGGGTATCGAGGAGGTTGGCATCTACAG GATATCGGGCGTGGCCACGGACATCCAGGCGCTCAAGGCCGTCTTCGATGCCAATAACAAGGACATCCTGCTGATGCTGAGTGACATGGA CATCAACGCCATCGCCGGGACGCTCAAGCTGTACTTCCGGGAACTGCCCGAGCCGCTCCTCACGGACCGACTCTACCCAGCCTTCATGGA GGGCATCGCCCTGTCAGACCCTGCTGCCAAGGAAAACTGCATGATGCACCTGCTCCGCTCCCTGCCCGACCCCAACCTCATCACCTTCCT CTTCCTGCTGGAACACTTGAAAAGGGTTGCCGAGAAGGAGCCCATCAACAAAATGTCACTTCACAACCTGGCTACCGTGTTTGGACCCAC GTTACTGAGACCCTCAGAAGTGGAGAGCAAAGCACACCTCACCTCGGCTGCGGACATCTGGTCCCATGACGTCATGGCGCAGGTCCAGGT CCTCCTCTACTACCTGCAGCACCCCCCCATTTCCTTCGCAGAACTCAAGCGGAACACACTGTACTTCTCCACCGACGTGTAGCCCGAGGC AGGGTGGCTGCGGGCGGGTGGTGGAACCAGCCCCTCCAGCCTGGGGTCCAACTCAGACTTGAAAGACTGCAATAGAAAACTCCCAAACCC AGCACTCCAGACTCGAGGGAAGCCAGCTTCCAAGAACTGGAATGCGTACGTCTTTTGTGCCACCTTGTACAAAGCCGGCTGCCCAGCCCC AGCCTCACCACCGCATCCCACCTCCTGCCCTCCATACCTCTAGTTGTGTCTGATGCTCCGTGCTGTTCGGGAATTGTTTTATGTACACTT GTCAGGCAGAAAAGGTAGTGACCGGCCCGGCGTGGGCACACAGACAGCCCGCTTTGTTCTTTCATTTCCTCCAGCACTTTCTTTCCGCCT GAGTCCAGCCCAAGGCCTTTTATTTTGCGCTGTGTAACTGCTGCCAGCTTCTCTCTTGGCCCTGCTCCCAGATGGCGGTCTCCTGGCAGC CTCCCCTCAGTCTTCCTCCACCCGCTCTTCCTTCCCAGCCTGCCTGCATGCATGTGCACCCTTGGTCTTCGCTCCATCGCCTTGAAAGCT CTGAAGAGGCCCTGGGTTGCCGCGGCAGCAGTGGTCTGTTTGATGCTGCCGTTTGCCGCTGCCGGCCCCTCCTCAGACTCCGCCTTTGGG AGCACACCTGCTTTGCCTTGCTGCCTGTGCAAATGTTGGACAAGCAGACACACTCACACTCGTCCCCAGCTTAGCACAGAGCTGGAGCGC CCATTTCTGGAATTTTCCGTTTGGGAATCTCCACTTCTGGGGTTTACCTGTTCGGCCTCCTGTCTATCAGTGAGGCATCTCTGACTGTTT CTTCTACTGCTTTTCAGTTCCCTTCCCTGCTGTTCTATTTCCTTTGAGTGTAAAGACTCACAGGTGACCTGCTATCGAGATAGCCAGAGG GTCAGGAGAGAATGGGGGAGGAGGCGGTCAGGCTGCTGAGGAAACACCACAGGCTGAACGGGGGAGGAATGCACATGCCACGCTGGGTGT CCCGGGTCGCGGGGAGGCAGCTCAGCTCTTAGGAGCAAGTTGTGGGGGCTTTTCAAGAGGGGCCAGGCTTCCTGGAGGGTGACTGATGTG GCCGAAGCAGGTGTCCAGGCAGGTAGGCTGCAGCCAGGAGCTCCCTGGCACCGCAGGACCTCGTGGTACTCTTGCCTTAGATTTTACACA CACTCCACAGCCAAGCACTGCCACGGTCCTCCAGGACCTGGGAAGCAAAGGCACAGGCCCACGGTGGCCAGCCATTGTGGTGCCGCCCCA GCTTCTGGATACAGCCTTTTGGGTAAACACTGGGAACTCCAGAAGTTGTGGGGAGAGTGGGGAATCAGACAGCCGCCTCTAGGGGCTGGG TTCTGCTGGGGCCTCCTTGTTGGTGCTGTAGGCACCCGCCAGGGAGCAGGGACCCGACTTGCAGACGCATTGCCCGGTACTAGGAAGGAG TGAGGTGTGTTCCCACCGTACACTTCCCACACGAGCTGCGGCTGCCAGCCTCGGGCCATCAGCCTAGGAGAGCAGATGCAGCTCCAGGGG CTCGACTTATAGCCAGTTACAGCTCCCCGGCTCTTCTGTGTGGCAGAGCGTCGTTTCCGGGCCCTCAGGGCTGGGGAGCTCAGTTCCCAT TGCTTGTGCTCAGGGCTGAGTCTTAAAGAAGGGTTTGCCGGCCCTAACGCTGCAGCGCGTGCGCGGTGAGAGGCCCTTTTTGAGCCTGTT TACTCCTGTGGCCTTGGGCAGAACAGTAAATACTCTGTGCACGGAGGAAAGACATGCCCAAGAGGAAGGAAGTACTGACCATCGGCTGCC TGTGAGCAGCTTAGCAAGGAGCCCTTGCTCCCTGGGAAAGGCGGTGAACTTGAGTCTAAAGATGCAGTGCCTGGCCCTTCCTAAGGTCCC TGCCTGGCATCCGAGTGTCGGTGTGTGGCACAGAAGGCTCCTGCTTGCTTCCAAAGTGATGGACAGGAAGGGGCAGAGTGAGTCACGGCC CAGACTGGGCACCTTCGCGTCTCAGCCTCAGGGAGCCCCACAGCCCCAAGCTCGCTGAGGCAACGTGAGAACAGGCTATGGGAAGGCTGC AAAGGCTGAGAAATGCAAAGGCTCATATTTATAAATCCCACCCCCAGAGTGGGGAGGGTCAGGTGCCAGACCTGGACTAAACTGCACCAA GGAAACACCCAGCAGGGTCTCCTGTGAGCCGGGGACCATGCAGCCCGAAACCTCCAGTCACTGCGCCCGGCAGGAGTCAGGAGCCAGGGA CTGTGCAGCCTGGAACCTCCAGTCACTGTGCCCAGCAGGGTGGGCTGTGCCCAGCAGGAGTCAGGCTAAGAAACGCCAGGTCTGCCTGTT CTTGCTGGGCAATGGCTGATGGCTGCCAGTTTCTGCTGATACACAGGTAGGATGGGACCCTTCATGAATATCTGACTTTAATAAGTTGGT AAGGATATATTTTTTTGTCTATGTTCTGTTTCAACTTATGTAGATTATTATAAATTGATGTAAACCACGTGAGAGGAAAATGTTAATAAA |
Top |
FusionGenePPI for CRK_ABR |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CRK | PLSCR1, DPPA4, BUB1, PSMC6, EGFR, ERBB4, BCAR1, SRCIN1, ARHGAP32, DOCK1, SRC, PTK2, MAP4K1, EPHA3, SH3KBP1, SOCS1, IRS4, MAPK8, KHDRBS1, ASAP1, PDGFRA, AVIL, GRB2, ARHGAP17, RET, PXN, PDGFRB, NEDD9, EPHB3, FRS2, MAP4K5, EPHB2, RAPGEF1, SH3BP1, SOS1, XPO1, WEE1, SHB, ZAP70, EPS15, CBL, PTPN1, CBLC, MICAL1, SYN1, PPP1CA, BCR, CSE1L, PIK3R1, TERF2IP, POT1, FASLG, EFS, ATXN1, KIT, ABL1, UBASH3B, PIK3R2, SHC1, PIK3CB, KRT1, PIK3CA, KRT2, KRT9, KRT10, HSPA8, KRT14, KRT5, KRT16, KRT6A, HSPA1B, KRT6B, PIK3C2B, TUBB, TUBB4B, CASS4, PTPN11, INPPL1, KRT17, ACTB, TUBB2A, SOS2, NCKIPSD, EDC4, HSPA1L, TUBB3, TUBA1A, CBLB, ABL2, HSPA9, RPS19, PIK3R3, PEAK1, GAB2, HSPA6, KRT3, KRT19, KRT15, HSPA5, AP2A1, KRT76, KRT77, PIK3CD, GAB1, KRT73, KRT8, AGO2, YWHAG, KRT79, KRT78, UBC, EEF1A1, YWHAQ, CORO1C, AP2B1, RPS5, DDX3X, DDX6, UBASH3A, KRT24, RPS25, SFN, ASAP3, KRT12, KRT4, AGO1, DNAJA3, RNGTT, RPL23, HSP90AB1, TUBA4B, LYZ, DDX5, RPS3, SERPINB6, HSPBP1, DSC1, AP2M1, GGA3, FUBP1, ATIC, SERPINH1, NANS, DHX9, HSPB1, SPR, DOK1, ERBB2, ERBB3, PPFIBP2, LMNA, BAG3, PTPN4, MAPK4, MET, SPRR2A, HUWE1, FAM154A, CAST, GFPT1, SRM, BEX5, RTCB, CHTF18, CNDP2, DOK2, DOK3, DOK7, ELK1, EPYC, EYA3, GAREM, FSTL1, GABPB2, HSH2D, KCTD13, KLHL20, LASP1, MAGEC3, MPG, MYLIP, MYOZ2, NUFIP2, OFCC1, PAFAH1B2, PHC2, PRKACA, PRRG2, RAB2B, SEMA4D, SH2D2A, SOCS6, STAT4, TCAP, TM4SF19, VAC14, ANKZF1, ANLN, ASB9, ASCL4, PRRC2B, BATF3, C4orf17, SETD9, C6orf141, CORO6, ESD, HABP4, IFT140, INO80E, ISL1, KCTD17, KLF15, LHX8, MNDA, PSMC1, PTTG1, RYBP, SEPT6, STRN4, TDG, TP53, TUBA1C, TWIST2, WDR83, ZKSCAN7, ZNF557, ATF3, FER, CLNK, RIN3, CCP110, CEP128, CEP89, ODF2, CEP19, COX6C, HIST1H1D, PPP1R12A, NUMA1, KAT6A, MPDZ, ARPC1B, SLC25A13, C10orf12, MRPL48, INF2, FLNA, STAT5A, FGFR1, TRIM15, TSG101, CDH1 | ABR | LNX1, APP, ECT2, ERBB2IP, AURKB, CDKN1A, CEP250, CEP57, CEP76, TP53, MOV10, NXF1, HERC2, TRIM25 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CRK_ABR |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CRK_ABR |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CRK | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | ABR | C0033578 | Prostatic Neoplasms | 1 | CTD_human |