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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 8489

FusionGeneSummary for CRK_ABR

check button Fusion gene summary
Fusion gene informationFusion gene name: CRK_ABR
Fusion gene ID: 8489
HgeneTgene
Gene symbol

CRK

ABR

Gene ID

1398

29

Gene nameCRK proto-oncogene, adaptor proteinABR, RhoGEF and GTPase activating protein
SynonymsCRKII|p38MDB
Cytomap

17p13.3

17p13.3

Type of geneprotein-codingprotein-coding
Descriptionadapter molecule crkproto-oncogene c-Crkv-crk avian sarcoma virus CT10 oncogene homologv-crk sarcoma virus CT10 oncogene-like proteinactive breakpoint cluster region-related proteinactive BCR-related
Modification date2018052220180523
UniProtAcc

P46108

Q12979

Ensembl transtripts involved in fusion geneENST00000398970, ENST00000300574, 
ENST00000574295, ENST00000572145, 
ENST00000302538, ENST00000544583, 
ENST00000572441, ENST00000574437, 
ENST00000291107, ENST00000543210, 
ENST00000536794, ENST00000573895, 
Fusion gene scores* DoF score10 X 5 X 6=30014 X 13 X 8=1456
# samples 1018
** MAII scorelog2(10/300*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/1456*10)=-3.01594154386902
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CRK [Title/Abstract] AND ABR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCRK

GO:0009966

regulation of signal transduction

17515907

HgeneCRK

GO:0032956

regulation of actin cytoskeleton organization

11870224

HgeneCRK

GO:0043087

regulation of GTPase activity

11870224

HgeneCRK

GO:0048013

ephrin receptor signaling pathway

11870224

HgeneCRK

GO:0061045

negative regulation of wound healing

17515907

HgeneCRK

GO:0071538

SH2 domain-mediated complex assembly

12384576

HgeneCRK

GO:2000146

negative regulation of cell motility

17515907


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A1KY-01ACRKchr17

1340084

-ABRchr17

1028702

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000398970ENST00000302538CRKchr17

1340084

-ABRchr17

1028702

-
5CDS-5UTRENST00000398970ENST00000544583CRKchr17

1340084

-ABRchr17

1028702

-
5CDS-intronENST00000398970ENST00000572441CRKchr17

1340084

-ABRchr17

1028702

-
5CDS-5UTRENST00000398970ENST00000574437CRKchr17

1340084

-ABRchr17

1028702

-
5CDS-intronENST00000398970ENST00000291107CRKchr17

1340084

-ABRchr17

1028702

-
5CDS-intronENST00000398970ENST00000543210CRKchr17

1340084

-ABRchr17

1028702

-
5CDS-intronENST00000398970ENST00000536794CRKchr17

1340084

-ABRchr17

1028702

-
5CDS-intronENST00000398970ENST00000573895CRKchr17

1340084

-ABRchr17

1028702

-
intron-3CDSENST00000300574ENST00000302538CRKchr17

1340084

-ABRchr17

1028702

-
intron-5UTRENST00000300574ENST00000544583CRKchr17

1340084

-ABRchr17

1028702

-
intron-intronENST00000300574ENST00000572441CRKchr17

1340084

-ABRchr17

1028702

-
intron-5UTRENST00000300574ENST00000574437CRKchr17

1340084

-ABRchr17

1028702

-
intron-intronENST00000300574ENST00000291107CRKchr17

1340084

-ABRchr17

1028702

-
intron-intronENST00000300574ENST00000543210CRKchr17

1340084

-ABRchr17

1028702

-
intron-intronENST00000300574ENST00000536794CRKchr17

1340084

-ABRchr17

1028702

-
intron-intronENST00000300574ENST00000573895CRKchr17

1340084

-ABRchr17

1028702

-
intron-3CDSENST00000574295ENST00000302538CRKchr17

1340084

-ABRchr17

1028702

-
intron-5UTRENST00000574295ENST00000544583CRKchr17

1340084

-ABRchr17

1028702

-
intron-intronENST00000574295ENST00000572441CRKchr17

1340084

-ABRchr17

1028702

-
intron-5UTRENST00000574295ENST00000574437CRKchr17

1340084

-ABRchr17

1028702

-
intron-intronENST00000574295ENST00000291107CRKchr17

1340084

-ABRchr17

1028702

-
intron-intronENST00000574295ENST00000543210CRKchr17

1340084

-ABRchr17

1028702

-
intron-intronENST00000574295ENST00000536794CRKchr17

1340084

-ABRchr17

1028702

-
intron-intronENST00000574295ENST00000573895CRKchr17

1340084

-ABRchr17

1028702

-
5UTR-3CDSENST00000572145ENST00000302538CRKchr17

1340084

-ABRchr17

1028702

-
5UTR-5UTRENST00000572145ENST00000544583CRKchr17

1340084

-ABRchr17

1028702

-
5UTR-intronENST00000572145ENST00000572441CRKchr17

1340084

-ABRchr17

1028702

-
5UTR-5UTRENST00000572145ENST00000574437CRKchr17

1340084

-ABRchr17

1028702

-
5UTR-intronENST00000572145ENST00000291107CRKchr17

1340084

-ABRchr17

1028702

-
5UTR-intronENST00000572145ENST00000543210CRKchr17

1340084

-ABRchr17

1028702

-
5UTR-intronENST00000572145ENST00000536794CRKchr17

1340084

-ABRchr17

1028702

-
5UTR-intronENST00000572145ENST00000573895CRKchr17

1340084

-ABRchr17

1028702

-

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FusionProtFeatures for CRK_ABR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRK

P46108

ABR

Q12979

Isoform Crk-II: Regulates cell adhesion, spreading andmigration. Mediates attachment-induced MAPK8 activation, membraneruffling and cell motility in a Rac-dependent manner. Involved inphagocytosis of apoptotic cells and cell motility via itsinteraction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3signaling. {ECO:0000269|PubMed:11870224,ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907,ECO:0000269|PubMed:19004829}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCRKchr17:1340084chr17:1028702ENST00000398970-23132_192202205DomainSH3 1
HgeneCRKchr17:1340084chr17:1028702ENST00000398970-2313_118202205DomainSH2
TgeneABRchr17:1340084chr17:1028702ENST00000291107-022417_420-11823Compositional biasNote=Poly-Leu
TgeneABRchr17:1340084chr17:1028702ENST00000302538-023417_42020860Compositional biasNote=Poly-Leu
TgeneABRchr17:1340084chr17:1028702ENST00000543210-08417_420-33311Compositional biasNote=Poly-Leu
TgeneABRchr17:1340084chr17:1028702ENST00000544583-023417_420-26814Compositional biasNote=Poly-Leu
TgeneABRchr17:1340084chr17:1028702ENST00000574437-022417_420-155814Compositional biasNote=Poly-Leu
TgeneABRchr17:1340084chr17:1028702ENST00000291107-022301_459-11823DomainPH
TgeneABRchr17:1340084chr17:1028702ENST00000291107-022463_595-11823DomainC2
TgeneABRchr17:1340084chr17:1028702ENST00000291107-022647_845-11823DomainRho-GAP
TgeneABRchr17:1340084chr17:1028702ENST00000291107-02291_284-11823DomainDH
TgeneABRchr17:1340084chr17:1028702ENST00000302538-023301_45920860DomainPH
TgeneABRchr17:1340084chr17:1028702ENST00000302538-023463_59520860DomainC2
TgeneABRchr17:1340084chr17:1028702ENST00000302538-023647_84520860DomainRho-GAP
TgeneABRchr17:1340084chr17:1028702ENST00000302538-02391_28420860DomainDH
TgeneABRchr17:1340084chr17:1028702ENST00000543210-08301_459-33311DomainPH
TgeneABRchr17:1340084chr17:1028702ENST00000543210-08463_595-33311DomainC2
TgeneABRchr17:1340084chr17:1028702ENST00000543210-08647_845-33311DomainRho-GAP
TgeneABRchr17:1340084chr17:1028702ENST00000543210-0891_284-33311DomainDH
TgeneABRchr17:1340084chr17:1028702ENST00000544583-023301_459-26814DomainPH
TgeneABRchr17:1340084chr17:1028702ENST00000544583-023463_595-26814DomainC2
TgeneABRchr17:1340084chr17:1028702ENST00000544583-023647_845-26814DomainRho-GAP
TgeneABRchr17:1340084chr17:1028702ENST00000544583-02391_284-26814DomainDH
TgeneABRchr17:1340084chr17:1028702ENST00000574437-022301_459-155814DomainPH
TgeneABRchr17:1340084chr17:1028702ENST00000574437-022463_595-155814DomainC2
TgeneABRchr17:1340084chr17:1028702ENST00000574437-022647_845-155814DomainRho-GAP
TgeneABRchr17:1340084chr17:1028702ENST00000574437-02291_284-155814DomainDH

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCRKchr17:1340084chr17:1028702ENST00000300574-13132_192-47305DomainSH3 1
HgeneCRKchr17:1340084chr17:1028702ENST00000300574-1313_118-47305DomainSH2
HgeneCRKchr17:1340084chr17:1028702ENST00000300574-13235_296-47305DomainSH3 2
HgeneCRKchr17:1340084chr17:1028702ENST00000398970-23235_296202205DomainSH3 2


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FusionGeneSequence for CRK_ABR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CRK_ENST00000398970_chr17_1340084_-_ABR_ENST00000302538_chr17_1028702_-_1042aa
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDTVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIG
DQEFDSLPALLEFYKIHTLDTTTLIEPVSRSRQGSGVILRQEEAETVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG
MIPVPYVEKTRPASASVSALIGDFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKG
LEMRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDITEIHKEFTDNLCPKVQQWDSQVTMGHLFQKLA
SQLGVYKAFVDNTKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQ
DALRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQTDCKWYIPLADLVFP
SPEESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERS
EWREAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDDDESPGLTGFLHVIVHSAKGFKQSANLYCTLEVDSFGTFVSKA
KTRVFRDTAEPKWDEEFEIELEGSQSLRILCTEKCTDKTKVNKDNNEIVDKIMGKGQIQLDPQTVETKNWHTDVIEMNGIKVEFSMKFTS
RDMSLKRTPSKKQTGVFGVKISVVTKRERSKVPYIVRQCVEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDMDINAIA
GTLKLYFRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAEKEPINKMSLHNLATVFGPTLLRPS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CRK_ENST00000398970_chr17_1340084_-_ABR_ENST00000302538_chr17_1028702_-_3126nt
ATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGCGCTGCTGCAGGGCCAG
CGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTCGCGCGTCTCCCACTAC
ATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGGGGTGAGCCCCTCCAGACTCCGAATAGGA
GATCAAGAGTTTGATTCATTGCCTGCTTTACTGGAATTCTACAAAATACACTATTTGGACACTACAACGTTGATAGAACCAGTTTCCAGA
TCCAGGCAGGGTAGTGGAGTGATTCTCAGGCAGGAGGAGGCGGAGTATGTGCGAGCCCTCTTTGACTTTAATGGGAATGATGAGGAAGAT
CTTCCCTTTAAGAAAGGAGACATCTTGAGAATCCGGGACAAGCCTGAAGAGCAGTGGTGGAATGCGGAGGACAGCGAAGGCAAGAGAGGG
ATGATTCCAGTCCCTTACGTCGAGAAGTATAGACCTGCCTCCGCCTCAGTATCGGCTCTGATTGGAGACTTCAGCTACGGGACGGACGAG
TACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCGGAGGGCTCAGAGACCATGCCGTACATCGATGAGTCGCCCACCATGTCCCCG
CAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTCTCCCCGACTCCACCTGAGGGACTGGCTCCTGGGGTGGAAGCAGGGAAAGGC
CTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCCAGCGAAGAGATCTACATTAACCAGCTGGAAGCCCTGTTGCTGCCCATGAAA
CCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTCACCATCCAGCAGATCGAGACCATCTTCTACAAGATCCAGGACATCTATGAG
ATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTGCAACAGTGGGACAGCCAGGTCACCATGGGCCACCTCTTCCAGAAGCTGGCC
AGCCAGCTCGGTGTGTACAAAGCGTTTGTCGATAACTATAAAGTCGCTCTGGAGACAGCTGAGAAGTGCAGCCAGTCCAACAACCAGTTC
CAGAAGATCTCAGAGGAACTCAAAGTGAAAGGTCCCAAGGACTCCAAGGACAGCCACACGTCTGTCACCATGGAAGCTCTGCTCTACAAG
CCCATTGACCGGGTCACTCGGAGCACCCTAGTCCTACACGACCTGCTGAAGCACACACCTGTGGACCACCCCGACTACCCGCTGCTGCAG
GATGCCCTCCGCATCTCCCAGAACTTCCTGTCCAGCATCAACGAGGACATCGACCCCCGCCGGACTGCAGTGACAACGCCCAAGGGGGAG
ACGCGACAGCTGGTGAAGGACGGCTTCCTGGTGGAAGTGTCAGAGAGCTCCCGGAAGCTGCGGCACGTCTTCCTCTTTACAGATGTCCTA
CTGTGTGCCAAGCTGAAGAAGACCTCTGCAGGGAAGCACCAGCAGTATGACTGTAAGTGGTACATCCCCCTGGCCGACCTGGTGTTTCCA
TCCCCCGAGGAGTCTGAGGCCAGCCCCCAGGTGCACCCCTTCCCAGACCATGAGCTGGAGGACATGAAGATGAAGATCTCTGCCCTCAAG
AGTGAAATCCAGAAGGAGAAAGCCAACAAAGGCCAGAGCCGGGCCATCGAGCGCCTGAAGAAGAAGATGTTTGAGAATGAGTTCCTGCTG
CTGCTCAACTCCCCCACAATCCCGTTCAGGATCCACAATCGGAATGGAAAGAGTTACCTGTTCCTACTGTCCTCGGACTACGAGAGGTCA
GAGTGGAGAGAAGCAATTCAGAAACTACAGAAGAAGGATCTCCAGGCCTTTGTCCTGAGCTCAGTGGAGCTCCAGGTGCTCACAGGATCC
TGTTTCAAGCTTAGGACTGTACACAACATTCCTGTCACCAGCAATAAAGACGACGATGAGTCTCCAGGACTCTATGGCTTCCTTCATGTC
ATCGTCCACTCTGCCAAGGGATTTAAGCAATCAGCCAACCTGTACTGTACCCTGGAGGTGGATTCCTTCGGCTATTTTGTCAGCAAAGCC
AAAACCAGGGTGTTCCGGGACACAGCGGAGCCCAAGTGGGATGAGGAGTTTGAGATCGAGCTGGAGGGCTCCCAGTCCCTGAGGATCCTG
TGCTATGAGAAGTGCTATGACAAGACCAAGGTCAACAAGGACAACAATGAGATCGTGGACAAGATCATGGGCAAAGGACAGATCCAGCTG
GACCCACAAACCGTGGAGACCAAGAACTGGCACACGGACGTGATTGAGATGAACGGGATCAAAGTGGAATTTTCCATGAAATTCACCAGC
CGAGATATGAGCCTGAAGAGGACCCCGTCCAAAAAGCAGACCGGCGTCTTCGGTGTGAAGATCAGCGTGGTGACGAAGCGGGAGCGCTCC
AAGGTGCCCTACATCGTCCGGCAGTGTGTGGAGGAGGTGGAGAAGAGGGGTATCGAGGAGGTTGGCATCTACAGGATATCGGGCGTGGCC
ACGGACATCCAGGCGCTCAAGGCCGTCTTCGATGCCAATAACAAGGACATCCTGCTGATGCTGAGTGACATGGACATCAACGCCATCGCC
GGGACGCTCAAGCTGTACTTCCGGGAACTGCCCGAGCCGCTCCTCACGGACCGACTCTACCCAGCCTTCATGGAGGGCATCGCCCTGTCA
GACCCTGCTGCCAAGGAAAACTGCATGATGCACCTGCTCCGCTCCCTGCCCGACCCCAACCTCATCACCTTCCTCTTCCTGCTGGAACAC
TTGAAAAGGGTTGCCGAGAAGGAGCCCATCAACAAAATGTCACTTCACAACCTGGCTACCGTGTTTGGACCCACGTTACTGAGACCCTCA
GAAGTGGAGAGCAAAGCACACCTCACCTCGGCTGCGGACATCTGGTCCCATGACGTCATGGCGCAGGTCCAGGTCCTCCTCTACTACCTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_CRK_ENST00000398970_chr17_1340084_-_ABR_ENST00000302538_chr17_1028702_-_5794nt
GCTGCTGTGAAGCTGAAACCGGAGCCGGTCCGCTGGGCGGCGGGCGCCGGGGGCCGGAGGGGCGCGCGCGGCGGCGGCACCCCAGCGTTT
AGGCGCGGAGGCAGCCATGGCGGGCAACTTCGACTCGGAGGAGCGGAGTAGCTGGTACTGGGGGAGGTTGAGTCGGCAGGAGGCGGTGGC
GCTGCTGCAGGGCCAGCGGCACGGGGTGTTCCTGGTGCGGGACTCGAGCACCAGCCCCGGGGACTATGTGCTCAGCGTCTCAGAGAACTC
GCGCGTCTCCCACTACATCATCAACAGCAGCGGCCCGCGCCCGCCGGTGCCACCGTCGCCCGCCCAGCCTCCGCCCGGGGTGAGCCCCTC
CAGACTCCGAATAGGAGATCAAGAGTTTGATTCATTGCCTGCTTTACTGGAATTCTACAAAATACACTATTTGGACACTACAACGTTGAT
AGAACCAGTTTCCAGATCCAGGCAGGGTAGTGGAGTGATTCTCAGGCAGGAGGAGGCGGAGTATGTGCGAGCCCTCTTTGACTTTAATGG
GAATGATGAGGAAGATCTTCCCTTTAAGAAAGGAGACATCTTGAGAATCCGGGACAAGCCTGAAGAGCAGTGGTGGAATGCGGAGGACAG
CGAAGGCAAGAGAGGGATGATTCCAGTCCCTTACGTCGAGAAGTATAGACCTGCCTCCGCCTCAGTATCGGCTCTGATTGGAGACTTCAG
CTACGGGACGGACGAGTACGACGGAGAGGGGAATGAGGAGCAGAAGGGGCCCCCGGAGGGCTCAGAGACCATGCCGTACATCGATGAGTC
GCCCACCATGTCCCCGCAGCTCAGCGCCCGCAGCCAGGGCGGGGGGGATGGCGTCTCCCCGACTCCACCTGAGGGACTGGCTCCTGGGGT
GGAAGCAGGGAAAGGCCTGGAGATGAGGAAGCTGGTTCTCTCGGGGTTCTTGGCCAGCGAAGAGATCTACATTAACCAGCTGGAAGCCCT
GTTGCTGCCCATGAAACCCCTGAAGGCCACCGCCACCACCTCCCAGCCCGTGCTCACCATCCAGCAGATCGAGACCATCTTCTACAAGAT
CCAGGACATCTATGAGATCCACAAGGAGTTCTATGACAACCTGTGCCCCAAGGTGCAACAGTGGGACAGCCAGGTCACCATGGGCCACCT
CTTCCAGAAGCTGGCCAGCCAGCTCGGTGTGTACAAAGCGTTTGTCGATAACTATAAAGTCGCTCTGGAGACAGCTGAGAAGTGCAGCCA
GTCCAACAACCAGTTCCAGAAGATCTCAGAGGAACTCAAAGTGAAAGGTCCCAAGGACTCCAAGGACAGCCACACGTCTGTCACCATGGA
AGCTCTGCTCTACAAGCCCATTGACCGGGTCACTCGGAGCACCCTAGTCCTACACGACCTGCTGAAGCACACACCTGTGGACCACCCCGA
CTACCCGCTGCTGCAGGATGCCCTCCGCATCTCCCAGAACTTCCTGTCCAGCATCAACGAGGACATCGACCCCCGCCGGACTGCAGTGAC
AACGCCCAAGGGGGAGACGCGACAGCTGGTGAAGGACGGCTTCCTGGTGGAAGTGTCAGAGAGCTCCCGGAAGCTGCGGCACGTCTTCCT
CTTTACAGATGTCCTACTGTGTGCCAAGCTGAAGAAGACCTCTGCAGGGAAGCACCAGCAGTATGACTGTAAGTGGTACATCCCCCTGGC
CGACCTGGTGTTTCCATCCCCCGAGGAGTCTGAGGCCAGCCCCCAGGTGCACCCCTTCCCAGACCATGAGCTGGAGGACATGAAGATGAA
GATCTCTGCCCTCAAGAGTGAAATCCAGAAGGAGAAAGCCAACAAAGGCCAGAGCCGGGCCATCGAGCGCCTGAAGAAGAAGATGTTTGA
GAATGAGTTCCTGCTGCTGCTCAACTCCCCCACAATCCCGTTCAGGATCCACAATCGGAATGGAAAGAGTTACCTGTTCCTACTGTCCTC
GGACTACGAGAGGTCAGAGTGGAGAGAAGCAATTCAGAAACTACAGAAGAAGGATCTCCAGGCCTTTGTCCTGAGCTCAGTGGAGCTCCA
GGTGCTCACAGGATCCTGTTTCAAGCTTAGGACTGTACACAACATTCCTGTCACCAGCAATAAAGACGACGATGAGTCTCCAGGACTCTA
TGGCTTCCTTCATGTCATCGTCCACTCTGCCAAGGGATTTAAGCAATCAGCCAACCTGTACTGTACCCTGGAGGTGGATTCCTTCGGCTA
TTTTGTCAGCAAAGCCAAAACCAGGGTGTTCCGGGACACAGCGGAGCCCAAGTGGGATGAGGAGTTTGAGATCGAGCTGGAGGGCTCCCA
GTCCCTGAGGATCCTGTGCTATGAGAAGTGCTATGACAAGACCAAGGTCAACAAGGACAACAATGAGATCGTGGACAAGATCATGGGCAA
AGGACAGATCCAGCTGGACCCACAAACCGTGGAGACCAAGAACTGGCACACGGACGTGATTGAGATGAACGGGATCAAAGTGGAATTTTC
CATGAAATTCACCAGCCGAGATATGAGCCTGAAGAGGACCCCGTCCAAAAAGCAGACCGGCGTCTTCGGTGTGAAGATCAGCGTGGTGAC
GAAGCGGGAGCGCTCCAAGGTGCCCTACATCGTCCGGCAGTGTGTGGAGGAGGTGGAGAAGAGGGGTATCGAGGAGGTTGGCATCTACAG
GATATCGGGCGTGGCCACGGACATCCAGGCGCTCAAGGCCGTCTTCGATGCCAATAACAAGGACATCCTGCTGATGCTGAGTGACATGGA
CATCAACGCCATCGCCGGGACGCTCAAGCTGTACTTCCGGGAACTGCCCGAGCCGCTCCTCACGGACCGACTCTACCCAGCCTTCATGGA
GGGCATCGCCCTGTCAGACCCTGCTGCCAAGGAAAACTGCATGATGCACCTGCTCCGCTCCCTGCCCGACCCCAACCTCATCACCTTCCT
CTTCCTGCTGGAACACTTGAAAAGGGTTGCCGAGAAGGAGCCCATCAACAAAATGTCACTTCACAACCTGGCTACCGTGTTTGGACCCAC
GTTACTGAGACCCTCAGAAGTGGAGAGCAAAGCACACCTCACCTCGGCTGCGGACATCTGGTCCCATGACGTCATGGCGCAGGTCCAGGT
CCTCCTCTACTACCTGCAGCACCCCCCCATTTCCTTCGCAGAACTCAAGCGGAACACACTGTACTTCTCCACCGACGTGTAGCCCGAGGC
AGGGTGGCTGCGGGCGGGTGGTGGAACCAGCCCCTCCAGCCTGGGGTCCAACTCAGACTTGAAAGACTGCAATAGAAAACTCCCAAACCC
AGCACTCCAGACTCGAGGGAAGCCAGCTTCCAAGAACTGGAATGCGTACGTCTTTTGTGCCACCTTGTACAAAGCCGGCTGCCCAGCCCC
AGCCTCACCACCGCATCCCACCTCCTGCCCTCCATACCTCTAGTTGTGTCTGATGCTCCGTGCTGTTCGGGAATTGTTTTATGTACACTT
GTCAGGCAGAAAAGGTAGTGACCGGCCCGGCGTGGGCACACAGACAGCCCGCTTTGTTCTTTCATTTCCTCCAGCACTTTCTTTCCGCCT
GAGTCCAGCCCAAGGCCTTTTATTTTGCGCTGTGTAACTGCTGCCAGCTTCTCTCTTGGCCCTGCTCCCAGATGGCGGTCTCCTGGCAGC
CTCCCCTCAGTCTTCCTCCACCCGCTCTTCCTTCCCAGCCTGCCTGCATGCATGTGCACCCTTGGTCTTCGCTCCATCGCCTTGAAAGCT
CTGAAGAGGCCCTGGGTTGCCGCGGCAGCAGTGGTCTGTTTGATGCTGCCGTTTGCCGCTGCCGGCCCCTCCTCAGACTCCGCCTTTGGG
AGCACACCTGCTTTGCCTTGCTGCCTGTGCAAATGTTGGACAAGCAGACACACTCACACTCGTCCCCAGCTTAGCACAGAGCTGGAGCGC
CCATTTCTGGAATTTTCCGTTTGGGAATCTCCACTTCTGGGGTTTACCTGTTCGGCCTCCTGTCTATCAGTGAGGCATCTCTGACTGTTT
CTTCTACTGCTTTTCAGTTCCCTTCCCTGCTGTTCTATTTCCTTTGAGTGTAAAGACTCACAGGTGACCTGCTATCGAGATAGCCAGAGG
GTCAGGAGAGAATGGGGGAGGAGGCGGTCAGGCTGCTGAGGAAACACCACAGGCTGAACGGGGGAGGAATGCACATGCCACGCTGGGTGT
CCCGGGTCGCGGGGAGGCAGCTCAGCTCTTAGGAGCAAGTTGTGGGGGCTTTTCAAGAGGGGCCAGGCTTCCTGGAGGGTGACTGATGTG
GCCGAAGCAGGTGTCCAGGCAGGTAGGCTGCAGCCAGGAGCTCCCTGGCACCGCAGGACCTCGTGGTACTCTTGCCTTAGATTTTACACA
CACTCCACAGCCAAGCACTGCCACGGTCCTCCAGGACCTGGGAAGCAAAGGCACAGGCCCACGGTGGCCAGCCATTGTGGTGCCGCCCCA
GCTTCTGGATACAGCCTTTTGGGTAAACACTGGGAACTCCAGAAGTTGTGGGGAGAGTGGGGAATCAGACAGCCGCCTCTAGGGGCTGGG
TTCTGCTGGGGCCTCCTTGTTGGTGCTGTAGGCACCCGCCAGGGAGCAGGGACCCGACTTGCAGACGCATTGCCCGGTACTAGGAAGGAG
TGAGGTGTGTTCCCACCGTACACTTCCCACACGAGCTGCGGCTGCCAGCCTCGGGCCATCAGCCTAGGAGAGCAGATGCAGCTCCAGGGG
CTCGACTTATAGCCAGTTACAGCTCCCCGGCTCTTCTGTGTGGCAGAGCGTCGTTTCCGGGCCCTCAGGGCTGGGGAGCTCAGTTCCCAT
TGCTTGTGCTCAGGGCTGAGTCTTAAAGAAGGGTTTGCCGGCCCTAACGCTGCAGCGCGTGCGCGGTGAGAGGCCCTTTTTGAGCCTGTT
TACTCCTGTGGCCTTGGGCAGAACAGTAAATACTCTGTGCACGGAGGAAAGACATGCCCAAGAGGAAGGAAGTACTGACCATCGGCTGCC
TGTGAGCAGCTTAGCAAGGAGCCCTTGCTCCCTGGGAAAGGCGGTGAACTTGAGTCTAAAGATGCAGTGCCTGGCCCTTCCTAAGGTCCC
TGCCTGGCATCCGAGTGTCGGTGTGTGGCACAGAAGGCTCCTGCTTGCTTCCAAAGTGATGGACAGGAAGGGGCAGAGTGAGTCACGGCC
CAGACTGGGCACCTTCGCGTCTCAGCCTCAGGGAGCCCCACAGCCCCAAGCTCGCTGAGGCAACGTGAGAACAGGCTATGGGAAGGCTGC
AAAGGCTGAGAAATGCAAAGGCTCATATTTATAAATCCCACCCCCAGAGTGGGGAGGGTCAGGTGCCAGACCTGGACTAAACTGCACCAA
GGAAACACCCAGCAGGGTCTCCTGTGAGCCGGGGACCATGCAGCCCGAAACCTCCAGTCACTGCGCCCGGCAGGAGTCAGGAGCCAGGGA
CTGTGCAGCCTGGAACCTCCAGTCACTGTGCCCAGCAGGGTGGGCTGTGCCCAGCAGGAGTCAGGCTAAGAAACGCCAGGTCTGCCTGTT
CTTGCTGGGCAATGGCTGATGGCTGCCAGTTTCTGCTGATACACAGGTAGGATGGGACCCTTCATGAATATCTGACTTTAATAAGTTGGT
AAGGATATATTTTTTTGTCTATGTTCTGTTTCAACTTATGTAGATTATTATAAATTGATGTAAACCACGTGAGAGGAAAATGTTAATAAA


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FusionGenePPI for CRK_ABR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CRKPLSCR1, DPPA4, BUB1, PSMC6, EGFR, ERBB4, BCAR1, SRCIN1, ARHGAP32, DOCK1, SRC, PTK2, MAP4K1, EPHA3, SH3KBP1, SOCS1, IRS4, MAPK8, KHDRBS1, ASAP1, PDGFRA, AVIL, GRB2, ARHGAP17, RET, PXN, PDGFRB, NEDD9, EPHB3, FRS2, MAP4K5, EPHB2, RAPGEF1, SH3BP1, SOS1, XPO1, WEE1, SHB, ZAP70, EPS15, CBL, PTPN1, CBLC, MICAL1, SYN1, PPP1CA, BCR, CSE1L, PIK3R1, TERF2IP, POT1, FASLG, EFS, ATXN1, KIT, ABL1, UBASH3B, PIK3R2, SHC1, PIK3CB, KRT1, PIK3CA, KRT2, KRT9, KRT10, HSPA8, KRT14, KRT5, KRT16, KRT6A, HSPA1B, KRT6B, PIK3C2B, TUBB, TUBB4B, CASS4, PTPN11, INPPL1, KRT17, ACTB, TUBB2A, SOS2, NCKIPSD, EDC4, HSPA1L, TUBB3, TUBA1A, CBLB, ABL2, HSPA9, RPS19, PIK3R3, PEAK1, GAB2, HSPA6, KRT3, KRT19, KRT15, HSPA5, AP2A1, KRT76, KRT77, PIK3CD, GAB1, KRT73, KRT8, AGO2, YWHAG, KRT79, KRT78, UBC, EEF1A1, YWHAQ, CORO1C, AP2B1, RPS5, DDX3X, DDX6, UBASH3A, KRT24, RPS25, SFN, ASAP3, KRT12, KRT4, AGO1, DNAJA3, RNGTT, RPL23, HSP90AB1, TUBA4B, LYZ, DDX5, RPS3, SERPINB6, HSPBP1, DSC1, AP2M1, GGA3, FUBP1, ATIC, SERPINH1, NANS, DHX9, HSPB1, SPR, DOK1, ERBB2, ERBB3, PPFIBP2, LMNA, BAG3, PTPN4, MAPK4, MET, SPRR2A, HUWE1, FAM154A, CAST, GFPT1, SRM, BEX5, RTCB, CHTF18, CNDP2, DOK2, DOK3, DOK7, ELK1, EPYC, EYA3, GAREM, FSTL1, GABPB2, HSH2D, KCTD13, KLHL20, LASP1, MAGEC3, MPG, MYLIP, MYOZ2, NUFIP2, OFCC1, PAFAH1B2, PHC2, PRKACA, PRRG2, RAB2B, SEMA4D, SH2D2A, SOCS6, STAT4, TCAP, TM4SF19, VAC14, ANKZF1, ANLN, ASB9, ASCL4, PRRC2B, BATF3, C4orf17, SETD9, C6orf141, CORO6, ESD, HABP4, IFT140, INO80E, ISL1, KCTD17, KLF15, LHX8, MNDA, PSMC1, PTTG1, RYBP, SEPT6, STRN4, TDG, TP53, TUBA1C, TWIST2, WDR83, ZKSCAN7, ZNF557, ATF3, FER, CLNK, RIN3, CCP110, CEP128, CEP89, ODF2, CEP19, COX6C, HIST1H1D, PPP1R12A, NUMA1, KAT6A, MPDZ, ARPC1B, SLC25A13, C10orf12, MRPL48, INF2, FLNA, STAT5A, FGFR1, TRIM15, TSG101, CDH1ABRLNX1, APP, ECT2, ERBB2IP, AURKB, CDKN1A, CEP250, CEP57, CEP76, TP53, MOV10, NXF1, HERC2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CRK_ABR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CRK_ABR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCRKC0151744Myocardial Ischemia1CTD_human
TgeneABRC0033578Prostatic Neoplasms1CTD_human