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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8483

FusionGeneSummary for CRISPLD2_MPZL2

check button Fusion gene summary
Fusion gene informationFusion gene name: CRISPLD2_MPZL2
Fusion gene ID: 8483
HgeneTgene
Gene symbol

CRISPLD2

MPZL2

Gene ID

83716

10205

Gene namecysteine rich secretory protein LCCL domain containing 2myelin protein zero like 2
SynonymsCRISP11|LCRISP2|LGL1EVA|EVA1
Cytomap

16q24.1

11q23.3

Type of geneprotein-codingprotein-coding
Descriptioncysteine-rich secretory protein LCCL domain-containing 2CRISP-11LCCL domain-containing cysteine-rich secretory protein 2cysteine-rich secretory protein 11late gestation lung 1testis secretory sperm-binding protein Li 207atrypsin inhibitormyelin protein zero-like protein 2epithelial V-like antigen 1
Modification date2018052320180519
UniProtAcc

Q9H0B8

O60487

Ensembl transtripts involved in fusion geneENST00000262424, ENST00000567845, 
ENST00000566431, ENST00000564567, 
ENST00000569090, 
ENST00000278937, 
ENST00000438295, ENST00000525647, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: CRISPLD2 [Title/Abstract] AND MPZL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-EB-A4XL-01ACRISPLD2chr16

84922969

+MPZL2chr11

118125948

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000262424ENST00000278937CRISPLD2chr16

84922969

+MPZL2chr11

118125948

-
5CDS-intronENST00000262424ENST00000438295CRISPLD2chr16

84922969

+MPZL2chr11

118125948

-
5CDS-intronENST00000262424ENST00000525647CRISPLD2chr16

84922969

+MPZL2chr11

118125948

-
5CDS-3UTRENST00000567845ENST00000278937CRISPLD2chr16

84922969

+MPZL2chr11

118125948

-
5CDS-intronENST00000567845ENST00000438295CRISPLD2chr16

84922969

+MPZL2chr11

118125948

-
5CDS-intronENST00000567845ENST00000525647CRISPLD2chr16

84922969

+MPZL2chr11

118125948

-
intron-3UTRENST00000566431ENST00000278937CRISPLD2chr16

84922969

+MPZL2chr11

118125948

-
intron-intronENST00000566431ENST00000438295CRISPLD2chr16

84922969

+MPZL2chr11

118125948

-
intron-intronENST00000566431ENST00000525647CRISPLD2chr16

84922969

+MPZL2chr11

118125948

-
intron-3UTRENST00000564567ENST00000278937CRISPLD2chr16

84922969

+MPZL2chr11

118125948

-
intron-intronENST00000564567ENST00000438295CRISPLD2chr16

84922969

+MPZL2chr11

118125948

-
intron-intronENST00000564567ENST00000525647CRISPLD2chr16

84922969

+MPZL2chr11

118125948

-
intron-3UTRENST00000569090ENST00000278937CRISPLD2chr16

84922969

+MPZL2chr11

118125948

-
intron-intronENST00000569090ENST00000438295CRISPLD2chr16

84922969

+MPZL2chr11

118125948

-
intron-intronENST00000569090ENST00000525647CRISPLD2chr16

84922969

+MPZL2chr11

118125948

-

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FusionProtFeatures for CRISPLD2_MPZL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRISPLD2

Q9H0B8

MPZL2

O60487

Promotes matrix assembly. {ECO:0000250}. Mediates homophilic cell-cell adhesion.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CRISPLD2_MPZL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CRISPLD2_MPZL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CRISPLD2IQCB1, HSP90AB1MPZL2MPZL3, ATF4, MEST, AP1M1, OCLN, EGFR, ERBB2, IGF1R, INSR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CRISPLD2_MPZL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CRISPLD2_MPZL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCRISPLD2C0023895Liver diseases1CTD_human
HgeneCRISPLD2C0024115Lung diseases1CTD_human
HgeneCRISPLD2C0235032Neurotoxicity Syndromes1CTD_human