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Fusion gene ID: 8483 |
FusionGeneSummary for CRISPLD2_MPZL2 |
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Fusion gene information | Fusion gene name: CRISPLD2_MPZL2 | Fusion gene ID: 8483 | Hgene | Tgene | Gene symbol | CRISPLD2 | MPZL2 | Gene ID | 83716 | 10205 |
Gene name | cysteine rich secretory protein LCCL domain containing 2 | myelin protein zero like 2 | |
Synonyms | CRISP11|LCRISP2|LGL1 | EVA|EVA1 | |
Cytomap | 16q24.1 | 11q23.3 | |
Type of gene | protein-coding | protein-coding | |
Description | cysteine-rich secretory protein LCCL domain-containing 2CRISP-11LCCL domain-containing cysteine-rich secretory protein 2cysteine-rich secretory protein 11late gestation lung 1testis secretory sperm-binding protein Li 207atrypsin inhibitor | myelin protein zero-like protein 2epithelial V-like antigen 1 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9H0B8 | O60487 | |
Ensembl transtripts involved in fusion gene | ENST00000262424, ENST00000567845, ENST00000566431, ENST00000564567, ENST00000569090, | ENST00000278937, ENST00000438295, ENST00000525647, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: CRISPLD2 [Title/Abstract] AND MPZL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-EB-A4XL-01A | CRISPLD2 | chr16 | 84922969 | + | MPZL2 | chr11 | 118125948 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000262424 | ENST00000278937 | CRISPLD2 | chr16 | 84922969 | + | MPZL2 | chr11 | 118125948 | - |
5CDS-intron | ENST00000262424 | ENST00000438295 | CRISPLD2 | chr16 | 84922969 | + | MPZL2 | chr11 | 118125948 | - |
5CDS-intron | ENST00000262424 | ENST00000525647 | CRISPLD2 | chr16 | 84922969 | + | MPZL2 | chr11 | 118125948 | - |
5CDS-3UTR | ENST00000567845 | ENST00000278937 | CRISPLD2 | chr16 | 84922969 | + | MPZL2 | chr11 | 118125948 | - |
5CDS-intron | ENST00000567845 | ENST00000438295 | CRISPLD2 | chr16 | 84922969 | + | MPZL2 | chr11 | 118125948 | - |
5CDS-intron | ENST00000567845 | ENST00000525647 | CRISPLD2 | chr16 | 84922969 | + | MPZL2 | chr11 | 118125948 | - |
intron-3UTR | ENST00000566431 | ENST00000278937 | CRISPLD2 | chr16 | 84922969 | + | MPZL2 | chr11 | 118125948 | - |
intron-intron | ENST00000566431 | ENST00000438295 | CRISPLD2 | chr16 | 84922969 | + | MPZL2 | chr11 | 118125948 | - |
intron-intron | ENST00000566431 | ENST00000525647 | CRISPLD2 | chr16 | 84922969 | + | MPZL2 | chr11 | 118125948 | - |
intron-3UTR | ENST00000564567 | ENST00000278937 | CRISPLD2 | chr16 | 84922969 | + | MPZL2 | chr11 | 118125948 | - |
intron-intron | ENST00000564567 | ENST00000438295 | CRISPLD2 | chr16 | 84922969 | + | MPZL2 | chr11 | 118125948 | - |
intron-intron | ENST00000564567 | ENST00000525647 | CRISPLD2 | chr16 | 84922969 | + | MPZL2 | chr11 | 118125948 | - |
intron-3UTR | ENST00000569090 | ENST00000278937 | CRISPLD2 | chr16 | 84922969 | + | MPZL2 | chr11 | 118125948 | - |
intron-intron | ENST00000569090 | ENST00000438295 | CRISPLD2 | chr16 | 84922969 | + | MPZL2 | chr11 | 118125948 | - |
intron-intron | ENST00000569090 | ENST00000525647 | CRISPLD2 | chr16 | 84922969 | + | MPZL2 | chr11 | 118125948 | - |
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FusionProtFeatures for CRISPLD2_MPZL2 |
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Hgene | Tgene |
CRISPLD2 | MPZL2 |
Promotes matrix assembly. {ECO:0000250}. | Mediates homophilic cell-cell adhesion. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CRISPLD2_MPZL2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CRISPLD2_MPZL2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CRISPLD2 | IQCB1, HSP90AB1 | MPZL2 | MPZL3, ATF4, MEST, AP1M1, OCLN, EGFR, ERBB2, IGF1R, INSR |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CRISPLD2_MPZL2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CRISPLD2_MPZL2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CRISPLD2 | C0023895 | Liver diseases | 1 | CTD_human |
Hgene | CRISPLD2 | C0024115 | Lung diseases | 1 | CTD_human |
Hgene | CRISPLD2 | C0235032 | Neurotoxicity Syndromes | 1 | CTD_human |