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Fusion gene ID: 8468 |
FusionGeneSummary for CRIM1_TACR1 |
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Fusion gene information | Fusion gene name: CRIM1_TACR1 | Fusion gene ID: 8468 | Hgene | Tgene | Gene symbol | CRIM1 | TACR1 | Gene ID | 51232 | 6869 |
Gene name | cysteine rich transmembrane BMP regulator 1 | tachykinin receptor 1 | |
Synonyms | CRIM-1|S52 | NK1R|NKIR|SPR|TAC1R | |
Cytomap | 2p22.2 | 2p12 | |
Type of gene | protein-coding | protein-coding | |
Description | cysteine-rich motor neuron 1 proteincysteine rich transmembrane BMP regulator 1 (chordin-like)cysteine-rich repeat-containing protein S52 | substance-P receptorNK-1 receptorNK-1Rtachykinin receptor 1 (substance P receptor; neurokinin-1 receptor) | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9NZV1 | P25103 | |
Ensembl transtripts involved in fusion gene | ENST00000280527, ENST00000473403, | ENST00000305249, ENST00000409848, ENST00000497764, | |
Fusion gene scores | * DoF score | 10 X 8 X 6=480 | 3 X 3 X 3=27 |
# samples | 10 | 3 | |
** MAII score | log2(10/480*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CRIM1 [Title/Abstract] AND TACR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TACR1 | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 12716968 |
Tgene | TACR1 | GO:0007217 | tachykinin receptor signaling pathway | 17986524 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | KIRC | TCGA-CJ-5681-01A | CRIM1 | chr2 | 36749456 | + | TACR1 | chr2 | 75347894 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000280527 | ENST00000305249 | CRIM1 | chr2 | 36749456 | + | TACR1 | chr2 | 75347894 | - |
Frame-shift | ENST00000280527 | ENST00000409848 | CRIM1 | chr2 | 36749456 | + | TACR1 | chr2 | 75347894 | - |
Frame-shift | ENST00000280527 | ENST00000497764 | CRIM1 | chr2 | 36749456 | + | TACR1 | chr2 | 75347894 | - |
intron-3CDS | ENST00000473403 | ENST00000305249 | CRIM1 | chr2 | 36749456 | + | TACR1 | chr2 | 75347894 | - |
intron-3CDS | ENST00000473403 | ENST00000409848 | CRIM1 | chr2 | 36749456 | + | TACR1 | chr2 | 75347894 | - |
intron-3CDS | ENST00000473403 | ENST00000497764 | CRIM1 | chr2 | 36749456 | + | TACR1 | chr2 | 75347894 | - |
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FusionProtFeatures for CRIM1_TACR1 |
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Hgene | Tgene |
CRIM1 | TACR1 |
May play a role in CNS development by interacting withgrowth factors implicated in motor neuron differentiation andsurvival. May play a role in capillary formation and maintenanceduring angiogenesis. Modulates BMP activity by affecting itsprocessing and delivery to the cell surface.{ECO:0000269|PubMed:12464430, ECO:0000269|PubMed:12805376}. | This is a receptor for the tachykinin neuropeptidesubstance P. It is probably associated with G proteins thatactivate a phosphatidylinositol-calcium second messenger system.The rank order of affinity of this receptor to tachykinins is:substance P > substance K > neuromedin-K. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CRIM1_TACR1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CRIM1_TACR1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CRIM1 | ATXN7, CACNA1A, TRIM25 | TACR1 | TAC1, GRK5, TAC4, RDH14, CAV1, FADS1, SLMAP, NDUFB8, PKP2, ARVCF, COX1, GPR89A, ARL6IP5, ATP8, MFSD5, NDUFS6, LPCAT3, ND5, ATP12A, KIAA1715, ND4, NDUFB5, PKP4, STX4, ADIPOR1, YIPF3, ND1, CERS2, GPRC5C, SYNGR2, ATP5B, TSPAN3, SLC25A46, KIRREL, FAM213A, TSPAN15, ATP5F1, TMEM164, NDUFC2, RGPD2, GOLGA5, LMBRD2, GPR50, ATP5H, LMBR1, PTPLB |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CRIM1_TACR1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | TACR1 | P25103 | DB00673 | Aprepitant | Substance-P receptor | small molecule | approved|investigational |
Tgene | TACR1 | P25103 | DB04894 | Vapreotide | Substance-P receptor | small molecule | approved|investigational |
Tgene | TACR1 | P25103 | DB01221 | Ketamine | Substance-P receptor | small molecule | approved|vet_approved |
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RelatedDiseases for CRIM1_TACR1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TACR1 | C0001973 | Alcoholic Intoxication, Chronic | 5 | CTD_human;PSYGENET |
Tgene | TACR1 | C0011570 | Mental Depression | 5 | PSYGENET |
Tgene | TACR1 | C0011581 | Depressive disorder | 5 | PSYGENET |
Tgene | TACR1 | C0525045 | Mood Disorders | 5 | PSYGENET |
Tgene | TACR1 | C0005586 | Bipolar Disorder | 3 | CTD_human;PSYGENET |
Tgene | TACR1 | C0020429 | Hyperalgesia | 2 | CTD_human |
Tgene | TACR1 | C0600467 | Neurogenic Inflammation | 2 | CTD_human |
Tgene | TACR1 | C0006261 | Bronchial Diseases | 1 | CTD_human |
Tgene | TACR1 | C0020538 | Hypertensive disease | 1 | CTD_human |
Tgene | TACR1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | TACR1 | C0038587 | Substance Withdrawal Syndrome | 1 | CTD_human |
Tgene | TACR1 | C0042963 | Vomiting | 1 | CTD_human |
Tgene | TACR1 | C0428977 | Bradycardia | 1 | CTD_human |
Tgene | TACR1 | C1263846 | Attention deficit hyperactivity disorder | 1 | CTD_human |