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Fusion gene ID: 8465 |
FusionGeneSummary for CRIM1_RAPGEF5 |
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Fusion gene information | Fusion gene name: CRIM1_RAPGEF5 | Fusion gene ID: 8465 | Hgene | Tgene | Gene symbol | CRIM1 | RAPGEF5 | Gene ID | 51232 | 9771 |
Gene name | cysteine rich transmembrane BMP regulator 1 | Rap guanine nucleotide exchange factor 5 | |
Synonyms | CRIM-1|S52 | GFR|MR-GEF|REPAC | |
Cytomap | 2p22.2 | 7p15.3 | |
Type of gene | protein-coding | protein-coding | |
Description | cysteine-rich motor neuron 1 proteincysteine rich transmembrane BMP regulator 1 (chordin-like)cysteine-rich repeat-containing protein S52 | rap guanine nucleotide exchange factor 5M-Ras-regulated GEFM-Ras-regulated Rap GEFRap guanine nucleotide exchange factor (GEF) 5guanine nucleotide exchange factor for Rap1related to Epac | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9NZV1 | Q92565 | |
Ensembl transtripts involved in fusion gene | ENST00000280527, ENST00000473403, | ENST00000344041, ENST00000475788, ENST00000405243, ENST00000401957, | |
Fusion gene scores | * DoF score | 10 X 8 X 6=480 | 4 X 4 X 2=32 |
# samples | 10 | 4 | |
** MAII score | log2(10/480*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CRIM1 [Title/Abstract] AND RAPGEF5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF841281 | CRIM1 | chr2 | 36750511 | + | RAPGEF5 | chr7 | 22364653 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000280527 | ENST00000344041 | CRIM1 | chr2 | 36750511 | + | RAPGEF5 | chr7 | 22364653 | + |
intron-intron | ENST00000280527 | ENST00000475788 | CRIM1 | chr2 | 36750511 | + | RAPGEF5 | chr7 | 22364653 | + |
intron-intron | ENST00000280527 | ENST00000405243 | CRIM1 | chr2 | 36750511 | + | RAPGEF5 | chr7 | 22364653 | + |
intron-intron | ENST00000280527 | ENST00000401957 | CRIM1 | chr2 | 36750511 | + | RAPGEF5 | chr7 | 22364653 | + |
intron-intron | ENST00000473403 | ENST00000344041 | CRIM1 | chr2 | 36750511 | + | RAPGEF5 | chr7 | 22364653 | + |
intron-intron | ENST00000473403 | ENST00000475788 | CRIM1 | chr2 | 36750511 | + | RAPGEF5 | chr7 | 22364653 | + |
intron-intron | ENST00000473403 | ENST00000405243 | CRIM1 | chr2 | 36750511 | + | RAPGEF5 | chr7 | 22364653 | + |
intron-intron | ENST00000473403 | ENST00000401957 | CRIM1 | chr2 | 36750511 | + | RAPGEF5 | chr7 | 22364653 | + |
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FusionProtFeatures for CRIM1_RAPGEF5 |
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Hgene | Tgene |
CRIM1 | RAPGEF5 |
May play a role in CNS development by interacting withgrowth factors implicated in motor neuron differentiation andsurvival. May play a role in capillary formation and maintenanceduring angiogenesis. Modulates BMP activity by affecting itsprocessing and delivery to the cell surface.{ECO:0000269|PubMed:12464430, ECO:0000269|PubMed:12805376}. | Guanine nucleotide exchange factor (GEF) for RAP1A,RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1activation. {ECO:0000269|PubMed:10777494,ECO:0000269|PubMed:10934204}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CRIM1_RAPGEF5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CRIM1_RAPGEF5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CRIM1_RAPGEF5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CRIM1_RAPGEF5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | RAPGEF5 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | RAPGEF5 | C0033975 | Psychotic Disorders | 1 | PSYGENET |
Tgene | RAPGEF5 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | RAPGEF5 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | RAPGEF5 | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
Tgene | RAPGEF5 | C0349204 | Nonorganic psychosis | 1 | PSYGENET |
Tgene | RAPGEF5 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |