FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 8465

FusionGeneSummary for CRIM1_RAPGEF5

check button Fusion gene summary
Fusion gene informationFusion gene name: CRIM1_RAPGEF5
Fusion gene ID: 8465
HgeneTgene
Gene symbol

CRIM1

RAPGEF5

Gene ID

51232

9771

Gene namecysteine rich transmembrane BMP regulator 1Rap guanine nucleotide exchange factor 5
SynonymsCRIM-1|S52GFR|MR-GEF|REPAC
Cytomap

2p22.2

7p15.3

Type of geneprotein-codingprotein-coding
Descriptioncysteine-rich motor neuron 1 proteincysteine rich transmembrane BMP regulator 1 (chordin-like)cysteine-rich repeat-containing protein S52rap guanine nucleotide exchange factor 5M-Ras-regulated GEFM-Ras-regulated Rap GEFRap guanine nucleotide exchange factor (GEF) 5guanine nucleotide exchange factor for Rap1related to Epac
Modification date2018051920180519
UniProtAcc

Q9NZV1

Q92565

Ensembl transtripts involved in fusion geneENST00000280527, ENST00000473403, 
ENST00000344041, ENST00000475788, 
ENST00000405243, ENST00000401957, 
Fusion gene scores* DoF score10 X 8 X 6=4804 X 4 X 2=32
# samples 104
** MAII scorelog2(10/480*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CRIM1 [Title/Abstract] AND RAPGEF5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF841281CRIM1chr2

36750511

+RAPGEF5chr7

22364653

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000280527ENST00000344041CRIM1chr2

36750511

+RAPGEF5chr7

22364653

+
intron-intronENST00000280527ENST00000475788CRIM1chr2

36750511

+RAPGEF5chr7

22364653

+
intron-intronENST00000280527ENST00000405243CRIM1chr2

36750511

+RAPGEF5chr7

22364653

+
intron-intronENST00000280527ENST00000401957CRIM1chr2

36750511

+RAPGEF5chr7

22364653

+
intron-intronENST00000473403ENST00000344041CRIM1chr2

36750511

+RAPGEF5chr7

22364653

+
intron-intronENST00000473403ENST00000475788CRIM1chr2

36750511

+RAPGEF5chr7

22364653

+
intron-intronENST00000473403ENST00000405243CRIM1chr2

36750511

+RAPGEF5chr7

22364653

+
intron-intronENST00000473403ENST00000401957CRIM1chr2

36750511

+RAPGEF5chr7

22364653

+

Top

FusionProtFeatures for CRIM1_RAPGEF5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CRIM1

Q9NZV1

RAPGEF5

Q92565

May play a role in CNS development by interacting withgrowth factors implicated in motor neuron differentiation andsurvival. May play a role in capillary formation and maintenanceduring angiogenesis. Modulates BMP activity by affecting itsprocessing and delivery to the cell surface.{ECO:0000269|PubMed:12464430, ECO:0000269|PubMed:12805376}. Guanine nucleotide exchange factor (GEF) for RAP1A,RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1activation. {ECO:0000269|PubMed:10777494,ECO:0000269|PubMed:10934204}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for CRIM1_RAPGEF5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for CRIM1_RAPGEF5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CRIM1_RAPGEF5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CRIM1_RAPGEF5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRAPGEF5C0005586Bipolar Disorder1PSYGENET
TgeneRAPGEF5C0033975Psychotic Disorders1PSYGENET
TgeneRAPGEF5C0036341Schizophrenia1PSYGENET
TgeneRAPGEF5C0041696Unipolar Depression1PSYGENET
TgeneRAPGEF5C0236733Amphetamine-Related Disorders1CTD_human
TgeneRAPGEF5C0349204Nonorganic psychosis1PSYGENET
TgeneRAPGEF5C1269683Major Depressive Disorder1PSYGENET