FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 8422

FusionGeneSummary for CREBBP_ADCY9

check button Fusion gene summary
Fusion gene informationFusion gene name: CREBBP_ADCY9
Fusion gene ID: 8422
HgeneTgene
Gene symbol

CREBBP

ADCY9

Gene ID

1387

115

Gene nameCREB binding proteinadenylate cyclase 9
SynonymsCBP|KAT3A|RSTS|RSTS1AC9|ACIX
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
DescriptionCREB-binding proteinadenylate cyclase type 9ATP pyrophosphate-lyase 9adenylate cyclase type IXadenylyl cyclase 9type IX ATP pyrophosphate-lyase
Modification date2018052220180522
UniProtAcc

Q92793

O60503

Ensembl transtripts involved in fusion geneENST00000262367, ENST00000382070, 
ENST00000294016, ENST00000571889, 
Fusion gene scores* DoF score25 X 18 X 14=63004 X 4 X 5=80
# samples 345
** MAII scorelog2(34/6300*10)=-4.21174517713694
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CREBBP [Title/Abstract] AND ADCY9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCREBBP

GO:0000122

negative regulation of transcription by RNA polymerase II

21539536

HgeneCREBBP

GO:0006355

regulation of transcription, DNA-templated

12169688

HgeneCREBBP

GO:0006473

protein acetylation

15273251|24939902

HgeneCREBBP

GO:0016573

histone acetylation

11742995

HgeneCREBBP

GO:0018076

N-terminal peptidyl-lysine acetylation

12435739

HgeneCREBBP

GO:0034644

cellular response to UV

24939902

HgeneCREBBP

GO:0045893

positive regulation of transcription, DNA-templated

11742995

TgeneADCY9

GO:0006171

cAMP biosynthetic process

9628827|10987815

TgeneADCY9

GO:0007189

adenylate cyclase-activating G-protein coupled receptor signaling pathway

9628827


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-UY-A9PB-01ACREBBPchr16

3929833

-ADCY9chr16

4016967

-
TCGALDESCATCGA-L5-A43M-01ACREBBPchr16

3929833

-ADCY9chr16

4043511

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000262367ENST00000294016CREBBPchr16

3929833

-ADCY9chr16

4016967

-
5CDS-intronENST00000262367ENST00000571889CREBBPchr16

3929833

-ADCY9chr16

4016967

-
In-frameENST00000382070ENST00000294016CREBBPchr16

3929833

-ADCY9chr16

4016967

-
5CDS-intronENST00000382070ENST00000571889CREBBPchr16

3929833

-ADCY9chr16

4016967

-
In-frameENST00000262367ENST00000294016CREBBPchr16

3929833

-ADCY9chr16

4043511

-
5CDS-5UTRENST00000262367ENST00000571889CREBBPchr16

3929833

-ADCY9chr16

4043511

-
In-frameENST00000382070ENST00000294016CREBBPchr16

3929833

-ADCY9chr16

4043511

-
5CDS-5UTRENST00000382070ENST00000571889CREBBPchr16

3929833

-ADCY9chr16

4043511

-

Top

FusionProtFeatures for CREBBP_ADCY9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CREBBP

Q92793

ADCY9

O60503

Acetylates histones, giving a specific tag fortranscriptional activation. Also acetylates non-histone proteins,like NCOA3 and FOXO1. Binds specifically to phosphorylated CREBand enhances its transcriptional activity toward cAMP-responsivegenes. Acts as a coactivator of ALX1. Acts as a circadiantranscriptional coactivator which enhances the activity of thecircadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotesremoval of chromatin-bound PCNA and its degradation duringnucleotide excision repair (NER) (PubMed:24939902).{ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767,ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221,ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:9707565}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-9111058_11989561354DomainGuanylate cyclase 2
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-2111058_11986281354DomainGuanylate cyclase 2
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-9111185_11879561354Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-9111192_11969561354Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-2111185_11876281354Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-2111192_11966281354Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911997_13539561354Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211808_8186281354Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211840_8676281354Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211889_8916281354Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211913_9206281354Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211942_9756281354Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211997_13536281354Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911976_9969561354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211787_8076281354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211819_8396281354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211868_8886281354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211892_9126281354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211921_9416281354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211976_9966281354TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311061_1064282443Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311199_1487282443Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311555_1562282443Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311943_1948282443Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311967_1970282443Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1312081_2085282443Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1312199_2216282443Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1312245_2248282443Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1312297_2300282443Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301061_1064282405Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301199_1487282405Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301555_1562282405Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301943_1948282405Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301967_1970282405Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1302081_2085282405Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1302199_2216282405Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1302245_2248282405Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1302297_2300282405Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311061_1064282443Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311199_1487282443Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311555_1562282443Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311943_1948282443Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311967_1970282443Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1312081_2085282443Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1312199_2216282443Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1312245_2248282443Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1312297_2300282443Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301061_1064282405Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301199_1487282405Compositional biasNote=Cys/His-rich
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301555_1562282405Compositional biasNote=Poly-Glu
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301943_1948282405Compositional biasNote=Poly-Pro
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301967_1970282405Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1302081_2085282405Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1302199_2216282405Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1302245_2248282405Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1302297_2300282405Compositional biasNote=Poly-Gln
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311103_1175282443DomainBromo
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311323_1700282443DomainCBP/p300-type HAT
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-131587_666282443DomainKIX
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301103_1175282405DomainBromo
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301323_1700282405DomainCBP/p300-type HAT
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-130587_666282405DomainKIX
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311103_1175282443DomainBromo
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311323_1700282443DomainCBP/p300-type HAT
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-131587_666282443DomainKIX
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301103_1175282405DomainBromo
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301323_1700282405DomainCBP/p300-type HAT
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-130587_666282405DomainKIX
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311434_1436282443RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311446_1447282443RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301434_1436282405RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301446_1447282405RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311434_1436282443RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311446_1447282443RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301434_1436282405RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301446_1447282405RegionAcetyl-CoA binding
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311701_1744282443Zinc fingerZZ-type
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311765_1846282443Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-131347_433282443Zinc fingerTAZ-type 1
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301701_1744282405Zinc fingerZZ-type
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301765_1846282405Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-130347_433282405Zinc fingerTAZ-type 1
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311701_1744282443Zinc fingerZZ-type
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311765_1846282443Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-131347_433282443Zinc fingerTAZ-type 1
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301701_1744282405Zinc fingerZZ-type
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301765_1846282405Zinc fingerTAZ-type 2
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-130347_433282405Zinc fingerTAZ-type 1
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911394_5219561354DomainGuanylate cyclase 1
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211394_5216281354DomainGuanylate cyclase 1
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911399_4049561354Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911441_4439561354Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211399_4046281354Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211441_4436281354Nucleotide bindingATP
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911139_1419561354Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911163_1719561354Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911193_2159561354Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-9111_1179561354Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911236_2419561354Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911260_2809561354Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911302_7869561354Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911808_8189561354Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911840_8679561354Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911889_8919561354Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911913_9209561354Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911942_9759561354Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211139_1416281354Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211163_1716281354Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211193_2156281354Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-2111_1176281354Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211236_2416281354Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211260_2806281354Topological domainExtracellular
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211302_7866281354Topological domainCytoplasmic
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911118_1389561354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911142_1629561354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911172_1929561354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911216_2359561354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911242_2599561354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911281_3019561354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911787_8079561354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911819_8399561354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911868_8889561354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911892_9129561354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4016967ENST00000294016-911921_9419561354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211118_1386281354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211142_1626281354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211172_1926281354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211216_2356281354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211242_2596281354TransmembraneHelical
TgeneADCY9chr16:3929833chr16:4043511ENST00000294016-211281_3016281354TransmembraneHelical


Top

FusionGeneSequence for CREBBP_ADCY9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CREBBP_ENST00000262367_chr16_3929833_-_ADCY9_ENST00000294016_chr16_4043511_-_754aa
MAENLLDGPPNPKRAKLSSPGFSANDSTDLPFVRNHICSQIXSRRRGRSTSKRLPRRAXKQHQGFWRTXSQNSERAPQPSPRGEAHQQSD
FSVXDLAGEGKVGRGEPGPVGSPSAEVQEHPGENGRPLCGRYQRRQPDERLLFXAAHXSVQPELPGSGAGAILQDQLSGRGHKELPREDV
CXSHLQLPPGCVSVDHSVSDAVHHLLPEVRGGHRASPARRPGGLQCSPAAGGAVPRGVHQDGVLPGGRHGLHQAPAGVDRRLATTSLHRG
HPGVASRTGRLLPCHLRIXDQHTLPSVHRLGRADCRRALLXLLPAQLLDEVLPRHRRGGRAAAPALRLPVPRQFCINFAPXRSTEFQFRE
EPVQXFGAAXPPAARQPHRPGGGSRLLSPALVGLVPESRIXSQLPPPLPRRRGSGSSPHQDPEHAGPGRLAAEEHHPLPRGXAAEGVPDL
LQEPXQRRGDLRQHRQLQRVLRGELRGRQGVLPGPQRAHRGLXRAPKQAGLQQHREDQDHRSHVHGGVRAEHRAGPGRQPPAGAPADPVR
VRQGDDARGGRLQQQHAVVQLQAPRRLQPWAPHGRGHRHHQAAVRHLGRHRQHRQQDGHHRRGVPHPGERRELPRLEQDGLXLRLQRDRE
CQGERPDEDLPVPKVHGSQGHPTAPAVHLPRHPRPGGWQHRTVSHRRDCQPGAFCPVCGQDISGFXQQHAGQGCPPVPQETVEGARQSRR

>In-frame_CREBBP_ENST00000382070_chr16_3929833_-_ADCY9_ENST00000294016_chr16_4043511_-_754aa
MAENLLDGPPNPKRAKLSSPGFSANDSTDLPFVRNHICSQIXSRRRGRSTSKRLPRRAXKQHQGFWRTXSQNSERAPQPSPRGEAHQQSD
FSVXDLAGEGKVGRGEPGPVGSPSAEVQEHPGENGRPLCGRYQRRQPDERLLFXAAHXSVQPELPGSGAGAILQDQLSGRGHKELPREDV
CXSHLQLPPGCVSVDHSVSDAVHHLLPEVRGGHRASPARRPGGLQCSPAAGGAVPRGVHQDGVLPGGRHGLHQAPAGVDRRLATTSLHRG
HPGVASRTGRLLPCHLRIXDQHTLPSVHRLGRADCRRALLXLLPAQLLDEVLPRHRRGGRAAAPALRLPVPRQFCINFAPXRSTEFQFRE
EPVQXFGAAXPPAARQPHRPGGGSRLLSPALVGLVPESRIXSQLPPPLPRRRGSGSSPHQDPEHAGPGRLAAEEHHPLPRGXAAEGVPDL
LQEPXQRRGDLRQHRQLQRVLRGELRGRQGVLPGPQRAHRGLXRAPKQAGLQQHREDQDHRSHVHGGVRAEHRAGPGRQPPAGAPADPVR
VRQGDDARGGRLQQQHAVVQLQAPRRLQPWAPHGRGHRHHQAAVRHLGRHRQHRQQDGHHRRGVPHPGERRELPRLEQDGLXLRLQRDRE
CQGERPDEDLPVPKVHGSQGHPTAPAVHLPRHPRPGGWQHRTVSHRRDCQPGAFCPVCGQDISGFXQQHAGQGCPPVPQETVEGARQSRR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CREBBP_ENST00000262367_chr16_3929833_-_ADCY9_ENST00000294016_chr16_4043511_-_2263nt
ATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTCTCGGCGAATGACAGCACAGACCTG
CCCTTCGTGCGGAATCACATTTGCTCCCAAATCTGAAGCCGGCGCCGAGGGAGGAGCACCTCAAAACGGCTGCCAAGACGAGCATAAAAA
CAGCACCAAGGCTTCTGGAGGACCTAATCCCAAAACTCAGAACGGGCTCCTCAGCCCTCCCCAAGAGGAGAAGCTCACCAACAGTCAGAC
TTCTCTGTGTGAGATCTTGCAGGAGAAGGGAAGGTGGGCAGGGGTGAGCCTGGACCAGTCGGCTCTCCTTCCGCTGAGGTTCAAGAACAT
CCGGGAGAAAACGGACGCCCACTTTGTGGACGTTATCAAAGAAGACAGCCTGATGAAAGATTACTTTTTTAAGCCGCCCATTAATCAGTT
CAGCCTGAACTTCCTGGATCAGGAGCTGGAGCGATCCTACAGGACCAGCTATCAGGAAGAGGTCATAAAGAACTCCCCCGTGAAGACGTT
TGCTAGTCCCACCTTCAGCTCCCTCCTGGATGTGTTTCTGTCGACCACAGTGTTTCTGACGCTGTCCACCACCTGCTTCCTGAAGTACGA
GGCGGCCACCGTGCCTCCCCCGCCCGCCGCCCTGGCGGTCTTCAGTGCAGCCCTGCTGCTGGAGGTGCTGTCCCTCGCGGTGTCCATCAG
GATGGTGTTCTTCCTGGAGGACGTCATGGCCTGCACCAAGCGCCTGCTGGAGTGGATCGCCGGCTGGCTACCACGTCACTGCATCGGGGC
CATCCTGGTGTCGCTTCCCGCACTGGCCGTCTACTCCCATGTCACCTCCGAATATGAGACCAACATACACTTCCCAGTGTTCACAGGCTC
GGCCGCGCTGATTGCCGTCGTGCACTACTGTAACTTCTGCCAGCTCAGCTCCTGGATGAGGTCCTCCCTCGCCACCGTCGTGGGGGCCGG
GCCGCTGCTCCTGCTCTACGTCTCCCTGTGCCCAGACAGTTCTGTATTAACTTCGCCCCTTGACGCAGTACAGAATTTCAGTTCCGAGAG
GAACCCGTGCAATAGTTCGGTGCCGCGTGACCTCCGGCGGCCCGCCAGCCTCATCGGCCAGGAGGTGGTTCTCGTCTTCTTTCTCCTGCT
CTTGTTGGTCTGGTTCCTGAATCGCGAATTTGAAGTCAGCTACCGCCTCCACTACCACGGAGACGTGGAAGCGGATCTTCACCGCACCAA
GATCCAGAGCATGCGGGACCAGGCAGACTGGCTGCTGAGGAACATCATCCCCTACCACGTGGCTGAGCAGCTGAAGGTGTCCCAGACCTA
CTCCAAGAACCATGACAGCGGAGGGGTGATCTTCGCCAGCATCGTCAACTTCAGCGAGTTCTACGAGGAGAACTACGAGGGCGGCAAGGA
GTGCTACCGGGTCCTCAACGAGCTCATCGGGGACTTTGACGAGCTCCTAAGCAAGCCGGACTACAGCAGCATCGAGAAGATCAAGACCAT
CGGAGCCACGTACATGGCGGCGTCAGGGCTGAACACCGCGCAGGCCCAGGACGGCAGCCACCCGCAGGAGCACCTGCAGATCCTGTTCGA
GTTCGCCAAGGAGATGATGCGCGTGGTGGACGACTTCAACAACAACATGCTGTGGTTCAACTTCAAGCTCCGCGTCGGCTTCAACCATGG
GCCCCTCACGGCCGGGGTCATCGGCACCACCAAGCTGCTGTACGACATCTGGGGAGACACCGTCAACATCGCCAGCAGGATGGACACCAC
CGGCGTGGAGTGCCGCATCCAGGTGAGCGAAGAGAGCTACCGCGTCTTGAGCAAGATGGGCTATGACTTCGACTACAGAGGGACCGTGAA
TGTCAAGGGGAAAGGCCAGATGAAGACCTACCTGTACCCAAAGTGCACGGATCACAGGGTCATCCCACAGCACCAGCTGTCCATCTCCCC
AGACATCCGCGTCCAGGTGGATGGCAGCATCGGACGGTCTCCCACAGACGAGATTGCCAACCTGGTGCCTTCTGTCCAGTATGTGGACAA
GACATCTCTGGGTTCTGACAGCAGCACGCAGGCCAAGGATGCCCACCTGTCCCCCAAGAGACCGTGGAAGGAGCCCGTCAAAGCCGAAGA
AAGGGGTCGATTTGGCAAAGCCATAGAGAAAGACGACTGTGACGAAACAGGAATAGAAGAAGCCAACGAACTCACCAAGCTCAACGTTTC

>In-frame_CREBBP_ENST00000382070_chr16_3929833_-_ADCY9_ENST00000294016_chr16_4043511_-_2263nt
ATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTCTCGGCGAATGACAGCACAGACCTG
CCCTTCGTGCGGAATCACATTTGCTCCCAAATCTGAAGCCGGCGCCGAGGGAGGAGCACCTCAAAACGGCTGCCAAGACGAGCATAAAAA
CAGCACCAAGGCTTCTGGAGGACCTAATCCCAAAACTCAGAACGGGCTCCTCAGCCCTCCCCAAGAGGAGAAGCTCACCAACAGTCAGAC
TTCTCTGTGTGAGATCTTGCAGGAGAAGGGAAGGTGGGCAGGGGTGAGCCTGGACCAGTCGGCTCTCCTTCCGCTGAGGTTCAAGAACAT
CCGGGAGAAAACGGACGCCCACTTTGTGGACGTTATCAAAGAAGACAGCCTGATGAAAGATTACTTTTTTAAGCCGCCCATTAATCAGTT
CAGCCTGAACTTCCTGGATCAGGAGCTGGAGCGATCCTACAGGACCAGCTATCAGGAAGAGGTCATAAAGAACTCCCCCGTGAAGACGTT
TGCTAGTCCCACCTTCAGCTCCCTCCTGGATGTGTTTCTGTCGACCACAGTGTTTCTGACGCTGTCCACCACCTGCTTCCTGAAGTACGA
GGCGGCCACCGTGCCTCCCCCGCCCGCCGCCCTGGCGGTCTTCAGTGCAGCCCTGCTGCTGGAGGTGCTGTCCCTCGCGGTGTCCATCAG
GATGGTGTTCTTCCTGGAGGACGTCATGGCCTGCACCAAGCGCCTGCTGGAGTGGATCGCCGGCTGGCTACCACGTCACTGCATCGGGGC
CATCCTGGTGTCGCTTCCCGCACTGGCCGTCTACTCCCATGTCACCTCCGAATATGAGACCAACATACACTTCCCAGTGTTCACAGGCTC
GGCCGCGCTGATTGCCGTCGTGCACTACTGTAACTTCTGCCAGCTCAGCTCCTGGATGAGGTCCTCCCTCGCCACCGTCGTGGGGGCCGG
GCCGCTGCTCCTGCTCTACGTCTCCCTGTGCCCAGACAGTTCTGTATTAACTTCGCCCCTTGACGCAGTACAGAATTTCAGTTCCGAGAG
GAACCCGTGCAATAGTTCGGTGCCGCGTGACCTCCGGCGGCCCGCCAGCCTCATCGGCCAGGAGGTGGTTCTCGTCTTCTTTCTCCTGCT
CTTGTTGGTCTGGTTCCTGAATCGCGAATTTGAAGTCAGCTACCGCCTCCACTACCACGGAGACGTGGAAGCGGATCTTCACCGCACCAA
GATCCAGAGCATGCGGGACCAGGCAGACTGGCTGCTGAGGAACATCATCCCCTACCACGTGGCTGAGCAGCTGAAGGTGTCCCAGACCTA
CTCCAAGAACCATGACAGCGGAGGGGTGATCTTCGCCAGCATCGTCAACTTCAGCGAGTTCTACGAGGAGAACTACGAGGGCGGCAAGGA
GTGCTACCGGGTCCTCAACGAGCTCATCGGGGACTTTGACGAGCTCCTAAGCAAGCCGGACTACAGCAGCATCGAGAAGATCAAGACCAT
CGGAGCCACGTACATGGCGGCGTCAGGGCTGAACACCGCGCAGGCCCAGGACGGCAGCCACCCGCAGGAGCACCTGCAGATCCTGTTCGA
GTTCGCCAAGGAGATGATGCGCGTGGTGGACGACTTCAACAACAACATGCTGTGGTTCAACTTCAAGCTCCGCGTCGGCTTCAACCATGG
GCCCCTCACGGCCGGGGTCATCGGCACCACCAAGCTGCTGTACGACATCTGGGGAGACACCGTCAACATCGCCAGCAGGATGGACACCAC
CGGCGTGGAGTGCCGCATCCAGGTGAGCGAAGAGAGCTACCGCGTCTTGAGCAAGATGGGCTATGACTTCGACTACAGAGGGACCGTGAA
TGTCAAGGGGAAAGGCCAGATGAAGACCTACCTGTACCCAAAGTGCACGGATCACAGGGTCATCCCACAGCACCAGCTGTCCATCTCCCC
AGACATCCGCGTCCAGGTGGATGGCAGCATCGGACGGTCTCCCACAGACGAGATTGCCAACCTGGTGCCTTCTGTCCAGTATGTGGACAA
GACATCTCTGGGTTCTGACAGCAGCACGCAGGCCAAGGATGCCCACCTGTCCCCCAAGAGACCGTGGAAGGAGCCCGTCAAAGCCGAAGA
AAGGGGTCGATTTGGCAAAGCCATAGAGAAAGACGACTGTGACGAAACAGGAATAGAAGAAGCCAACGAACTCACCAAGCTCAACGTTTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_CREBBP_ENST00000262367_chr16_3929833_-_ADCY9_ENST00000294016_chr16_4043511_-_6197nt
TTCTTTTTTTTTTAATTGAGGAATCAACAGCCGCCATCTTGTCGCGGACCCGACCGGGGCTTCGAGCGCGATCTACTCGGCCCCGCCGGT
CCCGGGCCCCACAACCGCCCGCGCACCCCGCTCCGCCCGGCCGGCCCGCTCCGCCCGGCCCTCGGCGCCCGCCCCGGCGGCCCCGCTCGC
CTCTCGGCTCGGCCTCCCGGAGCCCGGCGGCGGCGGCGGCGGCAGCGGCGGCGGCGGCGGCGGAACGGGGGGTGGGGGGGCCGCGGCGGC
GGCGGCGACCCCGCTCGGCGCATTGTTTTTCCTCACGGCGGCGGCGGCGGCGGGCCGCGGGCCGGGAGCGGAGCCCGGAGCCCCCTCGTC
GTCGGGCCGCGAGCGAATTCATTAAGTGGGGCGCGGGGGGGGAGCGAGGCGGCGGCGGCGGCGGCACCATGTTCTCGGGGACTGCCTGAG
CCGCCCGGCCGGGCGCCGTCGCTGCCAGCCGGGCCCGGGGGGGCGGCCGGGCCGCCGGGGCGCCCCCACCGCGGAGTGTCGCGCTCGGGA
GGCGGGCAGGGGATGAGGGGGCCGCGGCCGGCGGCGGCGGCGGCGGCCGGGGGCGGGCGGTGAGCGCTGCGGGGCGCTGTTGCTGTGGCT
GAGATTTGGCCGCCGCCTCCCCCACCCGGCCTGCGCCCTCCCTCTCCCTCGGCGCCCGCCCGCCCGCTCGCGGCCCGCGCTCGCTCCTCT
CCCTCGCAGCCGGCAGGGCCCCCGACCCCCGTCCGGGCCCTCGCCGGCCCGGCCGCCCGTGCCCGGGGCTGTTTTCGCGAGCAGGTGAAA
ATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTCTCGGCGAATGACAGCACAGACCTG
CCCTTCGTGCGGAATCACATTTGCTCCCAAATCTGAAGCCGGCGCCGAGGGAGGAGCACCTCAAAACGGCTGCCAAGACGAGCATAAAAA
CAGCACCAAGGCTTCTGGAGGACCTAATCCCAAAACTCAGAACGGGCTCCTCAGCCCTCCCCAAGAGGAGAAGCTCACCAACAGTCAGAC
TTCTCTGTGTGAGATCTTGCAGGAGAAGGGAAGGTGGGCAGGGGTGAGCCTGGACCAGTCGGCTCTCCTTCCGCTGAGGTTCAAGAACAT
CCGGGAGAAAACGGACGCCCACTTTGTGGACGTTATCAAAGAAGACAGCCTGATGAAAGATTACTTTTTTAAGCCGCCCATTAATCAGTT
CAGCCTGAACTTCCTGGATCAGGAGCTGGAGCGATCCTACAGGACCAGCTATCAGGAAGAGGTCATAAAGAACTCCCCCGTGAAGACGTT
TGCTAGTCCCACCTTCAGCTCCCTCCTGGATGTGTTTCTGTCGACCACAGTGTTTCTGACGCTGTCCACCACCTGCTTCCTGAAGTACGA
GGCGGCCACCGTGCCTCCCCCGCCCGCCGCCCTGGCGGTCTTCAGTGCAGCCCTGCTGCTGGAGGTGCTGTCCCTCGCGGTGTCCATCAG
GATGGTGTTCTTCCTGGAGGACGTCATGGCCTGCACCAAGCGCCTGCTGGAGTGGATCGCCGGCTGGCTACCACGTCACTGCATCGGGGC
CATCCTGGTGTCGCTTCCCGCACTGGCCGTCTACTCCCATGTCACCTCCGAATATGAGACCAACATACACTTCCCAGTGTTCACAGGCTC
GGCCGCGCTGATTGCCGTCGTGCACTACTGTAACTTCTGCCAGCTCAGCTCCTGGATGAGGTCCTCCCTCGCCACCGTCGTGGGGGCCGG
GCCGCTGCTCCTGCTCTACGTCTCCCTGTGCCCAGACAGTTCTGTATTAACTTCGCCCCTTGACGCAGTACAGAATTTCAGTTCCGAGAG
GAACCCGTGCAATAGTTCGGTGCCGCGTGACCTCCGGCGGCCCGCCAGCCTCATCGGCCAGGAGGTGGTTCTCGTCTTCTTTCTCCTGCT
CTTGTTGGTCTGGTTCCTGAATCGCGAATTTGAAGTCAGCTACCGCCTCCACTACCACGGAGACGTGGAAGCGGATCTTCACCGCACCAA
GATCCAGAGCATGCGGGACCAGGCAGACTGGCTGCTGAGGAACATCATCCCCTACCACGTGGCTGAGCAGCTGAAGGTGTCCCAGACCTA
CTCCAAGAACCATGACAGCGGAGGGGTGATCTTCGCCAGCATCGTCAACTTCAGCGAGTTCTACGAGGAGAACTACGAGGGCGGCAAGGA
GTGCTACCGGGTCCTCAACGAGCTCATCGGGGACTTTGACGAGCTCCTAAGCAAGCCGGACTACAGCAGCATCGAGAAGATCAAGACCAT
CGGAGCCACGTACATGGCGGCGTCAGGGCTGAACACCGCGCAGGCCCAGGACGGCAGCCACCCGCAGGAGCACCTGCAGATCCTGTTCGA
GTTCGCCAAGGAGATGATGCGCGTGGTGGACGACTTCAACAACAACATGCTGTGGTTCAACTTCAAGCTCCGCGTCGGCTTCAACCATGG
GCCCCTCACGGCCGGGGTCATCGGCACCACCAAGCTGCTGTACGACATCTGGGGAGACACCGTCAACATCGCCAGCAGGATGGACACCAC
CGGCGTGGAGTGCCGCATCCAGGTGAGCGAAGAGAGCTACCGCGTCTTGAGCAAGATGGGCTATGACTTCGACTACAGAGGGACCGTGAA
TGTCAAGGGGAAAGGCCAGATGAAGACCTACCTGTACCCAAAGTGCACGGATCACAGGGTCATCCCACAGCACCAGCTGTCCATCTCCCC
AGACATCCGCGTCCAGGTGGATGGCAGCATCGGACGGTCTCCCACAGACGAGATTGCCAACCTGGTGCCTTCTGTCCAGTATGTGGACAA
GACATCTCTGGGTTCTGACAGCAGCACGCAGGCCAAGGATGCCCACCTGTCCCCCAAGAGACCGTGGAAGGAGCCCGTCAAAGCCGAAGA
AAGGGGTCGATTTGGCAAAGCCATAGAGAAAGACGACTGTGACGAAACAGGAATAGAAGAAGCCAACGAACTCACCAAGCTCAACGTTTC
AAAGAGTGTGTGAGGCGGCGCCCACCCGCTGCCCGAGGTGCTCTGTTTGTCGAAACACAGTAATATTTGTATTTGGCTGTTGTGCTTTCC
AAGCGCCACAGTTGCCCTCCCCGGACGTGGTGTTATGTGGTCATTTCAGCCCTAACTTCTGTGTGGATCACAGTTATTCAGGGTTCATTT
TCATCCATTCTTCCCTTTCGCTCCCTTCCCTGGAAACCCCGCTGCCTCTGGGTCATCCGTTCAGCACGTGGTGGAGAACAAGTGCCTTCA
GGGCTGGCCTCGGCCTCGAGTCTCGGGACAGAGGCCGCCAGTGGAGATCATGGCTTTGGGTATTATTTGACTTTTAGAACAAAAGCTGTG
GTTAAGATCTCATTTTTATTGCTTTTTCCCACGTCCCACGAGACACTATTTTCGGTTCTCTGGCTAATACCCTGTTTTTGAGTTTATTTT
GTTTCTGTCTATGTCACAGTGTTCCTCTACGACCCGACCTCTCTATGTAAGCACACATGCGCACACACACTTGCATTCATGAATCTGATA
TAAAGTGCCAGTAATCCGCCAAGAGGGGGTGCGAAGGGGGCATGTCACGACAGCTCCGCCACCCCCCATTGCCCACCCGCACTTTCCCGA
GCACCGCGCCCCGTGGGCTGTGGGTGAGCCGCGCTCCCTGCACTGAGCGGGTTTAGGGGCTCGCCCACATGCATGCAGGCCAAGACAGCA
AATGCCAGCCGGGCACGACGCCCGTGTGCCCAGGCCTCGGGGGTCTCAGAGCCGCCTCTCACCCCCGACCCTCCACCCAGGGGTCTCCCC
ATCGGGAGTGGAGGTGTTGGTCCTGGAAGCTGACTCATCGGAGAGGGAAATACCAAATAAACATCCGAGGTTGCATTTATTTATTTATTT
ATTTACCCGGAAGCATGTGCGCTCCCGGGAGGGGTGCTGGGTCCTCAGGGTGGGGGGTCATAGCCACAGGGGAGGGCAGTTCCCAGGAAG
GTAACCAGATGTCTCTTTTGTGTTTTGGCCACCTGGGGCCGCCCCCAACCTCCCCACCCCAAGAGGGGTCTGAGTGGGACCTCAAAGCAT
GGCCAGTGCAATTCTGAGGCTAGGGGAATAGGAGAAGCCCACCAGCTGCCCCTGCCACCCACGGGGGCTCCTCCCTGCCGGGGTCCAGCT
CAGAACCACGGGGGTCTGTGCCGGCAGCACCGGTGCCATCTTGGCTTCCACAAATTCCAGAAGTTTCTTGGCTGCCTCCCGCTCTCAGAT
GGCACAGGGCCTATCAGTGGCAGGATTTAATCTGGGGAGCAAATTCCAGCTCTGAAATGGAGTTCTCACACCGTATCTAGGGACAGAGGC
ATCTGGATGCAAACGCGGGGTTTGTTAGGGGCGGAATCCCGAGGGTGGTGTGGGGGAGCTCCGTCCGGGCAGTTGGCTGCTGGTCCTGTC
TGATTATGTTTTGCCATATTGAGTCTGAAGTTTGTGTGGAAGTGAGCTCGCCCGAGTTGTCCGGTCGGAGTTGTAGCCAGTCTTTCAGGG
GACCCCGGGACGCTGATGAGGCCCAGGGTGCACTCCTTGTCAGTCTTGCCCGTTGTCCCTGTGCATTTTGCTTTCCGCTGTCAAATCTCA
CTGTCTCGTTTTCACACCGCATCAGTCCCCATCATCACTACTCCTCCCCAGAGACATACAGATTGCCCTCCCCGGCATGAAGAAGTCACA
ATTCTGACCCGCCACCTCTCCAGGGGCGGTGCCTGGGATGGCCACCCATCAGGACAGCCAGAGCCAGGGTCCCGGCGTCCTGAGAGTCCA
GGGCACCTCCCCCCATTAGCTGTAAGGTTTCCTGTCAGGTGTGACTGTCAGTTTGCTGGTCTTCCAATACCGAAGAAAGGGTGGTTGTGA
CAATACCTCTTGCTTCTAAAGAATGTATTATAAAACACCGCAGATTTTTTTTTTTCCTTAAAAAACACTACCTGATGCTTTCCTTGTTCG
TGGGGATTGTGGTCACATGAAGCTCTTTCTGCATCAGTATTAAGGTGTATATTTGAATGTCCTCCCCTCCCCTTTCCCCTCCAGGCTGTG
TAGCTTTGAGGGGCTGGGCGTTTGCTCACGACCTTGCTGTCTCGCTCAGAACATGCTCCGCAAAGTTCTCCGCACACACTTCTTCCCCAT
CAAGCCCATTTCCTTCCCCAACCACAAAGGTGTTTGTGATTCCTCACCCCGGGAAACCAAGGAGCTGCAAAGTGGAGTCTGGTTCAGCCC
CGTGCAGACTCACCCAGAGCTTAACGTTGTCTTTCAAACACCCTGAGCCTTCCTAAACAGCCAGTGCAGACGTTCTCTCTGGGCCACGAA
GCCCCTCGGGTCCTCCCCGTCCCCTGCTCCGATGCATACCTCAGTGCAGAACCACAGAATCTCTGCAGCGGAAACGCCGTGCATCTCTTG
TCTGTTGGCAGCGAGCACATCGTGCTGGAGACACGAGTTTCTAAGCAGCTGGCACGAGGGCTGCTGACGGCATGGGTCGTGCTTCAGGGT
GGCAATACCTCTTAGGAACTTAGGGCAGGAAGCAATACTTCAGCATTGAATGTGTGTAAATAGTTGCTTTGAGTTGCAATTGCTATTTTC
TTCTCAGTCCCAGCTCAGATCGAATTATATATCCATATATATATATATATATATATATATATATATATATATATATATATGGTAAACAAG
CACACACAATTTTATCCAATGCAAACAAATGTAGAGCATCAGTTACAAAACCCTCGAATAGCTTGAGAGCCCCACAGGCTCTGCCACACC
CGTGACTTCATCCACACTGACGTCACCCGCGGGGGCTCCCCCTGCACATTTGCACACGATCCGGAGAGCCGAAGGCCGCGTGCTTCCTGT
CACATGGGCTGTAATCATTTGTAGTTTCCAAAGACACGTCTGCATTTGAATTTCTAGATTTTCGAGGTAAGGAGTTTTTTTTAATTGGTT
GTTTGGAAAATCACATCATGCCTAGAATCTGAAATTGAATTAGCAAGAACCGACTGTTTGCATTTTCCATATATCCTTTTATCTGCTCTT

>In-frame_CREBBP_ENST00000382070_chr16_3929833_-_ADCY9_ENST00000294016_chr16_4043511_-_5591nt
CTGCGGGGCGCTGTTGCTGTGGCTGAGATTTGGCCGCCGCCTCCCCCACCCGGCCTGCGCCCTCCCTCTCCCTCGGCGCCCGCCCGCCCG
CTCGCGGCCCGCGCTCGCTCCTCTCCCTCGCAGCCGGCAGGGCCCCCGACCCCCGTCCGGGCCCTCGCCGGCCCGGCCGCCCGTGCCCGG
GGCTGTTTTCGCGAGCAGGTGAAAATGGCTGAGAACTTGCTGGACGGACCGCCCAACCCCAAAAGAGCCAAACTCAGCTCGCCCGGTTTC
TCGGCGAATGACAGCACAGACCTGCCCTTCGTGCGGAATCACATTTGCTCCCAAATCTGAAGCCGGCGCCGAGGGAGGAGCACCTCAAAA
CGGCTGCCAAGACGAGCATAAAAACAGCACCAAGGCTTCTGGAGGACCTAATCCCAAAACTCAGAACGGGCTCCTCAGCCCTCCCCAAGA
GGAGAAGCTCACCAACAGTCAGACTTCTCTGTGTGAGATCTTGCAGGAGAAGGGAAGGTGGGCAGGGGTGAGCCTGGACCAGTCGGCTCT
CCTTCCGCTGAGGTTCAAGAACATCCGGGAGAAAACGGACGCCCACTTTGTGGACGTTATCAAAGAAGACAGCCTGATGAAAGATTACTT
TTTTAAGCCGCCCATTAATCAGTTCAGCCTGAACTTCCTGGATCAGGAGCTGGAGCGATCCTACAGGACCAGCTATCAGGAAGAGGTCAT
AAAGAACTCCCCCGTGAAGACGTTTGCTAGTCCCACCTTCAGCTCCCTCCTGGATGTGTTTCTGTCGACCACAGTGTTTCTGACGCTGTC
CACCACCTGCTTCCTGAAGTACGAGGCGGCCACCGTGCCTCCCCCGCCCGCCGCCCTGGCGGTCTTCAGTGCAGCCCTGCTGCTGGAGGT
GCTGTCCCTCGCGGTGTCCATCAGGATGGTGTTCTTCCTGGAGGACGTCATGGCCTGCACCAAGCGCCTGCTGGAGTGGATCGCCGGCTG
GCTACCACGTCACTGCATCGGGGCCATCCTGGTGTCGCTTCCCGCACTGGCCGTCTACTCCCATGTCACCTCCGAATATGAGACCAACAT
ACACTTCCCAGTGTTCACAGGCTCGGCCGCGCTGATTGCCGTCGTGCACTACTGTAACTTCTGCCAGCTCAGCTCCTGGATGAGGTCCTC
CCTCGCCACCGTCGTGGGGGCCGGGCCGCTGCTCCTGCTCTACGTCTCCCTGTGCCCAGACAGTTCTGTATTAACTTCGCCCCTTGACGC
AGTACAGAATTTCAGTTCCGAGAGGAACCCGTGCAATAGTTCGGTGCCGCGTGACCTCCGGCGGCCCGCCAGCCTCATCGGCCAGGAGGT
GGTTCTCGTCTTCTTTCTCCTGCTCTTGTTGGTCTGGTTCCTGAATCGCGAATTTGAAGTCAGCTACCGCCTCCACTACCACGGAGACGT
GGAAGCGGATCTTCACCGCACCAAGATCCAGAGCATGCGGGACCAGGCAGACTGGCTGCTGAGGAACATCATCCCCTACCACGTGGCTGA
GCAGCTGAAGGTGTCCCAGACCTACTCCAAGAACCATGACAGCGGAGGGGTGATCTTCGCCAGCATCGTCAACTTCAGCGAGTTCTACGA
GGAGAACTACGAGGGCGGCAAGGAGTGCTACCGGGTCCTCAACGAGCTCATCGGGGACTTTGACGAGCTCCTAAGCAAGCCGGACTACAG
CAGCATCGAGAAGATCAAGACCATCGGAGCCACGTACATGGCGGCGTCAGGGCTGAACACCGCGCAGGCCCAGGACGGCAGCCACCCGCA
GGAGCACCTGCAGATCCTGTTCGAGTTCGCCAAGGAGATGATGCGCGTGGTGGACGACTTCAACAACAACATGCTGTGGTTCAACTTCAA
GCTCCGCGTCGGCTTCAACCATGGGCCCCTCACGGCCGGGGTCATCGGCACCACCAAGCTGCTGTACGACATCTGGGGAGACACCGTCAA
CATCGCCAGCAGGATGGACACCACCGGCGTGGAGTGCCGCATCCAGGTGAGCGAAGAGAGCTACCGCGTCTTGAGCAAGATGGGCTATGA
CTTCGACTACAGAGGGACCGTGAATGTCAAGGGGAAAGGCCAGATGAAGACCTACCTGTACCCAAAGTGCACGGATCACAGGGTCATCCC
ACAGCACCAGCTGTCCATCTCCCCAGACATCCGCGTCCAGGTGGATGGCAGCATCGGACGGTCTCCCACAGACGAGATTGCCAACCTGGT
GCCTTCTGTCCAGTATGTGGACAAGACATCTCTGGGTTCTGACAGCAGCACGCAGGCCAAGGATGCCCACCTGTCCCCCAAGAGACCGTG
GAAGGAGCCCGTCAAAGCCGAAGAAAGGGGTCGATTTGGCAAAGCCATAGAGAAAGACGACTGTGACGAAACAGGAATAGAAGAAGCCAA
CGAACTCACCAAGCTCAACGTTTCAAAGAGTGTGTGAGGCGGCGCCCACCCGCTGCCCGAGGTGCTCTGTTTGTCGAAACACAGTAATAT
TTGTATTTGGCTGTTGTGCTTTCCAAGCGCCACAGTTGCCCTCCCCGGACGTGGTGTTATGTGGTCATTTCAGCCCTAACTTCTGTGTGG
ATCACAGTTATTCAGGGTTCATTTTCATCCATTCTTCCCTTTCGCTCCCTTCCCTGGAAACCCCGCTGCCTCTGGGTCATCCGTTCAGCA
CGTGGTGGAGAACAAGTGCCTTCAGGGCTGGCCTCGGCCTCGAGTCTCGGGACAGAGGCCGCCAGTGGAGATCATGGCTTTGGGTATTAT
TTGACTTTTAGAACAAAAGCTGTGGTTAAGATCTCATTTTTATTGCTTTTTCCCACGTCCCACGAGACACTATTTTCGGTTCTCTGGCTA
ATACCCTGTTTTTGAGTTTATTTTGTTTCTGTCTATGTCACAGTGTTCCTCTACGACCCGACCTCTCTATGTAAGCACACATGCGCACAC
ACACTTGCATTCATGAATCTGATATAAAGTGCCAGTAATCCGCCAAGAGGGGGTGCGAAGGGGGCATGTCACGACAGCTCCGCCACCCCC
CATTGCCCACCCGCACTTTCCCGAGCACCGCGCCCCGTGGGCTGTGGGTGAGCCGCGCTCCCTGCACTGAGCGGGTTTAGGGGCTCGCCC
ACATGCATGCAGGCCAAGACAGCAAATGCCAGCCGGGCACGACGCCCGTGTGCCCAGGCCTCGGGGGTCTCAGAGCCGCCTCTCACCCCC
GACCCTCCACCCAGGGGTCTCCCCATCGGGAGTGGAGGTGTTGGTCCTGGAAGCTGACTCATCGGAGAGGGAAATACCAAATAAACATCC
GAGGTTGCATTTATTTATTTATTTATTTACCCGGAAGCATGTGCGCTCCCGGGAGGGGTGCTGGGTCCTCAGGGTGGGGGGTCATAGCCA
CAGGGGAGGGCAGTTCCCAGGAAGGTAACCAGATGTCTCTTTTGTGTTTTGGCCACCTGGGGCCGCCCCCAACCTCCCCACCCCAAGAGG
GGTCTGAGTGGGACCTCAAAGCATGGCCAGTGCAATTCTGAGGCTAGGGGAATAGGAGAAGCCCACCAGCTGCCCCTGCCACCCACGGGG
GCTCCTCCCTGCCGGGGTCCAGCTCAGAACCACGGGGGTCTGTGCCGGCAGCACCGGTGCCATCTTGGCTTCCACAAATTCCAGAAGTTT
CTTGGCTGCCTCCCGCTCTCAGATGGCACAGGGCCTATCAGTGGCAGGATTTAATCTGGGGAGCAAATTCCAGCTCTGAAATGGAGTTCT
CACACCGTATCTAGGGACAGAGGCATCTGGATGCAAACGCGGGGTTTGTTAGGGGCGGAATCCCGAGGGTGGTGTGGGGGAGCTCCGTCC
GGGCAGTTGGCTGCTGGTCCTGTCTGATTATGTTTTGCCATATTGAGTCTGAAGTTTGTGTGGAAGTGAGCTCGCCCGAGTTGTCCGGTC
GGAGTTGTAGCCAGTCTTTCAGGGGACCCCGGGACGCTGATGAGGCCCAGGGTGCACTCCTTGTCAGTCTTGCCCGTTGTCCCTGTGCAT
TTTGCTTTCCGCTGTCAAATCTCACTGTCTCGTTTTCACACCGCATCAGTCCCCATCATCACTACTCCTCCCCAGAGACATACAGATTGC
CCTCCCCGGCATGAAGAAGTCACAATTCTGACCCGCCACCTCTCCAGGGGCGGTGCCTGGGATGGCCACCCATCAGGACAGCCAGAGCCA
GGGTCCCGGCGTCCTGAGAGTCCAGGGCACCTCCCCCCATTAGCTGTAAGGTTTCCTGTCAGGTGTGACTGTCAGTTTGCTGGTCTTCCA
ATACCGAAGAAAGGGTGGTTGTGACAATACCTCTTGCTTCTAAAGAATGTATTATAAAACACCGCAGATTTTTTTTTTTCCTTAAAAAAC
ACTACCTGATGCTTTCCTTGTTCGTGGGGATTGTGGTCACATGAAGCTCTTTCTGCATCAGTATTAAGGTGTATATTTGAATGTCCTCCC
CTCCCCTTTCCCCTCCAGGCTGTGTAGCTTTGAGGGGCTGGGCGTTTGCTCACGACCTTGCTGTCTCGCTCAGAACATGCTCCGCAAAGT
TCTCCGCACACACTTCTTCCCCATCAAGCCCATTTCCTTCCCCAACCACAAAGGTGTTTGTGATTCCTCACCCCGGGAAACCAAGGAGCT
GCAAAGTGGAGTCTGGTTCAGCCCCGTGCAGACTCACCCAGAGCTTAACGTTGTCTTTCAAACACCCTGAGCCTTCCTAAACAGCCAGTG
CAGACGTTCTCTCTGGGCCACGAAGCCCCTCGGGTCCTCCCCGTCCCCTGCTCCGATGCATACCTCAGTGCAGAACCACAGAATCTCTGC
AGCGGAAACGCCGTGCATCTCTTGTCTGTTGGCAGCGAGCACATCGTGCTGGAGACACGAGTTTCTAAGCAGCTGGCACGAGGGCTGCTG
ACGGCATGGGTCGTGCTTCAGGGTGGCAATACCTCTTAGGAACTTAGGGCAGGAAGCAATACTTCAGCATTGAATGTGTGTAAATAGTTG
CTTTGAGTTGCAATTGCTATTTTCTTCTCAGTCCCAGCTCAGATCGAATTATATATCCATATATATATATATATATATATATATATATAT
ATATATATATATATGGTAAACAAGCACACACAATTTTATCCAATGCAAACAAATGTAGAGCATCAGTTACAAAACCCTCGAATAGCTTGA
GAGCCCCACAGGCTCTGCCACACCCGTGACTTCATCCACACTGACGTCACCCGCGGGGGCTCCCCCTGCACATTTGCACACGATCCGGAG
AGCCGAAGGCCGCGTGCTTCCTGTCACATGGGCTGTAATCATTTGTAGTTTCCAAAGACACGTCTGCATTTGAATTTCTAGATTTTCGAG
GTAAGGAGTTTTTTTTAATTGGTTGTTTGGAAAATCACATCATGCCTAGAATCTGAAATTGAATTAGCAAGAACCGACTGTTTGCATTTT
CCATATATCCTTTTATCTGCTCTTTTTAAATTGTTAATTCTAATAATTTCAAAATGCATTCACTGAAGAAATGGACATTAAAATATTCTA


Top

FusionGenePPI for CREBBP_ADCY9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CREBBPEGR1, HNF4A, NFE2L2, TDG, AIRE, NCOA6, BRCA1, CREB1, AR, N4BP2, CTNNB1, RELA, SS18L1, PIAS3, NPAS2, EBF1, E2F1, E2F3, KLF5, PML, SRF, TP53, KLF1, ING1, SMAD1, CSNK2A1, CUX1, ATF1, EWSR1, NR3C1, HNF1A, HOXB7, MSX1, HTT, TCF3, MGMT, KMT2A, MYOD1, ATF2, JUN, MECOM, GLI3, DDX5, PTMA, MYB, FOXO1, FOXO4, RPS6KA3, CITED1, STAT1, STAT6, MAF, PELP1, RPS6KA2, RBBP4, RBBP7, ONECUT1, SERTAD1, SREBF1, SREBF2, NFATC2, TRIP4, HIF1A, NFE2, STAT2, SMARCA4, NCOA1, ESR1, MAML1, MYBL2, KAT2B, GTF2B, CITED2, IRF3, NUP98, TRERF1, TGS1, KLF4, STAT3, NEUROG1, HIPK2, KHDRBS1, GATA1, PHOX2A, SNIP1, NFATC4, KLF13, XRCC6, FOS, POLR2A, SMARCB1, CCNC, CDK8, MED21, NKX2-1, NCOA3, PPARG, ATF4, RPA2, PPARGC1A, HIST3H3, HIST4H4, EP300, ANAPC7, ANAPC5, CDC16, ANAPC2, CDH1, CDC20, REL, DDX17, GCM1, MAP3K5, MAPK10, MKNK1, APC, PAPOLA, CPSF6, TBX21, NCOR1, NCOR2, CARM1, ESR2, YY1, MYC, PLAGL1, MIER1, HDAC1, SP1, SP3, HDAC3, VDR, DAXX, CEBPB, CEBPD, PARP1, PTMS, ATXN3, CTBP1, HIST1H3A, MTF1, SETD1A, MYBL1, NLK, SMAD3, DEK, FGFR1, RPS6KA1, CDKN1A, SND1, NCOA2, KAT6A, SRCAP, TAF6L, ETS1, ETS2, RUNX2, MAFK, TCF12, HDAC2, HOXB6, KPNA2, KPNA6, NR5A1, HMGA1, FOXO3, HIST1H4A, HES6, RUVBL1, FOSL1, FOSB, JUNB, FOXM1, HMGB1, HMGB2, POU1F1, IRF1, SMAD2, RARA, SH3GL1, BCL6, GRIP1, KLF8, NFYB, TRIM28, POT1, WDR5, IRF5, AKT1, CDC27, ATF3, ATG3, MDM2, HOXB2, HOXB3, HOXB9, HOXD12, HOXD13, HOXD10, HOXD4, HOXB4, HOXA10, HOXA9, PBX1, SMARCA2, MYH9, MSH6, MSH2, ZBTB2, ZNF639, ACTA2, CSNK2A2, TP73, PRLR, MED25, PTOV1, IFNAR2, IRF9, TBP, RPS6KA5, IRF7, KAT5, PYGO2, HBP1, TACC2, NPAT, CCNE1, ELAVL1, KDM3B, PSMC5, MDC1, LYN, HCK, SRC, ZCCHC12, RAD23A, RUNX1, CHUK, IKBKB, IKBKG, HIST2H2BE, LIG4, TLR2, EPAS1, MTDH, MEIS1, LDLR, DYRK1B, DYRK1A, CDK2, EID1, COPS2, PSME3, WRN, KLF2, UBE2D1, CREBBP, UBE2I, MAPK3, FHL1, HIST1H2BB, EID3, POU2F3, ELK1, MAPK1, TFDP1, CREM, ZEB1, CRTC1, MAML2, CENPJ, HSF1, FHL2, CDH2, PHOX2B, DDIT3, XAF1, BMI1, CCND3, TXNDC11, CCNA2, C3orf62, PPP1R13L, BRMS1, PCNA, UBE2S, TLE3, MUS81, PTTG1, MED23, SNAI1, TFAP2B, SMAD4, NR3C2, ARNTL, CLOCK, SUMO1, NFATC1, CPSF4, RFPL3, CTGF, NFYA, KIAA0430, HELZ, NISCH, SOWAHA, PCGF3, EIF4ENIF1, PAN2, JUP, HSPA8, LAMP2, TRIM25ADCY9POPDC2, LGALS3, AREG, STX7, CD27, LGALS8, GINM1, HSPB1, TMEM17, CDH1, TPTE, TMEM194A, PIANP, GPR21, SLC20A1, PXYLP1, IER3IP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311162_1180282443ASF1A
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301162_1180282405ASF1A
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311162_1180282443ASF1A
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301162_1180282405ASF1A
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311433_1435282443histone
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301433_1435282405histone
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311433_1435282443histone
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301433_1435282405histone
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311124_1170282443histone
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301124_1170282405histone
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311124_1170282443histone
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301124_1170282405histone
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-131227_410282443SRCAP
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-130227_410282405SRCAP
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-131227_410282443SRCAP
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-130227_410282405SRCAP
HgeneCREBBPchr16:3929833chr16:4016967ENST00000262367-1311460_1891282443TRERF1
HgeneCREBBPchr16:3929833chr16:4016967ENST00000382070-1301460_1891282405TRERF1
HgeneCREBBPchr16:3929833chr16:4043511ENST00000262367-1311460_1891282443TRERF1
HgeneCREBBPchr16:3929833chr16:4043511ENST00000382070-1301460_1891282405TRERF1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for CREBBP_ADCY9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for CREBBP_ADCY9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCREBBPC0035934Rubinstein-Taybi Syndrome3CTD_human;ORPHANET;UNIPROT
HgeneCREBBPC0033578Prostatic Neoplasms2CTD_human
HgeneCREBBPC0005586Bipolar Disorder1PSYGENET
HgeneCREBBPC0005695Bladder Neoplasm1CTD_human
HgeneCREBBPC0007137Squamous cell carcinoma1CTD_human
HgeneCREBBPC0007138Carcinoma, Transitional Cell1CTD_human
HgeneCREBBPC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneCREBBPC0011573Endogenous depression1PSYGENET
HgeneCREBBPC0024301Lymphoma, Follicular1CTD_human
HgeneCREBBPC0036341Schizophrenia1PSYGENET
HgeneCREBBPC0036920Sezary Syndrome1CTD_human
HgeneCREBBPC0149925Small cell carcinoma of lung1CTD_human
HgeneCREBBPC0152013Adenocarcinoma of lung (disorder)1CTD_human
HgeneCREBBPC0279626Squamous cell carcinoma of esophagus1CTD_human
HgeneCREBBPC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human