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Fusion gene ID: 8417 |
FusionGeneSummary for CREB5_CD74 |
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Fusion gene information | Fusion gene name: CREB5_CD74 | Fusion gene ID: 8417 | Hgene | Tgene | Gene symbol | CREB5 | CD74 | Gene ID | 9586 | 972 |
Gene name | cAMP responsive element binding protein 5 | CD74 molecule | |
Synonyms | CRE-BPA|CREB-5 | DHLAG|HLADG|II|Ia-GAMMA | |
Cytomap | 7p15.1 | 5q33.1 | |
Type of gene | protein-coding | protein-coding | |
Description | cyclic AMP-responsive element-binding protein 5cAMP response element-binding protein CRE-BPa | HLA class II histocompatibility antigen gamma chainCD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)CD74 molecule, major histocompatibility complex, class II invariant chainHLA-DR antigens-associated | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q02930 | P04233 | |
Ensembl transtripts involved in fusion gene | ENST00000396299, ENST00000357727, ENST00000396300, ENST00000409603, ENST00000396298, ENST00000482692, | ENST00000377795, ENST00000353334, ENST00000524315, ENST00000009530, | |
Fusion gene scores | * DoF score | 6 X 5 X 5=150 | 16 X 15 X 5=1200 |
# samples | 6 | 27 | |
** MAII score | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(27/1200*10)=-2.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CREB5 [Title/Abstract] AND CD74 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CREB5 | GO:0045893 | positive regulation of transcription, DNA-templated | 8378084 |
Tgene | CD74 | GO:0001516 | prostaglandin biosynthetic process | 12782713 |
Tgene | CD74 | GO:0001934 | positive regulation of protein phosphorylation | 24942581 |
Tgene | CD74 | GO:0002792 | negative regulation of peptide secretion | 19849849 |
Tgene | CD74 | GO:0007165 | signal transduction | 12782713 |
Tgene | CD74 | GO:0008283 | cell proliferation | 12782713 |
Tgene | CD74 | GO:0033674 | positive regulation of kinase activity | 24942581 |
Tgene | CD74 | GO:0043066 | negative regulation of apoptotic process | 12782713 |
Tgene | CD74 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 24942581 |
Tgene | CD74 | GO:0043410 | positive regulation of MAPK cascade | 24942581 |
Tgene | CD74 | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator | 17045821 |
Tgene | CD74 | GO:0045657 | positive regulation of monocyte differentiation | 24942581 |
Tgene | CD74 | GO:0045893 | positive regulation of transcription, DNA-templated | 24942581 |
Tgene | CD74 | GO:0046598 | positive regulation of viral entry into host cell | 24942581 |
Tgene | CD74 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 17045821 |
Tgene | CD74 | GO:0051290 | protein heterotetramerization | 24942581 |
Tgene | CD74 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 17045821|24942581 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA981541 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000396299 | ENST00000377795 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000396299 | ENST00000353334 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000396299 | ENST00000524315 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000396299 | ENST00000009530 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000357727 | ENST00000377795 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000357727 | ENST00000353334 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000357727 | ENST00000524315 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000357727 | ENST00000009530 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000396300 | ENST00000377795 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000396300 | ENST00000353334 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000396300 | ENST00000524315 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000396300 | ENST00000009530 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000409603 | ENST00000377795 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000409603 | ENST00000353334 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000409603 | ENST00000524315 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000409603 | ENST00000009530 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000396298 | ENST00000377795 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000396298 | ENST00000353334 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000396298 | ENST00000524315 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000396298 | ENST00000009530 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000482692 | ENST00000377795 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000482692 | ENST00000353334 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000482692 | ENST00000524315 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
intron-5UTR | ENST00000482692 | ENST00000009530 | CREB5 | chr7 | 28849918 | + | CD74 | chr5 | 149792314 | - |
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FusionProtFeatures for CREB5_CD74 |
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Hgene | Tgene |
CREB5 | CD74 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CREB5_CD74 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CREB5_CD74 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CREB5_CD74 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CREB5_CD74 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CD74 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Tgene | CD74 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | CD74 | C0162557 | Liver Failure, Acute | 1 | CTD_human |
Tgene | CD74 | C1458155 | Mammary Neoplasms | 1 | CTD_human |