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Fusion gene ID: 8413 |
FusionGeneSummary for CREB3L4_FCER1A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CREB3L4_FCER1A | Fusion gene ID: 8413 | Hgene | Tgene | Gene symbol | CREB3L4 | FCER1A | Gene ID | 148327 | 2205 |
| Gene name | cAMP responsive element binding protein 3 like 4 | Fc fragment of IgE receptor Ia | |
| Synonyms | AIBZIP|ATCE1|CREB3|CREB4|JAL|hJAL | FCE1A|FcERI | |
| Cytomap | 1q21.3 | 1q23.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclic AMP-responsive element-binding protein 3-like protein 4CREB-4androgen-induced basic leucine zipper proteinattaching to CRE-like 1cAMP responsive element binding protein 1cAMP-responsive element-binding protein 3-like protein 4cAMP-responsive | high affinity immunoglobulin epsilon receptor subunit alphaFc IgE receptor, alpha polypeptideFc epsilon RI alpha-chainFc epsilon receptor IaFc fragment of IgE, high affinity I, receptor for; alpha polypeptideFc-epsilon RI-alphahigh affinity immunogl | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q8TEY5 | P12319 | |
| Ensembl transtripts involved in fusion gene | ENST00000405694, ENST00000368607, ENST00000271889, ENST00000368601, ENST00000368603, ENST00000368600, ENST00000468845, | ENST00000368115, ENST00000368114, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CREB3L4 [Title/Abstract] AND FCER1A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CREB3L4 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16236796 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A1L2-01A | CREB3L4 | chr1 | 153941931 | + | FCER1A | chr1 | 159272644 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000405694 | ENST00000368115 | CREB3L4 | chr1 | 153941931 | + | FCER1A | chr1 | 159272644 | + |
| Frame-shift | ENST00000405694 | ENST00000368114 | CREB3L4 | chr1 | 153941931 | + | FCER1A | chr1 | 159272644 | + |
| Frame-shift | ENST00000368607 | ENST00000368115 | CREB3L4 | chr1 | 153941931 | + | FCER1A | chr1 | 159272644 | + |
| Frame-shift | ENST00000368607 | ENST00000368114 | CREB3L4 | chr1 | 153941931 | + | FCER1A | chr1 | 159272644 | + |
| Frame-shift | ENST00000271889 | ENST00000368115 | CREB3L4 | chr1 | 153941931 | + | FCER1A | chr1 | 159272644 | + |
| Frame-shift | ENST00000271889 | ENST00000368114 | CREB3L4 | chr1 | 153941931 | + | FCER1A | chr1 | 159272644 | + |
| Frame-shift | ENST00000368601 | ENST00000368115 | CREB3L4 | chr1 | 153941931 | + | FCER1A | chr1 | 159272644 | + |
| Frame-shift | ENST00000368601 | ENST00000368114 | CREB3L4 | chr1 | 153941931 | + | FCER1A | chr1 | 159272644 | + |
| Frame-shift | ENST00000368603 | ENST00000368115 | CREB3L4 | chr1 | 153941931 | + | FCER1A | chr1 | 159272644 | + |
| Frame-shift | ENST00000368603 | ENST00000368114 | CREB3L4 | chr1 | 153941931 | + | FCER1A | chr1 | 159272644 | + |
| Frame-shift | ENST00000368600 | ENST00000368115 | CREB3L4 | chr1 | 153941931 | + | FCER1A | chr1 | 159272644 | + |
| Frame-shift | ENST00000368600 | ENST00000368114 | CREB3L4 | chr1 | 153941931 | + | FCER1A | chr1 | 159272644 | + |
| 3UTR-3CDS | ENST00000468845 | ENST00000368115 | CREB3L4 | chr1 | 153941931 | + | FCER1A | chr1 | 159272644 | + |
| 3UTR-3CDS | ENST00000468845 | ENST00000368114 | CREB3L4 | chr1 | 153941931 | + | FCER1A | chr1 | 159272644 | + |
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FusionProtFeatures for CREB3L4_FCER1A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CREB3L4 | FCER1A |
| Transcriptional activator that may play a role in theunfolded protein response. Binds to the UPR element (UPRE) but notto CRE element. Preferentially binds DNA with to the consensussequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptionalactivation activity from UPRE. Binds to NF-kappa-B site and hastranscriptional activation activity from NF-kappa-B-containingregulatory elements (By similarity). {ECO:0000250,ECO:0000269|PubMed:16236796}. | Binds to the Fc region of immunoglobulins epsilon. Highaffinity receptor. Responsible for initiating the allergicresponse. Binding of allergen to receptor-bound IgE leads to cellactivation and the release of mediators (such as histamine)responsible for the manifestations of allergy. The same receptoralso induces the secretion of important lymphokines. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CREB3L4_FCER1A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CREB3L4_FCER1A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CREB3L4 | CREM, SOX9, LRRC4C, GANAB, SLC19A3, MOV10, NXF1, CREB3 | FCER1A | SYK, PDHB, LMNA |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CREB3L4_FCER1A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | FCER1A | P12319 | DB00895 | Benzylpenicilloyl Polylysine | High affinity immunoglobulin epsilon receptor subunit alpha | small molecule | approved |
| Tgene | FCER1A | P12319 | DB00043 | Omalizumab | High affinity immunoglobulin epsilon receptor subunit alpha | biotech | approved|investigational |
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RelatedDiseases for CREB3L4_FCER1A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | FCER1A | C0013182 | Drug Allergy | 2 | CTD_human |
| Tgene | FCER1A | C0042109 | Urticaria | 2 | CTD_human |
| Tgene | FCER1A | C0011609 | Drug Eruptions | 1 | CTD_human |
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