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Fusion gene ID: 8411 |
FusionGeneSummary for CREB3L3_PKN3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CREB3L3_PKN3 | Fusion gene ID: 8411 | Hgene | Tgene | Gene symbol | CREB3L3 | PKN3 | Gene ID | 84699 | 29941 |
| Gene name | cAMP responsive element binding protein 3 like 3 | protein kinase N3 | |
| Synonyms | CREB-H|CREBH|HYST1481 | UTDP4-1 | |
| Cytomap | 19p13.3 | 9q34.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cyclic AMP-responsive element-binding protein 3-like protein 3CREB/ATF family transcription factor | serine/threonine-protein kinase N3protein kinase PKN-betaprotein-kinase C-related kinase 3 | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q68CJ9 | Q6P5Z2 | |
| Ensembl transtripts involved in fusion gene | ENST00000078445, ENST00000252587, ENST00000595923, ENST00000602257, ENST00000602147, | ENST00000291906, ENST00000485301, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
| # samples | 1 | 1 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CREB3L3 [Title/Abstract] AND PKN3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CREB3L3 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | 16469704 |
| Tgene | PKN3 | GO:0010631 | epithelial cell migration | 21754995 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LIHC | TCGA-G3-A7M7-01A | CREB3L3 | chr19 | 4171172 | + | PKN3 | chr9 | 131467582 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000078445 | ENST00000291906 | CREB3L3 | chr19 | 4171172 | + | PKN3 | chr9 | 131467582 | + |
| 5CDS-intron | ENST00000078445 | ENST00000485301 | CREB3L3 | chr19 | 4171172 | + | PKN3 | chr9 | 131467582 | + |
| intron-3CDS | ENST00000252587 | ENST00000291906 | CREB3L3 | chr19 | 4171172 | + | PKN3 | chr9 | 131467582 | + |
| intron-intron | ENST00000252587 | ENST00000485301 | CREB3L3 | chr19 | 4171172 | + | PKN3 | chr9 | 131467582 | + |
| In-frame | ENST00000595923 | ENST00000291906 | CREB3L3 | chr19 | 4171172 | + | PKN3 | chr9 | 131467582 | + |
| 5CDS-intron | ENST00000595923 | ENST00000485301 | CREB3L3 | chr19 | 4171172 | + | PKN3 | chr9 | 131467582 | + |
| In-frame | ENST00000602257 | ENST00000291906 | CREB3L3 | chr19 | 4171172 | + | PKN3 | chr9 | 131467582 | + |
| 5CDS-intron | ENST00000602257 | ENST00000485301 | CREB3L3 | chr19 | 4171172 | + | PKN3 | chr9 | 131467582 | + |
| Frame-shift | ENST00000602147 | ENST00000291906 | CREB3L3 | chr19 | 4171172 | + | PKN3 | chr9 | 131467582 | + |
| 5CDS-intron | ENST00000602147 | ENST00000485301 | CREB3L3 | chr19 | 4171172 | + | PKN3 | chr9 | 131467582 | + |
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FusionProtFeatures for CREB3L3_PKN3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CREB3L3 | PKN3 |
| Transcription factor that may act during endoplasmicreticulum stress by activating unfolded protein response targetgenes. Activated in response to cAMP stimulation. In vitro, bindsto the cAMP response element (CRE) and box-B element. Activatestranscription through box-B element. Activates transcriptionthrough CRE (By similarity). Seems to function synergisticallywith ATF6. In acute inflammatory response, may activate expressionof acute phase response (APR) genes. May be involved in growthsuppression. {ECO:0000250, ECO:0000269|PubMed:11353085,ECO:0000269|PubMed:15800215, ECO:0000269|PubMed:16469704}. | Contributes to invasiveness in malignant prostatecancer. {ECO:0000269|PubMed:15282551}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CREB3L3 | chr19:4171172 | chr9:131467582 | ENST00000078445 | + | 8 | 10 | 243_306 | 325 | 462 | Domain | bZIP |
| Hgene | CREB3L3 | chr19:4171172 | chr9:131467582 | ENST00000595923 | + | 8 | 10 | 243_306 | 324 | 461 | Domain | bZIP |
| Hgene | CREB3L3 | chr19:4171172 | chr9:131467582 | ENST00000078445 | + | 8 | 10 | 245_274 | 325 | 462 | Region | Basic motif |
| Hgene | CREB3L3 | chr19:4171172 | chr9:131467582 | ENST00000078445 | + | 8 | 10 | 285_306 | 325 | 462 | Region | Leucine-zipper |
| Hgene | CREB3L3 | chr19:4171172 | chr9:131467582 | ENST00000595923 | + | 8 | 10 | 245_274 | 324 | 461 | Region | Basic motif |
| Hgene | CREB3L3 | chr19:4171172 | chr9:131467582 | ENST00000595923 | + | 8 | 10 | 285_306 | 324 | 461 | Region | Leucine-zipper |
| Hgene | CREB3L3 | chr19:4171172 | chr9:131467582 | ENST00000078445 | + | 8 | 10 | 1_322 | 325 | 462 | Topological domain | Cytoplasmic |
| Hgene | CREB3L3 | chr19:4171172 | chr9:131467582 | ENST00000595923 | + | 8 | 10 | 1_322 | 324 | 461 | Topological domain | Cytoplasmic |
| Tgene | >PKN3 | chr19:4171172 | chr9:131467582 | ENST00000291906 | + | 0 | 22 | 463_554 | 8 | 890 | Compositional bias | Note=Pro-rich |
| Tgene | >PKN3 | chr19:4171172 | chr9:131467582 | ENST00000291906 | + | 0 | 22 | 165_245 | 8 | 890 | Domain | REM-1 3 |
| Tgene | >PKN3 | chr19:4171172 | chr9:131467582 | ENST00000291906 | + | 0 | 22 | 559_818 | 8 | 890 | Domain | Protein kinase |
| Tgene | >PKN3 | chr19:4171172 | chr9:131467582 | ENST00000291906 | + | 0 | 22 | 5_80 | 8 | 890 | Domain | REM-1 1 |
| Tgene | >PKN3 | chr19:4171172 | chr9:131467582 | ENST00000291906 | + | 0 | 22 | 819_889 | 8 | 890 | Domain | Note=AGC-kinase C-terminal |
| Tgene | >PKN3 | chr19:4171172 | chr9:131467582 | ENST00000291906 | + | 0 | 22 | 93_163 | 8 | 890 | Domain | REM-1 2 |
| Tgene | >PKN3 | chr19:4171172 | chr9:131467582 | ENST00000291906 | + | 0 | 22 | 565_573 | 8 | 890 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CREB3L3 | chr19:4171172 | chr9:131467582 | ENST00000078445 | + | 8 | 10 | 344_461 | 325 | 462 | Topological domain | Lumenal |
| Hgene | >CREB3L3 | chr19:4171172 | chr9:131467582 | ENST00000595923 | + | 8 | 10 | 344_461 | 324 | 461 | Topological domain | Lumenal |
| Hgene | >CREB3L3 | chr19:4171172 | chr9:131467582 | ENST00000078445 | + | 8 | 10 | 323_343 | 325 | 462 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Hgene | >CREB3L3 | chr19:4171172 | chr9:131467582 | ENST00000595923 | + | 8 | 10 | 323_343 | 324 | 461 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for CREB3L3_PKN3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CREB3L3_ENST00000078445_chr19_4171172_+_PKN3_ENST00000291906_chr9_131467582_+_1207aa MNTDLAAGKMASAACSMDPIDSFELLDLLFDRQDGILRHVELGEGWGHVKDQQVLPNPDSDDFLSSILGSGDSLPSSPLWSPEGSDSGIS EDLPSDPQDTPPRSGPATSPAGCHPAQPGKGPCLSYHPGNSCSTTTPGPVIQVPEASVTIDLEMWSPGGRICAEKPADPVDLSPRCNLTV KDLLLSGSSGDLQQHHLGASYLLRPGAGHCQELVLTEDEKKLLAKEGITLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDG LETRMSACTAQNQELQRKVLHLEKQNLSLLEQLKKLQAIVVQSTSKSAQTGTCVAPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRV ATDRRHLGHVQQLLRSSNRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCAS GTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQ ESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSPAAALASSPSEGWL RTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSL VPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRTPTTLREASDPATP SNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGK YYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQARFYVACVVLGLQ FLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDT EEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFT >In-frame_CREB3L3_ENST00000595923_chr19_4171172_+_PKN3_ENST00000291906_chr9_131467582_+_1206aa MNTDLAAGKMASAACSMDPIDSFELLDLLFDRQDGILRHVELGEGWGHVKDQVLPNPDSDDFLSSILGSGDSLPSSPLWSPEGSDSGISE DLPSDPQDTPPRSGPATSPAGCHPAQPGKGPCLSYHPGNSCSTTTPGPVIQVPEASVTIDLEMWSPGGRICAEKPADPVDLSPRCNLTVK DLLLSGSSGDLQQHHLGASYLLRPGAGHCQELVLTEDEKKLLAKEGITLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGL ETRMSACTAQNQELQRKVLHLEKQNLSLLEQLKKLQAIVVQSTSKSAQTGTCVAPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVA TDRRHLGHVQQLLRSSNRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCASG TPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQE SSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSPAAALASSPSEGWLR TKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLV PQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRTPTTLREASDPATPS NFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKY YAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQARFYVACVVLGLQF LHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTE EEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTG >In-frame_CREB3L3_ENST00000602257_chr19_4171172_+_PKN3_ENST00000291906_chr9_131467582_+_1205aa MNTDLAAGKMASAACSMDPIDSFELLDLLFDRQDGILRHVELGEGWGHVKDQQVLPNPDSDDFLSSILGSGDSLPSSPLWSPEGSDSGIS EDLPSDPQDTPPRSGPATSPAGCHPAQPGKGPCLSYHPGNSCSTTTPGPVIQVPEASVTIDLEMWSPGGRICAEKPADPVDLSPRCNLTV KDLLLSGSSGDLHHLGASYLLRPGAGHCQELVLTEDEKKLLAKEGITLPTQLPLTKYEERVLKKIRRKIRNKQSAQESRKKKKEYIDGLE TRMSACTAQNQELQRKVLHLEKQNLSLLEQLKKLQAIVVQSTSKSAQTGTCVAPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVAT DRRHLGHVQQLLRSSNRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCASGT PKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQES SQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSPAAALASSPSEGWLRT KAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVP QGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRTPTTLREASDPATPSN FLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYY AIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQARFYVACVVLGLQFL HEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEE EVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CREB3L3_ENST00000078445_chr19_4171172_+_PKN3_ENST00000291906_chr9_131467582_+_3621nt ATGAATACGGATTTAGCTGCTGGAAAGATGGCTTCTGCTGCCTGCTCCATGGACCCCATCGACAGCTTTGAGCTCCTGGATCTCCTGTTT GACCGGCAGGACGGCATCCTGAGACACGTGGAGCTGGGCGAGGGCTGGGGTCACGTCAAGGACCAGCAGGTCCTGCCAAACCCCGACTCT GACGACTTCCTCAGCTCCATCCTGGGCTCTGGAGACTCACTGCCCAGCTCCCCACTCTGGTCCCCCGAAGGCAGTGATAGTGGCATCTCC GAAGACCTCCCCTCCGACCCCCAGGACACCCCTCCACGCAGCGGACCAGCCACCTCCCCCGCCGGCTGCCATCCTGCCCAGCCTGGCAAG GGGCCCTGCCTCTCCTATCATCCTGGCAACTCTTGCTCCACCACAACCCCAGGGCCAGTGATCCAAGTACCTGAAGCCTCTGTGACCATA GACCTGGAAATGTGGAGCCCAGGAGGAAGGATCTGTGCTGAGAAGCCGGCTGATCCGGTGGACCTGTCCCCACGATGCAATCTCACCGTG AAAGACCTCCTCCTTTCGGGCAGCAGTGGGGACCTGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGT CAGGAGCTGGTGCTCACCGAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAG GAGCGAGTGCTGAAAAAAATCCGCCGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGC CTGGAGACTCGGATGTCAGCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTG GAGCAACTGAAGAAACTCCAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCACCTGGGCCGAGCCAG TGGCCCCCAGAGGATGAGAAGGAGGTGATCCGCCGGGCCATCCAGAAAGAGCTGAAGATCAAGGAGGGGGTGGAGAACCTGCGGCGCGTG GCCACAGACCGCCGCCACTTGGGCCATGTGCAGCAGCTGCTGCGGTCCTCCAACCGCCGCCTGGAGCAGCTGCATGGCGAGCTGCGGGAG CTGCACGCCCGAATCCTGCTGCCCGGCCCTGGGCCTGGCCCAGCTGAGCCTGTGGCCTCAGGACCCCGGCCGTGGGCAGAGCAGCTCAGG GCTCGGCACCTAGAGGCTCTCCGGAGGCAGCTGCATGTGGAGCTGAAGGTGAAGCAGGGGGCTGAGAACATGACCCACACGTGCGCCAGT GGCACCCCCAAGGAGAGGAAGCTCCTGGCAGCTGCCCAGCAGATGCTGCGGGACAGCCAGCTGAAGGTGGCCCTGCTGCGGATGAAGATC AGCAGCCTGGAGGCCAGTGGGTCCCCGGAGCCAGGGCCTGAGCTGCTGGCGGAGGAGCTACAGCATCGACTGCACGTTGAGGCAGCTGTG GCTGAGGGCGCCAAGAACGTGGTGAAACTGCTTAGTAGCCGGAGAACACAGGACCGCAAGGCACTGGCTGAGGCCCAGGCCCAGCTACAG GAGTCCTCTCAGAAACTGGACCTCCTGCGCCTGGCCTTGGAGCAGCTGCTGGAGCAACTGCCTCCTGCCCACCCTTTGCGCAGCAGAGTG ACCCGAGAGTTGCGGGCTGCGGTGCCTGGATACCCCCAGCCTTCAGGGACACCTGTGAAGCCCACCGCCCTAACAGGGACACTGCAGGTC CGCCTCCTGGGCTGTGAACAGTTGCTGACAGCCGTGCCTGGGCGCTCCCCAGCGGCCGCACTGGCCAGCAGCCCCTCCGAGGGCTGGCTT CGGACCAAGGCCAAGCACCAGCGTGGCCGAGGCGAGCTTGCCAGCGAGGTGCTGGCTGTGCTAAAGGTGGACAACCGTGTTGTGGGGCAG ACGGGCTGGGGGCAGGTGGCCGAACAGTCCTGGGACCAGACCTTTGTCATCCCACTGGAGCGAGCCCGTGAGCTGGAGATTGGGGTACAC TGGCGGGACTGGCGGCAGCTATGTGGCGTGGCCTTCCTGAGACTTGAGGACTTCCTGGACAATGCCTGTCACCAACTGTCCCTCAGCCTG GTACCGCAGGGACTGCTTTTTGCCCAGGTGACCTTCTGCGATCCTGTCATTGAGAGGCGGCCCCGGCTGCAGAGGCAGGAACGCATCTTC TCTAAACGCAGAGGCCAGGACTTCCTGAGGGCTTCGCAGATGAACCTCGGCATGGCGGCCTGGGGGCGCCTCGTCATGAACCTGCTGCCC CCCTGCAGCTCCCCGAGCACAATCAGCCCCCCTAAAGGATGCCCTCGGACCCCAACAACACTGCGAGAGGCCTCTGACCCTGCCACTCCC AGTAATTTCCTGCCCAAGAAGACCCCCTTGGGTGAAGAGATGACACCCCCACCCAAGCCCCCACGCCTCTACCTCCCCCAGGAGCCAACA TCCGAGGAGACTCCGCGCACCAAACGTCCCCATATGGAGCCTAGGACTCGACGTGGGCCATCTCCACCAGCCTCCCCCACCAGGAAACCC CCTCGGCTTCAGGACTTCCGCTGCTTAGCTGTGCTGGGCCGGGGACACTTTGGGAAGGTCCTCCTGGTCCAGTTCAAGGGGACAGGGAAA TACTACGCCATCAAAGCACTGAAGAAGCAGGAGGTGCTCAGCCGGGACGAGATAGAGAGCCTGTACTGCGAGAAGCGGATCCTGGAGGCT GTGGGCTGCACAGGGCACCCTTTCCTGCTCTCCCTCCTTGCCTGCTTCCAGACCTCCAGCCATGCCTGCTTTGTGACTGAGTTTGTGCCT GGTGGTGACCTCATGATGCAGATCCACGAGGATGTCTTCCCCGAGCCCCAGGCCCGCTTCTACGTGGCTTGTGTTGTCCTGGGGCTGCAG TTCTTACACGAGAAGAAGATCATTTACAGGGACCTGAAGTTGGATAACCTTCTGCTGGATGCCCAGGGATTCCTGAAGATCGCAGACTTT GGACTCTGCAAGGAAGGGATCGGCTTCGGGGACCGGACTAGCACCTTCTGTGGCACCCCGGAGTTCCTGGCTCCCGAGGTGCTGACCCAG GAGGCATACACACGGGCTGTGGACTGGTGGGGGCTGGGTGTGCTGCTCTACGAGATGCTGGTGGGTGAGTGCCCGTTCCCAGGGGACACA GAGGAAGAGGTGTTTGACTGCATCGTCAACATGGACGCCCCCTACCCCGGCTTTCTGTCGGTGCAAGGGCTTGAGTTCATTCAGAAGCTC CTCCAGAAGTGCCCGGAGAAGCGCCTCGGGGCAGGTGAGCAGGATGCCGAGGAGATCAAGGTCCAGCCATTCTTCAGGACCACCAACTGG CAAGCCCTGCTCGCCCGCACCATCCAGCCCCCCTTCGTGCCTACCCTGTGTGGCCCTGCGGACCTGCGCTACTTTGAGGGCGAGTTCACA GGGCTGCCGCCTGCCCTGACCCCACCTGCACCCCACAGCCTCCTCACTGCCCGCCAACAGGCCGCCTTCCGGGACTTCGACTTTGTGTCA >In-frame_CREB3L3_ENST00000595923_chr19_4171172_+_PKN3_ENST00000291906_chr9_131467582_+_3618nt ATGAATACGGATTTAGCTGCTGGAAAGATGGCTTCTGCTGCCTGCTCCATGGACCCCATCGACAGCTTTGAGCTCCTGGATCTCCTGTTT GACCGGCAGGACGGCATCCTGAGACACGTGGAGCTGGGCGAGGGCTGGGGTCACGTCAAGGACCAGGTCCTGCCAAACCCCGACTCTGAC GACTTCCTCAGCTCCATCCTGGGCTCTGGAGACTCACTGCCCAGCTCCCCACTCTGGTCCCCCGAAGGCAGTGATAGTGGCATCTCCGAA GACCTCCCCTCCGACCCCCAGGACACCCCTCCACGCAGCGGACCAGCCACCTCCCCCGCCGGCTGCCATCCTGCCCAGCCTGGCAAGGGG CCCTGCCTCTCCTATCATCCTGGCAACTCTTGCTCCACCACAACCCCAGGGCCAGTGATCCAAGTACCTGAAGCCTCTGTGACCATAGAC CTGGAAATGTGGAGCCCAGGAGGAAGGATCTGTGCTGAGAAGCCGGCTGATCCGGTGGACCTGTCCCCACGATGCAATCTCACCGTGAAA GACCTCCTCCTTTCGGGCAGCAGTGGGGACCTGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAG GAGCTGGTGCTCACCGAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAG CGAGTGCTGAAAAAAATCCGCCGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTG GAGACTCGGATGTCAGCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAG CAACTGAAGAAACTCCAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCACCTGGGCCGAGCCAGTGG CCCCCAGAGGATGAGAAGGAGGTGATCCGCCGGGCCATCCAGAAAGAGCTGAAGATCAAGGAGGGGGTGGAGAACCTGCGGCGCGTGGCC ACAGACCGCCGCCACTTGGGCCATGTGCAGCAGCTGCTGCGGTCCTCCAACCGCCGCCTGGAGCAGCTGCATGGCGAGCTGCGGGAGCTG CACGCCCGAATCCTGCTGCCCGGCCCTGGGCCTGGCCCAGCTGAGCCTGTGGCCTCAGGACCCCGGCCGTGGGCAGAGCAGCTCAGGGCT CGGCACCTAGAGGCTCTCCGGAGGCAGCTGCATGTGGAGCTGAAGGTGAAGCAGGGGGCTGAGAACATGACCCACACGTGCGCCAGTGGC ACCCCCAAGGAGAGGAAGCTCCTGGCAGCTGCCCAGCAGATGCTGCGGGACAGCCAGCTGAAGGTGGCCCTGCTGCGGATGAAGATCAGC AGCCTGGAGGCCAGTGGGTCCCCGGAGCCAGGGCCTGAGCTGCTGGCGGAGGAGCTACAGCATCGACTGCACGTTGAGGCAGCTGTGGCT GAGGGCGCCAAGAACGTGGTGAAACTGCTTAGTAGCCGGAGAACACAGGACCGCAAGGCACTGGCTGAGGCCCAGGCCCAGCTACAGGAG TCCTCTCAGAAACTGGACCTCCTGCGCCTGGCCTTGGAGCAGCTGCTGGAGCAACTGCCTCCTGCCCACCCTTTGCGCAGCAGAGTGACC CGAGAGTTGCGGGCTGCGGTGCCTGGATACCCCCAGCCTTCAGGGACACCTGTGAAGCCCACCGCCCTAACAGGGACACTGCAGGTCCGC CTCCTGGGCTGTGAACAGTTGCTGACAGCCGTGCCTGGGCGCTCCCCAGCGGCCGCACTGGCCAGCAGCCCCTCCGAGGGCTGGCTTCGG ACCAAGGCCAAGCACCAGCGTGGCCGAGGCGAGCTTGCCAGCGAGGTGCTGGCTGTGCTAAAGGTGGACAACCGTGTTGTGGGGCAGACG GGCTGGGGGCAGGTGGCCGAACAGTCCTGGGACCAGACCTTTGTCATCCCACTGGAGCGAGCCCGTGAGCTGGAGATTGGGGTACACTGG CGGGACTGGCGGCAGCTATGTGGCGTGGCCTTCCTGAGACTTGAGGACTTCCTGGACAATGCCTGTCACCAACTGTCCCTCAGCCTGGTA CCGCAGGGACTGCTTTTTGCCCAGGTGACCTTCTGCGATCCTGTCATTGAGAGGCGGCCCCGGCTGCAGAGGCAGGAACGCATCTTCTCT AAACGCAGAGGCCAGGACTTCCTGAGGGCTTCGCAGATGAACCTCGGCATGGCGGCCTGGGGGCGCCTCGTCATGAACCTGCTGCCCCCC TGCAGCTCCCCGAGCACAATCAGCCCCCCTAAAGGATGCCCTCGGACCCCAACAACACTGCGAGAGGCCTCTGACCCTGCCACTCCCAGT AATTTCCTGCCCAAGAAGACCCCCTTGGGTGAAGAGATGACACCCCCACCCAAGCCCCCACGCCTCTACCTCCCCCAGGAGCCAACATCC GAGGAGACTCCGCGCACCAAACGTCCCCATATGGAGCCTAGGACTCGACGTGGGCCATCTCCACCAGCCTCCCCCACCAGGAAACCCCCT CGGCTTCAGGACTTCCGCTGCTTAGCTGTGCTGGGCCGGGGACACTTTGGGAAGGTCCTCCTGGTCCAGTTCAAGGGGACAGGGAAATAC TACGCCATCAAAGCACTGAAGAAGCAGGAGGTGCTCAGCCGGGACGAGATAGAGAGCCTGTACTGCGAGAAGCGGATCCTGGAGGCTGTG GGCTGCACAGGGCACCCTTTCCTGCTCTCCCTCCTTGCCTGCTTCCAGACCTCCAGCCATGCCTGCTTTGTGACTGAGTTTGTGCCTGGT GGTGACCTCATGATGCAGATCCACGAGGATGTCTTCCCCGAGCCCCAGGCCCGCTTCTACGTGGCTTGTGTTGTCCTGGGGCTGCAGTTC TTACACGAGAAGAAGATCATTTACAGGGACCTGAAGTTGGATAACCTTCTGCTGGATGCCCAGGGATTCCTGAAGATCGCAGACTTTGGA CTCTGCAAGGAAGGGATCGGCTTCGGGGACCGGACTAGCACCTTCTGTGGCACCCCGGAGTTCCTGGCTCCCGAGGTGCTGACCCAGGAG GCATACACACGGGCTGTGGACTGGTGGGGGCTGGGTGTGCTGCTCTACGAGATGCTGGTGGGTGAGTGCCCGTTCCCAGGGGACACAGAG GAAGAGGTGTTTGACTGCATCGTCAACATGGACGCCCCCTACCCCGGCTTTCTGTCGGTGCAAGGGCTTGAGTTCATTCAGAAGCTCCTC CAGAAGTGCCCGGAGAAGCGCCTCGGGGCAGGTGAGCAGGATGCCGAGGAGATCAAGGTCCAGCCATTCTTCAGGACCACCAACTGGCAA GCCCTGCTCGCCCGCACCATCCAGCCCCCCTTCGTGCCTACCCTGTGTGGCCCTGCGGACCTGCGCTACTTTGAGGGCGAGTTCACAGGG CTGCCGCCTGCCCTGACCCCACCTGCACCCCACAGCCTCCTCACTGCCCGCCAACAGGCCGCCTTCCGGGACTTCGACTTTGTGTCAGAG >In-frame_CREB3L3_ENST00000602257_chr19_4171172_+_PKN3_ENST00000291906_chr9_131467582_+_3615nt ATGAATACGGATTTAGCTGCTGGAAAGATGGCTTCTGCTGCCTGCTCCATGGACCCCATCGACAGCTTTGAGCTCCTGGATCTCCTGTTT GACCGGCAGGACGGCATCCTGAGACACGTGGAGCTGGGCGAGGGCTGGGGTCACGTCAAGGACCAGCAGGTCCTGCCAAACCCCGACTCT GACGACTTCCTCAGCTCCATCCTGGGCTCTGGAGACTCACTGCCCAGCTCCCCACTCTGGTCCCCCGAAGGCAGTGATAGTGGCATCTCC GAAGACCTCCCCTCCGACCCCCAGGACACCCCTCCACGCAGCGGACCAGCCACCTCCCCCGCCGGCTGCCATCCTGCCCAGCCTGGCAAG GGGCCCTGCCTCTCCTATCATCCTGGCAACTCTTGCTCCACCACAACCCCAGGGCCAGTGATCCAAGTACCTGAAGCCTCTGTGACCATA GACCTGGAAATGTGGAGCCCAGGAGGAAGGATCTGTGCTGAGAAGCCGGCTGATCCGGTGGACCTGTCCCCACGATGCAATCTCACCGTG AAAGACCTCCTCCTTTCGGGCAGCAGTGGGGACCTGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAG CTGGTGCTCACCGAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGA GTGCTGAAAAAAATCCGCCGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAG ACTCGGATGTCAGCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAA CTGAAGAAACTCCAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCACCTGGGCCGAGCCAGTGGCCC CCAGAGGATGAGAAGGAGGTGATCCGCCGGGCCATCCAGAAAGAGCTGAAGATCAAGGAGGGGGTGGAGAACCTGCGGCGCGTGGCCACA GACCGCCGCCACTTGGGCCATGTGCAGCAGCTGCTGCGGTCCTCCAACCGCCGCCTGGAGCAGCTGCATGGCGAGCTGCGGGAGCTGCAC GCCCGAATCCTGCTGCCCGGCCCTGGGCCTGGCCCAGCTGAGCCTGTGGCCTCAGGACCCCGGCCGTGGGCAGAGCAGCTCAGGGCTCGG CACCTAGAGGCTCTCCGGAGGCAGCTGCATGTGGAGCTGAAGGTGAAGCAGGGGGCTGAGAACATGACCCACACGTGCGCCAGTGGCACC CCCAAGGAGAGGAAGCTCCTGGCAGCTGCCCAGCAGATGCTGCGGGACAGCCAGCTGAAGGTGGCCCTGCTGCGGATGAAGATCAGCAGC CTGGAGGCCAGTGGGTCCCCGGAGCCAGGGCCTGAGCTGCTGGCGGAGGAGCTACAGCATCGACTGCACGTTGAGGCAGCTGTGGCTGAG GGCGCCAAGAACGTGGTGAAACTGCTTAGTAGCCGGAGAACACAGGACCGCAAGGCACTGGCTGAGGCCCAGGCCCAGCTACAGGAGTCC TCTCAGAAACTGGACCTCCTGCGCCTGGCCTTGGAGCAGCTGCTGGAGCAACTGCCTCCTGCCCACCCTTTGCGCAGCAGAGTGACCCGA GAGTTGCGGGCTGCGGTGCCTGGATACCCCCAGCCTTCAGGGACACCTGTGAAGCCCACCGCCCTAACAGGGACACTGCAGGTCCGCCTC CTGGGCTGTGAACAGTTGCTGACAGCCGTGCCTGGGCGCTCCCCAGCGGCCGCACTGGCCAGCAGCCCCTCCGAGGGCTGGCTTCGGACC AAGGCCAAGCACCAGCGTGGCCGAGGCGAGCTTGCCAGCGAGGTGCTGGCTGTGCTAAAGGTGGACAACCGTGTTGTGGGGCAGACGGGC TGGGGGCAGGTGGCCGAACAGTCCTGGGACCAGACCTTTGTCATCCCACTGGAGCGAGCCCGTGAGCTGGAGATTGGGGTACACTGGCGG GACTGGCGGCAGCTATGTGGCGTGGCCTTCCTGAGACTTGAGGACTTCCTGGACAATGCCTGTCACCAACTGTCCCTCAGCCTGGTACCG CAGGGACTGCTTTTTGCCCAGGTGACCTTCTGCGATCCTGTCATTGAGAGGCGGCCCCGGCTGCAGAGGCAGGAACGCATCTTCTCTAAA CGCAGAGGCCAGGACTTCCTGAGGGCTTCGCAGATGAACCTCGGCATGGCGGCCTGGGGGCGCCTCGTCATGAACCTGCTGCCCCCCTGC AGCTCCCCGAGCACAATCAGCCCCCCTAAAGGATGCCCTCGGACCCCAACAACACTGCGAGAGGCCTCTGACCCTGCCACTCCCAGTAAT TTCCTGCCCAAGAAGACCCCCTTGGGTGAAGAGATGACACCCCCACCCAAGCCCCCACGCCTCTACCTCCCCCAGGAGCCAACATCCGAG GAGACTCCGCGCACCAAACGTCCCCATATGGAGCCTAGGACTCGACGTGGGCCATCTCCACCAGCCTCCCCCACCAGGAAACCCCCTCGG CTTCAGGACTTCCGCTGCTTAGCTGTGCTGGGCCGGGGACACTTTGGGAAGGTCCTCCTGGTCCAGTTCAAGGGGACAGGGAAATACTAC GCCATCAAAGCACTGAAGAAGCAGGAGGTGCTCAGCCGGGACGAGATAGAGAGCCTGTACTGCGAGAAGCGGATCCTGGAGGCTGTGGGC TGCACAGGGCACCCTTTCCTGCTCTCCCTCCTTGCCTGCTTCCAGACCTCCAGCCATGCCTGCTTTGTGACTGAGTTTGTGCCTGGTGGT GACCTCATGATGCAGATCCACGAGGATGTCTTCCCCGAGCCCCAGGCCCGCTTCTACGTGGCTTGTGTTGTCCTGGGGCTGCAGTTCTTA CACGAGAAGAAGATCATTTACAGGGACCTGAAGTTGGATAACCTTCTGCTGGATGCCCAGGGATTCCTGAAGATCGCAGACTTTGGACTC TGCAAGGAAGGGATCGGCTTCGGGGACCGGACTAGCACCTTCTGTGGCACCCCGGAGTTCCTGGCTCCCGAGGTGCTGACCCAGGAGGCA TACACACGGGCTGTGGACTGGTGGGGGCTGGGTGTGCTGCTCTACGAGATGCTGGTGGGTGAGTGCCCGTTCCCAGGGGACACAGAGGAA GAGGTGTTTGACTGCATCGTCAACATGGACGCCCCCTACCCCGGCTTTCTGTCGGTGCAAGGGCTTGAGTTCATTCAGAAGCTCCTCCAG AAGTGCCCGGAGAAGCGCCTCGGGGCAGGTGAGCAGGATGCCGAGGAGATCAAGGTCCAGCCATTCTTCAGGACCACCAACTGGCAAGCC CTGCTCGCCCGCACCATCCAGCCCCCCTTCGTGCCTACCCTGTGTGGCCCTGCGGACCTGCGCTACTTTGAGGGCGAGTTCACAGGGCTG CCGCCTGCCCTGACCCCACCTGCACCCCACAGCCTCCTCACTGCCCGCCAACAGGCCGCCTTCCGGGACTTCGACTTTGTGTCAGAGCGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CREB3L3_ENST00000078445_chr19_4171172_+_PKN3_ENST00000291906_chr9_131467582_+_4080nt GTGACCGCTTCAGCATCTTTTGGGAGTGGTGACAGAGCCACAGAGGGCTGTGAGCTTGCCCGGCCCCAGGTAACGCTGGCGGTGGGTGGG CCTCCAGCTTGGAGCAGAGACCCCCCGAGGCATCTGCAGACAGAACTGGATGGACCCATGAATACGGATTTAGCTGCTGGAAAGATGGCT TCTGCTGCCTGCTCCATGGACCCCATCGACAGCTTTGAGCTCCTGGATCTCCTGTTTGACCGGCAGGACGGCATCCTGAGACACGTGGAG CTGGGCGAGGGCTGGGGTCACGTCAAGGACCAGCAGGTCCTGCCAAACCCCGACTCTGACGACTTCCTCAGCTCCATCCTGGGCTCTGGA GACTCACTGCCCAGCTCCCCACTCTGGTCCCCCGAAGGCAGTGATAGTGGCATCTCCGAAGACCTCCCCTCCGACCCCCAGGACACCCCT CCACGCAGCGGACCAGCCACCTCCCCCGCCGGCTGCCATCCTGCCCAGCCTGGCAAGGGGCCCTGCCTCTCCTATCATCCTGGCAACTCT TGCTCCACCACAACCCCAGGGCCAGTGATCCAAGTACCTGAAGCCTCTGTGACCATAGACCTGGAAATGTGGAGCCCAGGAGGAAGGATC TGTGCTGAGAAGCCGGCTGATCCGGTGGACCTGTCCCCACGATGCAATCTCACCGTGAAAGACCTCCTCCTTTCGGGCAGCAGTGGGGAC CTGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCACCGAGGATGAGAAGAAG CTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAAAAATCCGCCGGAAAATC CGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGATGTCAGCTTGCACTGCTCAG AATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAACTCCAGGCCATTGTGGTG CAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCACCTGGGCCGAGCCAGTGGCCCCCAGAGGATGAGAAGGAGGTGATCCGC CGGGCCATCCAGAAAGAGCTGAAGATCAAGGAGGGGGTGGAGAACCTGCGGCGCGTGGCCACAGACCGCCGCCACTTGGGCCATGTGCAG CAGCTGCTGCGGTCCTCCAACCGCCGCCTGGAGCAGCTGCATGGCGAGCTGCGGGAGCTGCACGCCCGAATCCTGCTGCCCGGCCCTGGG CCTGGCCCAGCTGAGCCTGTGGCCTCAGGACCCCGGCCGTGGGCAGAGCAGCTCAGGGCTCGGCACCTAGAGGCTCTCCGGAGGCAGCTG CATGTGGAGCTGAAGGTGAAGCAGGGGGCTGAGAACATGACCCACACGTGCGCCAGTGGCACCCCCAAGGAGAGGAAGCTCCTGGCAGCT GCCCAGCAGATGCTGCGGGACAGCCAGCTGAAGGTGGCCCTGCTGCGGATGAAGATCAGCAGCCTGGAGGCCAGTGGGTCCCCGGAGCCA GGGCCTGAGCTGCTGGCGGAGGAGCTACAGCATCGACTGCACGTTGAGGCAGCTGTGGCTGAGGGCGCCAAGAACGTGGTGAAACTGCTT AGTAGCCGGAGAACACAGGACCGCAAGGCACTGGCTGAGGCCCAGGCCCAGCTACAGGAGTCCTCTCAGAAACTGGACCTCCTGCGCCTG GCCTTGGAGCAGCTGCTGGAGCAACTGCCTCCTGCCCACCCTTTGCGCAGCAGAGTGACCCGAGAGTTGCGGGCTGCGGTGCCTGGATAC CCCCAGCCTTCAGGGACACCTGTGAAGCCCACCGCCCTAACAGGGACACTGCAGGTCCGCCTCCTGGGCTGTGAACAGTTGCTGACAGCC GTGCCTGGGCGCTCCCCAGCGGCCGCACTGGCCAGCAGCCCCTCCGAGGGCTGGCTTCGGACCAAGGCCAAGCACCAGCGTGGCCGAGGC GAGCTTGCCAGCGAGGTGCTGGCTGTGCTAAAGGTGGACAACCGTGTTGTGGGGCAGACGGGCTGGGGGCAGGTGGCCGAACAGTCCTGG GACCAGACCTTTGTCATCCCACTGGAGCGAGCCCGTGAGCTGGAGATTGGGGTACACTGGCGGGACTGGCGGCAGCTATGTGGCGTGGCC TTCCTGAGACTTGAGGACTTCCTGGACAATGCCTGTCACCAACTGTCCCTCAGCCTGGTACCGCAGGGACTGCTTTTTGCCCAGGTGACC TTCTGCGATCCTGTCATTGAGAGGCGGCCCCGGCTGCAGAGGCAGGAACGCATCTTCTCTAAACGCAGAGGCCAGGACTTCCTGAGGGCT TCGCAGATGAACCTCGGCATGGCGGCCTGGGGGCGCCTCGTCATGAACCTGCTGCCCCCCTGCAGCTCCCCGAGCACAATCAGCCCCCCT AAAGGATGCCCTCGGACCCCAACAACACTGCGAGAGGCCTCTGACCCTGCCACTCCCAGTAATTTCCTGCCCAAGAAGACCCCCTTGGGT GAAGAGATGACACCCCCACCCAAGCCCCCACGCCTCTACCTCCCCCAGGAGCCAACATCCGAGGAGACTCCGCGCACCAAACGTCCCCAT ATGGAGCCTAGGACTCGACGTGGGCCATCTCCACCAGCCTCCCCCACCAGGAAACCCCCTCGGCTTCAGGACTTCCGCTGCTTAGCTGTG CTGGGCCGGGGACACTTTGGGAAGGTCCTCCTGGTCCAGTTCAAGGGGACAGGGAAATACTACGCCATCAAAGCACTGAAGAAGCAGGAG GTGCTCAGCCGGGACGAGATAGAGAGCCTGTACTGCGAGAAGCGGATCCTGGAGGCTGTGGGCTGCACAGGGCACCCTTTCCTGCTCTCC CTCCTTGCCTGCTTCCAGACCTCCAGCCATGCCTGCTTTGTGACTGAGTTTGTGCCTGGTGGTGACCTCATGATGCAGATCCACGAGGAT GTCTTCCCCGAGCCCCAGGCCCGCTTCTACGTGGCTTGTGTTGTCCTGGGGCTGCAGTTCTTACACGAGAAGAAGATCATTTACAGGGAC CTGAAGTTGGATAACCTTCTGCTGGATGCCCAGGGATTCCTGAAGATCGCAGACTTTGGACTCTGCAAGGAAGGGATCGGCTTCGGGGAC CGGACTAGCACCTTCTGTGGCACCCCGGAGTTCCTGGCTCCCGAGGTGCTGACCCAGGAGGCATACACACGGGCTGTGGACTGGTGGGGG CTGGGTGTGCTGCTCTACGAGATGCTGGTGGGTGAGTGCCCGTTCCCAGGGGACACAGAGGAAGAGGTGTTTGACTGCATCGTCAACATG GACGCCCCCTACCCCGGCTTTCTGTCGGTGCAAGGGCTTGAGTTCATTCAGAAGCTCCTCCAGAAGTGCCCGGAGAAGCGCCTCGGGGCA GGTGAGCAGGATGCCGAGGAGATCAAGGTCCAGCCATTCTTCAGGACCACCAACTGGCAAGCCCTGCTCGCCCGCACCATCCAGCCCCCC TTCGTGCCTACCCTGTGTGGCCCTGCGGACCTGCGCTACTTTGAGGGCGAGTTCACAGGGCTGCCGCCTGCCCTGACCCCACCTGCACCC CACAGCCTCCTCACTGCCCGCCAACAGGCCGCCTTCCGGGACTTCGACTTTGTGTCAGAGCGATTCCTGGAACCCTGAGGGCATCTCCTG GCACCTCTGTCCCCTTCCCCCACAGACTGTTAGAGCCTCTGCTCGTTCACCCGTGCGCCCTGCCTGGAGGTCCAGGCCTTGCTGGGTACT TCTGAGCCCTTGGGATTCAAAGTGGCAGCCATGGGGCCACTGTTGTGGGCTTTGCTCAGTGTCACTGGGCAAAGTGTGTCCCTTCCCCCT CCAGCTCGCCCTCTTCTACCTCCCAGCGAGACCTGGCCCAGAAAGGGTGCCGCAGCAAGGAGTGATATGGTTTGTCTTTTTAAGACTGGA >In-frame_CREB3L3_ENST00000595923_chr19_4171172_+_PKN3_ENST00000291906_chr9_131467582_+_4038nt ACAGAGGGCTGTGAGCTTGCCCGGCCCCAGGTAACGCTGGCGGTGGGTGGGCCTCCAGCTTGGAGCAGAGACCCCCCGAGGCATCTGCAG ACAGAACTGGATGGACCCATGAATACGGATTTAGCTGCTGGAAAGATGGCTTCTGCTGCCTGCTCCATGGACCCCATCGACAGCTTTGAG CTCCTGGATCTCCTGTTTGACCGGCAGGACGGCATCCTGAGACACGTGGAGCTGGGCGAGGGCTGGGGTCACGTCAAGGACCAGGTCCTG CCAAACCCCGACTCTGACGACTTCCTCAGCTCCATCCTGGGCTCTGGAGACTCACTGCCCAGCTCCCCACTCTGGTCCCCCGAAGGCAGT GATAGTGGCATCTCCGAAGACCTCCCCTCCGACCCCCAGGACACCCCTCCACGCAGCGGACCAGCCACCTCCCCCGCCGGCTGCCATCCT GCCCAGCCTGGCAAGGGGCCCTGCCTCTCCTATCATCCTGGCAACTCTTGCTCCACCACAACCCCAGGGCCAGTGATCCAAGTACCTGAA GCCTCTGTGACCATAGACCTGGAAATGTGGAGCCCAGGAGGAAGGATCTGTGCTGAGAAGCCGGCTGATCCGGTGGACCTGTCCCCACGA TGCAATCTCACCGTGAAAGACCTCCTCCTTTCGGGCAGCAGTGGGGACCTGCAACAGCATCACCTGGGGGCCTCCTACCTCCTGCGACCT GGGGCTGGGCACTGTCAGGAGCTGGTGCTCACCGAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCC CTCACTAAGTACGAGGAGCGAGTGCTGAAAAAAATCCGCCGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAG GAATATATCGATGGCCTGGAGACTCGGATGTCAGCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAA AACCTGTCCCTCTTGGAGCAACTGAAGAAACTCCAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCA CCTGGGCCGAGCCAGTGGCCCCCAGAGGATGAGAAGGAGGTGATCCGCCGGGCCATCCAGAAAGAGCTGAAGATCAAGGAGGGGGTGGAG AACCTGCGGCGCGTGGCCACAGACCGCCGCCACTTGGGCCATGTGCAGCAGCTGCTGCGGTCCTCCAACCGCCGCCTGGAGCAGCTGCAT GGCGAGCTGCGGGAGCTGCACGCCCGAATCCTGCTGCCCGGCCCTGGGCCTGGCCCAGCTGAGCCTGTGGCCTCAGGACCCCGGCCGTGG GCAGAGCAGCTCAGGGCTCGGCACCTAGAGGCTCTCCGGAGGCAGCTGCATGTGGAGCTGAAGGTGAAGCAGGGGGCTGAGAACATGACC CACACGTGCGCCAGTGGCACCCCCAAGGAGAGGAAGCTCCTGGCAGCTGCCCAGCAGATGCTGCGGGACAGCCAGCTGAAGGTGGCCCTG CTGCGGATGAAGATCAGCAGCCTGGAGGCCAGTGGGTCCCCGGAGCCAGGGCCTGAGCTGCTGGCGGAGGAGCTACAGCATCGACTGCAC GTTGAGGCAGCTGTGGCTGAGGGCGCCAAGAACGTGGTGAAACTGCTTAGTAGCCGGAGAACACAGGACCGCAAGGCACTGGCTGAGGCC CAGGCCCAGCTACAGGAGTCCTCTCAGAAACTGGACCTCCTGCGCCTGGCCTTGGAGCAGCTGCTGGAGCAACTGCCTCCTGCCCACCCT TTGCGCAGCAGAGTGACCCGAGAGTTGCGGGCTGCGGTGCCTGGATACCCCCAGCCTTCAGGGACACCTGTGAAGCCCACCGCCCTAACA GGGACACTGCAGGTCCGCCTCCTGGGCTGTGAACAGTTGCTGACAGCCGTGCCTGGGCGCTCCCCAGCGGCCGCACTGGCCAGCAGCCCC TCCGAGGGCTGGCTTCGGACCAAGGCCAAGCACCAGCGTGGCCGAGGCGAGCTTGCCAGCGAGGTGCTGGCTGTGCTAAAGGTGGACAAC CGTGTTGTGGGGCAGACGGGCTGGGGGCAGGTGGCCGAACAGTCCTGGGACCAGACCTTTGTCATCCCACTGGAGCGAGCCCGTGAGCTG GAGATTGGGGTACACTGGCGGGACTGGCGGCAGCTATGTGGCGTGGCCTTCCTGAGACTTGAGGACTTCCTGGACAATGCCTGTCACCAA CTGTCCCTCAGCCTGGTACCGCAGGGACTGCTTTTTGCCCAGGTGACCTTCTGCGATCCTGTCATTGAGAGGCGGCCCCGGCTGCAGAGG CAGGAACGCATCTTCTCTAAACGCAGAGGCCAGGACTTCCTGAGGGCTTCGCAGATGAACCTCGGCATGGCGGCCTGGGGGCGCCTCGTC ATGAACCTGCTGCCCCCCTGCAGCTCCCCGAGCACAATCAGCCCCCCTAAAGGATGCCCTCGGACCCCAACAACACTGCGAGAGGCCTCT GACCCTGCCACTCCCAGTAATTTCCTGCCCAAGAAGACCCCCTTGGGTGAAGAGATGACACCCCCACCCAAGCCCCCACGCCTCTACCTC CCCCAGGAGCCAACATCCGAGGAGACTCCGCGCACCAAACGTCCCCATATGGAGCCTAGGACTCGACGTGGGCCATCTCCACCAGCCTCC CCCACCAGGAAACCCCCTCGGCTTCAGGACTTCCGCTGCTTAGCTGTGCTGGGCCGGGGACACTTTGGGAAGGTCCTCCTGGTCCAGTTC AAGGGGACAGGGAAATACTACGCCATCAAAGCACTGAAGAAGCAGGAGGTGCTCAGCCGGGACGAGATAGAGAGCCTGTACTGCGAGAAG CGGATCCTGGAGGCTGTGGGCTGCACAGGGCACCCTTTCCTGCTCTCCCTCCTTGCCTGCTTCCAGACCTCCAGCCATGCCTGCTTTGTG ACTGAGTTTGTGCCTGGTGGTGACCTCATGATGCAGATCCACGAGGATGTCTTCCCCGAGCCCCAGGCCCGCTTCTACGTGGCTTGTGTT GTCCTGGGGCTGCAGTTCTTACACGAGAAGAAGATCATTTACAGGGACCTGAAGTTGGATAACCTTCTGCTGGATGCCCAGGGATTCCTG AAGATCGCAGACTTTGGACTCTGCAAGGAAGGGATCGGCTTCGGGGACCGGACTAGCACCTTCTGTGGCACCCCGGAGTTCCTGGCTCCC GAGGTGCTGACCCAGGAGGCATACACACGGGCTGTGGACTGGTGGGGGCTGGGTGTGCTGCTCTACGAGATGCTGGTGGGTGAGTGCCCG TTCCCAGGGGACACAGAGGAAGAGGTGTTTGACTGCATCGTCAACATGGACGCCCCCTACCCCGGCTTTCTGTCGGTGCAAGGGCTTGAG TTCATTCAGAAGCTCCTCCAGAAGTGCCCGGAGAAGCGCCTCGGGGCAGGTGAGCAGGATGCCGAGGAGATCAAGGTCCAGCCATTCTTC AGGACCACCAACTGGCAAGCCCTGCTCGCCCGCACCATCCAGCCCCCCTTCGTGCCTACCCTGTGTGGCCCTGCGGACCTGCGCTACTTT GAGGGCGAGTTCACAGGGCTGCCGCCTGCCCTGACCCCACCTGCACCCCACAGCCTCCTCACTGCCCGCCAACAGGCCGCCTTCCGGGAC TTCGACTTTGTGTCAGAGCGATTCCTGGAACCCTGAGGGCATCTCCTGGCACCTCTGTCCCCTTCCCCCACAGACTGTTAGAGCCTCTGC TCGTTCACCCGTGCGCCCTGCCTGGAGGTCCAGGCCTTGCTGGGTACTTCTGAGCCCTTGGGATTCAAAGTGGCAGCCATGGGGCCACTG TTGTGGGCTTTGCTCAGTGTCACTGGGCAAAGTGTGTCCCTTCCCCCTCCAGCTCGCCCTCTTCTACCTCCCAGCGAGACCTGGCCCAGA >In-frame_CREB3L3_ENST00000602257_chr19_4171172_+_PKN3_ENST00000291906_chr9_131467582_+_4007nt AGGTAACGCTGGCGGTGGGTGGGCCTCCAGCTTGGAGCAGAGACCCCCCGAGGCATCTGCAGACAGAACTGGATGGACCCATGAATACGG ATTTAGCTGCTGGAAAGATGGCTTCTGCTGCCTGCTCCATGGACCCCATCGACAGCTTTGAGCTCCTGGATCTCCTGTTTGACCGGCAGG ACGGCATCCTGAGACACGTGGAGCTGGGCGAGGGCTGGGGTCACGTCAAGGACCAGCAGGTCCTGCCAAACCCCGACTCTGACGACTTCC TCAGCTCCATCCTGGGCTCTGGAGACTCACTGCCCAGCTCCCCACTCTGGTCCCCCGAAGGCAGTGATAGTGGCATCTCCGAAGACCTCC CCTCCGACCCCCAGGACACCCCTCCACGCAGCGGACCAGCCACCTCCCCCGCCGGCTGCCATCCTGCCCAGCCTGGCAAGGGGCCCTGCC TCTCCTATCATCCTGGCAACTCTTGCTCCACCACAACCCCAGGGCCAGTGATCCAAGTACCTGAAGCCTCTGTGACCATAGACCTGGAAA TGTGGAGCCCAGGAGGAAGGATCTGTGCTGAGAAGCCGGCTGATCCGGTGGACCTGTCCCCACGATGCAATCTCACCGTGAAAGACCTCC TCCTTTCGGGCAGCAGTGGGGACCTGCATCACCTGGGGGCCTCCTACCTCCTGCGACCTGGGGCTGGGCACTGTCAGGAGCTGGTGCTCA CCGAGGATGAGAAGAAGCTGCTGGCTAAAGAAGGCATCACCCTGCCCACTCAGCTGCCCCTCACTAAGTACGAGGAGCGAGTGCTGAAAA AAATCCGCCGGAAAATCCGGAACAAGCAGTCGGCGCAAGAAAGCAGGAAGAAGAAGAAGGAATATATCGATGGCCTGGAGACTCGGATGT CAGCTTGCACTGCTCAGAATCAGGAGTTACAGAGGAAAGTCTTGCATCTCGAGAAGCAAAACCTGTCCCTCTTGGAGCAACTGAAGAAAC TCCAGGCCATTGTGGTGCAGTCCACCAGCAAGTCAGCCCAGACAGGCACCTGTGTCGCACCTGGGCCGAGCCAGTGGCCCCCAGAGGATG AGAAGGAGGTGATCCGCCGGGCCATCCAGAAAGAGCTGAAGATCAAGGAGGGGGTGGAGAACCTGCGGCGCGTGGCCACAGACCGCCGCC ACTTGGGCCATGTGCAGCAGCTGCTGCGGTCCTCCAACCGCCGCCTGGAGCAGCTGCATGGCGAGCTGCGGGAGCTGCACGCCCGAATCC TGCTGCCCGGCCCTGGGCCTGGCCCAGCTGAGCCTGTGGCCTCAGGACCCCGGCCGTGGGCAGAGCAGCTCAGGGCTCGGCACCTAGAGG CTCTCCGGAGGCAGCTGCATGTGGAGCTGAAGGTGAAGCAGGGGGCTGAGAACATGACCCACACGTGCGCCAGTGGCACCCCCAAGGAGA GGAAGCTCCTGGCAGCTGCCCAGCAGATGCTGCGGGACAGCCAGCTGAAGGTGGCCCTGCTGCGGATGAAGATCAGCAGCCTGGAGGCCA GTGGGTCCCCGGAGCCAGGGCCTGAGCTGCTGGCGGAGGAGCTACAGCATCGACTGCACGTTGAGGCAGCTGTGGCTGAGGGCGCCAAGA ACGTGGTGAAACTGCTTAGTAGCCGGAGAACACAGGACCGCAAGGCACTGGCTGAGGCCCAGGCCCAGCTACAGGAGTCCTCTCAGAAAC TGGACCTCCTGCGCCTGGCCTTGGAGCAGCTGCTGGAGCAACTGCCTCCTGCCCACCCTTTGCGCAGCAGAGTGACCCGAGAGTTGCGGG CTGCGGTGCCTGGATACCCCCAGCCTTCAGGGACACCTGTGAAGCCCACCGCCCTAACAGGGACACTGCAGGTCCGCCTCCTGGGCTGTG AACAGTTGCTGACAGCCGTGCCTGGGCGCTCCCCAGCGGCCGCACTGGCCAGCAGCCCCTCCGAGGGCTGGCTTCGGACCAAGGCCAAGC ACCAGCGTGGCCGAGGCGAGCTTGCCAGCGAGGTGCTGGCTGTGCTAAAGGTGGACAACCGTGTTGTGGGGCAGACGGGCTGGGGGCAGG TGGCCGAACAGTCCTGGGACCAGACCTTTGTCATCCCACTGGAGCGAGCCCGTGAGCTGGAGATTGGGGTACACTGGCGGGACTGGCGGC AGCTATGTGGCGTGGCCTTCCTGAGACTTGAGGACTTCCTGGACAATGCCTGTCACCAACTGTCCCTCAGCCTGGTACCGCAGGGACTGC TTTTTGCCCAGGTGACCTTCTGCGATCCTGTCATTGAGAGGCGGCCCCGGCTGCAGAGGCAGGAACGCATCTTCTCTAAACGCAGAGGCC AGGACTTCCTGAGGGCTTCGCAGATGAACCTCGGCATGGCGGCCTGGGGGCGCCTCGTCATGAACCTGCTGCCCCCCTGCAGCTCCCCGA GCACAATCAGCCCCCCTAAAGGATGCCCTCGGACCCCAACAACACTGCGAGAGGCCTCTGACCCTGCCACTCCCAGTAATTTCCTGCCCA AGAAGACCCCCTTGGGTGAAGAGATGACACCCCCACCCAAGCCCCCACGCCTCTACCTCCCCCAGGAGCCAACATCCGAGGAGACTCCGC GCACCAAACGTCCCCATATGGAGCCTAGGACTCGACGTGGGCCATCTCCACCAGCCTCCCCCACCAGGAAACCCCCTCGGCTTCAGGACT TCCGCTGCTTAGCTGTGCTGGGCCGGGGACACTTTGGGAAGGTCCTCCTGGTCCAGTTCAAGGGGACAGGGAAATACTACGCCATCAAAG CACTGAAGAAGCAGGAGGTGCTCAGCCGGGACGAGATAGAGAGCCTGTACTGCGAGAAGCGGATCCTGGAGGCTGTGGGCTGCACAGGGC ACCCTTTCCTGCTCTCCCTCCTTGCCTGCTTCCAGACCTCCAGCCATGCCTGCTTTGTGACTGAGTTTGTGCCTGGTGGTGACCTCATGA TGCAGATCCACGAGGATGTCTTCCCCGAGCCCCAGGCCCGCTTCTACGTGGCTTGTGTTGTCCTGGGGCTGCAGTTCTTACACGAGAAGA AGATCATTTACAGGGACCTGAAGTTGGATAACCTTCTGCTGGATGCCCAGGGATTCCTGAAGATCGCAGACTTTGGACTCTGCAAGGAAG GGATCGGCTTCGGGGACCGGACTAGCACCTTCTGTGGCACCCCGGAGTTCCTGGCTCCCGAGGTGCTGACCCAGGAGGCATACACACGGG CTGTGGACTGGTGGGGGCTGGGTGTGCTGCTCTACGAGATGCTGGTGGGTGAGTGCCCGTTCCCAGGGGACACAGAGGAAGAGGTGTTTG ACTGCATCGTCAACATGGACGCCCCCTACCCCGGCTTTCTGTCGGTGCAAGGGCTTGAGTTCATTCAGAAGCTCCTCCAGAAGTGCCCGG AGAAGCGCCTCGGGGCAGGTGAGCAGGATGCCGAGGAGATCAAGGTCCAGCCATTCTTCAGGACCACCAACTGGCAAGCCCTGCTCGCCC GCACCATCCAGCCCCCCTTCGTGCCTACCCTGTGTGGCCCTGCGGACCTGCGCTACTTTGAGGGCGAGTTCACAGGGCTGCCGCCTGCCC TGACCCCACCTGCACCCCACAGCCTCCTCACTGCCCGCCAACAGGCCGCCTTCCGGGACTTCGACTTTGTGTCAGAGCGATTCCTGGAAC CCTGAGGGCATCTCCTGGCACCTCTGTCCCCTTCCCCCACAGACTGTTAGAGCCTCTGCTCGTTCACCCGTGCGCCCTGCCTGGAGGTCC AGGCCTTGCTGGGTACTTCTGAGCCCTTGGGATTCAAAGTGGCAGCCATGGGGCCACTGTTGTGGGCTTTGCTCAGTGTCACTGGGCAAA GTGTGTCCCTTCCCCCTCCAGCTCGCCCTCTTCTACCTCCCAGCGAGACCTGGCCCAGAAAGGGTGCCGCAGCAAGGAGTGATATGGTTT |
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FusionGenePPI for CREB3L3_PKN3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CREB3L3 | CREBZF, USP7, CREB3L1, CREB3L3, CREB3, KPNA2, RIOK3, KHDRBS1, PELI2, BAD, PPARGC1A, GSK3B, CSNK2A1, BTRC, CUL1, RBX1 | PKN3 | ARHGAP10, ARHGAP26, DHX40, HECW2, NUDCD3, EFNB2, TGFBR2, SKAP1, VSIG4, PTGER3, HNRNPD, HNRNPH2, HNRNPU, PPIA, PPP2CA, PPP2CB, TUBG1, HDAC6, KIF20A, ITGB3BP, TRIM29, STRN3, CPSF3, TUBA1C, SKA1, CEP170P1, CFAP97, DEF8, HAVCR2, RHOA, MANSC1, EFNB3, APBA3, ZNF785, TSPYL6, SSSCA1, PCDHGB1, P4HA2, MAS1, CDH5, IL17RA, NCKAP5L, TFPT, CCHCR1, YEATS4, TUFT1, GIT2, RABGAP1L, GOLGA5, CLOCK, PSMD9, VPS53, DZIP3, GRIPAP1, RCOR1, HMG20A, CCDC132, RABGEF1, CCDC93, OIP5, PHF21A, PTRF, PHLDB3, TSSC1, HAUS6, RABEP1, VPS51, RPRD1A, NUF2, THAP11, ARNTL, STRN, MAX, GIT1, CCDC122, MOB4, UBE2A |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CREB3L3_PKN3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CREB3L3_PKN3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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