![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 8406 |
FusionGeneSummary for CREB3L2_LASP1 |
![]() |
Fusion gene information | Fusion gene name: CREB3L2_LASP1 | Fusion gene ID: 8406 | Hgene | Tgene | Gene symbol | CREB3L2 | LASP1 | Gene ID | 64764 | 3927 |
Gene name | cAMP responsive element binding protein 3 like 2 | LIM and SH3 protein 1 | |
Synonyms | BBF2H7 | Lasp-1|MLN50 | |
Cytomap | 7q33 | 17q12 | |
Type of gene | protein-coding | protein-coding | |
Description | cyclic AMP-responsive element-binding protein 3-like protein 2B-ZIB transcription factorBBF2 human homolog on chromosome 7FUS/BBF2H7 proteinTCAG_1951439basic transcription factor 2cAMP-responsive element-binding protein 3-like protein 2 | LIM and SH3 domain protein 1metastatic lymph node gene 50 protein | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q70SY1 | Q14847 | |
Ensembl transtripts involved in fusion gene | ENST00000330387, ENST00000456390, ENST00000452463, ENST00000458726, ENST00000468127, | ENST00000318008, ENST00000433206, ENST00000435347, | |
Fusion gene scores | * DoF score | 11 X 10 X 3=330 | 13 X 12 X 7=1092 |
# samples | 13 | 16 | |
** MAII score | log2(13/330*10)=-1.34395440121736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/1092*10)=-2.77082904603249 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CREB3L2 [Title/Abstract] AND LASP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CREB3L2 | GO:0045893 | positive regulation of transcription, DNA-templated | 17178827 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-EW-A1OZ-01A | CREB3L2 | chr7 | 137569741 | - | LASP1 | chr17 | 37054665 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000330387 | ENST00000318008 | CREB3L2 | chr7 | 137569741 | - | LASP1 | chr17 | 37054665 | + |
Frame-shift | ENST00000330387 | ENST00000433206 | CREB3L2 | chr7 | 137569741 | - | LASP1 | chr17 | 37054665 | + |
Frame-shift | ENST00000330387 | ENST00000435347 | CREB3L2 | chr7 | 137569741 | - | LASP1 | chr17 | 37054665 | + |
intron-3CDS | ENST00000456390 | ENST00000318008 | CREB3L2 | chr7 | 137569741 | - | LASP1 | chr17 | 37054665 | + |
intron-3CDS | ENST00000456390 | ENST00000433206 | CREB3L2 | chr7 | 137569741 | - | LASP1 | chr17 | 37054665 | + |
intron-3CDS | ENST00000456390 | ENST00000435347 | CREB3L2 | chr7 | 137569741 | - | LASP1 | chr17 | 37054665 | + |
intron-3CDS | ENST00000452463 | ENST00000318008 | CREB3L2 | chr7 | 137569741 | - | LASP1 | chr17 | 37054665 | + |
intron-3CDS | ENST00000452463 | ENST00000433206 | CREB3L2 | chr7 | 137569741 | - | LASP1 | chr17 | 37054665 | + |
intron-3CDS | ENST00000452463 | ENST00000435347 | CREB3L2 | chr7 | 137569741 | - | LASP1 | chr17 | 37054665 | + |
intron-3CDS | ENST00000458726 | ENST00000318008 | CREB3L2 | chr7 | 137569741 | - | LASP1 | chr17 | 37054665 | + |
intron-3CDS | ENST00000458726 | ENST00000433206 | CREB3L2 | chr7 | 137569741 | - | LASP1 | chr17 | 37054665 | + |
intron-3CDS | ENST00000458726 | ENST00000435347 | CREB3L2 | chr7 | 137569741 | - | LASP1 | chr17 | 37054665 | + |
intron-3CDS | ENST00000468127 | ENST00000318008 | CREB3L2 | chr7 | 137569741 | - | LASP1 | chr17 | 37054665 | + |
intron-3CDS | ENST00000468127 | ENST00000433206 | CREB3L2 | chr7 | 137569741 | - | LASP1 | chr17 | 37054665 | + |
intron-3CDS | ENST00000468127 | ENST00000435347 | CREB3L2 | chr7 | 137569741 | - | LASP1 | chr17 | 37054665 | + |
Top |
FusionProtFeatures for CREB3L2_LASP1 |
![]() |
Hgene | Tgene |
CREB3L2 | LASP1 |
Transcription factor involved in unfolded proteinresponse (UPR). In the absence of endoplasmic reticulum (ER)stress, inserted into ER membranes, with N-terminal DNA-bindingand transcription activation domains oriented toward the cytosolicface of the membrane. In response to ER stress, transported to theGolgi, where it is cleaved in a site-specific manner by residentproteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminalcytosolic domain is translocated to the nucleus to effecttranscription of specific target genes. Plays a critical role inchondrogenesis by activating the transcription of SEC23A, whichpromotes the transport and secretion of cartilage matrix proteins,and possibly that of ER biogenesis-related genes (By similarity).In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcriptionof target genes via direct binding to the CRE site(PubMed:17178827). {ECO:0000250|UniProtKB:Q8BH52,ECO:0000269|PubMed:17178827}. | Plays an important role in the regulation of dynamicactin-based, cytoskeletal activities. Agonist-dependent changes inLASP1 phosphorylation may also serve to regulate actin-associatedion transport activities, not only in the parietal cell but alsoin certain other F-actin-rich secretory epithelial cell types (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CREB3L2_LASP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CREB3L2_LASP1 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CREB3L2 | ELAVL1, PTP4A1, RND1, ZNF212, CEP19, PXN, RGS16, GCFC2, GAS7, GULP1, CREB3, FBXW7, CREB3L1, TRIM25 | LASP1 | TRIP13, PLSCR1, FHL3, MDFI, ZYX, TERF1, TINF2, ACD, POT1, ATXN1, FN1, DAZAP2, CD81, GOLGA2, PSMA3, REL, TRIM27, TCF4, FXR2, SPRY2, ARHGEF15, ZC2HC1A, THAP1, SEPT3, LZTS2, RHOXF2, KRTAP4-2, ZBTB9, ZDHHC17, CCDC8, ILK, HAX1, DNAAF2, THAP8, FYTTD1, NFYA, OR10H3, RDH12, SLC25A32, SLC25A44, C11orf65, TAS2R41, AHNAK, ARFGAP1, DDB1, EIF4B, HSPB1, HSPE1, LGALS1, MAP4, NXF1, CRK, STAT3, SH2D2A, CEP170, FBF1, SCLT1, DCTN1, U2AF2, CDH1, ZNF764, SNRNP27, PGK1, EZR, SPTAN1, NCL, UHRF1, NAT10, PDIA5, API5, KRT18, KRT2, G3BP2, AP3M1, NCOR2, CDK12, MYO1C, ACTR3, CLTC, DNMT1, EHMT2, SNAI1, HIST1H3A, TRIM25, TES |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CREB3L2_LASP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CREB3L2_LASP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | LASP1 | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | LASP1 | C0036341 | Schizophrenia | 1 | PSYGENET |