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Fusion gene ID: 8400 |
FusionGeneSummary for CREB3L2_ATP6V0A4 |
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Fusion gene information | Fusion gene name: CREB3L2_ATP6V0A4 | Fusion gene ID: 8400 | Hgene | Tgene | Gene symbol | CREB3L2 | ATP6V0A4 | Gene ID | 64764 | 50617 |
Gene name | cAMP responsive element binding protein 3 like 2 | ATPase H+ transporting V0 subunit a4 | |
Synonyms | BBF2H7 | A4|ATP6N1B|ATP6N2|RDRTA2|RTA1C|RTADR|STV1|VPH1|VPP2 | |
Cytomap | 7q33 | 7q34 | |
Type of gene | protein-coding | protein-coding | |
Description | cyclic AMP-responsive element-binding protein 3-like protein 2B-ZIB transcription factorBBF2 human homolog on chromosome 7FUS/BBF2H7 proteinTCAG_1951439basic transcription factor 2cAMP-responsive element-binding protein 3-like protein 2 | V-type proton ATPase 116 kDa subunit a isoform 4V-type proton ATPase 116 kDa subunit aATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1BATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic ac | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q70SY1 | Q9HBG4 | |
Ensembl transtripts involved in fusion gene | ENST00000330387, ENST00000456390, ENST00000452463, ENST00000458726, ENST00000468127, | ENST00000393054, ENST00000310018, ENST00000353492, ENST00000483139, | |
Fusion gene scores | * DoF score | 11 X 10 X 3=330 | 2 X 2 X 2=8 |
# samples | 13 | 2 | |
** MAII score | log2(13/330*10)=-1.34395440121736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: CREB3L2 [Title/Abstract] AND ATP6V0A4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CREB3L2 | GO:0045893 | positive regulation of transcription, DNA-templated | 17178827 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-B6-A0RS-01A | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000330387 | ENST00000393054 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
intron-3CDS | ENST00000330387 | ENST00000310018 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
intron-3CDS | ENST00000330387 | ENST00000353492 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
intron-intron | ENST00000330387 | ENST00000483139 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
intron-3CDS | ENST00000456390 | ENST00000393054 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
intron-3CDS | ENST00000456390 | ENST00000310018 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
intron-3CDS | ENST00000456390 | ENST00000353492 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
intron-intron | ENST00000456390 | ENST00000483139 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
intron-3CDS | ENST00000452463 | ENST00000393054 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
intron-3CDS | ENST00000452463 | ENST00000310018 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
intron-3CDS | ENST00000452463 | ENST00000353492 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
intron-intron | ENST00000452463 | ENST00000483139 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
intron-3CDS | ENST00000458726 | ENST00000393054 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
intron-3CDS | ENST00000458726 | ENST00000310018 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
intron-3CDS | ENST00000458726 | ENST00000353492 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
intron-intron | ENST00000458726 | ENST00000483139 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
intron-3CDS | ENST00000468127 | ENST00000393054 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
intron-3CDS | ENST00000468127 | ENST00000310018 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
intron-3CDS | ENST00000468127 | ENST00000353492 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
intron-intron | ENST00000468127 | ENST00000483139 | CREB3L2 | chr7 | 137564036 | - | ATP6V0A4 | chr7 | 138434062 | - |
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FusionProtFeatures for CREB3L2_ATP6V0A4 |
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Hgene | Tgene |
CREB3L2 | ATP6V0A4 |
Transcription factor involved in unfolded proteinresponse (UPR). In the absence of endoplasmic reticulum (ER)stress, inserted into ER membranes, with N-terminal DNA-bindingand transcription activation domains oriented toward the cytosolicface of the membrane. In response to ER stress, transported to theGolgi, where it is cleaved in a site-specific manner by residentproteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminalcytosolic domain is translocated to the nucleus to effecttranscription of specific target genes. Plays a critical role inchondrogenesis by activating the transcription of SEC23A, whichpromotes the transport and secretion of cartilage matrix proteins,and possibly that of ER biogenesis-related genes (By similarity).In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcriptionof target genes via direct binding to the CRE site(PubMed:17178827). {ECO:0000250|UniProtKB:Q8BH52,ECO:0000269|PubMed:17178827}. | Part of the proton channel of the V-ATPase that isinvolved in normal vectorial acid transport into the urine by thekidney. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CREB3L2_ATP6V0A4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CREB3L2_ATP6V0A4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CREB3L2 | ELAVL1, PTP4A1, RND1, ZNF212, CEP19, PXN, RGS16, GCFC2, GAS7, GULP1, CREB3, FBXW7, CREB3L1, TRIM25 | ATP6V0A4 | PFKM, HYPK |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CREB3L2_ATP6V0A4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CREB3L2_ATP6V0A4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ATP6V0A4 | C1864498 | RENAL TUBULAR ACIDOSIS, DISTAL, AUTOSOMAL RECESSIVE | 2 | CTD_human;ORPHANET;UNIPROT |