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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 825

FusionGeneSummary for ADCY2_RPAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ADCY2_RPAP2
Fusion gene ID: 825
HgeneTgene
Gene symbol

ADCY2

RPAP2

Gene ID

108

79871

Gene nameadenylate cyclase 2RNA polymerase II associated protein 2
SynonymsAC2|HBAC2C1orf82|Rtr1
Cytomap

5p15.31

1p22.1

Type of geneprotein-codingprotein-coding
Descriptionadenylate cyclase type 23',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 2adenylate cyclase 2 (brain)adenylate cyclase IIadenylate cyclase type IIadenylyl cyclase 2type II adenylate cyclaseputative RNA polymerase II subunit B1 CTD phosphatase RPAP2
Modification date2018052220180523
UniProtAcc

Q08462

Q8IXW5

Ensembl transtripts involved in fusion geneENST00000338316, ENST00000537121, 
ENST00000513693, 
ENST00000610020, 
ENST00000484158, 
Fusion gene scores* DoF score20 X 19 X 5=19001 X 1 X 1=1
# samples 211
** MAII scorelog2(21/1900*10)=-3.17753818555219
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ADCY2 [Title/Abstract] AND RPAP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-FD-A3SR-01AADCY2chr5

7698487

+RPAP2chr1

92846281

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000338316ENST00000610020ADCY2chr5

7698487

+RPAP2chr1

92846281

+
5CDS-intronENST00000338316ENST00000484158ADCY2chr5

7698487

+RPAP2chr1

92846281

+
In-frameENST00000537121ENST00000610020ADCY2chr5

7698487

+RPAP2chr1

92846281

+
5CDS-intronENST00000537121ENST00000484158ADCY2chr5

7698487

+RPAP2chr1

92846281

+
intron-3CDSENST00000513693ENST00000610020ADCY2chr5

7698487

+RPAP2chr1

92846281

+
intron-intronENST00000513693ENST00000484158ADCY2chr5

7698487

+RPAP2chr1

92846281

+

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FusionProtFeatures for ADCY2_RPAP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADCY2

Q08462

RPAP2

Q8IXW5

Catalyzes the formation of the signaling molecule cAMPin response to G-protein signaling (PubMed:15385642). Down-streamsignaling cascades mediate changes in gene expression patterns andlead to increased IL6 production. Functions in signaling cascadesdownstream of the muscarinic acetylcholine receptors (Bysimilarity). {ECO:0000250|UniProtKB:P26769,ECO:0000269|PubMed:15385642}. Protein phosphatase that displays CTD phosphataseactivity and regulates transcription of snRNA genes. Recognizesand binds phosphorylated 'Ser-7' of the C-terminal heptapeptiderepeat domain (CTD) of the largest RNA polymerase II subunitPOLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD,thereby promoting transcription of snRNA genes.{ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:22137580,ECO:0000269|PubMed:24997600}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+725295_3003691092Nucleotide bindingATP
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+725337_3393691092Nucleotide bindingATP
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+7251_453691092Topological domainCytoplasmic
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+725108_1283691092TransmembraneHelical
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+725133_1533691092TransmembraneHelical
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+725159_1793691092TransmembraneHelical
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+725187_2073691092TransmembraneHelical
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+72546_663691092TransmembraneHelical
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+72576_963691092TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+7251019_10213691092Nucleotide bindingATP
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+7251026_10303691092Nucleotide bindingATP
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+725208_6013691092Topological domainCytoplasmic
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+725822_10913691092Topological domainCytoplasmic
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+725602_6223691092TransmembraneHelical
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+725628_6523691092TransmembraneHelical
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+725680_7013691092TransmembraneHelical
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+725734_7553691092TransmembraneHelical
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+725763_7803691092TransmembraneHelical
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+725801_8213691092TransmembraneHelical
TgeneRPAP2chr5:7698487chr1:92846281ENST00000610020+101333_68562613Coiled coilOntology_term=ECO:0000255
TgeneRPAP2chr5:7698487chr1:92846281ENST00000610020+101377_160562613Zinc fingerRTR1-type


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FusionGeneSequence for ADCY2_RPAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ADCY2_ENST00000338316_chr5_7698487_+_RPAP2_ENST00000610020_chr1_92846281_+_420aa
MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFF
AIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSAT
PGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAG
QMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK

>In-frame_ADCY2_ENST00000537121_chr5_7698487_+_RPAP2_ENST00000610020_chr1_92846281_+_240aa
MDLRWARDLHLREASRSVAFTTLRLGAVTTGLLTFREPGDKEKSGKGLGKRWRIQREESQERLLLSLLPAHIAMEMKAEIIQRLQGPKAG
QMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ADCY2_ENST00000338316_chr5_7698487_+_RPAP2_ENST00000610020_chr1_92846281_+_1260nt
ATGTGGCAGGAGGCGATGCGGCGCCGCCGCTACCTGCGGGACCGCTCCGAGGAGGCGGCGGGCGGCGGAGACGGGCTGCCGCGGTCCCGG
GACTGGCTCTACGAGTCCTACTACTGCATGAGCCAGCAGCACCCGCTCATCGTCTTCCTGCTGCTCATCGTCATGGGCTCCTGCCTCGCC
CTGCTCGCCGTCTTCTTCGCGCTCGGGCTGGAAGTTGAAGACCATGTGGCGTTTCTAATAACAGTTCCAACTGCCCTGGCGATTTTCTTT
GCGATATTTATCCTGGTCTGCATCGAGTCTGTGTTTAAGAAGCTGCTGCGCCTCTTCTCGTTGGTGATATGGATATGCCTTGTTGCCATG
GGATACCTGTTCATGTGTTTTGGAGGCACCGTCTCTCCCTGGGACCAGGTATCGTTCTTCCTCTTCATCATCTTCGTGGTGTACACCATG
CTGCCCTTCAACATGCGAGACGCCATCATTGCCAGCGTCCTCACCTCCTCCTCCCACACCATCGTGCTTAGCGTCTGCCTGTCTGCAACA
CCGGGAGGCAAGGAGCACCTGGTCTGGCAGATCCTGGCCAATGTGATCATTTTCATCTGTGGGAACCTGGCGGGAGCCTACCATAAGCAC
CTCATGGAACTCGCTCTTCAGCAAACATATCAGGACACCTGTAATTGCATCAAGTCGCGGATCAAGTTGGAATTTGAAAAACGTCAACAG
GAGCGGCTTCTGCTCTCCCTGCTGCCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGC
CAGATGGAGAACACAAATAACTTCCACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACC
CGGCTGGCAAGTGACTGCTCCCCGGGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAA
TGCATGAGAATTAAAATTTTAGGAGACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAA
ATGGGGCTGGACATGTGTGAAGCCATAAAACTGACCCCAATTCTTGGCATTCAGAAACATTCTCAGGAAGGTATGGTGTTTACACGGTTT
CTAGACACCCTCCTTGAAGAATTACATCTAAAAAATGAAGACCTTGAAAGTCTAACCATCATATTTAGAACCAGCTGTTTACCAGAGTGA

>In-frame_ADCY2_ENST00000537121_chr5_7698487_+_RPAP2_ENST00000610020_chr1_92846281_+_720nt
ATGGACCTGCGCTGGGCCAGAGATCTGCATTTGAGAGAAGCCAGCAGATCAGTAGCATTTACCACCCTGAGGCTGGGCGCAGTCACCACG
GGACTCCTGACATTCAGAGAGCCAGGAGATAAAGAGAAGTCAGGAAAGGGCCTTGGGAAGAGATGGCGCATCCAGCGAGAGGAAAGCCAG
GAGCGGCTTCTGCTCTCCCTGCTGCCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGC
CAGATGGAGAACACAAATAACTTCCACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACC
CGGCTGGCAAGTGACTGCTCCCCGGGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAA
TGCATGAGAATTAAAATTTTAGGAGACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAA
ATGGGGCTGGACATGTGTGAAGCCATAAAACTGACCCCAATTCTTGGCATTCAGAAACATTCTCAGGAAGGTATGGTGTTTACACGGTTT
CTAGACACCCTCCTTGAAGAATTACATCTAAAAAATGAAGACCTTGAAAGTCTAACCATCATATTTAGAACCAGCTGTTTACCAGAGTGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_ADCY2_ENST00000338316_chr5_7698487_+_RPAP2_ENST00000610020_chr1_92846281_+_16394nt
AGGCGGCGCGGGGGTGGGACGCGGGCGGCCGCGGCGAGCGGCGCTGCCCGGGCCGGGCGCGCACGGCGGGCGCCCTGTGAGCGGCCCCGA
TGTGGCAGGAGGCGATGCGGCGCCGCCGCTACCTGCGGGACCGCTCCGAGGAGGCGGCGGGCGGCGGAGACGGGCTGCCGCGGTCCCGGG
ACTGGCTCTACGAGTCCTACTACTGCATGAGCCAGCAGCACCCGCTCATCGTCTTCCTGCTGCTCATCGTCATGGGCTCCTGCCTCGCCC
TGCTCGCCGTCTTCTTCGCGCTCGGGCTGGAAGTTGAAGACCATGTGGCGTTTCTAATAACAGTTCCAACTGCCCTGGCGATTTTCTTTG
CGATATTTATCCTGGTCTGCATCGAGTCTGTGTTTAAGAAGCTGCTGCGCCTCTTCTCGTTGGTGATATGGATATGCCTTGTTGCCATGG
GATACCTGTTCATGTGTTTTGGAGGCACCGTCTCTCCCTGGGACCAGGTATCGTTCTTCCTCTTCATCATCTTCGTGGTGTACACCATGC
TGCCCTTCAACATGCGAGACGCCATCATTGCCAGCGTCCTCACCTCCTCCTCCCACACCATCGTGCTTAGCGTCTGCCTGTCTGCAACAC
CGGGAGGCAAGGAGCACCTGGTCTGGCAGATCCTGGCCAATGTGATCATTTTCATCTGTGGGAACCTGGCGGGAGCCTACCATAAGCACC
TCATGGAACTCGCTCTTCAGCAAACATATCAGGACACCTGTAATTGCATCAAGTCGCGGATCAAGTTGGAATTTGAAAAACGTCAACAGG
AGCGGCTTCTGCTCTCCCTGCTGCCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGCC
AGATGGAGAACACAAATAACTTCCACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACCC
GGCTGGCAAGTGACTGCTCCCCGGGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAAT
GCATGAGAATTAAAATTTTAGGAGACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAAA
TGGGGCTGGACATGTGTGAAGCCATAAAACTGACCCCAATTCTTGGCATTCAGAAACATTCTCAGGAAGGTATGGTGTTTACACGGTTTC
TAGACACCCTCCTTGAAGAATTACATCTAAAAAATGAAGACCTTGAAAGTCTAACCATCATATTTAGAACCAGCTGTTTACCAGAGTGAT
ATATTCCATGAAGACAAAATAGAAGATGAACTTCTATTCACCGTTTCTGGAATTCTAGCCGCCATGATGGTCTGGTGGTGACTGATAACT
AGTTTTATTCCAAGACATACCTTTACCTCTTTAAGTTTCAATCTCCCATCTCCCAGTCCTTCAGTCCCCAACTGCAGAGGATGACCTCCC
CAGATAGAGGAGAATCATTACTCCAACAAGAATAACCAAGTCTTTGTATCCCTAGTACAAGACATAGTATTTTTATTCGAAAATGAATGT
TTAAGTATTAAATTGAAACTTGAATGAATATTCAAGAAAATATAATGATCTCTACTTTTTCTGGATGATTTCCAGCCATCATATCAGTTT
GCCAAAAAAATTGAGAAAGTTATGATTTTGACCTCCCAACCTAAACTCTAAATTCTAAAGATCAGTAAACAATTAGGTCAATAAATACAT
ACAATTTAAGATGAAGCCCTTTGGAAGTCTAGTCCAAAACAGGAAAATCTCAGAACTTTCTGGACTCAAGGAAATGCTTTAAATGGAATC
TGTAGTTTGTTTGCAGGAGAGACAATTTCTAGAATTTAGATTGCTTTTCAAAATGTTTATCAGGTAGGCAAGTTAGCAGTTGAGGCGGAA
CACAGACAACTTGGGGAGCTTTACTGGAAGGCCAAGAAAATACTCTTGGACACTGGAGGAAATGACAGCTACTAAAGCCCAATCATGGAA
AAGGACCAGAAAGCAGCCCACTGGAATGGGGAGCTTAGTGGGCAAGGAGGTAGGGATATAATTTCTCTTCTTGGCTCCACCAGTAATTAG
CTCTGTGGCCCAGTCACCTAAACTTTCTGGACTTCAGTTCAGGTTGTATGGCAGTAGGCCATAGAATTGGCTACTGCCATACAATCTCTA
TGGGAAAGGACTGCAAAAACTAAATTTTATCTCTGTATGGGCAAAGGCTACTGTCATCCTGTTGTTGGTCTGGGGCCACTCTGACAATTT
TTTTTAACCTCATTTGATTGTGTAAGGGTCTAACCACAACAAAAAATCATAGTGTAATAGAATTAATCAAGTTCAGCAAGGTCACAGGCT
AGATCAATATACAGAAAATCAATTGTATTTTTCTGTTCAGAAAACTCCAAAAATGAAATAAAGAAAATTGTGTTCACAATATCACCAAAG
AGAATTAAATACTTAGGAATAAATTTAACAAAATAAGTATAAGACTTGTATAACGAAAACTATAAAACATTCAAGAGGGCTGGGCATGGT
GGCTCATGCCTTTAGTTCTAGCACTTTGGAGGCAGAGGCAGGAGGACTGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCAACAAAGTG
AGACCCTGTCTCCACAAAAAATAAAAATAAAAATAAATTGAAGATGGCCGAATAGGAACAGCTCCAGTCTACAGCTCCCAGCAGGATGGA
CACAGAAGATGGGTGATTTCTGCATTTTCAACTAAAGTACCTGGTTCGTCTCACTGGGACTGGCTGGACAGTGGGTGTAGCCCACAGAGG
GTTAGCCGAAGCAAGGTGGGGCATCGCCTCACCTGGGAAGCGCCAAGGGGTCGGGGGATTTCCCTTTCCTAGCCAAGGGAAGCCGTGAGT
GACTATACCTGGAGGAGGGGTACACTCCTGCCCAAATACTGCTCTTTTCCCACAGTCTTCGCAACTGGCAGACCACGAAATCCCCTCCCA
TGCCTGGTTCAGTGGGTCCCACGCCCACAGAGCCTTGCTCACTGCTAGCGCCAGCAGTCTGAAATCGACCTGGGACGTGGGAGCTTGGCG
GGGTAGAGGTGTCCGCCATTGCTGAGGCTTGAGTAGGCGGTTCTATGCTCACAGTGTAAACAAAGCAGCAGGGAAGCTCAAACTGGGCAG
AGCCCACCACAGCTCAGCAAGGCCTACTGTCTCTGTAGATTCCACCTCCAGGGGCAGGGCATATCTGAACAAAAGGCAGCAGACAGCTTC
TCCAGACTTAAACGTCCCTGCCTGACAGCTCTGAAGAGAGCAGTGGTTCTCCCAGCACCGCGTTCAAGCTCCGATAATAGACAGACTGCC
TCCTCAAGTGGGTCCCTGACCCCCGTGTAGCCTGACTGGGAGACATCTCCCAGTAGGCGCCGAAAGACACCTCAGAGAGGTAGATGCCCC
ACTGGAACGAAGCTTCCACAGTAAGGATCAGGCAGCAATATTTGCTGTTCTGCAGCCTCCACTGGTGACACCCAGGCAAACAGGGTCTGG
AGTGGACCTCCAGCAAACTCCAACAGACCTGCAGCTAAGGGGCCTGTCTATTAGAAGGAAAACTAACAGAAAGGAATAGCATCAACATCA
AAAAAAGGACATCTACACCAAAACCCCATCCATAGGACACCAACATCAGAGACCAAAGGTAGGTAAAACCACAAAGATGGGGAGAAACCA
GACCAGAAAGGCTGAAAATTCCAAAAACCAGAATGCCTCTTCTCCTCCAAAGGAACACAACTCCTTGCCAGCAAGGGAACAAAACTGGAC
AGAGAATGAGTTTGACAAGTTGACAGAAGTAGGCTTCAGAAGGTCGGTAATAACAAACTTCTCCAAGCTAAAGGAGCATGTTCTAATGCG
TCGCAAGGAAGCTAAAAATCTTGAAAAAAGGTTAGACAAATGGCTAACTAGAATAACCAGTGTAGAGAAGAGCTTAAATGACCTGATGGA
GCTGAAAACCACAGTACGGGAACTTCGTGAAGCATACACAAGCTTCAATAGCCAATTCGATCAAGTGGAAGAAAGGATATCAGTAACTGA
AGATCAAATTAATGAAATAAAGCGAGAGGACAAGATTAGAGAAAAAAGAGTGAAAAGAAATGAACAAAGCCTCCAAGAAATATGAGACTA
TGTGAAAAGACCAAATCTATGTTTGATTGGTGTACCTGAAAGTGATGGGGAGAACAGAACCAAGTTTGAAAACACTCTTCAGGATATTAT
CCAGGAGAGCTTCCCCAACCTAGCAAGGAAGGCCAACATTCAAATTCAGGAAATACAGAGAACACCACAAAGATACTCCTCAAGAAGAGC
AACCCCAAGACACATAATTGTCAGATTCACCAAGGTTGAAATGAAGGAAAAACTGTTAAGGGCAGCCAGAGAGAAAGGTCAGGTTACCCA
CAAAGGGAAGCCCATCAGATTAACAGCGGACCTCTGGGCAGAAACCCTACAAGCCAGAAGAGAATGGGGGCCAATATTCAACATTCTTAA
AGAAAAGAATTTTCAACCCAGAATCTCATATCCAGCCAAACTAAGCTTCTTAAGTGAAGGAGAAATAAAATCCTTTACAGACAAGCAAAT
GCTGAGAGATTTTGTCACCACCAGGCCTGCCTTACAAGAGCTCCTGAAGTAAGCACTAAAATGGACAGGAACAACCAGTACCAGCCACTG
CAAAAACATGCCAAATGGTAAAGACCATCAACACTATGAAGAAACTGCATCAATTAATGGATGAAATAACCAGCTAGCATCATAATGACA
GGATCAAATTCCCACATAACAATATTAACCTTAAATGTAAATGGGATAAATGCCCCAATTAAAAGACACAGACTGGCAAATTGAATAAAC
AGTCAAGACCCATCAGTGAGCTATATTCAGGAGACCCATCTCATGTGCAAAGACACACATAGGCTCAGAATAAAAGGATGTAGGAAGATT
TACCAAGCAAATGGAAAGCAGAAAAAAGCAGGGGTTGCAATCCTAGTCTCTGATAAAACAGACTTTAAACCAACAAAGATCAAAAGAGAC
AAAGAAGGTCATTACATAATGGTAAAGGGATCAATTCAACAAGAACAGCTAACTATCCTAAATATATATGCACCCAATACAGGAGCACCC
AGATTCATAAAGCAAGTTCTACAAAGAGATTTAGACTCCCACACAATATTAATGGGTGACTTTAACACCCCACTGTCAATATTAGACAGA
TCAACAAGACAGAAAATTAACAAAGATATCCAGGACTTGAACTCAGCTCTGGACCAAGCAGACCTAATAGACATCGACAGAACTCTCCAC
CCCAAATCAACAGAATATACATTCTTGTCAGCACCACATCACACTTATTCCAAAATTGACCACATAATTGGAAGTAAAGCACTCTTCAGC
AAATGCAAAAGAACAGAAATCACAACAAACCGTCTCAGACCACAATGCAATCAAATTAGAACTCAGGATCAAGAATCTCACTCAACTGCA
CAACTGCATGGAAACTGAACAACCTGTTCCTGAATGACTACTGGGTAAATAACGAAATGAAGGCAGAAATAAAGATGTTCTTTGGAACCA
ACGAGAACAAAGACACAATGTACCAGAATCTCTAGGACATGTTTAAAGCAGTATGTAGAGGGAAATTTATAGCACTAAATGCCCACAAGT
GAAAGCAGGAGTGATCTAAAATCAACACCCTAACATCACAATTAAAAGAACTAGAGAAGCAAGACCAAACAAATTCAAAAGCTAGCAGAA
GGCAAGAAATAACTAAGATCAGAGCAGAACTGAAGGAGATAGAGACTCAACAAACCCTTCAAAAAATCAGTGAATCCAGGAGCTAGTTTT
TTGAAAAGATCAACAAAATTGATAGACCGTTAGCAAGGCTAAAAAAGAAGAAAAGAGAGAAGAGTCAAATAGATGCAATAAAAAATGATA
AAGGGGATATCACCACTGATCCCACAGAAATACAAACTACCATCAGCGAATACTATAAACACCTCTACACAAATAAACTAGAAAATCTAG
AAGAAATGGATAAATTCCTCGACACATACACCCTCCCAAGACTAAACCAGGAAGAAGTTGAATCTCTGAATAAACCAGTAACAGGTTCTG
AAATTGAGGCAATAATTAATAGCCTACCAACCAAAAAAAGTCCAGGACCAGACGGATTCACAGCCAAATTCTACGAAAGGTACAAAGAGG
TGCTGGTACCATTCCTTCTGAAACTATTCCAATCAATAGAAGAAAAGGGAATCCTCCCTAACTCATTTTATGAGGCTAACATCATCCTGA
TACCAAAGCCTGGCAGAGACACAACAAAAAAAGAGAATTTTAGGCCAATATCCCTGATGAACATCGATGCGAAAATCCTCAATAAAATAC
TGGCAAACCGAATCCAGCAGCATATCAAAAAGCTTATCCACCACGATCAAGTCAGCTTCTTCCCTGGGATGCAAGGCTGGTTCAACATAT
GCAAATCAATAAACATAATCCATCACATAAACAGAACCAACGGCAAAAACCACATGATTATCTCAATAGATACAAAAAAGGCCTTCAACA
AAATTCAACAGCCTTTCATGCTAAAAACCCTCAATAAACTAGGTATTGATGGAATGTATCTCAATATAATAAGAGGTTATTTATGACAAA
CCCACAGCCAATAGCATACTGAATGGGCAAAAGCTGGAAGCATTTCCTTTGAAGACCAGCACAAGGCAAGGATGCCCTCTCTCACCACTC
CTATTCAACATAGTATTGGAAGTTCTGGCCAGGGCAATCAGGCAAGAGAAAGCAATAAAGCATATTCAAATAGGAAGAGAGGAAGTCAAA
TTGTCTCTGTTTGCAGATGACATGATTGTATATTTAGAAAACCCCATCGTCTCATCCCAAAATCTCCTTAAGCTGATAAGCAACTTCAGC
AAAGTCTCAGGATACAAAATCGGTGTGCAAAAATCACAAGCATTCCTATATACCAATAATAGACAAAGAGCCAAATCATGAGTGAACTCC
CATTCACAATTGCTACTAAGAAAATAAAATACAAAGCACTGCTCAAGGAAATAAGAGAGGACACAAACAAATGGAAAAACATTCCATGCT
CATGGATAGGAAGAATCAATATCATGACAATGGCCTTGTTGCCCAAACTGATTTATAGATTCAATGCTATCCCCATCAAGCTACCACTAA
CTTTCTTCACAGAATTGGAAAAAACTACTTTAAGATTCATATGGAACCAAAAAAGAGCCCACCTAGCCAAGACAATCCTGGGCAAGAAGA
ACAAAGCTGGAGGCATCACACTACCTGACTTCAAACTTTACTACAAGCCTACAGTAACCAAAACAGCATGGCACTGGTACAAAAACAGAT
ATGCAGACGAATGGAACAGAATGGAGGCCTCAGAAATAACACCACACGTCTACCACCATCTGATCTTTGACAAACCTGACACACACAAGC
AATGGGGAAAAGATTCCCTATTTAATAAATGGTGTTGGGAAAACGGGCTAGCCATATGCAGAAAACTGTAACTGGACCCTTTCCTTACAC
CTTATACAAAAATCAACTCAAGATGGAACAAAGACTTAAACGTAAGACCTAGGACCATAAAAATCCTAGAAGAAAACCTGGGCAATACCA
TTCAGGACATAGGCATGGGCAAAGACTTCATGTCTAAAACACCAAAAGCAATGGCAACAAAAGCCAAAATTGACAAATGGGTTCTAATTA
AAGAGCTTCTGCACAGCAAAATAAACTATCATCAGAGTGAACAGGCAACCTACAGAATGGGAGAACATTTTTGCAATATATCCATCTGAC
AAAGGGCTAATATCCAGAATCTACAAAGAACTTAAACAAATTTACAAGAAAAAAGCAAACAACCCCATCAAAAAATGGGCAAAGGATATG
AACAGATACTTCTCAAAAGAAGACATTTATGCAGCCAACAGACATATGAAAAAATGCTCATCATCACTAGTCATTAGAGAAATGAAAATC
AAAACCACAGTGAGATACCATCTCATGCCAGTTAGAATGGCGATCATTAAAAATCAGGAAACAATAGATGCTGGAGAGGTTGTGGAAAAA
TTGGAACGCTTTTACACTGTTGGTGGGAGTGCAAATTAGTCCGACCATTGTGGAAGTCAGTGTGACGACTCCTCAAGGATCTAGAACTGG
AAATACCATTTGACCCAGCAATCCCACTATTGGGCATATACCCAAAAGATTATAAATCATTCTACAATAAAGACACATGCACACGTATGT
TTATTGCTGCACTATTCACAATAGCAAAGATTTGAAACCAACCCAAATGCCCGTCAATGATAGACTGGATTAAGAAAATGTGGCACATGT
ATACCATGGAATACTATGCAGCCATAAAAAAGGATGAGTTCATGTCCTTTGCAGGGACATGGATAAAGCCGGAAACCATCATTCTCAGCA
AACTATCACAAGATCAGAAAACCAAACAACGCATGTTCTCACTCATAAGTGGGAGTTAAACAATGAGAACACATGGACACAGGGAGGGTA
ACATCACACACCAGGGCCTGTGGGGGGTGGGGGGCTAAGGGAGGGATAACATTAGGAGAAATACCTAATGTAGGTGACAGGTTGGTGGGT
GCAGCAAACCACCATGGCATGTGTATACCTATGTAACAAAACTACATGTTCTGCACATGTAACCCAGAACTTAAAGTATAATAAAAAAAA
TAATTATTAAATTTTAAAAAACTAGCCAGGCATGGTGCTGCACACCTGTAGTCCCAGCTACTTGAGAGGCTACATTGGGAGGATTGCCTG
AGCTTGGGAGGTTGAGGCTGCAGTTAGCTGTGACTGTGCCAGTGCACTCCAGCCTGGGCAACAGAGCAAGACCCTGTCTCAAAAAAAGAA
AAAGAAAAATTCAGAGAGATTAAAGAAGGTATCAAGAAATGTAGACACAATCCATGTTCATGAATTGGAAGATCAAATGTTGTTAAGATA
GCAGTTCTCCCCAAATTAATCTACAATGCAATCCCTATCAAAATCACAGCAGGCTTTTTTGAAAAATTGACAAGCCAATCTTAAAATCTG
TATGAAAACATAAAGGATTCAGAATAGCCAAAATAATTCTGAAAATGAAGAAATAATTCTGATCCAGAACTTACTACAAAGCTACATTAA
TCAAGACAGTGTGGTACTGATATAAAGATAGGCATACAGATCAGTGGAACAGAGTCCAGGAATAAACCTTCACATTTATGATCAATTAAG
TTTTGACAAAAATCCCAATGAAATTATGGAGAAAAGATGGTCTTTTCAACAAATAGTGCTAGGATATTTGGATATCAAATGCAGAAGAAA
TTAATTTAGATTCTTACCTCCTACCATATGCAAAAATAAACTCAAAATTGATCACACACCTACATGTAAGAGCTAAAACTATAAAACATG
TAGAAGAAAACATGGGAGAAAACCTAGATGACCTTGGTTTAGGAAGAATTCTTAAGACACTAATAGCACAATTCATAAAAGAAAATATTA
ATAAATTGGACTTCATTAAAATATAAAATTTTGTTTCAAAAAACTATTAAGAAAATTAATTGGCCCGGGGAGGTGGTTCACATCTGAAAT
CCCTGCACTTTCGGAAGCCAAGGAGGGTGGACCACTTGAGCTCAGGAATTTGAGACCAGACTGGACAACAGAGCAAAATGCCATCTCCAC
AAAAAATACAAAAATTAACCAGGCATGGTGGCGTGCTCCTGTAGTCCTGGCTACTCAGAAGGCTGAGGTGGGAGGATCTCTTGACCCTGG
GAGGCAGAGGTTGCAGTGAGCCAAGATCACACCACCGCACTAGAGCCTGGGTGACAGAGTGAGACCCTGTCTCAAAAAAAAAAAAAAAAA
AAAAAATTAATTGAAAAATCACAGACTGGGAGAAAATATTTTCAAACCATAATAAGTATCTGATAGAGGACTTGTATCTAGACTATGTAA
AGAATTCTTAAAACTCAAAAATAAGGCAGACAACTTAAAAATGGACAAAATGTTTGAATAGATATTTCAGCAAAGATATACAAATTGCTT
AGCATATGAAGAGATGTGTACTATCACTAGTCATTAGGAAAATACAAGTTAAAAGCAAAATTAGATACCATTTTGGACCCACTAAAATGA
CTATAATAAAAAAGACAGACAAAGATATGTGTTGGTGATGATGTGGAGAAACTGGAGCCCTAATGCATTGCTGGTGGGAATGTAAAATGG
TGCAGCCACTTTGGAAAACAGTTTGGCAGTTTCTTAAAAAGATAAACATAAGTTTACCATATGATCCTGCTATTCCATGAGAAGAGAAGT
GGAAATGTGTTCACATCAAGACTCGTAGGCAAATGTTCATAGCATTATCATTCATATTAGTCAAAAAGTGGAAACCAAATGACCATCAAC
TACTGGATTTTTTTTTTTTTTTTAAGAGATGAGGCCTCACTATGTTGCATACTCTGAAGTCAAACTCCTGGGCTCAAACAATCCTCCTGC
CTCAGCCTCCTCAGTAACTGGGACTGCAGGCAGGCACCAACATACCCAGATTATTTCTTTTTCTTTTTTTTTTTAACTGGTGGATTTCTT
TAAATGATATATGTATACAATGGAGTAGTGATATAGGCTACAATATGGATGCATCTCAAAACATTATGCTTAGTGAAAGAAGTCTGATGC
AATATCCCACATATGGTATGTTTCCATTTACAGTCCAGAAAAGGCATATACTAAATTAGCAGTTGCATGGGTCTGATGTGAAAACATGGA
TTGCCTGCAGATGGGCACAAGGGATCTTTTGGGGGTGACAAAAATGTTCCAAAACTAAGTTGTAATTTTTGCACAACTTTTATGTGTGTG
TGTGTGTGTGTGTGTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGCGATCTCAGCTCACCACAACCTCCGCCTCC
TGGGTTGAAGCATTTCTCCTGCCTCAGCTTCCTGAGTAGCTGGGATTACAGGCATGTGCCACCATGCCCGGCTAATTTTGTATTTTTAGT
AGAGACAGGTTTTCTCCAGGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCTCCTGCCTCGGCCTCCCAAAGCGCTGGGAT
TACAGGCGTGAGCCACCACACCCAGCCATTTTTGCACAACTTTATAAACTTTAAAAATAATTGATTTATGCACTTAAAACAGGTAAAGTT
TATGTGTATAAATTATACCTTAATAAAGCTATTAAAAGTCAAAGATTATAACAGGGCCTCTCTCTCTCTGACCTAGTGACCTAGGGTAAA
GAGAAAAAGAAGCTAGCCAGGCACAGGGGCTCACACCTGTAATCCCAGCACTTTGGGAAGCCAAGATGGGCTGATTGCTTGAGTCCAGGA
GTTTGAGACCAACTTGGGCAACATAGCAAAACCCTGTCTCCACCAAAAATAAAAAAAATTAGCCAGGCATGGCGGTGTATGCCTGGAGTC
CCAGCTACTCAGGAGTCAGAGGTGGGAGGATCACTTGAGCCCAGGAGGCAGAGGTTGTAGGGAGCCAAGATTGCACCACTGCACTCCAGC
CTGGGTGACAGAGCAAGACACTGTCTCAAAAATTAAAAATTAAAAAATGAGGGAAGCTGCTGTATCTCCACTTCTTCCCTCTCTGTGCCC
AGAGATATCTCTTCAGTTATCTCACATGCCCTACAAGTCTAGAGACCTCAGGTGAGGAGCCAGTAGCTCAGTATAGAAACTAAGGATCCA
AGTGGACAACTGCCACCAAGTCACCACAGGGCCAGCTGCTTTGGGAGGGTGCTGCATCTGCCTCCCATACACTTCTGCCAAGTTTATGTT
AGTTTGGGAGGACTGAAGCAGAATTCAGTTCAAAGTACTGTGCTGGATTTTGGTTTCTAAATATTTTCCAATAGAAAAGAACCCAGGCTT
CTTGAGAAAATAGCTAGGTTCTAAGGCTAGAGCCAAAAAAATGCAAGATAAGCCTGGAGCATCTTGTAGTACCAGAAACTAAGCAAGTGC
TCAAAAACAAAAGGATAGAAGCATGTCAGACAGACACAGGAGCCAATCTGAAAGAGCTCCCTGGCCGGGCACGGTGGCTCACGCCTGTAA
TCCCAGCACTTTGGGAGACTGAGGTGGGAGGATGACTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACATAGGGAGACCCCATCTCTA
CAAAAAAGTAAACAATTAGCCGGGCATGGTGGCACACGCCTATAGTCCCAGCTACTCAGGAGGGTGAAGATCACCTGAGACCAGGCGGTC
AAGGCTTCAGTGAGCCATGATTGTGGCACTGCACTCCAGCCTAGGCAATAGAGTGAGACTGTCTCAAAAAATAAAATTTTAAAATAACTG
AAGAGTATAACTGGATTGTTTGTAACACAAAGGATAAGTGCTTAAGATGATGGAAACCCTATTTATCCTGATGTGATTATTACACATTGC
ATGCCTGTACCAAAATATTTCATGTAACCCATAAATATATACATCTACTATGTACCCACAAAAATTAAAAAATGTTTACAGGAGTGAACC
ACCGCACCTGGCCAGTGGAGTCTTTTTAAGGTATTATTTAGCATCTTCTGCTTATAGTCATGTCCAAAAACCAGTTGATCTTCCTACTCA
TTAGGGGACAAGATCAATTCTCTAAAAAATTAACCTAGCCCAAGGTAAGTGGTACTATTCTGAAATCTGAAAATCTTTAGTAGCCTCACA
TTATAAGCCCTTCGTAGAAAAAGAAAAGTAAGCATTTCTAGAAGCACATTTTTGTTGGACTGAGGGTGGGGCAAGGAGCAGGGGTGACTT
TCATCTGAAATGTACCTAGGCAGGCCAGAGTCTGAGTTAGGACTGGCTCCTGGGACTTTGCCATCCAGGCCAAGAAGCATGCTCCAGTGT
GCATGCACTCTCATCAAAGCCCTAGTCAGGAATCCCAGCCACTCCTCTCCTGTGCAGCACAAGCTGAAGGATAAGGTGTGGGGCAGTGAC
TGCGTGGGGCTGCCTGTGTGATTCCTGATAAAGAAATGCCTTCATGAAATGTATTGTTCCCCAATAAAGCTCATTTTCTGTGAGAATTCA
TGTGTCCTTTTCCAAATTAAACTAGCAAAATATGAACTTTTGTAAAAGGTCCACACCCAGCCAGTTTTCTACTCTCTAAATGTTCAGGCC
TTTGCCTGTCCTTCCCTCAGCAAAAATACTGTGTTTTGGAAAACATTACCAATAAAGGAGCTGGGAGGTGGAATTGGATCAAAATACCTT
TAGATGAAAGCAGCAGCACAAGCCATTCCCTTTAAATGAGCTGGCCTCACCTCTGGGGCCTATGAAGAAAAGCCTGCTTCAAGGTGATAG
TTTTCATTTTGCTTCCCAGCACCTCTGCAGTCATAACCAAAGTGAAGGACAATATTGCATGACTTCAGAAGAAAGCCATCCAGCCACCTT
GCAACATGTTCAGGAAATTCTGGACTCCCTTGGGGCTTGCAAAACTCCCTATGTCTTGCAGACCAAAAGCAAGTTCTCAGTCACCTAGCT
CTAGTTTGCATAATTAAAGAAAGTGGAAGCTGGTTCTTTTCTGGGTGACCCTTCACCCAACCAAGCTCATAAGGACTTGTGACAAAAATA
AGAGCAATAAAATGAAGTTTTAACAGTGAAAACTTCTATCACTTAGATAAGCAGGAAAAGCCAGTCCCCTAGATGCCCATCTGACCCTAC
CTTACTGGGGTCATACAGCCAAAGCAGTGTCCACTTCAGGTACTGTAATGTTTTGAAGTTGACACATATAATTTAATGTAGTTTCATGTC
ATAAGTTATAAGACTTTTCAGAGAAACAATTTAGTAATATCTTCTGTAATACCCATCTTCATTTTTTATATGAAAAAGCATAGCCTATGA
TCTGTCACCTTGCTCACTCCCACATCCTTACCTCTTATCCTTCTCACATCGTCCCATTAACACATTATCCATCTTTGGGGGGAAAAAATA
CACTAAATTTTAGACAGAGTCACTTTCACTATGGCCACAATGGGAGAAAAGACAGTCCACCTTCAAAGTCAACCAGAATGACTCTTAACC
TCTCTTGTCTGGGTTGGGCATCCAGATAAGATTTTCTTCGTACAAAGAGTCTTGCTACTAGGAAAAAGAGTTTGAAAATCACTAGTCTAA
CTAAATATCTCACTTTAAAAAAAGCACAAACTAAGACTCAATGAGGTTTATCTTCCACAAGATCAGCCAGTTTTAGCAGAGCAGTTGCTA
AAACCCAGGTCTCAAACTCCTTGTCTATGGCTCATCTAACTAAGCAACAAAAAGCCCAATGAGCTCTGGAGAGAGAGAGGGAGCTAAAAC
AGGACTCAATCAAAACCCACTTGGGATTAGGGAAGCCACCCTCTGTGAGTGAGTTAAACTGAGATTCCCTCCCCTTCACCCTGGCTTCCT
TTGCAGAACAAGGGTCACCGCCAGAGGGAAAGCTGAGTTTACGGAGGGGATCCTGGTTGGAGTCAGAGTATACCTTGGTTTGGTTTTGTG
GGGTTTTTTGAGACAGGGTCTCACTGTCACCCAGGCTGGAGCACAGTGACAGTCATAGCTCACTATAGCCTCAGACTCCTGGCCTCAAGC
GATCCTCCCACCTCAACCTCCAGAGTATCTGGGACTATAGGCACGTACCACCATACCCAGCTAATATTTTTTTTAATTTTATATTTTTTA
GAGACAGGGTGTCACTATGTTACCCAGGTCTCAATCACTATGTTACTCCTTGCCTCAAGCAATCCTCTCACCTTGGCCTCCCAAAGTGCT
GAGCTTACAGGTGTCAACCACTGTGGCCAGCCACGCATTGGTTTTAAGGTCCAGAATTTTTCTGTTTGGAGCCTTCACAATTAGTTTTAG
GTTGGGAGACCGTGAACCCACCAAGCAGCCCTTTAGAGGCTGGAAAAAGAGTTTGGAAAAAGAACTCTGTGGCTTTAGGAATTTCTCTCG
GAAATCCTCTAGGGCAGAGAAGGAAAATTTACCAAATGGGAGAGTGTATTAGTCTATTCTTACATTGCTATAAGGAAATACCCCAGACTG
GGTAATTTATAAAGGAAAGAGTTTTAATTGACTCACAGTTCCACATGGCTGGGAAAGCCTCAGGAAACTTACAATCATAGCAGAAGGCAA
AGGGGAAGAAAGGCACCTTCTTCACAGGGCGGCAGGAAGGAGAAGTGCAGAGCAAAGTGGGGCAAAGCCTCTATAAAGCCATCAGATCTC
ATGAGAACTCACTATCATGAGAACAGCAGGGGAGAACCACCCCCATGATCCAATCACCTTCCACGAGGTCCCTCCCCCAACACGTGGGGA
TCACAATTTGGATTACAATTCAAGATGAGATTTGGGTGAGGACACAGAGCCGGACCATATCAGAGAGAAAGCTATTACTGAAGACCTTTC
TAACTCACTTCTGTAAAGATCAATTCAATAAAAGCAGCAAACACACATACTTTGCTTTCCTTGTGATTAATGCCTTGACTTTTTTGTGGA
AAGTAACACCCCAAGAAAGCCAGCTACTCATGTTGGCAATAAAGGTAAAAGTATCTATGGAATAAGGACCATTTTTAGGACAATACTTTC
CCTACTACTTAGTTCTAGTCCCTTTTTTGTAGAATTCTGAGGACTTTCTACATACACAATCATGTCATCAGCAAATAAAGATTATTGTAC
TTGTTCTTTGCCAACCCATATGTCTTGCCTTACTGCCCTGGTTAGGACCTTCAGAACAATACTGGATATAAGTGGTGAAAGCACATATCC
TCCCCTTGTTCCTAATTTTAGAGGGAAAGTACTCAGTCTTTCGCCATTAAGTACAATGTCAGCTGTAAGTTTTCCTAGAGACCCTTTCTC
AGCTTGAAGATGTTCCCTGGTATTCATAGTTTGCTAAAAGGTTTTTGTCATTTTAAATCATAAATGGGTGTTGAATTTTGTCAAAGGCTT
TTAATGCATCTATGGAGATGATCCAAGTTTTTTTCCTCCTTATTTCTGCTAAGGTTGTATAATTATGCTCATTGGTATTTTAAATGTTAA
ATTAACCTTGCGTTCCTGGGATAAGACCCACTGATCATGATGCATTTTCCTCTTTGTAAATTGCTGTATTCATTTTAGTTTCTTCAGGAT
TTTGCCTATGTTTGAAGGATATTGGTTTGTAATTTTTCTTGTAACATCTTTGTCTGGTTTTGAAATCAAAGTAATACTGGCCTAATAAAA

>In-frame_ADCY2_ENST00000537121_chr5_7698487_+_RPAP2_ENST00000610020_chr1_92846281_+_15831nt
GAGGAGTTTGGTAGAAATCCCAGAAGAGCTGTTGAGAAGACCAGTGGAGCCACACGTCTAGAGGTCATGGACCTGCGCTGGGCCAGAGAT
CTGCATTTGAGAGAAGCCAGCAGATCAGTAGCATTTACCACCCTGAGGCTGGGCGCAGTCACCACGGGACTCCTGACATTCAGAGAGCCA
GGAGATAAAGAGAAGTCAGGAAAGGGCCTTGGGAAGAGATGGCGCATCCAGCGAGAGGAAAGCCAGGAGCGGCTTCTGCTCTCCCTGCTG
CCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGCCAGATGGAGAACACAAATAACTTC
CACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACCCGGCTGGCAAGTGACTGCTCCCCG
GGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAATGCATGAGAATTAAAATTTTAGGA
GACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAAATGGGGCTGGACATGTGTGAAGCC
ATAAAACTGACCCCAATTCTTGGCATTCAGAAACATTCTCAGGAAGGTATGGTGTTTACACGGTTTCTAGACACCCTCCTTGAAGAATTA
CATCTAAAAAATGAAGACCTTGAAAGTCTAACCATCATATTTAGAACCAGCTGTTTACCAGAGTGATATATTCCATGAAGACAAAATAGA
AGATGAACTTCTATTCACCGTTTCTGGAATTCTAGCCGCCATGATGGTCTGGTGGTGACTGATAACTAGTTTTATTCCAAGACATACCTT
TACCTCTTTAAGTTTCAATCTCCCATCTCCCAGTCCTTCAGTCCCCAACTGCAGAGGATGACCTCCCCAGATAGAGGAGAATCATTACTC
CAACAAGAATAACCAAGTCTTTGTATCCCTAGTACAAGACATAGTATTTTTATTCGAAAATGAATGTTTAAGTATTAAATTGAAACTTGA
ATGAATATTCAAGAAAATATAATGATCTCTACTTTTTCTGGATGATTTCCAGCCATCATATCAGTTTGCCAAAAAAATTGAGAAAGTTAT
GATTTTGACCTCCCAACCTAAACTCTAAATTCTAAAGATCAGTAAACAATTAGGTCAATAAATACATACAATTTAAGATGAAGCCCTTTG
GAAGTCTAGTCCAAAACAGGAAAATCTCAGAACTTTCTGGACTCAAGGAAATGCTTTAAATGGAATCTGTAGTTTGTTTGCAGGAGAGAC
AATTTCTAGAATTTAGATTGCTTTTCAAAATGTTTATCAGGTAGGCAAGTTAGCAGTTGAGGCGGAACACAGACAACTTGGGGAGCTTTA
CTGGAAGGCCAAGAAAATACTCTTGGACACTGGAGGAAATGACAGCTACTAAAGCCCAATCATGGAAAAGGACCAGAAAGCAGCCCACTG
GAATGGGGAGCTTAGTGGGCAAGGAGGTAGGGATATAATTTCTCTTCTTGGCTCCACCAGTAATTAGCTCTGTGGCCCAGTCACCTAAAC
TTTCTGGACTTCAGTTCAGGTTGTATGGCAGTAGGCCATAGAATTGGCTACTGCCATACAATCTCTATGGGAAAGGACTGCAAAAACTAA
ATTTTATCTCTGTATGGGCAAAGGCTACTGTCATCCTGTTGTTGGTCTGGGGCCACTCTGACAATTTTTTTTAACCTCATTTGATTGTGT
AAGGGTCTAACCACAACAAAAAATCATAGTGTAATAGAATTAATCAAGTTCAGCAAGGTCACAGGCTAGATCAATATACAGAAAATCAAT
TGTATTTTTCTGTTCAGAAAACTCCAAAAATGAAATAAAGAAAATTGTGTTCACAATATCACCAAAGAGAATTAAATACTTAGGAATAAA
TTTAACAAAATAAGTATAAGACTTGTATAACGAAAACTATAAAACATTCAAGAGGGCTGGGCATGGTGGCTCATGCCTTTAGTTCTAGCA
CTTTGGAGGCAGAGGCAGGAGGACTGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCAACAAAGTGAGACCCTGTCTCCACAAAAAATA
AAAATAAAAATAAATTGAAGATGGCCGAATAGGAACAGCTCCAGTCTACAGCTCCCAGCAGGATGGACACAGAAGATGGGTGATTTCTGC
ATTTTCAACTAAAGTACCTGGTTCGTCTCACTGGGACTGGCTGGACAGTGGGTGTAGCCCACAGAGGGTTAGCCGAAGCAAGGTGGGGCA
TCGCCTCACCTGGGAAGCGCCAAGGGGTCGGGGGATTTCCCTTTCCTAGCCAAGGGAAGCCGTGAGTGACTATACCTGGAGGAGGGGTAC
ACTCCTGCCCAAATACTGCTCTTTTCCCACAGTCTTCGCAACTGGCAGACCACGAAATCCCCTCCCATGCCTGGTTCAGTGGGTCCCACG
CCCACAGAGCCTTGCTCACTGCTAGCGCCAGCAGTCTGAAATCGACCTGGGACGTGGGAGCTTGGCGGGGTAGAGGTGTCCGCCATTGCT
GAGGCTTGAGTAGGCGGTTCTATGCTCACAGTGTAAACAAAGCAGCAGGGAAGCTCAAACTGGGCAGAGCCCACCACAGCTCAGCAAGGC
CTACTGTCTCTGTAGATTCCACCTCCAGGGGCAGGGCATATCTGAACAAAAGGCAGCAGACAGCTTCTCCAGACTTAAACGTCCCTGCCT
GACAGCTCTGAAGAGAGCAGTGGTTCTCCCAGCACCGCGTTCAAGCTCCGATAATAGACAGACTGCCTCCTCAAGTGGGTCCCTGACCCC
CGTGTAGCCTGACTGGGAGACATCTCCCAGTAGGCGCCGAAAGACACCTCAGAGAGGTAGATGCCCCACTGGAACGAAGCTTCCACAGTA
AGGATCAGGCAGCAATATTTGCTGTTCTGCAGCCTCCACTGGTGACACCCAGGCAAACAGGGTCTGGAGTGGACCTCCAGCAAACTCCAA
CAGACCTGCAGCTAAGGGGCCTGTCTATTAGAAGGAAAACTAACAGAAAGGAATAGCATCAACATCAAAAAAAGGACATCTACACCAAAA
CCCCATCCATAGGACACCAACATCAGAGACCAAAGGTAGGTAAAACCACAAAGATGGGGAGAAACCAGACCAGAAAGGCTGAAAATTCCA
AAAACCAGAATGCCTCTTCTCCTCCAAAGGAACACAACTCCTTGCCAGCAAGGGAACAAAACTGGACAGAGAATGAGTTTGACAAGTTGA
CAGAAGTAGGCTTCAGAAGGTCGGTAATAACAAACTTCTCCAAGCTAAAGGAGCATGTTCTAATGCGTCGCAAGGAAGCTAAAAATCTTG
AAAAAAGGTTAGACAAATGGCTAACTAGAATAACCAGTGTAGAGAAGAGCTTAAATGACCTGATGGAGCTGAAAACCACAGTACGGGAAC
TTCGTGAAGCATACACAAGCTTCAATAGCCAATTCGATCAAGTGGAAGAAAGGATATCAGTAACTGAAGATCAAATTAATGAAATAAAGC
GAGAGGACAAGATTAGAGAAAAAAGAGTGAAAAGAAATGAACAAAGCCTCCAAGAAATATGAGACTATGTGAAAAGACCAAATCTATGTT
TGATTGGTGTACCTGAAAGTGATGGGGAGAACAGAACCAAGTTTGAAAACACTCTTCAGGATATTATCCAGGAGAGCTTCCCCAACCTAG
CAAGGAAGGCCAACATTCAAATTCAGGAAATACAGAGAACACCACAAAGATACTCCTCAAGAAGAGCAACCCCAAGACACATAATTGTCA
GATTCACCAAGGTTGAAATGAAGGAAAAACTGTTAAGGGCAGCCAGAGAGAAAGGTCAGGTTACCCACAAAGGGAAGCCCATCAGATTAA
CAGCGGACCTCTGGGCAGAAACCCTACAAGCCAGAAGAGAATGGGGGCCAATATTCAACATTCTTAAAGAAAAGAATTTTCAACCCAGAA
TCTCATATCCAGCCAAACTAAGCTTCTTAAGTGAAGGAGAAATAAAATCCTTTACAGACAAGCAAATGCTGAGAGATTTTGTCACCACCA
GGCCTGCCTTACAAGAGCTCCTGAAGTAAGCACTAAAATGGACAGGAACAACCAGTACCAGCCACTGCAAAAACATGCCAAATGGTAAAG
ACCATCAACACTATGAAGAAACTGCATCAATTAATGGATGAAATAACCAGCTAGCATCATAATGACAGGATCAAATTCCCACATAACAAT
ATTAACCTTAAATGTAAATGGGATAAATGCCCCAATTAAAAGACACAGACTGGCAAATTGAATAAACAGTCAAGACCCATCAGTGAGCTA
TATTCAGGAGACCCATCTCATGTGCAAAGACACACATAGGCTCAGAATAAAAGGATGTAGGAAGATTTACCAAGCAAATGGAAAGCAGAA
AAAAGCAGGGGTTGCAATCCTAGTCTCTGATAAAACAGACTTTAAACCAACAAAGATCAAAAGAGACAAAGAAGGTCATTACATAATGGT
AAAGGGATCAATTCAACAAGAACAGCTAACTATCCTAAATATATATGCACCCAATACAGGAGCACCCAGATTCATAAAGCAAGTTCTACA
AAGAGATTTAGACTCCCACACAATATTAATGGGTGACTTTAACACCCCACTGTCAATATTAGACAGATCAACAAGACAGAAAATTAACAA
AGATATCCAGGACTTGAACTCAGCTCTGGACCAAGCAGACCTAATAGACATCGACAGAACTCTCCACCCCAAATCAACAGAATATACATT
CTTGTCAGCACCACATCACACTTATTCCAAAATTGACCACATAATTGGAAGTAAAGCACTCTTCAGCAAATGCAAAAGAACAGAAATCAC
AACAAACCGTCTCAGACCACAATGCAATCAAATTAGAACTCAGGATCAAGAATCTCACTCAACTGCACAACTGCATGGAAACTGAACAAC
CTGTTCCTGAATGACTACTGGGTAAATAACGAAATGAAGGCAGAAATAAAGATGTTCTTTGGAACCAACGAGAACAAAGACACAATGTAC
CAGAATCTCTAGGACATGTTTAAAGCAGTATGTAGAGGGAAATTTATAGCACTAAATGCCCACAAGTGAAAGCAGGAGTGATCTAAAATC
AACACCCTAACATCACAATTAAAAGAACTAGAGAAGCAAGACCAAACAAATTCAAAAGCTAGCAGAAGGCAAGAAATAACTAAGATCAGA
GCAGAACTGAAGGAGATAGAGACTCAACAAACCCTTCAAAAAATCAGTGAATCCAGGAGCTAGTTTTTTGAAAAGATCAACAAAATTGAT
AGACCGTTAGCAAGGCTAAAAAAGAAGAAAAGAGAGAAGAGTCAAATAGATGCAATAAAAAATGATAAAGGGGATATCACCACTGATCCC
ACAGAAATACAAACTACCATCAGCGAATACTATAAACACCTCTACACAAATAAACTAGAAAATCTAGAAGAAATGGATAAATTCCTCGAC
ACATACACCCTCCCAAGACTAAACCAGGAAGAAGTTGAATCTCTGAATAAACCAGTAACAGGTTCTGAAATTGAGGCAATAATTAATAGC
CTACCAACCAAAAAAAGTCCAGGACCAGACGGATTCACAGCCAAATTCTACGAAAGGTACAAAGAGGTGCTGGTACCATTCCTTCTGAAA
CTATTCCAATCAATAGAAGAAAAGGGAATCCTCCCTAACTCATTTTATGAGGCTAACATCATCCTGATACCAAAGCCTGGCAGAGACACA
ACAAAAAAAGAGAATTTTAGGCCAATATCCCTGATGAACATCGATGCGAAAATCCTCAATAAAATACTGGCAAACCGAATCCAGCAGCAT
ATCAAAAAGCTTATCCACCACGATCAAGTCAGCTTCTTCCCTGGGATGCAAGGCTGGTTCAACATATGCAAATCAATAAACATAATCCAT
CACATAAACAGAACCAACGGCAAAAACCACATGATTATCTCAATAGATACAAAAAAGGCCTTCAACAAAATTCAACAGCCTTTCATGCTA
AAAACCCTCAATAAACTAGGTATTGATGGAATGTATCTCAATATAATAAGAGGTTATTTATGACAAACCCACAGCCAATAGCATACTGAA
TGGGCAAAAGCTGGAAGCATTTCCTTTGAAGACCAGCACAAGGCAAGGATGCCCTCTCTCACCACTCCTATTCAACATAGTATTGGAAGT
TCTGGCCAGGGCAATCAGGCAAGAGAAAGCAATAAAGCATATTCAAATAGGAAGAGAGGAAGTCAAATTGTCTCTGTTTGCAGATGACAT
GATTGTATATTTAGAAAACCCCATCGTCTCATCCCAAAATCTCCTTAAGCTGATAAGCAACTTCAGCAAAGTCTCAGGATACAAAATCGG
TGTGCAAAAATCACAAGCATTCCTATATACCAATAATAGACAAAGAGCCAAATCATGAGTGAACTCCCATTCACAATTGCTACTAAGAAA
ATAAAATACAAAGCACTGCTCAAGGAAATAAGAGAGGACACAAACAAATGGAAAAACATTCCATGCTCATGGATAGGAAGAATCAATATC
ATGACAATGGCCTTGTTGCCCAAACTGATTTATAGATTCAATGCTATCCCCATCAAGCTACCACTAACTTTCTTCACAGAATTGGAAAAA
ACTACTTTAAGATTCATATGGAACCAAAAAAGAGCCCACCTAGCCAAGACAATCCTGGGCAAGAAGAACAAAGCTGGAGGCATCACACTA
CCTGACTTCAAACTTTACTACAAGCCTACAGTAACCAAAACAGCATGGCACTGGTACAAAAACAGATATGCAGACGAATGGAACAGAATG
GAGGCCTCAGAAATAACACCACACGTCTACCACCATCTGATCTTTGACAAACCTGACACACACAAGCAATGGGGAAAAGATTCCCTATTT
AATAAATGGTGTTGGGAAAACGGGCTAGCCATATGCAGAAAACTGTAACTGGACCCTTTCCTTACACCTTATACAAAAATCAACTCAAGA
TGGAACAAAGACTTAAACGTAAGACCTAGGACCATAAAAATCCTAGAAGAAAACCTGGGCAATACCATTCAGGACATAGGCATGGGCAAA
GACTTCATGTCTAAAACACCAAAAGCAATGGCAACAAAAGCCAAAATTGACAAATGGGTTCTAATTAAAGAGCTTCTGCACAGCAAAATA
AACTATCATCAGAGTGAACAGGCAACCTACAGAATGGGAGAACATTTTTGCAATATATCCATCTGACAAAGGGCTAATATCCAGAATCTA
CAAAGAACTTAAACAAATTTACAAGAAAAAAGCAAACAACCCCATCAAAAAATGGGCAAAGGATATGAACAGATACTTCTCAAAAGAAGA
CATTTATGCAGCCAACAGACATATGAAAAAATGCTCATCATCACTAGTCATTAGAGAAATGAAAATCAAAACCACAGTGAGATACCATCT
CATGCCAGTTAGAATGGCGATCATTAAAAATCAGGAAACAATAGATGCTGGAGAGGTTGTGGAAAAATTGGAACGCTTTTACACTGTTGG
TGGGAGTGCAAATTAGTCCGACCATTGTGGAAGTCAGTGTGACGACTCCTCAAGGATCTAGAACTGGAAATACCATTTGACCCAGCAATC
CCACTATTGGGCATATACCCAAAAGATTATAAATCATTCTACAATAAAGACACATGCACACGTATGTTTATTGCTGCACTATTCACAATA
GCAAAGATTTGAAACCAACCCAAATGCCCGTCAATGATAGACTGGATTAAGAAAATGTGGCACATGTATACCATGGAATACTATGCAGCC
ATAAAAAAGGATGAGTTCATGTCCTTTGCAGGGACATGGATAAAGCCGGAAACCATCATTCTCAGCAAACTATCACAAGATCAGAAAACC
AAACAACGCATGTTCTCACTCATAAGTGGGAGTTAAACAATGAGAACACATGGACACAGGGAGGGTAACATCACACACCAGGGCCTGTGG
GGGGTGGGGGGCTAAGGGAGGGATAACATTAGGAGAAATACCTAATGTAGGTGACAGGTTGGTGGGTGCAGCAAACCACCATGGCATGTG
TATACCTATGTAACAAAACTACATGTTCTGCACATGTAACCCAGAACTTAAAGTATAATAAAAAAAATAATTATTAAATTTTAAAAAACT
AGCCAGGCATGGTGCTGCACACCTGTAGTCCCAGCTACTTGAGAGGCTACATTGGGAGGATTGCCTGAGCTTGGGAGGTTGAGGCTGCAG
TTAGCTGTGACTGTGCCAGTGCACTCCAGCCTGGGCAACAGAGCAAGACCCTGTCTCAAAAAAAGAAAAAGAAAAATTCAGAGAGATTAA
AGAAGGTATCAAGAAATGTAGACACAATCCATGTTCATGAATTGGAAGATCAAATGTTGTTAAGATAGCAGTTCTCCCCAAATTAATCTA
CAATGCAATCCCTATCAAAATCACAGCAGGCTTTTTTGAAAAATTGACAAGCCAATCTTAAAATCTGTATGAAAACATAAAGGATTCAGA
ATAGCCAAAATAATTCTGAAAATGAAGAAATAATTCTGATCCAGAACTTACTACAAAGCTACATTAATCAAGACAGTGTGGTACTGATAT
AAAGATAGGCATACAGATCAGTGGAACAGAGTCCAGGAATAAACCTTCACATTTATGATCAATTAAGTTTTGACAAAAATCCCAATGAAA
TTATGGAGAAAAGATGGTCTTTTCAACAAATAGTGCTAGGATATTTGGATATCAAATGCAGAAGAAATTAATTTAGATTCTTACCTCCTA
CCATATGCAAAAATAAACTCAAAATTGATCACACACCTACATGTAAGAGCTAAAACTATAAAACATGTAGAAGAAAACATGGGAGAAAAC
CTAGATGACCTTGGTTTAGGAAGAATTCTTAAGACACTAATAGCACAATTCATAAAAGAAAATATTAATAAATTGGACTTCATTAAAATA
TAAAATTTTGTTTCAAAAAACTATTAAGAAAATTAATTGGCCCGGGGAGGTGGTTCACATCTGAAATCCCTGCACTTTCGGAAGCCAAGG
AGGGTGGACCACTTGAGCTCAGGAATTTGAGACCAGACTGGACAACAGAGCAAAATGCCATCTCCACAAAAAATACAAAAATTAACCAGG
CATGGTGGCGTGCTCCTGTAGTCCTGGCTACTCAGAAGGCTGAGGTGGGAGGATCTCTTGACCCTGGGAGGCAGAGGTTGCAGTGAGCCA
AGATCACACCACCGCACTAGAGCCTGGGTGACAGAGTGAGACCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAATTAATTGAAAAATCACA
GACTGGGAGAAAATATTTTCAAACCATAATAAGTATCTGATAGAGGACTTGTATCTAGACTATGTAAAGAATTCTTAAAACTCAAAAATA
AGGCAGACAACTTAAAAATGGACAAAATGTTTGAATAGATATTTCAGCAAAGATATACAAATTGCTTAGCATATGAAGAGATGTGTACTA
TCACTAGTCATTAGGAAAATACAAGTTAAAAGCAAAATTAGATACCATTTTGGACCCACTAAAATGACTATAATAAAAAAGACAGACAAA
GATATGTGTTGGTGATGATGTGGAGAAACTGGAGCCCTAATGCATTGCTGGTGGGAATGTAAAATGGTGCAGCCACTTTGGAAAACAGTT
TGGCAGTTTCTTAAAAAGATAAACATAAGTTTACCATATGATCCTGCTATTCCATGAGAAGAGAAGTGGAAATGTGTTCACATCAAGACT
CGTAGGCAAATGTTCATAGCATTATCATTCATATTAGTCAAAAAGTGGAAACCAAATGACCATCAACTACTGGATTTTTTTTTTTTTTTT
AAGAGATGAGGCCTCACTATGTTGCATACTCTGAAGTCAAACTCCTGGGCTCAAACAATCCTCCTGCCTCAGCCTCCTCAGTAACTGGGA
CTGCAGGCAGGCACCAACATACCCAGATTATTTCTTTTTCTTTTTTTTTTTAACTGGTGGATTTCTTTAAATGATATATGTATACAATGG
AGTAGTGATATAGGCTACAATATGGATGCATCTCAAAACATTATGCTTAGTGAAAGAAGTCTGATGCAATATCCCACATATGGTATGTTT
CCATTTACAGTCCAGAAAAGGCATATACTAAATTAGCAGTTGCATGGGTCTGATGTGAAAACATGGATTGCCTGCAGATGGGCACAAGGG
ATCTTTTGGGGGTGACAAAAATGTTCCAAAACTAAGTTGTAATTTTTGCACAACTTTTATGTGTGTGTGTGTGTGTGTGTGTGAGATGGA
GTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGCGATCTCAGCTCACCACAACCTCCGCCTCCTGGGTTGAAGCATTTCTCCTGCC
TCAGCTTCCTGAGTAGCTGGGATTACAGGCATGTGCCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACAGGTTTTCTCCAGGTTG
GTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCTCCTGCCTCGGCCTCCCAAAGCGCTGGGATTACAGGCGTGAGCCACCACACCC
AGCCATTTTTGCACAACTTTATAAACTTTAAAAATAATTGATTTATGCACTTAAAACAGGTAAAGTTTATGTGTATAAATTATACCTTAA
TAAAGCTATTAAAAGTCAAAGATTATAACAGGGCCTCTCTCTCTCTGACCTAGTGACCTAGGGTAAAGAGAAAAAGAAGCTAGCCAGGCA
CAGGGGCTCACACCTGTAATCCCAGCACTTTGGGAAGCCAAGATGGGCTGATTGCTTGAGTCCAGGAGTTTGAGACCAACTTGGGCAACA
TAGCAAAACCCTGTCTCCACCAAAAATAAAAAAAATTAGCCAGGCATGGCGGTGTATGCCTGGAGTCCCAGCTACTCAGGAGTCAGAGGT
GGGAGGATCACTTGAGCCCAGGAGGCAGAGGTTGTAGGGAGCCAAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACACTG
TCTCAAAAATTAAAAATTAAAAAATGAGGGAAGCTGCTGTATCTCCACTTCTTCCCTCTCTGTGCCCAGAGATATCTCTTCAGTTATCTC
ACATGCCCTACAAGTCTAGAGACCTCAGGTGAGGAGCCAGTAGCTCAGTATAGAAACTAAGGATCCAAGTGGACAACTGCCACCAAGTCA
CCACAGGGCCAGCTGCTTTGGGAGGGTGCTGCATCTGCCTCCCATACACTTCTGCCAAGTTTATGTTAGTTTGGGAGGACTGAAGCAGAA
TTCAGTTCAAAGTACTGTGCTGGATTTTGGTTTCTAAATATTTTCCAATAGAAAAGAACCCAGGCTTCTTGAGAAAATAGCTAGGTTCTA
AGGCTAGAGCCAAAAAAATGCAAGATAAGCCTGGAGCATCTTGTAGTACCAGAAACTAAGCAAGTGCTCAAAAACAAAAGGATAGAAGCA
TGTCAGACAGACACAGGAGCCAATCTGAAAGAGCTCCCTGGCCGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACTGAG
GTGGGAGGATGACTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACATAGGGAGACCCCATCTCTACAAAAAAGTAAACAATTAGCCGG
GCATGGTGGCACACGCCTATAGTCCCAGCTACTCAGGAGGGTGAAGATCACCTGAGACCAGGCGGTCAAGGCTTCAGTGAGCCATGATTG
TGGCACTGCACTCCAGCCTAGGCAATAGAGTGAGACTGTCTCAAAAAATAAAATTTTAAAATAACTGAAGAGTATAACTGGATTGTTTGT
AACACAAAGGATAAGTGCTTAAGATGATGGAAACCCTATTTATCCTGATGTGATTATTACACATTGCATGCCTGTACCAAAATATTTCAT
GTAACCCATAAATATATACATCTACTATGTACCCACAAAAATTAAAAAATGTTTACAGGAGTGAACCACCGCACCTGGCCAGTGGAGTCT
TTTTAAGGTATTATTTAGCATCTTCTGCTTATAGTCATGTCCAAAAACCAGTTGATCTTCCTACTCATTAGGGGACAAGATCAATTCTCT
AAAAAATTAACCTAGCCCAAGGTAAGTGGTACTATTCTGAAATCTGAAAATCTTTAGTAGCCTCACATTATAAGCCCTTCGTAGAAAAAG
AAAAGTAAGCATTTCTAGAAGCACATTTTTGTTGGACTGAGGGTGGGGCAAGGAGCAGGGGTGACTTTCATCTGAAATGTACCTAGGCAG
GCCAGAGTCTGAGTTAGGACTGGCTCCTGGGACTTTGCCATCCAGGCCAAGAAGCATGCTCCAGTGTGCATGCACTCTCATCAAAGCCCT
AGTCAGGAATCCCAGCCACTCCTCTCCTGTGCAGCACAAGCTGAAGGATAAGGTGTGGGGCAGTGACTGCGTGGGGCTGCCTGTGTGATT
CCTGATAAAGAAATGCCTTCATGAAATGTATTGTTCCCCAATAAAGCTCATTTTCTGTGAGAATTCATGTGTCCTTTTCCAAATTAAACT
AGCAAAATATGAACTTTTGTAAAAGGTCCACACCCAGCCAGTTTTCTACTCTCTAAATGTTCAGGCCTTTGCCTGTCCTTCCCTCAGCAA
AAATACTGTGTTTTGGAAAACATTACCAATAAAGGAGCTGGGAGGTGGAATTGGATCAAAATACCTTTAGATGAAAGCAGCAGCACAAGC
CATTCCCTTTAAATGAGCTGGCCTCACCTCTGGGGCCTATGAAGAAAAGCCTGCTTCAAGGTGATAGTTTTCATTTTGCTTCCCAGCACC
TCTGCAGTCATAACCAAAGTGAAGGACAATATTGCATGACTTCAGAAGAAAGCCATCCAGCCACCTTGCAACATGTTCAGGAAATTCTGG
ACTCCCTTGGGGCTTGCAAAACTCCCTATGTCTTGCAGACCAAAAGCAAGTTCTCAGTCACCTAGCTCTAGTTTGCATAATTAAAGAAAG
TGGAAGCTGGTTCTTTTCTGGGTGACCCTTCACCCAACCAAGCTCATAAGGACTTGTGACAAAAATAAGAGCAATAAAATGAAGTTTTAA
CAGTGAAAACTTCTATCACTTAGATAAGCAGGAAAAGCCAGTCCCCTAGATGCCCATCTGACCCTACCTTACTGGGGTCATACAGCCAAA
GCAGTGTCCACTTCAGGTACTGTAATGTTTTGAAGTTGACACATATAATTTAATGTAGTTTCATGTCATAAGTTATAAGACTTTTCAGAG
AAACAATTTAGTAATATCTTCTGTAATACCCATCTTCATTTTTTATATGAAAAAGCATAGCCTATGATCTGTCACCTTGCTCACTCCCAC
ATCCTTACCTCTTATCCTTCTCACATCGTCCCATTAACACATTATCCATCTTTGGGGGGAAAAAATACACTAAATTTTAGACAGAGTCAC
TTTCACTATGGCCACAATGGGAGAAAAGACAGTCCACCTTCAAAGTCAACCAGAATGACTCTTAACCTCTCTTGTCTGGGTTGGGCATCC
AGATAAGATTTTCTTCGTACAAAGAGTCTTGCTACTAGGAAAAAGAGTTTGAAAATCACTAGTCTAACTAAATATCTCACTTTAAAAAAA
GCACAAACTAAGACTCAATGAGGTTTATCTTCCACAAGATCAGCCAGTTTTAGCAGAGCAGTTGCTAAAACCCAGGTCTCAAACTCCTTG
TCTATGGCTCATCTAACTAAGCAACAAAAAGCCCAATGAGCTCTGGAGAGAGAGAGGGAGCTAAAACAGGACTCAATCAAAACCCACTTG
GGATTAGGGAAGCCACCCTCTGTGAGTGAGTTAAACTGAGATTCCCTCCCCTTCACCCTGGCTTCCTTTGCAGAACAAGGGTCACCGCCA
GAGGGAAAGCTGAGTTTACGGAGGGGATCCTGGTTGGAGTCAGAGTATACCTTGGTTTGGTTTTGTGGGGTTTTTTGAGACAGGGTCTCA
CTGTCACCCAGGCTGGAGCACAGTGACAGTCATAGCTCACTATAGCCTCAGACTCCTGGCCTCAAGCGATCCTCCCACCTCAACCTCCAG
AGTATCTGGGACTATAGGCACGTACCACCATACCCAGCTAATATTTTTTTTAATTTTATATTTTTTAGAGACAGGGTGTCACTATGTTAC
CCAGGTCTCAATCACTATGTTACTCCTTGCCTCAAGCAATCCTCTCACCTTGGCCTCCCAAAGTGCTGAGCTTACAGGTGTCAACCACTG
TGGCCAGCCACGCATTGGTTTTAAGGTCCAGAATTTTTCTGTTTGGAGCCTTCACAATTAGTTTTAGGTTGGGAGACCGTGAACCCACCA
AGCAGCCCTTTAGAGGCTGGAAAAAGAGTTTGGAAAAAGAACTCTGTGGCTTTAGGAATTTCTCTCGGAAATCCTCTAGGGCAGAGAAGG
AAAATTTACCAAATGGGAGAGTGTATTAGTCTATTCTTACATTGCTATAAGGAAATACCCCAGACTGGGTAATTTATAAAGGAAAGAGTT
TTAATTGACTCACAGTTCCACATGGCTGGGAAAGCCTCAGGAAACTTACAATCATAGCAGAAGGCAAAGGGGAAGAAAGGCACCTTCTTC
ACAGGGCGGCAGGAAGGAGAAGTGCAGAGCAAAGTGGGGCAAAGCCTCTATAAAGCCATCAGATCTCATGAGAACTCACTATCATGAGAA
CAGCAGGGGAGAACCACCCCCATGATCCAATCACCTTCCACGAGGTCCCTCCCCCAACACGTGGGGATCACAATTTGGATTACAATTCAA
GATGAGATTTGGGTGAGGACACAGAGCCGGACCATATCAGAGAGAAAGCTATTACTGAAGACCTTTCTAACTCACTTCTGTAAAGATCAA
TTCAATAAAAGCAGCAAACACACATACTTTGCTTTCCTTGTGATTAATGCCTTGACTTTTTTGTGGAAAGTAACACCCCAAGAAAGCCAG
CTACTCATGTTGGCAATAAAGGTAAAAGTATCTATGGAATAAGGACCATTTTTAGGACAATACTTTCCCTACTACTTAGTTCTAGTCCCT
TTTTTGTAGAATTCTGAGGACTTTCTACATACACAATCATGTCATCAGCAAATAAAGATTATTGTACTTGTTCTTTGCCAACCCATATGT
CTTGCCTTACTGCCCTGGTTAGGACCTTCAGAACAATACTGGATATAAGTGGTGAAAGCACATATCCTCCCCTTGTTCCTAATTTTAGAG
GGAAAGTACTCAGTCTTTCGCCATTAAGTACAATGTCAGCTGTAAGTTTTCCTAGAGACCCTTTCTCAGCTTGAAGATGTTCCCTGGTAT
TCATAGTTTGCTAAAAGGTTTTTGTCATTTTAAATCATAAATGGGTGTTGAATTTTGTCAAAGGCTTTTAATGCATCTATGGAGATGATC
CAAGTTTTTTTCCTCCTTATTTCTGCTAAGGTTGTATAATTATGCTCATTGGTATTTTAAATGTTAAATTAACCTTGCGTTCCTGGGATA
AGACCCACTGATCATGATGCATTTTCCTCTTTGTAAATTGCTGTATTCATTTTAGTTTCTTCAGGATTTTGCCTATGTTTGAAGGATATT


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FusionGenePPI for ADCY2_RPAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADCY2ADCY5, GNASRPAP2G3BP1, URI1, RPAP3, KHDRBS2, PIH1D1, POLR2A, POLR2B, POLR2H, RUVBL2, GPN1, POLR2J, POLR3A, POLR2G, PDRG1, MED17, INTS1, CCT5, PPP1CA, TCP1, INTS7, UXT, POLR3B, KHDRBS3, INTS4, GPN3, INTS3, MED4, GTF3C3, YBX1, EIF4A2, POLR2C, EHBP1, POLR3E, HELLS, LRCH2, RXRG, NELFE, PRPF31, DNM2, MED24, TOPBP1, ARMCX3, POLR2D, RFC4, BRCA1, ITCH, NEDD4, RPRD1B, PPP1CC, POLR2M, DXO, MED19, OFD1, CEP120, FGFR1OP, CNTRL, XPO1, POLR2F, WWP2, LMO2, ASB6, POLR2E, CPNE2, MED1, ZFC3H1, SYDE1, MED18, MED21, RNGTT, ZNHIT2, WDR92


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+725905_9223691092GNAS
HgeneADCY2chr5:7698487chr1:92846281ENST00000338316+725990_9933691092GNAS


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADCY2_RPAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneADCY2Q08462DB09121AurothioglucoseAdenylate cyclase type 2small moleculeapproved|withdrawn

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RelatedDiseases for ADCY2_RPAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADCY2C0004096Asthma1CTD_human
HgeneADCY2C0005586Bipolar Disorder1PSYGENET