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Fusion gene ID: 825 |
FusionGeneSummary for ADCY2_RPAP2 |
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Fusion gene information | Fusion gene name: ADCY2_RPAP2 | Fusion gene ID: 825 | Hgene | Tgene | Gene symbol | ADCY2 | RPAP2 | Gene ID | 108 | 79871 |
Gene name | adenylate cyclase 2 | RNA polymerase II associated protein 2 | |
Synonyms | AC2|HBAC2 | C1orf82|Rtr1 | |
Cytomap | 5p15.31 | 1p22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | adenylate cyclase type 23',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 2adenylate cyclase 2 (brain)adenylate cyclase IIadenylate cyclase type IIadenylyl cyclase 2type II adenylate cyclase | putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q08462 | Q8IXW5 | |
Ensembl transtripts involved in fusion gene | ENST00000338316, ENST00000537121, ENST00000513693, | ENST00000610020, ENST00000484158, | |
Fusion gene scores | * DoF score | 20 X 19 X 5=1900 | 1 X 1 X 1=1 |
# samples | 21 | 1 | |
** MAII score | log2(21/1900*10)=-3.17753818555219 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ADCY2 [Title/Abstract] AND RPAP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-FD-A3SR-01A | ADCY2 | chr5 | 7698487 | + | RPAP2 | chr1 | 92846281 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000338316 | ENST00000610020 | ADCY2 | chr5 | 7698487 | + | RPAP2 | chr1 | 92846281 | + |
5CDS-intron | ENST00000338316 | ENST00000484158 | ADCY2 | chr5 | 7698487 | + | RPAP2 | chr1 | 92846281 | + |
In-frame | ENST00000537121 | ENST00000610020 | ADCY2 | chr5 | 7698487 | + | RPAP2 | chr1 | 92846281 | + |
5CDS-intron | ENST00000537121 | ENST00000484158 | ADCY2 | chr5 | 7698487 | + | RPAP2 | chr1 | 92846281 | + |
intron-3CDS | ENST00000513693 | ENST00000610020 | ADCY2 | chr5 | 7698487 | + | RPAP2 | chr1 | 92846281 | + |
intron-intron | ENST00000513693 | ENST00000484158 | ADCY2 | chr5 | 7698487 | + | RPAP2 | chr1 | 92846281 | + |
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FusionProtFeatures for ADCY2_RPAP2 |
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Hgene | Tgene |
ADCY2 | RPAP2 |
Catalyzes the formation of the signaling molecule cAMPin response to G-protein signaling (PubMed:15385642). Down-streamsignaling cascades mediate changes in gene expression patterns andlead to increased IL6 production. Functions in signaling cascadesdownstream of the muscarinic acetylcholine receptors (Bysimilarity). {ECO:0000250|UniProtKB:P26769,ECO:0000269|PubMed:15385642}. | Protein phosphatase that displays CTD phosphataseactivity and regulates transcription of snRNA genes. Recognizesand binds phosphorylated 'Ser-7' of the C-terminal heptapeptiderepeat domain (CTD) of the largest RNA polymerase II subunitPOLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD,thereby promoting transcription of snRNA genes.{ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:22137580,ECO:0000269|PubMed:24997600}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 295_300 | 369 | 1092 | Nucleotide binding | ATP |
Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 337_339 | 369 | 1092 | Nucleotide binding | ATP |
Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 1_45 | 369 | 1092 | Topological domain | Cytoplasmic |
Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 108_128 | 369 | 1092 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 133_153 | 369 | 1092 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 159_179 | 369 | 1092 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 187_207 | 369 | 1092 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 46_66 | 369 | 1092 | Transmembrane | Helical |
Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 76_96 | 369 | 1092 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 1019_1021 | 369 | 1092 | Nucleotide binding | ATP |
Hgene | >ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 1026_1030 | 369 | 1092 | Nucleotide binding | ATP |
Hgene | >ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 208_601 | 369 | 1092 | Topological domain | Cytoplasmic |
Hgene | >ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 822_1091 | 369 | 1092 | Topological domain | Cytoplasmic |
Hgene | >ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 602_622 | 369 | 1092 | Transmembrane | Helical |
Hgene | >ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 628_652 | 369 | 1092 | Transmembrane | Helical |
Hgene | >ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 680_701 | 369 | 1092 | Transmembrane | Helical |
Hgene | >ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 734_755 | 369 | 1092 | Transmembrane | Helical |
Hgene | >ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 763_780 | 369 | 1092 | Transmembrane | Helical |
Hgene | >ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 801_821 | 369 | 1092 | Transmembrane | Helical |
Tgene | RPAP2 | chr5:7698487 | chr1:92846281 | ENST00000610020 | + | 10 | 13 | 33_68 | 562 | 613 | Coiled coil | Ontology_term=ECO:0000255 |
Tgene | RPAP2 | chr5:7698487 | chr1:92846281 | ENST00000610020 | + | 10 | 13 | 77_160 | 562 | 613 | Zinc finger | RTR1-type |
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FusionGeneSequence for ADCY2_RPAP2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_ADCY2_ENST00000338316_chr5_7698487_+_RPAP2_ENST00000610020_chr1_92846281_+_420aa MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFF AIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSAT PGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAG QMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK >In-frame_ADCY2_ENST00000537121_chr5_7698487_+_RPAP2_ENST00000610020_chr1_92846281_+_240aa MDLRWARDLHLREASRSVAFTTLRLGAVTTGLLTFREPGDKEKSGKGLGKRWRIQREESQERLLLSLLPAHIAMEMKAEIIQRLQGPKAG QMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_ADCY2_ENST00000338316_chr5_7698487_+_RPAP2_ENST00000610020_chr1_92846281_+_1260nt ATGTGGCAGGAGGCGATGCGGCGCCGCCGCTACCTGCGGGACCGCTCCGAGGAGGCGGCGGGCGGCGGAGACGGGCTGCCGCGGTCCCGG GACTGGCTCTACGAGTCCTACTACTGCATGAGCCAGCAGCACCCGCTCATCGTCTTCCTGCTGCTCATCGTCATGGGCTCCTGCCTCGCC CTGCTCGCCGTCTTCTTCGCGCTCGGGCTGGAAGTTGAAGACCATGTGGCGTTTCTAATAACAGTTCCAACTGCCCTGGCGATTTTCTTT GCGATATTTATCCTGGTCTGCATCGAGTCTGTGTTTAAGAAGCTGCTGCGCCTCTTCTCGTTGGTGATATGGATATGCCTTGTTGCCATG GGATACCTGTTCATGTGTTTTGGAGGCACCGTCTCTCCCTGGGACCAGGTATCGTTCTTCCTCTTCATCATCTTCGTGGTGTACACCATG CTGCCCTTCAACATGCGAGACGCCATCATTGCCAGCGTCCTCACCTCCTCCTCCCACACCATCGTGCTTAGCGTCTGCCTGTCTGCAACA CCGGGAGGCAAGGAGCACCTGGTCTGGCAGATCCTGGCCAATGTGATCATTTTCATCTGTGGGAACCTGGCGGGAGCCTACCATAAGCAC CTCATGGAACTCGCTCTTCAGCAAACATATCAGGACACCTGTAATTGCATCAAGTCGCGGATCAAGTTGGAATTTGAAAAACGTCAACAG GAGCGGCTTCTGCTCTCCCTGCTGCCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGC CAGATGGAGAACACAAATAACTTCCACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACC CGGCTGGCAAGTGACTGCTCCCCGGGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAA TGCATGAGAATTAAAATTTTAGGAGACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAA ATGGGGCTGGACATGTGTGAAGCCATAAAACTGACCCCAATTCTTGGCATTCAGAAACATTCTCAGGAAGGTATGGTGTTTACACGGTTT CTAGACACCCTCCTTGAAGAATTACATCTAAAAAATGAAGACCTTGAAAGTCTAACCATCATATTTAGAACCAGCTGTTTACCAGAGTGA >In-frame_ADCY2_ENST00000537121_chr5_7698487_+_RPAP2_ENST00000610020_chr1_92846281_+_720nt ATGGACCTGCGCTGGGCCAGAGATCTGCATTTGAGAGAAGCCAGCAGATCAGTAGCATTTACCACCCTGAGGCTGGGCGCAGTCACCACG GGACTCCTGACATTCAGAGAGCCAGGAGATAAAGAGAAGTCAGGAAAGGGCCTTGGGAAGAGATGGCGCATCCAGCGAGAGGAAAGCCAG GAGCGGCTTCTGCTCTCCCTGCTGCCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGC CAGATGGAGAACACAAATAACTTCCACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACC CGGCTGGCAAGTGACTGCTCCCCGGGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAA TGCATGAGAATTAAAATTTTAGGAGACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAA ATGGGGCTGGACATGTGTGAAGCCATAAAACTGACCCCAATTCTTGGCATTCAGAAACATTCTCAGGAAGGTATGGTGTTTACACGGTTT CTAGACACCCTCCTTGAAGAATTACATCTAAAAAATGAAGACCTTGAAAGTCTAACCATCATATTTAGAACCAGCTGTTTACCAGAGTGA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_ADCY2_ENST00000338316_chr5_7698487_+_RPAP2_ENST00000610020_chr1_92846281_+_16394nt AGGCGGCGCGGGGGTGGGACGCGGGCGGCCGCGGCGAGCGGCGCTGCCCGGGCCGGGCGCGCACGGCGGGCGCCCTGTGAGCGGCCCCGA TGTGGCAGGAGGCGATGCGGCGCCGCCGCTACCTGCGGGACCGCTCCGAGGAGGCGGCGGGCGGCGGAGACGGGCTGCCGCGGTCCCGGG ACTGGCTCTACGAGTCCTACTACTGCATGAGCCAGCAGCACCCGCTCATCGTCTTCCTGCTGCTCATCGTCATGGGCTCCTGCCTCGCCC TGCTCGCCGTCTTCTTCGCGCTCGGGCTGGAAGTTGAAGACCATGTGGCGTTTCTAATAACAGTTCCAACTGCCCTGGCGATTTTCTTTG CGATATTTATCCTGGTCTGCATCGAGTCTGTGTTTAAGAAGCTGCTGCGCCTCTTCTCGTTGGTGATATGGATATGCCTTGTTGCCATGG GATACCTGTTCATGTGTTTTGGAGGCACCGTCTCTCCCTGGGACCAGGTATCGTTCTTCCTCTTCATCATCTTCGTGGTGTACACCATGC TGCCCTTCAACATGCGAGACGCCATCATTGCCAGCGTCCTCACCTCCTCCTCCCACACCATCGTGCTTAGCGTCTGCCTGTCTGCAACAC CGGGAGGCAAGGAGCACCTGGTCTGGCAGATCCTGGCCAATGTGATCATTTTCATCTGTGGGAACCTGGCGGGAGCCTACCATAAGCACC TCATGGAACTCGCTCTTCAGCAAACATATCAGGACACCTGTAATTGCATCAAGTCGCGGATCAAGTTGGAATTTGAAAAACGTCAACAGG AGCGGCTTCTGCTCTCCCTGCTGCCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGCC AGATGGAGAACACAAATAACTTCCACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACCC GGCTGGCAAGTGACTGCTCCCCGGGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAAT GCATGAGAATTAAAATTTTAGGAGACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAAA TGGGGCTGGACATGTGTGAAGCCATAAAACTGACCCCAATTCTTGGCATTCAGAAACATTCTCAGGAAGGTATGGTGTTTACACGGTTTC TAGACACCCTCCTTGAAGAATTACATCTAAAAAATGAAGACCTTGAAAGTCTAACCATCATATTTAGAACCAGCTGTTTACCAGAGTGAT ATATTCCATGAAGACAAAATAGAAGATGAACTTCTATTCACCGTTTCTGGAATTCTAGCCGCCATGATGGTCTGGTGGTGACTGATAACT AGTTTTATTCCAAGACATACCTTTACCTCTTTAAGTTTCAATCTCCCATCTCCCAGTCCTTCAGTCCCCAACTGCAGAGGATGACCTCCC CAGATAGAGGAGAATCATTACTCCAACAAGAATAACCAAGTCTTTGTATCCCTAGTACAAGACATAGTATTTTTATTCGAAAATGAATGT TTAAGTATTAAATTGAAACTTGAATGAATATTCAAGAAAATATAATGATCTCTACTTTTTCTGGATGATTTCCAGCCATCATATCAGTTT GCCAAAAAAATTGAGAAAGTTATGATTTTGACCTCCCAACCTAAACTCTAAATTCTAAAGATCAGTAAACAATTAGGTCAATAAATACAT ACAATTTAAGATGAAGCCCTTTGGAAGTCTAGTCCAAAACAGGAAAATCTCAGAACTTTCTGGACTCAAGGAAATGCTTTAAATGGAATC TGTAGTTTGTTTGCAGGAGAGACAATTTCTAGAATTTAGATTGCTTTTCAAAATGTTTATCAGGTAGGCAAGTTAGCAGTTGAGGCGGAA CACAGACAACTTGGGGAGCTTTACTGGAAGGCCAAGAAAATACTCTTGGACACTGGAGGAAATGACAGCTACTAAAGCCCAATCATGGAA AAGGACCAGAAAGCAGCCCACTGGAATGGGGAGCTTAGTGGGCAAGGAGGTAGGGATATAATTTCTCTTCTTGGCTCCACCAGTAATTAG CTCTGTGGCCCAGTCACCTAAACTTTCTGGACTTCAGTTCAGGTTGTATGGCAGTAGGCCATAGAATTGGCTACTGCCATACAATCTCTA TGGGAAAGGACTGCAAAAACTAAATTTTATCTCTGTATGGGCAAAGGCTACTGTCATCCTGTTGTTGGTCTGGGGCCACTCTGACAATTT TTTTTAACCTCATTTGATTGTGTAAGGGTCTAACCACAACAAAAAATCATAGTGTAATAGAATTAATCAAGTTCAGCAAGGTCACAGGCT AGATCAATATACAGAAAATCAATTGTATTTTTCTGTTCAGAAAACTCCAAAAATGAAATAAAGAAAATTGTGTTCACAATATCACCAAAG AGAATTAAATACTTAGGAATAAATTTAACAAAATAAGTATAAGACTTGTATAACGAAAACTATAAAACATTCAAGAGGGCTGGGCATGGT GGCTCATGCCTTTAGTTCTAGCACTTTGGAGGCAGAGGCAGGAGGACTGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCAACAAAGTG AGACCCTGTCTCCACAAAAAATAAAAATAAAAATAAATTGAAGATGGCCGAATAGGAACAGCTCCAGTCTACAGCTCCCAGCAGGATGGA CACAGAAGATGGGTGATTTCTGCATTTTCAACTAAAGTACCTGGTTCGTCTCACTGGGACTGGCTGGACAGTGGGTGTAGCCCACAGAGG GTTAGCCGAAGCAAGGTGGGGCATCGCCTCACCTGGGAAGCGCCAAGGGGTCGGGGGATTTCCCTTTCCTAGCCAAGGGAAGCCGTGAGT GACTATACCTGGAGGAGGGGTACACTCCTGCCCAAATACTGCTCTTTTCCCACAGTCTTCGCAACTGGCAGACCACGAAATCCCCTCCCA TGCCTGGTTCAGTGGGTCCCACGCCCACAGAGCCTTGCTCACTGCTAGCGCCAGCAGTCTGAAATCGACCTGGGACGTGGGAGCTTGGCG GGGTAGAGGTGTCCGCCATTGCTGAGGCTTGAGTAGGCGGTTCTATGCTCACAGTGTAAACAAAGCAGCAGGGAAGCTCAAACTGGGCAG AGCCCACCACAGCTCAGCAAGGCCTACTGTCTCTGTAGATTCCACCTCCAGGGGCAGGGCATATCTGAACAAAAGGCAGCAGACAGCTTC TCCAGACTTAAACGTCCCTGCCTGACAGCTCTGAAGAGAGCAGTGGTTCTCCCAGCACCGCGTTCAAGCTCCGATAATAGACAGACTGCC TCCTCAAGTGGGTCCCTGACCCCCGTGTAGCCTGACTGGGAGACATCTCCCAGTAGGCGCCGAAAGACACCTCAGAGAGGTAGATGCCCC ACTGGAACGAAGCTTCCACAGTAAGGATCAGGCAGCAATATTTGCTGTTCTGCAGCCTCCACTGGTGACACCCAGGCAAACAGGGTCTGG AGTGGACCTCCAGCAAACTCCAACAGACCTGCAGCTAAGGGGCCTGTCTATTAGAAGGAAAACTAACAGAAAGGAATAGCATCAACATCA AAAAAAGGACATCTACACCAAAACCCCATCCATAGGACACCAACATCAGAGACCAAAGGTAGGTAAAACCACAAAGATGGGGAGAAACCA GACCAGAAAGGCTGAAAATTCCAAAAACCAGAATGCCTCTTCTCCTCCAAAGGAACACAACTCCTTGCCAGCAAGGGAACAAAACTGGAC AGAGAATGAGTTTGACAAGTTGACAGAAGTAGGCTTCAGAAGGTCGGTAATAACAAACTTCTCCAAGCTAAAGGAGCATGTTCTAATGCG TCGCAAGGAAGCTAAAAATCTTGAAAAAAGGTTAGACAAATGGCTAACTAGAATAACCAGTGTAGAGAAGAGCTTAAATGACCTGATGGA GCTGAAAACCACAGTACGGGAACTTCGTGAAGCATACACAAGCTTCAATAGCCAATTCGATCAAGTGGAAGAAAGGATATCAGTAACTGA AGATCAAATTAATGAAATAAAGCGAGAGGACAAGATTAGAGAAAAAAGAGTGAAAAGAAATGAACAAAGCCTCCAAGAAATATGAGACTA TGTGAAAAGACCAAATCTATGTTTGATTGGTGTACCTGAAAGTGATGGGGAGAACAGAACCAAGTTTGAAAACACTCTTCAGGATATTAT CCAGGAGAGCTTCCCCAACCTAGCAAGGAAGGCCAACATTCAAATTCAGGAAATACAGAGAACACCACAAAGATACTCCTCAAGAAGAGC AACCCCAAGACACATAATTGTCAGATTCACCAAGGTTGAAATGAAGGAAAAACTGTTAAGGGCAGCCAGAGAGAAAGGTCAGGTTACCCA CAAAGGGAAGCCCATCAGATTAACAGCGGACCTCTGGGCAGAAACCCTACAAGCCAGAAGAGAATGGGGGCCAATATTCAACATTCTTAA AGAAAAGAATTTTCAACCCAGAATCTCATATCCAGCCAAACTAAGCTTCTTAAGTGAAGGAGAAATAAAATCCTTTACAGACAAGCAAAT GCTGAGAGATTTTGTCACCACCAGGCCTGCCTTACAAGAGCTCCTGAAGTAAGCACTAAAATGGACAGGAACAACCAGTACCAGCCACTG CAAAAACATGCCAAATGGTAAAGACCATCAACACTATGAAGAAACTGCATCAATTAATGGATGAAATAACCAGCTAGCATCATAATGACA GGATCAAATTCCCACATAACAATATTAACCTTAAATGTAAATGGGATAAATGCCCCAATTAAAAGACACAGACTGGCAAATTGAATAAAC AGTCAAGACCCATCAGTGAGCTATATTCAGGAGACCCATCTCATGTGCAAAGACACACATAGGCTCAGAATAAAAGGATGTAGGAAGATT TACCAAGCAAATGGAAAGCAGAAAAAAGCAGGGGTTGCAATCCTAGTCTCTGATAAAACAGACTTTAAACCAACAAAGATCAAAAGAGAC AAAGAAGGTCATTACATAATGGTAAAGGGATCAATTCAACAAGAACAGCTAACTATCCTAAATATATATGCACCCAATACAGGAGCACCC AGATTCATAAAGCAAGTTCTACAAAGAGATTTAGACTCCCACACAATATTAATGGGTGACTTTAACACCCCACTGTCAATATTAGACAGA TCAACAAGACAGAAAATTAACAAAGATATCCAGGACTTGAACTCAGCTCTGGACCAAGCAGACCTAATAGACATCGACAGAACTCTCCAC CCCAAATCAACAGAATATACATTCTTGTCAGCACCACATCACACTTATTCCAAAATTGACCACATAATTGGAAGTAAAGCACTCTTCAGC AAATGCAAAAGAACAGAAATCACAACAAACCGTCTCAGACCACAATGCAATCAAATTAGAACTCAGGATCAAGAATCTCACTCAACTGCA CAACTGCATGGAAACTGAACAACCTGTTCCTGAATGACTACTGGGTAAATAACGAAATGAAGGCAGAAATAAAGATGTTCTTTGGAACCA ACGAGAACAAAGACACAATGTACCAGAATCTCTAGGACATGTTTAAAGCAGTATGTAGAGGGAAATTTATAGCACTAAATGCCCACAAGT GAAAGCAGGAGTGATCTAAAATCAACACCCTAACATCACAATTAAAAGAACTAGAGAAGCAAGACCAAACAAATTCAAAAGCTAGCAGAA GGCAAGAAATAACTAAGATCAGAGCAGAACTGAAGGAGATAGAGACTCAACAAACCCTTCAAAAAATCAGTGAATCCAGGAGCTAGTTTT TTGAAAAGATCAACAAAATTGATAGACCGTTAGCAAGGCTAAAAAAGAAGAAAAGAGAGAAGAGTCAAATAGATGCAATAAAAAATGATA AAGGGGATATCACCACTGATCCCACAGAAATACAAACTACCATCAGCGAATACTATAAACACCTCTACACAAATAAACTAGAAAATCTAG AAGAAATGGATAAATTCCTCGACACATACACCCTCCCAAGACTAAACCAGGAAGAAGTTGAATCTCTGAATAAACCAGTAACAGGTTCTG AAATTGAGGCAATAATTAATAGCCTACCAACCAAAAAAAGTCCAGGACCAGACGGATTCACAGCCAAATTCTACGAAAGGTACAAAGAGG TGCTGGTACCATTCCTTCTGAAACTATTCCAATCAATAGAAGAAAAGGGAATCCTCCCTAACTCATTTTATGAGGCTAACATCATCCTGA TACCAAAGCCTGGCAGAGACACAACAAAAAAAGAGAATTTTAGGCCAATATCCCTGATGAACATCGATGCGAAAATCCTCAATAAAATAC TGGCAAACCGAATCCAGCAGCATATCAAAAAGCTTATCCACCACGATCAAGTCAGCTTCTTCCCTGGGATGCAAGGCTGGTTCAACATAT GCAAATCAATAAACATAATCCATCACATAAACAGAACCAACGGCAAAAACCACATGATTATCTCAATAGATACAAAAAAGGCCTTCAACA AAATTCAACAGCCTTTCATGCTAAAAACCCTCAATAAACTAGGTATTGATGGAATGTATCTCAATATAATAAGAGGTTATTTATGACAAA CCCACAGCCAATAGCATACTGAATGGGCAAAAGCTGGAAGCATTTCCTTTGAAGACCAGCACAAGGCAAGGATGCCCTCTCTCACCACTC CTATTCAACATAGTATTGGAAGTTCTGGCCAGGGCAATCAGGCAAGAGAAAGCAATAAAGCATATTCAAATAGGAAGAGAGGAAGTCAAA TTGTCTCTGTTTGCAGATGACATGATTGTATATTTAGAAAACCCCATCGTCTCATCCCAAAATCTCCTTAAGCTGATAAGCAACTTCAGC AAAGTCTCAGGATACAAAATCGGTGTGCAAAAATCACAAGCATTCCTATATACCAATAATAGACAAAGAGCCAAATCATGAGTGAACTCC CATTCACAATTGCTACTAAGAAAATAAAATACAAAGCACTGCTCAAGGAAATAAGAGAGGACACAAACAAATGGAAAAACATTCCATGCT CATGGATAGGAAGAATCAATATCATGACAATGGCCTTGTTGCCCAAACTGATTTATAGATTCAATGCTATCCCCATCAAGCTACCACTAA CTTTCTTCACAGAATTGGAAAAAACTACTTTAAGATTCATATGGAACCAAAAAAGAGCCCACCTAGCCAAGACAATCCTGGGCAAGAAGA ACAAAGCTGGAGGCATCACACTACCTGACTTCAAACTTTACTACAAGCCTACAGTAACCAAAACAGCATGGCACTGGTACAAAAACAGAT ATGCAGACGAATGGAACAGAATGGAGGCCTCAGAAATAACACCACACGTCTACCACCATCTGATCTTTGACAAACCTGACACACACAAGC AATGGGGAAAAGATTCCCTATTTAATAAATGGTGTTGGGAAAACGGGCTAGCCATATGCAGAAAACTGTAACTGGACCCTTTCCTTACAC CTTATACAAAAATCAACTCAAGATGGAACAAAGACTTAAACGTAAGACCTAGGACCATAAAAATCCTAGAAGAAAACCTGGGCAATACCA TTCAGGACATAGGCATGGGCAAAGACTTCATGTCTAAAACACCAAAAGCAATGGCAACAAAAGCCAAAATTGACAAATGGGTTCTAATTA AAGAGCTTCTGCACAGCAAAATAAACTATCATCAGAGTGAACAGGCAACCTACAGAATGGGAGAACATTTTTGCAATATATCCATCTGAC AAAGGGCTAATATCCAGAATCTACAAAGAACTTAAACAAATTTACAAGAAAAAAGCAAACAACCCCATCAAAAAATGGGCAAAGGATATG AACAGATACTTCTCAAAAGAAGACATTTATGCAGCCAACAGACATATGAAAAAATGCTCATCATCACTAGTCATTAGAGAAATGAAAATC AAAACCACAGTGAGATACCATCTCATGCCAGTTAGAATGGCGATCATTAAAAATCAGGAAACAATAGATGCTGGAGAGGTTGTGGAAAAA TTGGAACGCTTTTACACTGTTGGTGGGAGTGCAAATTAGTCCGACCATTGTGGAAGTCAGTGTGACGACTCCTCAAGGATCTAGAACTGG AAATACCATTTGACCCAGCAATCCCACTATTGGGCATATACCCAAAAGATTATAAATCATTCTACAATAAAGACACATGCACACGTATGT TTATTGCTGCACTATTCACAATAGCAAAGATTTGAAACCAACCCAAATGCCCGTCAATGATAGACTGGATTAAGAAAATGTGGCACATGT ATACCATGGAATACTATGCAGCCATAAAAAAGGATGAGTTCATGTCCTTTGCAGGGACATGGATAAAGCCGGAAACCATCATTCTCAGCA AACTATCACAAGATCAGAAAACCAAACAACGCATGTTCTCACTCATAAGTGGGAGTTAAACAATGAGAACACATGGACACAGGGAGGGTA ACATCACACACCAGGGCCTGTGGGGGGTGGGGGGCTAAGGGAGGGATAACATTAGGAGAAATACCTAATGTAGGTGACAGGTTGGTGGGT GCAGCAAACCACCATGGCATGTGTATACCTATGTAACAAAACTACATGTTCTGCACATGTAACCCAGAACTTAAAGTATAATAAAAAAAA TAATTATTAAATTTTAAAAAACTAGCCAGGCATGGTGCTGCACACCTGTAGTCCCAGCTACTTGAGAGGCTACATTGGGAGGATTGCCTG AGCTTGGGAGGTTGAGGCTGCAGTTAGCTGTGACTGTGCCAGTGCACTCCAGCCTGGGCAACAGAGCAAGACCCTGTCTCAAAAAAAGAA AAAGAAAAATTCAGAGAGATTAAAGAAGGTATCAAGAAATGTAGACACAATCCATGTTCATGAATTGGAAGATCAAATGTTGTTAAGATA GCAGTTCTCCCCAAATTAATCTACAATGCAATCCCTATCAAAATCACAGCAGGCTTTTTTGAAAAATTGACAAGCCAATCTTAAAATCTG TATGAAAACATAAAGGATTCAGAATAGCCAAAATAATTCTGAAAATGAAGAAATAATTCTGATCCAGAACTTACTACAAAGCTACATTAA TCAAGACAGTGTGGTACTGATATAAAGATAGGCATACAGATCAGTGGAACAGAGTCCAGGAATAAACCTTCACATTTATGATCAATTAAG TTTTGACAAAAATCCCAATGAAATTATGGAGAAAAGATGGTCTTTTCAACAAATAGTGCTAGGATATTTGGATATCAAATGCAGAAGAAA TTAATTTAGATTCTTACCTCCTACCATATGCAAAAATAAACTCAAAATTGATCACACACCTACATGTAAGAGCTAAAACTATAAAACATG TAGAAGAAAACATGGGAGAAAACCTAGATGACCTTGGTTTAGGAAGAATTCTTAAGACACTAATAGCACAATTCATAAAAGAAAATATTA ATAAATTGGACTTCATTAAAATATAAAATTTTGTTTCAAAAAACTATTAAGAAAATTAATTGGCCCGGGGAGGTGGTTCACATCTGAAAT CCCTGCACTTTCGGAAGCCAAGGAGGGTGGACCACTTGAGCTCAGGAATTTGAGACCAGACTGGACAACAGAGCAAAATGCCATCTCCAC AAAAAATACAAAAATTAACCAGGCATGGTGGCGTGCTCCTGTAGTCCTGGCTACTCAGAAGGCTGAGGTGGGAGGATCTCTTGACCCTGG GAGGCAGAGGTTGCAGTGAGCCAAGATCACACCACCGCACTAGAGCCTGGGTGACAGAGTGAGACCCTGTCTCAAAAAAAAAAAAAAAAA AAAAAATTAATTGAAAAATCACAGACTGGGAGAAAATATTTTCAAACCATAATAAGTATCTGATAGAGGACTTGTATCTAGACTATGTAA AGAATTCTTAAAACTCAAAAATAAGGCAGACAACTTAAAAATGGACAAAATGTTTGAATAGATATTTCAGCAAAGATATACAAATTGCTT AGCATATGAAGAGATGTGTACTATCACTAGTCATTAGGAAAATACAAGTTAAAAGCAAAATTAGATACCATTTTGGACCCACTAAAATGA CTATAATAAAAAAGACAGACAAAGATATGTGTTGGTGATGATGTGGAGAAACTGGAGCCCTAATGCATTGCTGGTGGGAATGTAAAATGG TGCAGCCACTTTGGAAAACAGTTTGGCAGTTTCTTAAAAAGATAAACATAAGTTTACCATATGATCCTGCTATTCCATGAGAAGAGAAGT GGAAATGTGTTCACATCAAGACTCGTAGGCAAATGTTCATAGCATTATCATTCATATTAGTCAAAAAGTGGAAACCAAATGACCATCAAC TACTGGATTTTTTTTTTTTTTTTAAGAGATGAGGCCTCACTATGTTGCATACTCTGAAGTCAAACTCCTGGGCTCAAACAATCCTCCTGC CTCAGCCTCCTCAGTAACTGGGACTGCAGGCAGGCACCAACATACCCAGATTATTTCTTTTTCTTTTTTTTTTTAACTGGTGGATTTCTT TAAATGATATATGTATACAATGGAGTAGTGATATAGGCTACAATATGGATGCATCTCAAAACATTATGCTTAGTGAAAGAAGTCTGATGC AATATCCCACATATGGTATGTTTCCATTTACAGTCCAGAAAAGGCATATACTAAATTAGCAGTTGCATGGGTCTGATGTGAAAACATGGA TTGCCTGCAGATGGGCACAAGGGATCTTTTGGGGGTGACAAAAATGTTCCAAAACTAAGTTGTAATTTTTGCACAACTTTTATGTGTGTG TGTGTGTGTGTGTGTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGCGATCTCAGCTCACCACAACCTCCGCCTCC TGGGTTGAAGCATTTCTCCTGCCTCAGCTTCCTGAGTAGCTGGGATTACAGGCATGTGCCACCATGCCCGGCTAATTTTGTATTTTTAGT AGAGACAGGTTTTCTCCAGGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCTCCTGCCTCGGCCTCCCAAAGCGCTGGGAT TACAGGCGTGAGCCACCACACCCAGCCATTTTTGCACAACTTTATAAACTTTAAAAATAATTGATTTATGCACTTAAAACAGGTAAAGTT TATGTGTATAAATTATACCTTAATAAAGCTATTAAAAGTCAAAGATTATAACAGGGCCTCTCTCTCTCTGACCTAGTGACCTAGGGTAAA GAGAAAAAGAAGCTAGCCAGGCACAGGGGCTCACACCTGTAATCCCAGCACTTTGGGAAGCCAAGATGGGCTGATTGCTTGAGTCCAGGA GTTTGAGACCAACTTGGGCAACATAGCAAAACCCTGTCTCCACCAAAAATAAAAAAAATTAGCCAGGCATGGCGGTGTATGCCTGGAGTC CCAGCTACTCAGGAGTCAGAGGTGGGAGGATCACTTGAGCCCAGGAGGCAGAGGTTGTAGGGAGCCAAGATTGCACCACTGCACTCCAGC CTGGGTGACAGAGCAAGACACTGTCTCAAAAATTAAAAATTAAAAAATGAGGGAAGCTGCTGTATCTCCACTTCTTCCCTCTCTGTGCCC AGAGATATCTCTTCAGTTATCTCACATGCCCTACAAGTCTAGAGACCTCAGGTGAGGAGCCAGTAGCTCAGTATAGAAACTAAGGATCCA AGTGGACAACTGCCACCAAGTCACCACAGGGCCAGCTGCTTTGGGAGGGTGCTGCATCTGCCTCCCATACACTTCTGCCAAGTTTATGTT AGTTTGGGAGGACTGAAGCAGAATTCAGTTCAAAGTACTGTGCTGGATTTTGGTTTCTAAATATTTTCCAATAGAAAAGAACCCAGGCTT CTTGAGAAAATAGCTAGGTTCTAAGGCTAGAGCCAAAAAAATGCAAGATAAGCCTGGAGCATCTTGTAGTACCAGAAACTAAGCAAGTGC TCAAAAACAAAAGGATAGAAGCATGTCAGACAGACACAGGAGCCAATCTGAAAGAGCTCCCTGGCCGGGCACGGTGGCTCACGCCTGTAA TCCCAGCACTTTGGGAGACTGAGGTGGGAGGATGACTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACATAGGGAGACCCCATCTCTA CAAAAAAGTAAACAATTAGCCGGGCATGGTGGCACACGCCTATAGTCCCAGCTACTCAGGAGGGTGAAGATCACCTGAGACCAGGCGGTC AAGGCTTCAGTGAGCCATGATTGTGGCACTGCACTCCAGCCTAGGCAATAGAGTGAGACTGTCTCAAAAAATAAAATTTTAAAATAACTG AAGAGTATAACTGGATTGTTTGTAACACAAAGGATAAGTGCTTAAGATGATGGAAACCCTATTTATCCTGATGTGATTATTACACATTGC ATGCCTGTACCAAAATATTTCATGTAACCCATAAATATATACATCTACTATGTACCCACAAAAATTAAAAAATGTTTACAGGAGTGAACC ACCGCACCTGGCCAGTGGAGTCTTTTTAAGGTATTATTTAGCATCTTCTGCTTATAGTCATGTCCAAAAACCAGTTGATCTTCCTACTCA TTAGGGGACAAGATCAATTCTCTAAAAAATTAACCTAGCCCAAGGTAAGTGGTACTATTCTGAAATCTGAAAATCTTTAGTAGCCTCACA TTATAAGCCCTTCGTAGAAAAAGAAAAGTAAGCATTTCTAGAAGCACATTTTTGTTGGACTGAGGGTGGGGCAAGGAGCAGGGGTGACTT TCATCTGAAATGTACCTAGGCAGGCCAGAGTCTGAGTTAGGACTGGCTCCTGGGACTTTGCCATCCAGGCCAAGAAGCATGCTCCAGTGT GCATGCACTCTCATCAAAGCCCTAGTCAGGAATCCCAGCCACTCCTCTCCTGTGCAGCACAAGCTGAAGGATAAGGTGTGGGGCAGTGAC TGCGTGGGGCTGCCTGTGTGATTCCTGATAAAGAAATGCCTTCATGAAATGTATTGTTCCCCAATAAAGCTCATTTTCTGTGAGAATTCA TGTGTCCTTTTCCAAATTAAACTAGCAAAATATGAACTTTTGTAAAAGGTCCACACCCAGCCAGTTTTCTACTCTCTAAATGTTCAGGCC TTTGCCTGTCCTTCCCTCAGCAAAAATACTGTGTTTTGGAAAACATTACCAATAAAGGAGCTGGGAGGTGGAATTGGATCAAAATACCTT TAGATGAAAGCAGCAGCACAAGCCATTCCCTTTAAATGAGCTGGCCTCACCTCTGGGGCCTATGAAGAAAAGCCTGCTTCAAGGTGATAG TTTTCATTTTGCTTCCCAGCACCTCTGCAGTCATAACCAAAGTGAAGGACAATATTGCATGACTTCAGAAGAAAGCCATCCAGCCACCTT GCAACATGTTCAGGAAATTCTGGACTCCCTTGGGGCTTGCAAAACTCCCTATGTCTTGCAGACCAAAAGCAAGTTCTCAGTCACCTAGCT CTAGTTTGCATAATTAAAGAAAGTGGAAGCTGGTTCTTTTCTGGGTGACCCTTCACCCAACCAAGCTCATAAGGACTTGTGACAAAAATA AGAGCAATAAAATGAAGTTTTAACAGTGAAAACTTCTATCACTTAGATAAGCAGGAAAAGCCAGTCCCCTAGATGCCCATCTGACCCTAC CTTACTGGGGTCATACAGCCAAAGCAGTGTCCACTTCAGGTACTGTAATGTTTTGAAGTTGACACATATAATTTAATGTAGTTTCATGTC ATAAGTTATAAGACTTTTCAGAGAAACAATTTAGTAATATCTTCTGTAATACCCATCTTCATTTTTTATATGAAAAAGCATAGCCTATGA TCTGTCACCTTGCTCACTCCCACATCCTTACCTCTTATCCTTCTCACATCGTCCCATTAACACATTATCCATCTTTGGGGGGAAAAAATA CACTAAATTTTAGACAGAGTCACTTTCACTATGGCCACAATGGGAGAAAAGACAGTCCACCTTCAAAGTCAACCAGAATGACTCTTAACC TCTCTTGTCTGGGTTGGGCATCCAGATAAGATTTTCTTCGTACAAAGAGTCTTGCTACTAGGAAAAAGAGTTTGAAAATCACTAGTCTAA CTAAATATCTCACTTTAAAAAAAGCACAAACTAAGACTCAATGAGGTTTATCTTCCACAAGATCAGCCAGTTTTAGCAGAGCAGTTGCTA AAACCCAGGTCTCAAACTCCTTGTCTATGGCTCATCTAACTAAGCAACAAAAAGCCCAATGAGCTCTGGAGAGAGAGAGGGAGCTAAAAC AGGACTCAATCAAAACCCACTTGGGATTAGGGAAGCCACCCTCTGTGAGTGAGTTAAACTGAGATTCCCTCCCCTTCACCCTGGCTTCCT TTGCAGAACAAGGGTCACCGCCAGAGGGAAAGCTGAGTTTACGGAGGGGATCCTGGTTGGAGTCAGAGTATACCTTGGTTTGGTTTTGTG GGGTTTTTTGAGACAGGGTCTCACTGTCACCCAGGCTGGAGCACAGTGACAGTCATAGCTCACTATAGCCTCAGACTCCTGGCCTCAAGC GATCCTCCCACCTCAACCTCCAGAGTATCTGGGACTATAGGCACGTACCACCATACCCAGCTAATATTTTTTTTAATTTTATATTTTTTA GAGACAGGGTGTCACTATGTTACCCAGGTCTCAATCACTATGTTACTCCTTGCCTCAAGCAATCCTCTCACCTTGGCCTCCCAAAGTGCT GAGCTTACAGGTGTCAACCACTGTGGCCAGCCACGCATTGGTTTTAAGGTCCAGAATTTTTCTGTTTGGAGCCTTCACAATTAGTTTTAG GTTGGGAGACCGTGAACCCACCAAGCAGCCCTTTAGAGGCTGGAAAAAGAGTTTGGAAAAAGAACTCTGTGGCTTTAGGAATTTCTCTCG GAAATCCTCTAGGGCAGAGAAGGAAAATTTACCAAATGGGAGAGTGTATTAGTCTATTCTTACATTGCTATAAGGAAATACCCCAGACTG GGTAATTTATAAAGGAAAGAGTTTTAATTGACTCACAGTTCCACATGGCTGGGAAAGCCTCAGGAAACTTACAATCATAGCAGAAGGCAA AGGGGAAGAAAGGCACCTTCTTCACAGGGCGGCAGGAAGGAGAAGTGCAGAGCAAAGTGGGGCAAAGCCTCTATAAAGCCATCAGATCTC ATGAGAACTCACTATCATGAGAACAGCAGGGGAGAACCACCCCCATGATCCAATCACCTTCCACGAGGTCCCTCCCCCAACACGTGGGGA TCACAATTTGGATTACAATTCAAGATGAGATTTGGGTGAGGACACAGAGCCGGACCATATCAGAGAGAAAGCTATTACTGAAGACCTTTC TAACTCACTTCTGTAAAGATCAATTCAATAAAAGCAGCAAACACACATACTTTGCTTTCCTTGTGATTAATGCCTTGACTTTTTTGTGGA AAGTAACACCCCAAGAAAGCCAGCTACTCATGTTGGCAATAAAGGTAAAAGTATCTATGGAATAAGGACCATTTTTAGGACAATACTTTC CCTACTACTTAGTTCTAGTCCCTTTTTTGTAGAATTCTGAGGACTTTCTACATACACAATCATGTCATCAGCAAATAAAGATTATTGTAC TTGTTCTTTGCCAACCCATATGTCTTGCCTTACTGCCCTGGTTAGGACCTTCAGAACAATACTGGATATAAGTGGTGAAAGCACATATCC TCCCCTTGTTCCTAATTTTAGAGGGAAAGTACTCAGTCTTTCGCCATTAAGTACAATGTCAGCTGTAAGTTTTCCTAGAGACCCTTTCTC AGCTTGAAGATGTTCCCTGGTATTCATAGTTTGCTAAAAGGTTTTTGTCATTTTAAATCATAAATGGGTGTTGAATTTTGTCAAAGGCTT TTAATGCATCTATGGAGATGATCCAAGTTTTTTTCCTCCTTATTTCTGCTAAGGTTGTATAATTATGCTCATTGGTATTTTAAATGTTAA ATTAACCTTGCGTTCCTGGGATAAGACCCACTGATCATGATGCATTTTCCTCTTTGTAAATTGCTGTATTCATTTTAGTTTCTTCAGGAT TTTGCCTATGTTTGAAGGATATTGGTTTGTAATTTTTCTTGTAACATCTTTGTCTGGTTTTGAAATCAAAGTAATACTGGCCTAATAAAA >In-frame_ADCY2_ENST00000537121_chr5_7698487_+_RPAP2_ENST00000610020_chr1_92846281_+_15831nt GAGGAGTTTGGTAGAAATCCCAGAAGAGCTGTTGAGAAGACCAGTGGAGCCACACGTCTAGAGGTCATGGACCTGCGCTGGGCCAGAGAT CTGCATTTGAGAGAAGCCAGCAGATCAGTAGCATTTACCACCCTGAGGCTGGGCGCAGTCACCACGGGACTCCTGACATTCAGAGAGCCA GGAGATAAAGAGAAGTCAGGAAAGGGCCTTGGGAAGAGATGGCGCATCCAGCGAGAGGAAAGCCAGGAGCGGCTTCTGCTCTCCCTGCTG CCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGCCAGATGGAGAACACAAATAACTTC CACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACCCGGCTGGCAAGTGACTGCTCCCCG GGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAATGCATGAGAATTAAAATTTTAGGA GACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAAATGGGGCTGGACATGTGTGAAGCC ATAAAACTGACCCCAATTCTTGGCATTCAGAAACATTCTCAGGAAGGTATGGTGTTTACACGGTTTCTAGACACCCTCCTTGAAGAATTA CATCTAAAAAATGAAGACCTTGAAAGTCTAACCATCATATTTAGAACCAGCTGTTTACCAGAGTGATATATTCCATGAAGACAAAATAGA AGATGAACTTCTATTCACCGTTTCTGGAATTCTAGCCGCCATGATGGTCTGGTGGTGACTGATAACTAGTTTTATTCCAAGACATACCTT TACCTCTTTAAGTTTCAATCTCCCATCTCCCAGTCCTTCAGTCCCCAACTGCAGAGGATGACCTCCCCAGATAGAGGAGAATCATTACTC CAACAAGAATAACCAAGTCTTTGTATCCCTAGTACAAGACATAGTATTTTTATTCGAAAATGAATGTTTAAGTATTAAATTGAAACTTGA ATGAATATTCAAGAAAATATAATGATCTCTACTTTTTCTGGATGATTTCCAGCCATCATATCAGTTTGCCAAAAAAATTGAGAAAGTTAT GATTTTGACCTCCCAACCTAAACTCTAAATTCTAAAGATCAGTAAACAATTAGGTCAATAAATACATACAATTTAAGATGAAGCCCTTTG GAAGTCTAGTCCAAAACAGGAAAATCTCAGAACTTTCTGGACTCAAGGAAATGCTTTAAATGGAATCTGTAGTTTGTTTGCAGGAGAGAC AATTTCTAGAATTTAGATTGCTTTTCAAAATGTTTATCAGGTAGGCAAGTTAGCAGTTGAGGCGGAACACAGACAACTTGGGGAGCTTTA CTGGAAGGCCAAGAAAATACTCTTGGACACTGGAGGAAATGACAGCTACTAAAGCCCAATCATGGAAAAGGACCAGAAAGCAGCCCACTG GAATGGGGAGCTTAGTGGGCAAGGAGGTAGGGATATAATTTCTCTTCTTGGCTCCACCAGTAATTAGCTCTGTGGCCCAGTCACCTAAAC TTTCTGGACTTCAGTTCAGGTTGTATGGCAGTAGGCCATAGAATTGGCTACTGCCATACAATCTCTATGGGAAAGGACTGCAAAAACTAA ATTTTATCTCTGTATGGGCAAAGGCTACTGTCATCCTGTTGTTGGTCTGGGGCCACTCTGACAATTTTTTTTAACCTCATTTGATTGTGT AAGGGTCTAACCACAACAAAAAATCATAGTGTAATAGAATTAATCAAGTTCAGCAAGGTCACAGGCTAGATCAATATACAGAAAATCAAT TGTATTTTTCTGTTCAGAAAACTCCAAAAATGAAATAAAGAAAATTGTGTTCACAATATCACCAAAGAGAATTAAATACTTAGGAATAAA TTTAACAAAATAAGTATAAGACTTGTATAACGAAAACTATAAAACATTCAAGAGGGCTGGGCATGGTGGCTCATGCCTTTAGTTCTAGCA CTTTGGAGGCAGAGGCAGGAGGACTGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCAACAAAGTGAGACCCTGTCTCCACAAAAAATA AAAATAAAAATAAATTGAAGATGGCCGAATAGGAACAGCTCCAGTCTACAGCTCCCAGCAGGATGGACACAGAAGATGGGTGATTTCTGC ATTTTCAACTAAAGTACCTGGTTCGTCTCACTGGGACTGGCTGGACAGTGGGTGTAGCCCACAGAGGGTTAGCCGAAGCAAGGTGGGGCA TCGCCTCACCTGGGAAGCGCCAAGGGGTCGGGGGATTTCCCTTTCCTAGCCAAGGGAAGCCGTGAGTGACTATACCTGGAGGAGGGGTAC ACTCCTGCCCAAATACTGCTCTTTTCCCACAGTCTTCGCAACTGGCAGACCACGAAATCCCCTCCCATGCCTGGTTCAGTGGGTCCCACG CCCACAGAGCCTTGCTCACTGCTAGCGCCAGCAGTCTGAAATCGACCTGGGACGTGGGAGCTTGGCGGGGTAGAGGTGTCCGCCATTGCT GAGGCTTGAGTAGGCGGTTCTATGCTCACAGTGTAAACAAAGCAGCAGGGAAGCTCAAACTGGGCAGAGCCCACCACAGCTCAGCAAGGC CTACTGTCTCTGTAGATTCCACCTCCAGGGGCAGGGCATATCTGAACAAAAGGCAGCAGACAGCTTCTCCAGACTTAAACGTCCCTGCCT GACAGCTCTGAAGAGAGCAGTGGTTCTCCCAGCACCGCGTTCAAGCTCCGATAATAGACAGACTGCCTCCTCAAGTGGGTCCCTGACCCC CGTGTAGCCTGACTGGGAGACATCTCCCAGTAGGCGCCGAAAGACACCTCAGAGAGGTAGATGCCCCACTGGAACGAAGCTTCCACAGTA AGGATCAGGCAGCAATATTTGCTGTTCTGCAGCCTCCACTGGTGACACCCAGGCAAACAGGGTCTGGAGTGGACCTCCAGCAAACTCCAA CAGACCTGCAGCTAAGGGGCCTGTCTATTAGAAGGAAAACTAACAGAAAGGAATAGCATCAACATCAAAAAAAGGACATCTACACCAAAA CCCCATCCATAGGACACCAACATCAGAGACCAAAGGTAGGTAAAACCACAAAGATGGGGAGAAACCAGACCAGAAAGGCTGAAAATTCCA AAAACCAGAATGCCTCTTCTCCTCCAAAGGAACACAACTCCTTGCCAGCAAGGGAACAAAACTGGACAGAGAATGAGTTTGACAAGTTGA CAGAAGTAGGCTTCAGAAGGTCGGTAATAACAAACTTCTCCAAGCTAAAGGAGCATGTTCTAATGCGTCGCAAGGAAGCTAAAAATCTTG AAAAAAGGTTAGACAAATGGCTAACTAGAATAACCAGTGTAGAGAAGAGCTTAAATGACCTGATGGAGCTGAAAACCACAGTACGGGAAC TTCGTGAAGCATACACAAGCTTCAATAGCCAATTCGATCAAGTGGAAGAAAGGATATCAGTAACTGAAGATCAAATTAATGAAATAAAGC GAGAGGACAAGATTAGAGAAAAAAGAGTGAAAAGAAATGAACAAAGCCTCCAAGAAATATGAGACTATGTGAAAAGACCAAATCTATGTT TGATTGGTGTACCTGAAAGTGATGGGGAGAACAGAACCAAGTTTGAAAACACTCTTCAGGATATTATCCAGGAGAGCTTCCCCAACCTAG CAAGGAAGGCCAACATTCAAATTCAGGAAATACAGAGAACACCACAAAGATACTCCTCAAGAAGAGCAACCCCAAGACACATAATTGTCA GATTCACCAAGGTTGAAATGAAGGAAAAACTGTTAAGGGCAGCCAGAGAGAAAGGTCAGGTTACCCACAAAGGGAAGCCCATCAGATTAA CAGCGGACCTCTGGGCAGAAACCCTACAAGCCAGAAGAGAATGGGGGCCAATATTCAACATTCTTAAAGAAAAGAATTTTCAACCCAGAA TCTCATATCCAGCCAAACTAAGCTTCTTAAGTGAAGGAGAAATAAAATCCTTTACAGACAAGCAAATGCTGAGAGATTTTGTCACCACCA GGCCTGCCTTACAAGAGCTCCTGAAGTAAGCACTAAAATGGACAGGAACAACCAGTACCAGCCACTGCAAAAACATGCCAAATGGTAAAG ACCATCAACACTATGAAGAAACTGCATCAATTAATGGATGAAATAACCAGCTAGCATCATAATGACAGGATCAAATTCCCACATAACAAT ATTAACCTTAAATGTAAATGGGATAAATGCCCCAATTAAAAGACACAGACTGGCAAATTGAATAAACAGTCAAGACCCATCAGTGAGCTA TATTCAGGAGACCCATCTCATGTGCAAAGACACACATAGGCTCAGAATAAAAGGATGTAGGAAGATTTACCAAGCAAATGGAAAGCAGAA AAAAGCAGGGGTTGCAATCCTAGTCTCTGATAAAACAGACTTTAAACCAACAAAGATCAAAAGAGACAAAGAAGGTCATTACATAATGGT AAAGGGATCAATTCAACAAGAACAGCTAACTATCCTAAATATATATGCACCCAATACAGGAGCACCCAGATTCATAAAGCAAGTTCTACA AAGAGATTTAGACTCCCACACAATATTAATGGGTGACTTTAACACCCCACTGTCAATATTAGACAGATCAACAAGACAGAAAATTAACAA AGATATCCAGGACTTGAACTCAGCTCTGGACCAAGCAGACCTAATAGACATCGACAGAACTCTCCACCCCAAATCAACAGAATATACATT CTTGTCAGCACCACATCACACTTATTCCAAAATTGACCACATAATTGGAAGTAAAGCACTCTTCAGCAAATGCAAAAGAACAGAAATCAC AACAAACCGTCTCAGACCACAATGCAATCAAATTAGAACTCAGGATCAAGAATCTCACTCAACTGCACAACTGCATGGAAACTGAACAAC CTGTTCCTGAATGACTACTGGGTAAATAACGAAATGAAGGCAGAAATAAAGATGTTCTTTGGAACCAACGAGAACAAAGACACAATGTAC CAGAATCTCTAGGACATGTTTAAAGCAGTATGTAGAGGGAAATTTATAGCACTAAATGCCCACAAGTGAAAGCAGGAGTGATCTAAAATC AACACCCTAACATCACAATTAAAAGAACTAGAGAAGCAAGACCAAACAAATTCAAAAGCTAGCAGAAGGCAAGAAATAACTAAGATCAGA GCAGAACTGAAGGAGATAGAGACTCAACAAACCCTTCAAAAAATCAGTGAATCCAGGAGCTAGTTTTTTGAAAAGATCAACAAAATTGAT AGACCGTTAGCAAGGCTAAAAAAGAAGAAAAGAGAGAAGAGTCAAATAGATGCAATAAAAAATGATAAAGGGGATATCACCACTGATCCC ACAGAAATACAAACTACCATCAGCGAATACTATAAACACCTCTACACAAATAAACTAGAAAATCTAGAAGAAATGGATAAATTCCTCGAC ACATACACCCTCCCAAGACTAAACCAGGAAGAAGTTGAATCTCTGAATAAACCAGTAACAGGTTCTGAAATTGAGGCAATAATTAATAGC CTACCAACCAAAAAAAGTCCAGGACCAGACGGATTCACAGCCAAATTCTACGAAAGGTACAAAGAGGTGCTGGTACCATTCCTTCTGAAA CTATTCCAATCAATAGAAGAAAAGGGAATCCTCCCTAACTCATTTTATGAGGCTAACATCATCCTGATACCAAAGCCTGGCAGAGACACA ACAAAAAAAGAGAATTTTAGGCCAATATCCCTGATGAACATCGATGCGAAAATCCTCAATAAAATACTGGCAAACCGAATCCAGCAGCAT ATCAAAAAGCTTATCCACCACGATCAAGTCAGCTTCTTCCCTGGGATGCAAGGCTGGTTCAACATATGCAAATCAATAAACATAATCCAT CACATAAACAGAACCAACGGCAAAAACCACATGATTATCTCAATAGATACAAAAAAGGCCTTCAACAAAATTCAACAGCCTTTCATGCTA AAAACCCTCAATAAACTAGGTATTGATGGAATGTATCTCAATATAATAAGAGGTTATTTATGACAAACCCACAGCCAATAGCATACTGAA TGGGCAAAAGCTGGAAGCATTTCCTTTGAAGACCAGCACAAGGCAAGGATGCCCTCTCTCACCACTCCTATTCAACATAGTATTGGAAGT TCTGGCCAGGGCAATCAGGCAAGAGAAAGCAATAAAGCATATTCAAATAGGAAGAGAGGAAGTCAAATTGTCTCTGTTTGCAGATGACAT GATTGTATATTTAGAAAACCCCATCGTCTCATCCCAAAATCTCCTTAAGCTGATAAGCAACTTCAGCAAAGTCTCAGGATACAAAATCGG TGTGCAAAAATCACAAGCATTCCTATATACCAATAATAGACAAAGAGCCAAATCATGAGTGAACTCCCATTCACAATTGCTACTAAGAAA ATAAAATACAAAGCACTGCTCAAGGAAATAAGAGAGGACACAAACAAATGGAAAAACATTCCATGCTCATGGATAGGAAGAATCAATATC ATGACAATGGCCTTGTTGCCCAAACTGATTTATAGATTCAATGCTATCCCCATCAAGCTACCACTAACTTTCTTCACAGAATTGGAAAAA ACTACTTTAAGATTCATATGGAACCAAAAAAGAGCCCACCTAGCCAAGACAATCCTGGGCAAGAAGAACAAAGCTGGAGGCATCACACTA CCTGACTTCAAACTTTACTACAAGCCTACAGTAACCAAAACAGCATGGCACTGGTACAAAAACAGATATGCAGACGAATGGAACAGAATG GAGGCCTCAGAAATAACACCACACGTCTACCACCATCTGATCTTTGACAAACCTGACACACACAAGCAATGGGGAAAAGATTCCCTATTT AATAAATGGTGTTGGGAAAACGGGCTAGCCATATGCAGAAAACTGTAACTGGACCCTTTCCTTACACCTTATACAAAAATCAACTCAAGA TGGAACAAAGACTTAAACGTAAGACCTAGGACCATAAAAATCCTAGAAGAAAACCTGGGCAATACCATTCAGGACATAGGCATGGGCAAA GACTTCATGTCTAAAACACCAAAAGCAATGGCAACAAAAGCCAAAATTGACAAATGGGTTCTAATTAAAGAGCTTCTGCACAGCAAAATA AACTATCATCAGAGTGAACAGGCAACCTACAGAATGGGAGAACATTTTTGCAATATATCCATCTGACAAAGGGCTAATATCCAGAATCTA CAAAGAACTTAAACAAATTTACAAGAAAAAAGCAAACAACCCCATCAAAAAATGGGCAAAGGATATGAACAGATACTTCTCAAAAGAAGA CATTTATGCAGCCAACAGACATATGAAAAAATGCTCATCATCACTAGTCATTAGAGAAATGAAAATCAAAACCACAGTGAGATACCATCT CATGCCAGTTAGAATGGCGATCATTAAAAATCAGGAAACAATAGATGCTGGAGAGGTTGTGGAAAAATTGGAACGCTTTTACACTGTTGG TGGGAGTGCAAATTAGTCCGACCATTGTGGAAGTCAGTGTGACGACTCCTCAAGGATCTAGAACTGGAAATACCATTTGACCCAGCAATC CCACTATTGGGCATATACCCAAAAGATTATAAATCATTCTACAATAAAGACACATGCACACGTATGTTTATTGCTGCACTATTCACAATA GCAAAGATTTGAAACCAACCCAAATGCCCGTCAATGATAGACTGGATTAAGAAAATGTGGCACATGTATACCATGGAATACTATGCAGCC ATAAAAAAGGATGAGTTCATGTCCTTTGCAGGGACATGGATAAAGCCGGAAACCATCATTCTCAGCAAACTATCACAAGATCAGAAAACC AAACAACGCATGTTCTCACTCATAAGTGGGAGTTAAACAATGAGAACACATGGACACAGGGAGGGTAACATCACACACCAGGGCCTGTGG GGGGTGGGGGGCTAAGGGAGGGATAACATTAGGAGAAATACCTAATGTAGGTGACAGGTTGGTGGGTGCAGCAAACCACCATGGCATGTG TATACCTATGTAACAAAACTACATGTTCTGCACATGTAACCCAGAACTTAAAGTATAATAAAAAAAATAATTATTAAATTTTAAAAAACT AGCCAGGCATGGTGCTGCACACCTGTAGTCCCAGCTACTTGAGAGGCTACATTGGGAGGATTGCCTGAGCTTGGGAGGTTGAGGCTGCAG TTAGCTGTGACTGTGCCAGTGCACTCCAGCCTGGGCAACAGAGCAAGACCCTGTCTCAAAAAAAGAAAAAGAAAAATTCAGAGAGATTAA AGAAGGTATCAAGAAATGTAGACACAATCCATGTTCATGAATTGGAAGATCAAATGTTGTTAAGATAGCAGTTCTCCCCAAATTAATCTA CAATGCAATCCCTATCAAAATCACAGCAGGCTTTTTTGAAAAATTGACAAGCCAATCTTAAAATCTGTATGAAAACATAAAGGATTCAGA ATAGCCAAAATAATTCTGAAAATGAAGAAATAATTCTGATCCAGAACTTACTACAAAGCTACATTAATCAAGACAGTGTGGTACTGATAT AAAGATAGGCATACAGATCAGTGGAACAGAGTCCAGGAATAAACCTTCACATTTATGATCAATTAAGTTTTGACAAAAATCCCAATGAAA TTATGGAGAAAAGATGGTCTTTTCAACAAATAGTGCTAGGATATTTGGATATCAAATGCAGAAGAAATTAATTTAGATTCTTACCTCCTA CCATATGCAAAAATAAACTCAAAATTGATCACACACCTACATGTAAGAGCTAAAACTATAAAACATGTAGAAGAAAACATGGGAGAAAAC CTAGATGACCTTGGTTTAGGAAGAATTCTTAAGACACTAATAGCACAATTCATAAAAGAAAATATTAATAAATTGGACTTCATTAAAATA TAAAATTTTGTTTCAAAAAACTATTAAGAAAATTAATTGGCCCGGGGAGGTGGTTCACATCTGAAATCCCTGCACTTTCGGAAGCCAAGG AGGGTGGACCACTTGAGCTCAGGAATTTGAGACCAGACTGGACAACAGAGCAAAATGCCATCTCCACAAAAAATACAAAAATTAACCAGG CATGGTGGCGTGCTCCTGTAGTCCTGGCTACTCAGAAGGCTGAGGTGGGAGGATCTCTTGACCCTGGGAGGCAGAGGTTGCAGTGAGCCA AGATCACACCACCGCACTAGAGCCTGGGTGACAGAGTGAGACCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAATTAATTGAAAAATCACA GACTGGGAGAAAATATTTTCAAACCATAATAAGTATCTGATAGAGGACTTGTATCTAGACTATGTAAAGAATTCTTAAAACTCAAAAATA AGGCAGACAACTTAAAAATGGACAAAATGTTTGAATAGATATTTCAGCAAAGATATACAAATTGCTTAGCATATGAAGAGATGTGTACTA TCACTAGTCATTAGGAAAATACAAGTTAAAAGCAAAATTAGATACCATTTTGGACCCACTAAAATGACTATAATAAAAAAGACAGACAAA GATATGTGTTGGTGATGATGTGGAGAAACTGGAGCCCTAATGCATTGCTGGTGGGAATGTAAAATGGTGCAGCCACTTTGGAAAACAGTT TGGCAGTTTCTTAAAAAGATAAACATAAGTTTACCATATGATCCTGCTATTCCATGAGAAGAGAAGTGGAAATGTGTTCACATCAAGACT CGTAGGCAAATGTTCATAGCATTATCATTCATATTAGTCAAAAAGTGGAAACCAAATGACCATCAACTACTGGATTTTTTTTTTTTTTTT AAGAGATGAGGCCTCACTATGTTGCATACTCTGAAGTCAAACTCCTGGGCTCAAACAATCCTCCTGCCTCAGCCTCCTCAGTAACTGGGA CTGCAGGCAGGCACCAACATACCCAGATTATTTCTTTTTCTTTTTTTTTTTAACTGGTGGATTTCTTTAAATGATATATGTATACAATGG AGTAGTGATATAGGCTACAATATGGATGCATCTCAAAACATTATGCTTAGTGAAAGAAGTCTGATGCAATATCCCACATATGGTATGTTT CCATTTACAGTCCAGAAAAGGCATATACTAAATTAGCAGTTGCATGGGTCTGATGTGAAAACATGGATTGCCTGCAGATGGGCACAAGGG ATCTTTTGGGGGTGACAAAAATGTTCCAAAACTAAGTTGTAATTTTTGCACAACTTTTATGTGTGTGTGTGTGTGTGTGTGTGAGATGGA GTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGCGATCTCAGCTCACCACAACCTCCGCCTCCTGGGTTGAAGCATTTCTCCTGCC TCAGCTTCCTGAGTAGCTGGGATTACAGGCATGTGCCACCATGCCCGGCTAATTTTGTATTTTTAGTAGAGACAGGTTTTCTCCAGGTTG GTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCTCCTGCCTCGGCCTCCCAAAGCGCTGGGATTACAGGCGTGAGCCACCACACCC AGCCATTTTTGCACAACTTTATAAACTTTAAAAATAATTGATTTATGCACTTAAAACAGGTAAAGTTTATGTGTATAAATTATACCTTAA TAAAGCTATTAAAAGTCAAAGATTATAACAGGGCCTCTCTCTCTCTGACCTAGTGACCTAGGGTAAAGAGAAAAAGAAGCTAGCCAGGCA CAGGGGCTCACACCTGTAATCCCAGCACTTTGGGAAGCCAAGATGGGCTGATTGCTTGAGTCCAGGAGTTTGAGACCAACTTGGGCAACA TAGCAAAACCCTGTCTCCACCAAAAATAAAAAAAATTAGCCAGGCATGGCGGTGTATGCCTGGAGTCCCAGCTACTCAGGAGTCAGAGGT GGGAGGATCACTTGAGCCCAGGAGGCAGAGGTTGTAGGGAGCCAAGATTGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACACTG TCTCAAAAATTAAAAATTAAAAAATGAGGGAAGCTGCTGTATCTCCACTTCTTCCCTCTCTGTGCCCAGAGATATCTCTTCAGTTATCTC ACATGCCCTACAAGTCTAGAGACCTCAGGTGAGGAGCCAGTAGCTCAGTATAGAAACTAAGGATCCAAGTGGACAACTGCCACCAAGTCA CCACAGGGCCAGCTGCTTTGGGAGGGTGCTGCATCTGCCTCCCATACACTTCTGCCAAGTTTATGTTAGTTTGGGAGGACTGAAGCAGAA TTCAGTTCAAAGTACTGTGCTGGATTTTGGTTTCTAAATATTTTCCAATAGAAAAGAACCCAGGCTTCTTGAGAAAATAGCTAGGTTCTA AGGCTAGAGCCAAAAAAATGCAAGATAAGCCTGGAGCATCTTGTAGTACCAGAAACTAAGCAAGTGCTCAAAAACAAAAGGATAGAAGCA TGTCAGACAGACACAGGAGCCAATCTGAAAGAGCTCCCTGGCCGGGCACGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGACTGAG GTGGGAGGATGACTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACATAGGGAGACCCCATCTCTACAAAAAAGTAAACAATTAGCCGG GCATGGTGGCACACGCCTATAGTCCCAGCTACTCAGGAGGGTGAAGATCACCTGAGACCAGGCGGTCAAGGCTTCAGTGAGCCATGATTG TGGCACTGCACTCCAGCCTAGGCAATAGAGTGAGACTGTCTCAAAAAATAAAATTTTAAAATAACTGAAGAGTATAACTGGATTGTTTGT AACACAAAGGATAAGTGCTTAAGATGATGGAAACCCTATTTATCCTGATGTGATTATTACACATTGCATGCCTGTACCAAAATATTTCAT GTAACCCATAAATATATACATCTACTATGTACCCACAAAAATTAAAAAATGTTTACAGGAGTGAACCACCGCACCTGGCCAGTGGAGTCT TTTTAAGGTATTATTTAGCATCTTCTGCTTATAGTCATGTCCAAAAACCAGTTGATCTTCCTACTCATTAGGGGACAAGATCAATTCTCT AAAAAATTAACCTAGCCCAAGGTAAGTGGTACTATTCTGAAATCTGAAAATCTTTAGTAGCCTCACATTATAAGCCCTTCGTAGAAAAAG AAAAGTAAGCATTTCTAGAAGCACATTTTTGTTGGACTGAGGGTGGGGCAAGGAGCAGGGGTGACTTTCATCTGAAATGTACCTAGGCAG GCCAGAGTCTGAGTTAGGACTGGCTCCTGGGACTTTGCCATCCAGGCCAAGAAGCATGCTCCAGTGTGCATGCACTCTCATCAAAGCCCT AGTCAGGAATCCCAGCCACTCCTCTCCTGTGCAGCACAAGCTGAAGGATAAGGTGTGGGGCAGTGACTGCGTGGGGCTGCCTGTGTGATT CCTGATAAAGAAATGCCTTCATGAAATGTATTGTTCCCCAATAAAGCTCATTTTCTGTGAGAATTCATGTGTCCTTTTCCAAATTAAACT AGCAAAATATGAACTTTTGTAAAAGGTCCACACCCAGCCAGTTTTCTACTCTCTAAATGTTCAGGCCTTTGCCTGTCCTTCCCTCAGCAA AAATACTGTGTTTTGGAAAACATTACCAATAAAGGAGCTGGGAGGTGGAATTGGATCAAAATACCTTTAGATGAAAGCAGCAGCACAAGC CATTCCCTTTAAATGAGCTGGCCTCACCTCTGGGGCCTATGAAGAAAAGCCTGCTTCAAGGTGATAGTTTTCATTTTGCTTCCCAGCACC TCTGCAGTCATAACCAAAGTGAAGGACAATATTGCATGACTTCAGAAGAAAGCCATCCAGCCACCTTGCAACATGTTCAGGAAATTCTGG ACTCCCTTGGGGCTTGCAAAACTCCCTATGTCTTGCAGACCAAAAGCAAGTTCTCAGTCACCTAGCTCTAGTTTGCATAATTAAAGAAAG TGGAAGCTGGTTCTTTTCTGGGTGACCCTTCACCCAACCAAGCTCATAAGGACTTGTGACAAAAATAAGAGCAATAAAATGAAGTTTTAA CAGTGAAAACTTCTATCACTTAGATAAGCAGGAAAAGCCAGTCCCCTAGATGCCCATCTGACCCTACCTTACTGGGGTCATACAGCCAAA GCAGTGTCCACTTCAGGTACTGTAATGTTTTGAAGTTGACACATATAATTTAATGTAGTTTCATGTCATAAGTTATAAGACTTTTCAGAG AAACAATTTAGTAATATCTTCTGTAATACCCATCTTCATTTTTTATATGAAAAAGCATAGCCTATGATCTGTCACCTTGCTCACTCCCAC ATCCTTACCTCTTATCCTTCTCACATCGTCCCATTAACACATTATCCATCTTTGGGGGGAAAAAATACACTAAATTTTAGACAGAGTCAC TTTCACTATGGCCACAATGGGAGAAAAGACAGTCCACCTTCAAAGTCAACCAGAATGACTCTTAACCTCTCTTGTCTGGGTTGGGCATCC AGATAAGATTTTCTTCGTACAAAGAGTCTTGCTACTAGGAAAAAGAGTTTGAAAATCACTAGTCTAACTAAATATCTCACTTTAAAAAAA GCACAAACTAAGACTCAATGAGGTTTATCTTCCACAAGATCAGCCAGTTTTAGCAGAGCAGTTGCTAAAACCCAGGTCTCAAACTCCTTG TCTATGGCTCATCTAACTAAGCAACAAAAAGCCCAATGAGCTCTGGAGAGAGAGAGGGAGCTAAAACAGGACTCAATCAAAACCCACTTG GGATTAGGGAAGCCACCCTCTGTGAGTGAGTTAAACTGAGATTCCCTCCCCTTCACCCTGGCTTCCTTTGCAGAACAAGGGTCACCGCCA GAGGGAAAGCTGAGTTTACGGAGGGGATCCTGGTTGGAGTCAGAGTATACCTTGGTTTGGTTTTGTGGGGTTTTTTGAGACAGGGTCTCA CTGTCACCCAGGCTGGAGCACAGTGACAGTCATAGCTCACTATAGCCTCAGACTCCTGGCCTCAAGCGATCCTCCCACCTCAACCTCCAG AGTATCTGGGACTATAGGCACGTACCACCATACCCAGCTAATATTTTTTTTAATTTTATATTTTTTAGAGACAGGGTGTCACTATGTTAC CCAGGTCTCAATCACTATGTTACTCCTTGCCTCAAGCAATCCTCTCACCTTGGCCTCCCAAAGTGCTGAGCTTACAGGTGTCAACCACTG TGGCCAGCCACGCATTGGTTTTAAGGTCCAGAATTTTTCTGTTTGGAGCCTTCACAATTAGTTTTAGGTTGGGAGACCGTGAACCCACCA AGCAGCCCTTTAGAGGCTGGAAAAAGAGTTTGGAAAAAGAACTCTGTGGCTTTAGGAATTTCTCTCGGAAATCCTCTAGGGCAGAGAAGG AAAATTTACCAAATGGGAGAGTGTATTAGTCTATTCTTACATTGCTATAAGGAAATACCCCAGACTGGGTAATTTATAAAGGAAAGAGTT TTAATTGACTCACAGTTCCACATGGCTGGGAAAGCCTCAGGAAACTTACAATCATAGCAGAAGGCAAAGGGGAAGAAAGGCACCTTCTTC ACAGGGCGGCAGGAAGGAGAAGTGCAGAGCAAAGTGGGGCAAAGCCTCTATAAAGCCATCAGATCTCATGAGAACTCACTATCATGAGAA CAGCAGGGGAGAACCACCCCCATGATCCAATCACCTTCCACGAGGTCCCTCCCCCAACACGTGGGGATCACAATTTGGATTACAATTCAA GATGAGATTTGGGTGAGGACACAGAGCCGGACCATATCAGAGAGAAAGCTATTACTGAAGACCTTTCTAACTCACTTCTGTAAAGATCAA TTCAATAAAAGCAGCAAACACACATACTTTGCTTTCCTTGTGATTAATGCCTTGACTTTTTTGTGGAAAGTAACACCCCAAGAAAGCCAG CTACTCATGTTGGCAATAAAGGTAAAAGTATCTATGGAATAAGGACCATTTTTAGGACAATACTTTCCCTACTACTTAGTTCTAGTCCCT TTTTTGTAGAATTCTGAGGACTTTCTACATACACAATCATGTCATCAGCAAATAAAGATTATTGTACTTGTTCTTTGCCAACCCATATGT CTTGCCTTACTGCCCTGGTTAGGACCTTCAGAACAATACTGGATATAAGTGGTGAAAGCACATATCCTCCCCTTGTTCCTAATTTTAGAG GGAAAGTACTCAGTCTTTCGCCATTAAGTACAATGTCAGCTGTAAGTTTTCCTAGAGACCCTTTCTCAGCTTGAAGATGTTCCCTGGTAT TCATAGTTTGCTAAAAGGTTTTTGTCATTTTAAATCATAAATGGGTGTTGAATTTTGTCAAAGGCTTTTAATGCATCTATGGAGATGATC CAAGTTTTTTTCCTCCTTATTTCTGCTAAGGTTGTATAATTATGCTCATTGGTATTTTAAATGTTAAATTAACCTTGCGTTCCTGGGATA AGACCCACTGATCATGATGCATTTTCCTCTTTGTAAATTGCTGTATTCATTTTAGTTTCTTCAGGATTTTGCCTATGTTTGAAGGATATT |
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FusionGenePPI for ADCY2_RPAP2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ADCY2 | ADCY5, GNAS | RPAP2 | G3BP1, URI1, RPAP3, KHDRBS2, PIH1D1, POLR2A, POLR2B, POLR2H, RUVBL2, GPN1, POLR2J, POLR3A, POLR2G, PDRG1, MED17, INTS1, CCT5, PPP1CA, TCP1, INTS7, UXT, POLR3B, KHDRBS3, INTS4, GPN3, INTS3, MED4, GTF3C3, YBX1, EIF4A2, POLR2C, EHBP1, POLR3E, HELLS, LRCH2, RXRG, NELFE, PRPF31, DNM2, MED24, TOPBP1, ARMCX3, POLR2D, RFC4, BRCA1, ITCH, NEDD4, RPRD1B, PPP1CC, POLR2M, DXO, MED19, OFD1, CEP120, FGFR1OP, CNTRL, XPO1, POLR2F, WWP2, LMO2, ASB6, POLR2E, CPNE2, MED1, ZFC3H1, SYDE1, MED18, MED21, RNGTT, ZNHIT2, WDR92 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 905_922 | 369 | 1092 | GNAS |
Hgene | ADCY2 | chr5:7698487 | chr1:92846281 | ENST00000338316 | + | 7 | 25 | 990_993 | 369 | 1092 | GNAS |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ADCY2_RPAP2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | ADCY2 | Q08462 | DB09121 | Aurothioglucose | Adenylate cyclase type 2 | small molecule | approved|withdrawn |
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RelatedDiseases for ADCY2_RPAP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ADCY2 | C0004096 | Asthma | 1 | CTD_human |
Hgene | ADCY2 | C0005586 | Bipolar Disorder | 1 | PSYGENET |