|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 8249 |
FusionGeneSummary for CPM_CCT2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CPM_CCT2 | Fusion gene ID: 8249 | Hgene | Tgene | Gene symbol | CPM | CCT2 | Gene ID | 1368 | 10576 |
| Gene name | carboxypeptidase M | chaperonin containing TCP1 subunit 2 | |
| Synonyms | - | 99D8.1|CCT-beta|CCTB|HEL-S-100n|PRO1633|TCP-1-beta | |
| Cytomap | 12q15 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | carboxypeptidase Mrenal carboxypeptidaseurinary carboxypeptidase B | T-complex protein 1 subunit betaT-complex protein 1, beta subunitchaperonin containing TCP1, subunit 2 (beta)chaperonin containing t-complex polypeptide 1, beta subunitchaperonin containing t-complex polypeptide 1, subunit 2epididymis secretory sperm | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P14384 | P78371 | |
| Ensembl transtripts involved in fusion gene | ENST00000546373, ENST00000551568, ENST00000338356, ENST00000549691, | ENST00000299300, ENST00000544368, ENST00000543146, | |
| Fusion gene scores | * DoF score | 12 X 5 X 6=360 | 10 X 8 X 5=400 |
| # samples | 12 | 10 | |
| ** MAII score | log2(12/360*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/400*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CPM [Title/Abstract] AND CCT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A1KU-01A | CPM | chr12 | 69279572 | - | CCT2 | chr12 | 69986756 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000546373 | ENST00000299300 | CPM | chr12 | 69279572 | - | CCT2 | chr12 | 69986756 | + |
| Frame-shift | ENST00000546373 | ENST00000544368 | CPM | chr12 | 69279572 | - | CCT2 | chr12 | 69986756 | + |
| Frame-shift | ENST00000546373 | ENST00000543146 | CPM | chr12 | 69279572 | - | CCT2 | chr12 | 69986756 | + |
| Frame-shift | ENST00000551568 | ENST00000299300 | CPM | chr12 | 69279572 | - | CCT2 | chr12 | 69986756 | + |
| Frame-shift | ENST00000551568 | ENST00000544368 | CPM | chr12 | 69279572 | - | CCT2 | chr12 | 69986756 | + |
| Frame-shift | ENST00000551568 | ENST00000543146 | CPM | chr12 | 69279572 | - | CCT2 | chr12 | 69986756 | + |
| In-frame | ENST00000338356 | ENST00000299300 | CPM | chr12 | 69279572 | - | CCT2 | chr12 | 69986756 | + |
| In-frame | ENST00000338356 | ENST00000544368 | CPM | chr12 | 69279572 | - | CCT2 | chr12 | 69986756 | + |
| In-frame | ENST00000338356 | ENST00000543146 | CPM | chr12 | 69279572 | - | CCT2 | chr12 | 69986756 | + |
| intron-3CDS | ENST00000549691 | ENST00000299300 | CPM | chr12 | 69279572 | - | CCT2 | chr12 | 69986756 | + |
| intron-3CDS | ENST00000549691 | ENST00000544368 | CPM | chr12 | 69279572 | - | CCT2 | chr12 | 69986756 | + |
| intron-3CDS | ENST00000549691 | ENST00000543146 | CPM | chr12 | 69279572 | - | CCT2 | chr12 | 69986756 | + |
Top |
FusionProtFeatures for CPM_CCT2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CPM | CCT2 |
| Specifically removes C-terminal basic residues (Arg orLys) from peptides and proteins. It is believed to play importantroles in the control of peptide hormone and growth factor activityat the cell surface, and in the membrane-localized degradation ofextracellular proteins. {ECO:0000269|PubMed:12457462}. | Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CPM_CCT2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CPM_ENST00000338356_chr12_69279572_-_CCT2_ENST00000299300_chr12_69986756_+_372aa MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDEIFGS RVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVKLG SCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQLANRTPGKEAV AMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGNTTAGLDMREGTIGDMAILGITESFQVKRQVLLSAAEAAEVILRVDNIIKAA >In-frame_CPM_ENST00000338356_chr12_69279572_-_CCT2_ENST00000544368_chr12_69986756_+_367aa MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDEIFGS RVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVKLG SCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQLANRTPGKEAV AMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGNTTAGLGNVSLITTPVKHSHVLSIFGPVSSKVVFERYSIKEDCGICLSVPII >In-frame_CPM_ENST00000338356_chr12_69279572_-_CCT2_ENST00000543146_chr12_69986756_+_372aa MDFPCLWLGLLLPLVAALDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFKYVANMHGDEIFGS RVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVKLG SCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQLANRTPGKEAV AMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGNTTAGLDMREGTIGDMAILGITESFQVKRQVLLSAAEAAEVILRVDNIIKAA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CPM_ENST00000338356_chr12_69279572_-_CCT2_ENST00000299300_chr12_69986756_+_1116nt ATGGACTTCCCGTGCCTCTGGCTAGGGCTGTTGCTGCCTTTGGTAGCTGCGCTGGATTTCAACTACCACCGCCAGGAAGGGATGGAAGCG TTTTTGAAGACTGTTGCCCAAAACTACAGTTCTGTCACTCACTTACACAGTATTGGGAAATCTGTGAAAGGTAGAAACCTGTGGGTTCTT GTTGTGGGGCGGTTTCCAAAGGAACACAGAATTGGGATTCCAGAGTTCAAATACGTGGCAAATATGCATGGAGATGAGATATTTGGTTCC CGGGTAAGAGTTGACTCTACAGCAAAGGTTGCAGAAATAGAACATGCGGAAAAGGAAAAAATGAAGGAGAAAGTTGAACGTATTCTTAAG CATGGAATAAATTGCTTTATTAACAGGCAATTAATTTATAATTATCCTGAACAGCTCTTTGGTGCTGCTGGTGTCATGGCTATTGAGCAT GCAGATTTTGCAGGTGTGGAACGCCTAGCTCTTGTCACAGGTGGTGAAATTGCCTCTACCTTTGATCACCCAGAACTGGTGAAGCTTGGA AGTTGCAAACTTATCGAGGAAGTCATGATTGGAGAAGACAAACTCATTCACTTTTCTGGGGTTGCCCTTGGTGAGGCTTGTACCATTGTT TTGCGTGGTGCCACTCAACAAATTTTAGATGAAGCAGAAAGATCATTGCATGATGCTCTTTGTGTTCTTGCGCAAACTGTAAAGGACTCT AGAACAGTTTATGGAGGAGGCTGTTCTGAGATGTTGATGGCTCATGCTGTGACACAGCTTGCCAATAGAACACCAGGCAAAGAAGCTGTT GCAATGGAGTCTTATGCTAAAGCACTGAGAATGTTGCCAACCATCATAGCTGACAATGCAGGCTATGACAGTGCAGACCTGGTGGCACAG CTCAGGGCTGCTCACAGTGAAGGCAATACCACTGCTGGATTGGATATGAGGGAAGGCACCATTGGAGATATGGCTATCCTGGGTATAACA GAAAGTTTTCAAGTGAAGCGACAGGTTCTTCTGAGTGCAGCTGAAGCAGCAGAGGTGATTCTGCGTGTGGACAACATCATCAAAGCGGCA >In-frame_CPM_ENST00000338356_chr12_69279572_-_CCT2_ENST00000544368_chr12_69986756_+_1101nt ATGGACTTCCCGTGCCTCTGGCTAGGGCTGTTGCTGCCTTTGGTAGCTGCGCTGGATTTCAACTACCACCGCCAGGAAGGGATGGAAGCG TTTTTGAAGACTGTTGCCCAAAACTACAGTTCTGTCACTCACTTACACAGTATTGGGAAATCTGTGAAAGGTAGAAACCTGTGGGTTCTT GTTGTGGGGCGGTTTCCAAAGGAACACAGAATTGGGATTCCAGAGTTCAAATACGTGGCAAATATGCATGGAGATGAGATATTTGGTTCC CGGGTAAGAGTTGACTCTACAGCAAAGGTTGCAGAAATAGAACATGCGGAAAAGGAAAAAATGAAGGAGAAAGTTGAACGTATTCTTAAG CATGGAATAAATTGCTTTATTAACAGGCAATTAATTTATAATTATCCTGAACAGCTCTTTGGTGCTGCTGGTGTCATGGCTATTGAGCAT GCAGATTTTGCAGGTGTGGAACGCCTAGCTCTTGTCACAGGTGGTGAAATTGCCTCTACCTTTGATCACCCAGAACTGGTGAAGCTTGGA AGTTGCAAACTTATCGAGGAAGTCATGATTGGAGAAGACAAACTCATTCACTTTTCTGGGGTTGCCCTTGGTGAGGCTTGTACCATTGTT TTGCGTGGTGCCACTCAACAAATTTTAGATGAAGCAGAAAGATCATTGCATGATGCTCTTTGTGTTCTTGCGCAAACTGTAAAGGACTCT AGAACAGTTTATGGAGGAGGCTGTTCTGAGATGTTGATGGCTCATGCTGTGACACAGCTTGCCAATAGAACACCAGGCAAAGAAGCTGTT GCAATGGAGTCTTATGCTAAAGCACTGAGAATGTTGCCAACCATCATAGCTGACAATGCAGGCTATGACAGTGCAGACCTGGTGGCACAG CTCAGGGCTGCTCACAGTGAAGGCAATACCACTGCTGGATTGGGAAACGTGTCCCTGATCACCACCCCTGTTAAGCATTCCCACGTGCTG TCGATCTTTGGACCAGTTTCTAGCAAAGTTGTGTTTGAAAGATACTCTATTAAAGAAGACTGTGGAATCTGTTTATCGGTGCCCATTATA >In-frame_CPM_ENST00000338356_chr12_69279572_-_CCT2_ENST00000543146_chr12_69986756_+_1116nt ATGGACTTCCCGTGCCTCTGGCTAGGGCTGTTGCTGCCTTTGGTAGCTGCGCTGGATTTCAACTACCACCGCCAGGAAGGGATGGAAGCG TTTTTGAAGACTGTTGCCCAAAACTACAGTTCTGTCACTCACTTACACAGTATTGGGAAATCTGTGAAAGGTAGAAACCTGTGGGTTCTT GTTGTGGGGCGGTTTCCAAAGGAACACAGAATTGGGATTCCAGAGTTCAAATACGTGGCAAATATGCATGGAGATGAGATATTTGGTTCC CGGGTAAGAGTTGACTCTACAGCAAAGGTTGCAGAAATAGAACATGCGGAAAAGGAAAAAATGAAGGAGAAAGTTGAACGTATTCTTAAG CATGGAATAAATTGCTTTATTAACAGGCAATTAATTTATAATTATCCTGAACAGCTCTTTGGTGCTGCTGGTGTCATGGCTATTGAGCAT GCAGATTTTGCAGGTGTGGAACGCCTAGCTCTTGTCACAGGTGGTGAAATTGCCTCTACCTTTGATCACCCAGAACTGGTGAAGCTTGGA AGTTGCAAACTTATCGAGGAAGTCATGATTGGAGAAGACAAACTCATTCACTTTTCTGGGGTTGCCCTTGGTGAGGCTTGTACCATTGTT TTGCGTGGTGCCACTCAACAAATTTTAGATGAAGCAGAAAGATCATTGCATGATGCTCTTTGTGTTCTTGCGCAAACTGTAAAGGACTCT AGAACAGTTTATGGAGGAGGCTGTTCTGAGATGTTGATGGCTCATGCTGTGACACAGCTTGCCAATAGAACACCAGGCAAAGAAGCTGTT GCAATGGAGTCTTATGCTAAAGCACTGAGAATGTTGCCAACCATCATAGCTGACAATGCAGGCTATGACAGTGCAGACCTGGTGGCACAG CTCAGGGCTGCTCACAGTGAAGGCAATACCACTGCTGGATTGGATATGAGGGAAGGCACCATTGGAGATATGGCTATCCTGGGTATAACA GAAAGTTTTCAAGTGAAGCGACAGGTTCTTCTGAGTGCAGCTGAAGCAGCAGAGGTGATTCTGCGTGTGGACAACATCATCAAAGCGGCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CPM_ENST00000338356_chr12_69279572_-_CCT2_ENST00000299300_chr12_69986756_+_1408nt CCCTCATGTGTTCTCAGGTTCTTCTTATTTTTATTCATCTCTAGAACATGGACTTCCCGTGCCTCTGGCTAGGGCTGTTGCTGCCTTTGG TAGCTGCGCTGGATTTCAACTACCACCGCCAGGAAGGGATGGAAGCGTTTTTGAAGACTGTTGCCCAAAACTACAGTTCTGTCACTCACT TACACAGTATTGGGAAATCTGTGAAAGGTAGAAACCTGTGGGTTCTTGTTGTGGGGCGGTTTCCAAAGGAACACAGAATTGGGATTCCAG AGTTCAAATACGTGGCAAATATGCATGGAGATGAGATATTTGGTTCCCGGGTAAGAGTTGACTCTACAGCAAAGGTTGCAGAAATAGAAC ATGCGGAAAAGGAAAAAATGAAGGAGAAAGTTGAACGTATTCTTAAGCATGGAATAAATTGCTTTATTAACAGGCAATTAATTTATAATT ATCCTGAACAGCTCTTTGGTGCTGCTGGTGTCATGGCTATTGAGCATGCAGATTTTGCAGGTGTGGAACGCCTAGCTCTTGTCACAGGTG GTGAAATTGCCTCTACCTTTGATCACCCAGAACTGGTGAAGCTTGGAAGTTGCAAACTTATCGAGGAAGTCATGATTGGAGAAGACAAAC TCATTCACTTTTCTGGGGTTGCCCTTGGTGAGGCTTGTACCATTGTTTTGCGTGGTGCCACTCAACAAATTTTAGATGAAGCAGAAAGAT CATTGCATGATGCTCTTTGTGTTCTTGCGCAAACTGTAAAGGACTCTAGAACAGTTTATGGAGGAGGCTGTTCTGAGATGTTGATGGCTC ATGCTGTGACACAGCTTGCCAATAGAACACCAGGCAAAGAAGCTGTTGCAATGGAGTCTTATGCTAAAGCACTGAGAATGTTGCCAACCA TCATAGCTGACAATGCAGGCTATGACAGTGCAGACCTGGTGGCACAGCTCAGGGCTGCTCACAGTGAAGGCAATACCACTGCTGGATTGG ATATGAGGGAAGGCACCATTGGAGATATGGCTATCCTGGGTATAACAGAAAGTTTTCAAGTGAAGCGACAGGTTCTTCTGAGTGCAGCTG AAGCAGCAGAGGTGATTCTGCGTGTGGACAACATCATCAAAGCGGCACCCAGGAAACGTGTCCCTGATCACCACCCCTGTTAAGCATTCC CACGTGCTGTCGATCTTTGGACCAGTTTCTAGCAAAGTTGTGTTTGAAAGATACTCTATTAAAGAAGACTGTGGAATCTGTTTATCGGTG CCCATTATATCCTTAAGTTTGGATATTTAGCTGACCTTCGCTTTAACATAGGTCTAATTTATTTGCCGTGTCATTTTCCATACAAATCAG >In-frame_CPM_ENST00000338356_chr12_69279572_-_CCT2_ENST00000544368_chr12_69986756_+_1221nt CCCTCATGTGTTCTCAGGTTCTTCTTATTTTTATTCATCTCTAGAACATGGACTTCCCGTGCCTCTGGCTAGGGCTGTTGCTGCCTTTGG TAGCTGCGCTGGATTTCAACTACCACCGCCAGGAAGGGATGGAAGCGTTTTTGAAGACTGTTGCCCAAAACTACAGTTCTGTCACTCACT TACACAGTATTGGGAAATCTGTGAAAGGTAGAAACCTGTGGGTTCTTGTTGTGGGGCGGTTTCCAAAGGAACACAGAATTGGGATTCCAG AGTTCAAATACGTGGCAAATATGCATGGAGATGAGATATTTGGTTCCCGGGTAAGAGTTGACTCTACAGCAAAGGTTGCAGAAATAGAAC ATGCGGAAAAGGAAAAAATGAAGGAGAAAGTTGAACGTATTCTTAAGCATGGAATAAATTGCTTTATTAACAGGCAATTAATTTATAATT ATCCTGAACAGCTCTTTGGTGCTGCTGGTGTCATGGCTATTGAGCATGCAGATTTTGCAGGTGTGGAACGCCTAGCTCTTGTCACAGGTG GTGAAATTGCCTCTACCTTTGATCACCCAGAACTGGTGAAGCTTGGAAGTTGCAAACTTATCGAGGAAGTCATGATTGGAGAAGACAAAC TCATTCACTTTTCTGGGGTTGCCCTTGGTGAGGCTTGTACCATTGTTTTGCGTGGTGCCACTCAACAAATTTTAGATGAAGCAGAAAGAT CATTGCATGATGCTCTTTGTGTTCTTGCGCAAACTGTAAAGGACTCTAGAACAGTTTATGGAGGAGGCTGTTCTGAGATGTTGATGGCTC ATGCTGTGACACAGCTTGCCAATAGAACACCAGGCAAAGAAGCTGTTGCAATGGAGTCTTATGCTAAAGCACTGAGAATGTTGCCAACCA TCATAGCTGACAATGCAGGCTATGACAGTGCAGACCTGGTGGCACAGCTCAGGGCTGCTCACAGTGAAGGCAATACCACTGCTGGATTGG GAAACGTGTCCCTGATCACCACCCCTGTTAAGCATTCCCACGTGCTGTCGATCTTTGGACCAGTTTCTAGCAAAGTTGTGTTTGAAAGAT ACTCTATTAAAGAAGACTGTGGAATCTGTTTATCGGTGCCCATTATATCCTTAAGTTTGGATATTTAGCTGACCTTCGCTTTAACATAGG >In-frame_CPM_ENST00000338356_chr12_69279572_-_CCT2_ENST00000543146_chr12_69986756_+_1403nt CCCTCATGTGTTCTCAGGTTCTTCTTATTTTTATTCATCTCTAGAACATGGACTTCCCGTGCCTCTGGCTAGGGCTGTTGCTGCCTTTGG TAGCTGCGCTGGATTTCAACTACCACCGCCAGGAAGGGATGGAAGCGTTTTTGAAGACTGTTGCCCAAAACTACAGTTCTGTCACTCACT TACACAGTATTGGGAAATCTGTGAAAGGTAGAAACCTGTGGGTTCTTGTTGTGGGGCGGTTTCCAAAGGAACACAGAATTGGGATTCCAG AGTTCAAATACGTGGCAAATATGCATGGAGATGAGATATTTGGTTCCCGGGTAAGAGTTGACTCTACAGCAAAGGTTGCAGAAATAGAAC ATGCGGAAAAGGAAAAAATGAAGGAGAAAGTTGAACGTATTCTTAAGCATGGAATAAATTGCTTTATTAACAGGCAATTAATTTATAATT ATCCTGAACAGCTCTTTGGTGCTGCTGGTGTCATGGCTATTGAGCATGCAGATTTTGCAGGTGTGGAACGCCTAGCTCTTGTCACAGGTG GTGAAATTGCCTCTACCTTTGATCACCCAGAACTGGTGAAGCTTGGAAGTTGCAAACTTATCGAGGAAGTCATGATTGGAGAAGACAAAC TCATTCACTTTTCTGGGGTTGCCCTTGGTGAGGCTTGTACCATTGTTTTGCGTGGTGCCACTCAACAAATTTTAGATGAAGCAGAAAGAT CATTGCATGATGCTCTTTGTGTTCTTGCGCAAACTGTAAAGGACTCTAGAACAGTTTATGGAGGAGGCTGTTCTGAGATGTTGATGGCTC ATGCTGTGACACAGCTTGCCAATAGAACACCAGGCAAAGAAGCTGTTGCAATGGAGTCTTATGCTAAAGCACTGAGAATGTTGCCAACCA TCATAGCTGACAATGCAGGCTATGACAGTGCAGACCTGGTGGCACAGCTCAGGGCTGCTCACAGTGAAGGCAATACCACTGCTGGATTGG ATATGAGGGAAGGCACCATTGGAGATATGGCTATCCTGGGTATAACAGAAAGTTTTCAAGTGAAGCGACAGGTTCTTCTGAGTGCAGCTG AAGCAGCAGAGGTGATTCTGCGTGTGGACAACATCATCAAAGCGGCACCCAGGAAACGTGTCCCTGATCACCACCCCTGTTAAGCATTCC CACGTGCTGTCGATCTTTGGACCAGTTTCTAGCAAAGTTGTGTTTGAAAGATACTCTATTAAAGAAGACTGTGGAATCTGTTTATCGGTG CCCATTATATCCTTAAGTTTGGATATTTAGCTGACCTTCGCTTTAACATAGGTCTAATTTATTTGCCGTGTCATTTTCCATACAAATCAG |
Top |
FusionGenePPI for CPM_CCT2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CPM | ELAVL1, CAPZA2, DBN1, FLNA, GAK, MYH9, PPP1CC, RAB7A, PDLIM7, ATP6AP2, SYNPO, MAPRE1, GOLT1B, LIMA1, ANLN, MYO19, ZSCAN12, ULBP1, FTH1, TBC1D22B, GTPBP3 | CCT2 | ACTB, PPP4C, CTTNBP2, MOB4, PPP2CA, STK24, STRN, STRN3, PPP2CB, PPP2R2C, IGBP1, TCP1, CCNE1, MEPCE, CDK7, RFWD2, ATG16L1, MLST8, MYC, PPP2R2A, PPP2R2B, PPP2R2D, PPP2R4, HDAC5, PSMA3, FBXW8, PCK1, VHL, RAD21, VAV2, FCHSD2, SIRT7, TCF3, ISG15, CUL3, CDK2, CUL1, COPS5, LRRK1, GRB2, SHC1, PACRG, PARK2, GPR37, CCT4, CCT5, CCT3, CCT8, CCT6A, CCT7, CCT6B, SF3B3, PRKCDBP, SSR1, NSFL1C, TRIM28, GSPT2, TXNL1, GSPT1, SMURF1, TUBB, ACTA1, TUBA1B, EEF2, RPS3, HSP90B1, ERLIN2, VCP, PSMD2, XIAP, CASP7, HSP90AB1, PSMC6, HSP90AA1, PPP1CC, FN1, VCAM1, ATF2, PEX14, NOS2, CAMKMT, FAM86B2, METTL18, METTL21B, ITGA4, PAN2, NPM1, HDAC3, FBXW4, FBXO6, PRPF40A, EEF1D, IQGAP1, PSMB8, VRK2, WWOX, CDK5, ILK, UBC, STAU1, CDC20, LGALS3BP, NEDD1, TP53, TUBG1, HUWE1, FUS, SSSCA1, NXF1, CUL7, OBSL1, CCDC8, BUB1B, IKBKE, IRAK1, JAK3, MAPK8, TSSK6, TYK2, WDR76, ESR1, POC1A, FYCO1, LFNG, ENDOV, C11orf54, WDR83, BUB3, DCAF5, PEX7, MAPK10, TUBB2A, TUBB2B, ACTR1B, SEC31B, TUBAL3, ACTL6A, TTLL3, TUBA3E, WRAP73, ATP6V1B1, CDK15, RPS6KB2, DCAF7, AMBRA1, CYB5B, DNAJA1, DNAJA4, GTF2I, HSPA4, HSPH1, PSMC2, HSPE1, KPNA4, NTRK1, KRAS, BTRC, B9D1, MKS1, CETN2, POC1B, AHSA1, DDB2, HDAC1, PDK3, NSMAF, NIPSNAP1, PRPF4, ACTR2, PLK4, WRAP53, RFWD3, KIF21A, TUBA1C, ARMC6, GAN, CRY2, ALKBH3, MCM2, SNW1, CDC5L, U2AF2, TTC27, NLE1, CDC73, WWP2, FLCN, PPM1J, DNAI2, DCAF11, KLHL33, HCFC2, KLHDC8A, P4HA2, RAP2C, WDR86, WDR77, TXNDC9, THOC3, KDM4B, TBL1Y, DCAF10, DCAF8, KLHDC2, HDAC11, TUBG2, WDR34, WDTC1, GNB2, PDDC1, TSSC1, GANAB, TTLL9, ACTBL2, ODF1, WDR5B, KBTBD4, CDK10, CDK11A, ACTR3B, ACTR3, GNB5, STRADB, SMOX, ANGPTL7, MAPK15, PLB1, LCMT2, PNPLA5, THBS3, DCAF4, WDR37, TRMT12, TUBA3C, LRRC10, CELA1, KLHL34, PNPLA1, CYLD, WDR92, DLD, DLST, DNM1L, HSD17B10, PDHA1, SDHA, SOD1, BRCA1, YAP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CPM_CCT2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CPM_CCT2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CPM | C0014175 | Endometriosis | 1 | CTD_human |
| Hgene | CPM | C0037116 | Silicosis | 1 | CTD_human |
| Tgene | CCT2 | C0029456 | Osteoporosis | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|