![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 8244 |
FusionGeneSummary for CPLX1_GAK |
![]() |
Fusion gene information | Fusion gene name: CPLX1_GAK | Fusion gene ID: 8244 | Hgene | Tgene | Gene symbol | CPLX1 | GAK | Gene ID | 10815 | 2580 |
Gene name | complexin 1 | cyclin G associated kinase | |
Synonyms | CPX-I|CPX1|EIEE63 | DNAJ26|DNAJC26 | |
Cytomap | 4p16.3 | 4p16.3 | |
Type of gene | protein-coding | protein-coding | |
Description | complexin-1CPX Icomplexin Isynaphin 2 | cyclin-G-associated kinaseauxilin-2 | |
Modification date | 20180525 | 20180523 | |
UniProtAcc | O14810 | O14976 | |
Ensembl transtripts involved in fusion gene | ENST00000304062, ENST00000505203, | ENST00000314167, ENST00000511163, ENST00000509566, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 5 X 4=80 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/80*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CPLX1 [Title/Abstract] AND GAK [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | GAK | GO:0010977 | negative regulation of neuron projection development | 24510904 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LGG | TCGA-S9-A6WE-01A | CPLX1 | chr4 | 818280 | - | GAK | chr4 | 845762 | - |
TCGA | LD | LGG | TCGA-S9-A6WE-01A | CPLX1 | chr4 | 818280 | - | GAK | chr4 | 844872 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000304062 | ENST00000314167 | CPLX1 | chr4 | 818280 | - | GAK | chr4 | 845762 | - |
Frame-shift | ENST00000304062 | ENST00000511163 | CPLX1 | chr4 | 818280 | - | GAK | chr4 | 845762 | - |
5CDS-5UTR | ENST00000304062 | ENST00000509566 | CPLX1 | chr4 | 818280 | - | GAK | chr4 | 845762 | - |
Frame-shift | ENST00000505203 | ENST00000314167 | CPLX1 | chr4 | 818280 | - | GAK | chr4 | 845762 | - |
Frame-shift | ENST00000505203 | ENST00000511163 | CPLX1 | chr4 | 818280 | - | GAK | chr4 | 845762 | - |
5CDS-5UTR | ENST00000505203 | ENST00000509566 | CPLX1 | chr4 | 818280 | - | GAK | chr4 | 845762 | - |
Frame-shift | ENST00000304062 | ENST00000314167 | CPLX1 | chr4 | 818280 | - | GAK | chr4 | 844872 | - |
Frame-shift | ENST00000304062 | ENST00000511163 | CPLX1 | chr4 | 818280 | - | GAK | chr4 | 844872 | - |
5CDS-5UTR | ENST00000304062 | ENST00000509566 | CPLX1 | chr4 | 818280 | - | GAK | chr4 | 844872 | - |
Frame-shift | ENST00000505203 | ENST00000314167 | CPLX1 | chr4 | 818280 | - | GAK | chr4 | 844872 | - |
Frame-shift | ENST00000505203 | ENST00000511163 | CPLX1 | chr4 | 818280 | - | GAK | chr4 | 844872 | - |
5CDS-5UTR | ENST00000505203 | ENST00000509566 | CPLX1 | chr4 | 818280 | - | GAK | chr4 | 844872 | - |
Top |
FusionProtFeatures for CPLX1_GAK |
![]() |
Hgene | Tgene |
CPLX1 | GAK |
Positively regulates a late step in exocytosis ofvarious cytoplasmic vesicles, such as synaptic vesicles and othersecretory vesicles (PubMed:21785414). Organizes the SNAREs into across-linked zigzag topology that, when interposed between thevesicle and plasma membranes, is incompatible with fusion, therebypreventing SNAREs from releasing neurotransmitters until an actionpotential arrives at the synapse (PubMed:21785414). Also involvedin glucose-induced secretion of insulin by pancreatic beta-cells.Essential for motor behavior. {ECO:0000250|UniProtKB:P63040,ECO:0000269|PubMed:21785414}. | Associates with cyclin G and CDK5. Seems to act as anauxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expressionoscillates slightly during the cell cycle, peaking at G1.{ECO:0000269|PubMed:10625686}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CPLX1_GAK |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CPLX1_GAK |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CPLX1 | STX1A, SNAP25, VAMP2, FLNA, KHSRP, PPIA, SEC24C, STAM, GGA2, TACC3, DPY30, GLO1, NDRG3, PFDN5, S100A9, SGTA, UBE2V2, UBE2B, PSMD9, SNRPA, PSMD2, POMP, TAGLN2, RNF114, TRIP6, HBS1L, HN1, NEDD8, NENF, NUBP2, GINS3, IQCB1, AGTRAP, CMTM5, CPLX2, VAMP3, GYPB | GAK | USO1, AXIN1, CDK5, CCNG1, ALK, ATP13A2, APP, LGR4, DMWD, STAMBP, NTRK1, PPM1B, AP2A1, AP2A2, AP2B1, CALM1, CALML3, CAPZB, AP2M1, CLTA, CLTB, CLTC, CPM, DAB2, DBN1, EPS15, PHKG2, PICALM, SEC16A, GTSE1, GOLGB1, HIP1, MYO1C, MYO6, PIK3C2A, PSMA5, SEC13, SP1, SPTAN1, CLTCL1, NUMB, TNK1, HIP1R, XPR1, SEC24C, CLINT1, FEM1B, TNK2, RBM14, KIF3A, SYNPO, CEP162, AAK1, EDRF1, PHGDH, CHMP4A, LIMA1, PLXNA3, BMP2K, KIDINS220, STAMBPL1, DENND1A, AFAP1, ZNF106, INF2, WNK1, CPSF7, PUS7L, PARP10, STON2, MISP, ACTRT1, FAM83B, FAM83H, FBXW7, GPX7, HSPA8, RABGEF1, HSPBP1, C5AR2, IARS2, CBLC, CLASRP, MPP5, FAM174A, TRIM25 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CPLX1_GAK |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CPLX1_GAK |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CPLX1 | C0005586 | Bipolar Disorder | 1 | CTD_human |
Hgene | CPLX1 | C0011570 | Mental Depression | 1 | PSYGENET |
Hgene | CPLX1 | C0011581 | Depressive disorder | 1 | PSYGENET |
Hgene | CPLX1 | C0033975 | Psychotic Disorders | 1 | CTD_human |
Hgene | CPLX1 | C0036341 | Schizophrenia | 1 | CTD_human |
Tgene | GAK | C0030567 | Parkinson Disease | 1 | CTD_human |