|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 8232 |
FusionGeneSummary for CPEB3_LY86-AS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CPEB3_LY86-AS1 | Fusion gene ID: 8232 | Hgene | Tgene | Gene symbol | CPEB3 | LY86-AS1 | Gene ID | 22849 | 285780 |
| Gene name | cytoplasmic polyadenylation element binding protein 3 | LY86 antisense RNA 1 | |
| Synonyms | - | LY86-AS|LY86AS | |
| Cytomap | 10q23.32 | 6p25.1 | |
| Type of gene | protein-coding | ncRNA | |
| Description | cytoplasmic polyadenylation element-binding protein 3CPE-BP3CPE-binding protein 3hCPEB-3 | LY86 antisense RNA (non-protein coding)LY86 antisense RNA 1 (non-protein coding) | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | Q8NE35 | ||
| Ensembl transtripts involved in fusion gene | ENST00000412050, ENST00000265997, | ENST00000429345, ENST00000435641, ENST00000447858, ENST00000606992, ENST00000607278, ENST00000606044, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CPEB3 [Title/Abstract] AND LY86-AS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CPEB3 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 20639532 |
| Hgene | CPEB3 | GO:0017148 | negative regulation of translation | 21336257|22711986 |
| Hgene | CPEB3 | GO:0060213 | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening | 21336257 |
| Hgene | CPEB3 | GO:0061158 | 3'-UTR-mediated mRNA destabilization | 21336257 |
| Hgene | CPEB3 | GO:0071230 | cellular response to amino acid stimulus | 20639532|22730302 |
| Hgene | CPEB3 | GO:1900153 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 21336257 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE837631 | CPEB3 | chr10 | 93870322 | - | LY86-AS1 | chr6 | 6491981 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000412050 | ENST00000429345 | CPEB3 | chr10 | 93870322 | - | LY86-AS1 | chr6 | 6491981 | - |
| intron-intron | ENST00000412050 | ENST00000435641 | CPEB3 | chr10 | 93870322 | - | LY86-AS1 | chr6 | 6491981 | - |
| intron-intron | ENST00000412050 | ENST00000447858 | CPEB3 | chr10 | 93870322 | - | LY86-AS1 | chr6 | 6491981 | - |
| intron-intron | ENST00000412050 | ENST00000606992 | CPEB3 | chr10 | 93870322 | - | LY86-AS1 | chr6 | 6491981 | - |
| intron-intron | ENST00000412050 | ENST00000607278 | CPEB3 | chr10 | 93870322 | - | LY86-AS1 | chr6 | 6491981 | - |
| intron-intron | ENST00000412050 | ENST00000606044 | CPEB3 | chr10 | 93870322 | - | LY86-AS1 | chr6 | 6491981 | - |
| intron-intron | ENST00000265997 | ENST00000429345 | CPEB3 | chr10 | 93870322 | - | LY86-AS1 | chr6 | 6491981 | - |
| intron-intron | ENST00000265997 | ENST00000435641 | CPEB3 | chr10 | 93870322 | - | LY86-AS1 | chr6 | 6491981 | - |
| intron-intron | ENST00000265997 | ENST00000447858 | CPEB3 | chr10 | 93870322 | - | LY86-AS1 | chr6 | 6491981 | - |
| intron-intron | ENST00000265997 | ENST00000606992 | CPEB3 | chr10 | 93870322 | - | LY86-AS1 | chr6 | 6491981 | - |
| intron-intron | ENST00000265997 | ENST00000607278 | CPEB3 | chr10 | 93870322 | - | LY86-AS1 | chr6 | 6491981 | - |
| intron-intron | ENST00000265997 | ENST00000606044 | CPEB3 | chr10 | 93870322 | - | LY86-AS1 | chr6 | 6491981 | - |
Top |
FusionProtFeatures for CPEB3_LY86-AS1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CPEB3 | LY86-AS1 |
| Sequence-specific RNA-binding protein which acts as atranslational repressor in the basal unstimulated state but,following neuronal stimulation, acts as a translational activator(By similarity). In contrast to CPEB1, does not bind to thecytoplasmic polyadenylation element (CPE), a uridine-rich sequenceelement within the mRNA 3'-UTR, but binds to a U-rich loop withina stem-loop structure (By similarity). Required for theconsolidation and maintenance of hippocampal-based long termmemory (By similarity). In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negativelyregulates their translation (By similarity). Also represses thetranslation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity).When activated, acts as a translational activator of GRIA1 andGRIA2 (By similarity). In the basal state, suppresses SUMO2translation but activates it following neuronal stimulation (Bysimilarity). Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1translation which is required to maintain normal thermoception (Bysimilarity). Binds actin mRNA, leading to actin translationalrepression in the basal state and to translational activationfollowing neuronal stimulation (By similarity). Negativelyregulates target mRNA levels by binding to TOB1 which recruitsCNOT7/CAF1 to a ternary complex and this leads to target mRNAdeadenylation and decay (PubMed:21336257). In addition to its rolein translation, binds to and inhibits the transcriptionalactivation activity of STAT5B without affecting its dimerizationor DNA-binding activity. This, in turn, represses transcription ofthe STAT5B target gene EGFR which has been shown to play a role inenhancing learning and memory performance (PubMed:20639532). Incontrast to CPEB1, CPEB2 and CPEB4, not required for cell cycleprogression (PubMed:26398195). {ECO:0000250|UniProtKB:Q7TN99,ECO:0000269|PubMed:20639532, ECO:0000269|PubMed:21336257,ECO:0000269|PubMed:26398195}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CPEB3_LY86-AS1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CPEB3_LY86-AS1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CPEB3_LY86-AS1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CPEB3_LY86-AS1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|